Erythrocytes from GGTA1/CMAH knockout pigs: Implications for xenotransfusion and testing in non-human primates

Xenotransplantation

Volumn 21, Issue 4, 2014, Pages 376-384

  Wang, Zheng Yu ^a   Burlak, Christopher ^a   Estrada, Jose L ^a   Li, Ping ^a   Tector, Matthew F ^a   Tector, A Joseph ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

erythrocyte; Neu5Gc; xenoantigen; xenotransfusion

Indexed keywords

GALACTOSYLGALACTOSE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; N GLYCOLOYLNEURAMINIC ACID; NEURAMINIC ACID; ALPHA-1,3-GALACTOSYLTRANSFERASE 1, PORCINE; CMPACETYLNEURAMINATE MONOOXYGENASE; GALACTOSYLTRANSFERASE; HETEROPHILE ANTIBODY; MIXED FUNCTION OXIDASE;

ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BABOON; COMPLEMENT HEMOLYSIS TEST; CONTROLLED STUDY; CYTOTOXICITY; DOMESTIC PIG; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; FLOW CYTOMETRY; GENETIC ENGINEERING; HEMAGGLUTINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TRANSGENIC ANIMAL; XENOTRANSPLANTATION; ADVERSE EFFECTS; ANIMAL; ANIMAL MODEL; BLOOD; DEFICIENCY; ERYTHROCYTE TRANSFUSION; GENE INACTIVATION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; PIG; PRIMATE; PROCEDURES; VETERINARY; XENOGRAFT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, HETEROPHILE; ERYTHROCYTE TRANSFUSION; ERYTHROCYTES; GALACTOSYLTRANSFERASES; GENE KNOCKOUT TECHNIQUES; HUMANS; IMMUNITY, INNATE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MIXED FUNCTION OXYGENASES; MODELS, ANIMAL; PAPIO; PRIMATES; SUS SCROFA; TRANSPLANTATION, HETEROLOGOUS;

EID: 84905722921     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/xen.12106     Document Type: Article

References (24)

1. Cooper DK,. Porcine red blood cells as a source of blood transfusion in humans. Xenotransplantation 2003; 10: 384-386.
2. Roux FA, Sai P, Deschamps JY,. Xenotransfusions, past and present. Xenotransplantation 2007; 14: 208-216.
3. Cooper DK, Hara H, Yazer M,. Genetically engineered pigs as a source for clinical red blood cell transfusion. Clin Lab Med 2010; 30: 365-380.
4. Good AH, Cooper DK, Malcolm AJ, et al. Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant Proc 1992; 24: 559-562.
5. Li P, Estrada JL, Burlak C, Tector AJ,. Biallelic knockout of the alpha-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases. J Surg Res 2013; 181: e39-e45.
6. Zhu A, Hurst R,. Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum. Xenotransplantation 2002; 9: 376-381.
7. Eckermann JM, Buhler LH, Zhu A, et al. Initial investigation of the potential of modified porcine erythrocytes for transfusion in primates. Xenotransplantation 2004; 11: 18-26.
8. Rouhani FJ, Dor FJ, Cooper DK,. Investigation of red blood cells from alpha1,3-galactosyltransferase-knockout pigs for human blood transfusion. Transfusion 2004; 44: 1004-1012.
9. Long C, Hara H, Pawlikowski Z, et al. Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies. Transfusion 2009; 49: 2418-2429.
10. Varki A,. Loss of N-glycolylneuraminic acid in humans: mechanisms, consequences, and implications for hominid evolution. Am J Phys Anthropol 2001; 116 (Suppl. 33): 54-69.
11. Muchmore EA, Diaz S, Varki A,. A structural difference between the cell surfaces of humans and the great apes. Am J Phys Anthropol 1998; 107: 187-198.
12. Zhu A, Hurst R,. Human natural antibodies that recognize nonalphaGal antigens on porcine red blood cells. Transplant Proc 2000; 32: 872-873.
13. Lutz AJ, Li P, Estrada JL, et al. Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose alpha-1,3-Galactose reduce the humoral barrier to xenotransplantation. Xenotransplantation 2013; 20: 27-35.
14. Varki A,. N-glycolylneuraminic acid deficiency in humans. Biochimie 2001; 83: 615-622.
15. Burlak C, Wang ZY, Chihara RK, et al. Identification of human preformed antibody targets in GTKO pigs. Xenotransplantation 2012; 19: 92-101.
16. Tangvoranuntakul P, Gagneux P, Diaz S, et al. Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci USA 2003; 100: 12045-12050.
17. Chen G, Qian H, Starzl T, et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nat Med 2005; 11: 1295-1298.
18. Basnet NB, Ide K, Tahara H, Tanaka Y, Ohdan H,. Deficiency of N-glycolylneuraminic acid and Galalpha1-3Galbeta1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies. Xenotransplantation 2010; 17: 440-448.
19. Brock LG, Delputte PL, Waldman JP, Nauwynck HJ, Rees MA,. Porcine sialoadhesin: a newly identified xenogeneic innate immune receptor. Am J Transplant 2012; 12: 3272-3282.
20. Rees MA, Butler AJ, Brons IG, et al. Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization. Xenotransplantation 2005; 12: 13-19.
21. Hu Z, van Rooijen N, Yang YG,. Macrophages prevent human red blood cell reconstitution in immunodeficient mice. Blood 2011; 118: 5938-5946.
22. Ide K, Ohdan H, Kobayashi T, et al. Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells. Xenotransplantation 2005; 12: 181-188.
23. King M, Pearson T, Shultz LD, et al. A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol 2008; 126: 303-314.
24. Ito M, Hiramatsu H, Kobayashi K, et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 2002; 100: 3175-3182.