The N-terminal domain of the androgen receptor drives its nuclear localization in castration-resistant prostate cancer cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 143, Issue , 2014, Pages 473-480

  Dar, Javid A ^a,d   Masoodi, Khalid Z ^a   Eisermann, Kurtis ^a   Isharwal, Sudhir ^a   Ai, Junkui ^a   Pascal, Laura E ^a   Nelson, Joel B ^a,c   Wang, Zhou ^a,b,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 90; ANDROGEN; AR PROTEIN, HUMAN; NCOA2 PROTEIN, HUMAN; NUCLEAR RECEPTOR COACTIVATOR 2; SMALL INTERFERING RNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CASTRATION RESISTANT PROSTATE CANCER; CELL MIGRATION; CELLULAR DISTRIBUTION; DELETION MUTANT; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LIGAND BINDING; MALE; MUTAGENESIS; NUCLEAR IMPORT; NUCLEAR LOCALIZATION SIGNAL; TRANSACTIVATION; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL NUCLEUS; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; CYTOPLASM; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANDROGENS; ANIMALS; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; NUCLEAR RECEPTOR COACTIVATOR 2; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; RECEPTORS, ANDROGEN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84905712572     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.03.004     Document Type: Article

References (49)

1. M. Welsh et al. Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism J. Clin. Invest. 118 April, 2008 1479
2. J.T. Isaacs, and D.S. Coffey Etiology and disease process of benign prostatic hyperplasia Prostate Suppl. 2 1989 33
3. K.J. O'Malley et al. The expression of androgen-responsive genes is up-regulated in the epithelia of benign prostatic hyperplasia Prostate 69 December 1, 2009 1716
4. J.M. Kozlowski, W.J. Ellis, and J.T. Grayhack Advanced prostatic carcinoma. Early versus late endocrine therapy Urol. Clin. North Am. 18 February, 1991 15
5. A. Jemal, R. Siegel, J. Xu, and E. Ward Cancer statistics, 2010 CA Cancer J. Clin. 60 September-October 2010 277
6. C.D. Chen et al. Molecular determinants of resistance to antiandrogen therapy Nat. Med. 10 January 2004 33
7. O.L. Zegarra-Moro, L.J. Schmidt, H. Huang, and D.J. Tindall Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells Cancer Res. 62 February 15, 2002 1008
8. A.J. Saporita, J. Ai, and Z. Wang The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells Prostate 67 April 1, 2007 509
9. E.L. Yong, F. Ghadessy, Q. Wang, A. Mifsud, and S.C. Ng Androgen receptor transactivation domain and control of spermatogenesis Rev. Reprod. 3 September 1998 141
10. J.A. Simental, M. Sar, M.V. Lane, F.S. French, and E.M. Wilson Transcriptional activation and nuclear targeting signals of the human androgen receptor J. Biol. Chem. 266 January 5, 1991 510
11. G. Jenster et al. Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization Mol. Endocrinol. 5 October 1991 1396
12. G. Jenster et al. Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites Biochemistry 33 November 29, 1994 14064
13. G. Jenster, H.A. van der Korput, J. Trapman, and A.O. Brinkmann Identification of two transcription activation units in the N-terminal domain of the human androgen receptor J. Biol. Chem. 270 March 31, 1995 7341
14. N.L. Chamberlain, D.C. Whitacre, and R.L. Miesfeld Delineation of two distinct type 1 activation functions in the androgen receptor amino-terminal domain J. Biol. Chem. 271 October 25, 1996 26772
15. T. Gao, M. Marcelli, and M.J. McPhaul Transcriptional activation and transient expression of the human androgen receptor J. Steroid Biochem. Mol. Biol. 59 September 1996 9
16. J. Reid, S.M. Kelly, K. Watt, N.C. Price, and I.J. McEwan Conformational analysis of the androgen receptor amino-terminal domain involved in transactivation. Influence of structure-stabilizing solutes and protein-protein interactions J. Biol. Chem. 277 May 31, 2002 20079
17. T. Ylikomi, M.T. Bocquel, M. Berry, H. Gronemeyer, and P. Chambon Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors EMBO J. 11 October 1992 3681
18. N. Kaku, K. Matsuda, A. Tsujimura, and M. Kawata Characterization of nuclear import of the domain-specific androgen receptor in association with the importin alpha/beta and Ran-guanosine 5′-triphosphate systems Endocrinology 149 August 2008 3960
19. A.J. Saporita et al. Identification and characterization of a ligand-regulated nuclear export signal in androgen receptor J. Biol. Chem. 278 October 24, 2003 41998
20. Z.X. Zhou, C.I. Wong, M. Sar, and E.M. Wilson The androgen receptor: an overview Recent Prog. Hormone Res. 49 1994 249
21. E.P. Gelmann Molecular biology of the androgen receptor J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 20 July 1, 2002 3001
22. C.S. Chang, J. Kokontis, and S.T. Liao Molecular cloning of human and rat complementary DNA encoding androgen receptors Science 240 April 15, 1988 324
23. D.B. Lubahn et al. Cloning of human androgen receptor complementary DNA and localization to the X chromosome Science 240 April 15, 1988 327
24. K.J. O'Malley et al. Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance Prostate 72 July 1, 2012 1117
25. J. Ai et al. HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer Mol. Endocrinol. 23 December 2009 1963
26. D.A. Monks et al. Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy Hormones Behav. 53 May 2008 729
27. I. Mazen, S. Lumbroso, S. Abdel Ghaffar, N. Salah, and C. Sultan Mutation of the androgen receptor (R840S) in an Egyptian patient with partial androgen insensitivity syndrome: review of the literature on the clinical expression of different R840 substitutions J. Endocrinol. Invest. 27 January 2004 57
28. C.A. Heinlein, and C. Chang Androgen receptor in prostate cancer Endocrine Rev. 25 April 2004 276
29. W.D. Tilley, G. Buchanan, T.E. Hickey, and J.M. Bentel Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. 2 February 1996 277
30. H. Kawate et al. Impaired nuclear translocation, nuclear matrix targeting, and intranuclear mobility of mutant androgen receptors carrying amino acid substitutions in the deoxyribonucleic acid-binding domain derived from androgen insensitivity syndrome patients J. Clin. Endocrinol. Metab. 90 November 2005 6162
31. M.L. Cutress, H.C. Whitaker, I.G. Mills, M. Stewart, and D.E. Neal Structural basis for the nuclear import of the human androgen receptor J. Cell Sci. 121 April 1, 2008 957
32. S. Zoppi et al. Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance Mol. Endocrinol. 6 March 1992 409
33. L.V. Nazareth et al. A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1) Mol. Endocrinol. 13 December 1999 2065
34. H.C. Wu et al. Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells Int. J. Cancer. (Journal international du cancer) 57 May 1, 1994 406
35. R.K. Tyagi et al. Dynamics of intracellular movement and nucleocytoplasmic recycling of the ligand-activated androgen receptor in living cells Mol. Endocrinol. 14 August 2000 1162
36. A.K. Roy et al. Androgen receptor: structural domains and functional dynamics after ligand-receptor interaction Ann. New York Acad. Sci. 949 December 2001 44
37. M.L. Zhu et al. Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer Cancer Res. 70 October 15, 2010 7992
38. J.A. Dar et al. N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization J. Steroid Biochem. Mol. Biol. October 4, 2013
39. R. Chmelar, G. Buchanan, E.F. Need, W. Tilley, and N.M. Greenberg Androgen receptor coregulators and their involvement in the development and progression of prostate cancer Int. J. Cancer 120 2007 719
40. L. Callewaert, N. Van Tilborgh, and F. Claessens Interplay between two hormone-independent activation domains in the androgen receptor Cancer Res. 66 January 1, 2006 543
41. S.M. Dehm, K.M. Regan, L.J. Schmidt, and D.J. Tindall Selective role of an NH2-terminal WxxLF motif for aberrant androgen receptor activation in androgen depletion independent prostate cancer cells Cancer Res. 67 October 15, 2007 10067
42. G. Han et al. Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer J. Biol. Chem. 276 April 6, 2001 11204
43. G. Han et al. Mutation of the androgen receptor causes oncogenic transformation of the prostate Proc. Natl. Acad. Sci. U.S.A. 102 January 25, 2005 1151
44. R.J. Andersen et al. Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor Cancer Cell 17 June 15, 2010 535
45. S.E. Rundlett, X.P. Wu, and R.L. Miesfeld Functional characterizations of the androgen receptor confirm that the molecular basis of androgen action is transcriptional regulation Mol. Endocrinol. 4 May, 1990 708
46. J.A. Dar et al. N-terminal domain of the androgen receptor contains a region that can promote cytoplasmic localization J. Steroid Biochem. Mol. Biol. 139 January, 2014 16
47. M. Gonit et al. Hormone depletion-insensitivity of prostate cancer cells is supported by the AR without binding to classical response elements Mol. Endocrinol. 25 April, 2011 621
48. E. Metzger, J.M. Muller, S. Ferrari, R. Buettner, and R. Schule A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer EMBO J. 22 January 15, 2003 270
49. Z.X. Zhou, M. Sar, J.A. Simental, M.V. Lane, and E.M. Wilson A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor: Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences J. Biol. Chem. 269 May 6, 1994 13115