Transcriptional activation and transient expression of the human androgen receptor

Journal of Steroid Biochemistry and Molecular Biology

Volumn 59, Issue 1, 1996, Pages 9-20

  Gao, Tianshu ^a   Marcelli, Marco ^b   McPhaul, Michael J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; COMPLEMENTARY DNA; LUCIFERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL LINE; CONTROLLED STUDY; DELETION MUTANT; FIBROBLAST; GENE ACTIVATION; GENE CONSTRUCT; GENE EXPRESSION; GENE TRANSFER; HUMAN; IMMUNOBLOTTING; MONKEY; NONHUMAN; OPEN READING FRAME; RECEPTOR DENSITY; REPORTER GENE;

ANIMALS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; DIHYDROTESTOSTERONE; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, ANDROGEN; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; TESTOSTERONE; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

ANIMALIA; MOUSE MAMMARY TUMOR VIRUS;

EID: 0030236944     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00097-0     Document Type: Article

References (34)

1. 1. Green S. and Chambon P.: Nuclear receptors enhance our understanding of transcription regulation. Trends Genet. 4 (1988) 309-314.
2. 2. Evans R. M.: The steroid and thyroid hormone receptor superfamily. Science 240 (1988) 889-895.
3. 3. Lubahn D. B., Joseph D. R., Sar M., Tan J., Higgs H. N., Larson R. E., French F. S. and Wilson E. M.: The human androgen receptor: complementary deoxyribonucleic acid cloning, sequence analysis and gene expression in prostate. Molec. Endocr. 2 (1988) 1265-1275.
4. 4. Chang C., Kokontis J. and Liao S. T.: Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Proc. Natn. Acad. Sci. U.S.A. 85 (1988) 7211-7215.
5. 5. Trapman J., Klaassen P., Kuiper G. G., van der Korput J. A., Faber P. W., van Rooij H. C., Guerts van Kessel A., Voorhorst M. M., Mulder E. and Brinkmann A. O.: Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem. Biophys. Res. Commun. 153 (1988) 241-248.
6. 6. Tilley W. D., Marcelli M., Wilson J. D. and McPhaul M. J.: Characterization and expression of a cDNA encoding the human androgen receptor. Proc. Natn. Acad. Sci U.S.A. 86 (1989) 327-331.
7. 7. Simental J. A., Sar M., Lane M. V., French F. S. and Wilson E. M.: Transcriptional activation and nuclear targeting signals of the human androgen receptor. J. Biol. Chem. 266 (1991) 510-518.
8. 8. Simental J. A., Zhou Z. X., Vilchis F., Sar M. and Wilson E. M.: A bipartite nuclear targeting signal spanning the DNA binding and hinge regions of the human androgen receptor. Program of the 74th Annual Meeting of The Endocrine Society, Washington, DC. 1991, p. 127 (A301).
9. 9. Jenster G., van der Korput H. A. G. M., van Vroonhoven C., van der Kwast T. H., Trapman J. and Brinkmann A. O.: Domains of the human androgen receptor involved in steroid binding, transcriptional activation, and subcellular localization. Molec. Endocr. 5 (1991) 1396-1404.
10. 10. Giguère V., Hollenberg S. M., Rosenfeld M. G. and Evans R. M.: Functional domains of the human glucocorticoid receptor. Cell 46 (1986) 645-652.
11. 11. Godowski P. J., Rusconi S., Miesfeld R. and Yamamoto K. R.: Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. Nature 325 (1987) 365-368.
12. 12. Webster N. J. G., Green S., Jin J. R. and Chambon P.: The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54 (1988) 199-207.
13. 13. Tora L., White J., Brou C., Tasset D., Webster N., Scheer E. and Chambon P.: The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell 59 (1989) 477-487.
14. 14. Meyer M. E., Pornon A., Ji J. W., Bocquel M. T., Chambon P. and Gronemeyer H.: Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor. EMBO J. 9 (1990) 3923-3932.
15. 15. Gerber H. P., Seipel K., Georgiev O., Höfferer M., Hug M., Rusconi S. and Schaffner W.: Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263 (1994) 808-811.
16. 16. Edwards A., Hammond H. A., Jin L., Caskey C. T. and Chakraborty R.: Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 12 (1992) 241-253.
17. 17. La Spada A. R., Wilson E. M., Lubahn D. B., Harding A. E. and Fischbeck K. H.: Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 352 (1991) 77-79.
18. 18. Matsuura T., Demura T., Aimoto Y., Mizuno T., Moriwaka F. and Tashiro K.: Androgen receptor abnormality in X-linked spinal and bulbar muscular atrophy. Neurology 42 (1992) 1724-1726.
19. 19. Amato A. A., Prior T. W., Barohn R. J., Snyder P., Papp A. and Mendell J. R.: Kennedy's disease: a clinicopathologic correlation with mutations in the androgen receptor gene. Neurology 43 (1993) 791-794.
20. 20. Mhatre A. N., Trifiro M. A., Kaufman M., Kazemi-Esfarjani P., Figlewicz D., Rouleau G. and Pinsky L.: Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Nature Genet. 5 (1993) 184-188.
21. 21. Chamberlain N. L., Driver E. D. and Miesfeld R. L.: The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain effect transactivation function. Nucl. Acids Res. 22 (1994) 3181-3186.
22. 22. Marcelli M., Tilley W. D., Wilson C. M., Griffin J. E., Wilson J. D. and McPhaul M. J.: Definition of the human androgen receptor gene structure permits the identification of mutations that cause androgen resistance: premature termination of the receptor protein at amino acid residue 588 causes complete androgen resistance. Molec. Endocr. 4 (1990) 1105-1116.
23. 23. Krongrad A., Wilson C. M., Wilson J. D., Allman D. R. and McPhaul M. J.: Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells. Molec. Cell. Endocr. 76 (1991) 79-88.
24. 24. McBroom L. D., Flock G. and Giguère V.: The nonconserved hinge region and distinct amino-terminal domains of the RORα orphan nuclear receptor isoforms are required for proper DNA bending and RORα-DNA interactions. Molec. Cell. Biol. 15 (1995) 796-808.
25. 25. Palvimo J. J., Kallio P. J., Ikonen T., Mehto M. and Jänne O. A.: Dominant negative regulation of trans-activation by the rat androgen receptor: roles of the N-terminal domain and heterodimer formation. Molec. Endocr. 7 (1993) 1399-1407.
26. 26. Kuiper G. G. J. M., De Ruiter P. E., Trapman J., Boersma W. J. A., Grootegoed J. A. and Brinkmann A. O.: Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor. Biochem. J. 291 (1993) 95-101.
27. 27. Zhou Z. X., Kemppainen J. A. and Wilson E. M.: Identification of three proline-directed phosphorylation sites in the human androgen receptor. Molec. Endocr. 9 (1995) 605-615.
28. 28. Wilson C. M. and McPhaul M. J.: A and B forms at the androgen receptor are present in human genital skin fibroblasts. Proc. Natn. Acad. Sci. U.S.A. 91 (1994) 1234-1238.
29. 29. Frost E. and Williams J.: Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue. Virology 91 (1978) 39-50.
30. 30. de Wet J. R., Wood K. V., DeLuca M., Helinski D. R. and Subramani S.: Firefly luciferase gene: structure and expression in mammalian cells. Molec. Cell. Biol. 7 (1987) 725-737.
31. 31. McPhaul M. J., Marcelli M., Tilley W. D., Griffin J. E., Isidro-Gutierrez R. F. and Wilson J. D.: Molecular basis of androgen resistance in a family with a qualitative abnormality of the androgen receptor and responsive to high-dose androgen therapy. J. Clin. Invest. 87 (1991) 1413-1421.
32. 32. Husmann D. A., Wilson C. M., McPhaul M. J., Tilley W. D. and Wilson J. D.: Antipeptide antibodies to two distinct regions of the androgen receptor localize the receptor protein to the nuclei of target cells in the rat and human prostate. Endocrinology 126 (1990) 2359-2368.
33. 33. Lowry O. H., Rosebrough N. J., Farr A. L. and Randall R. J.: Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275.
34. 34. Zhou Z. X., Lane M. V., Kemppainen J. A., French F. S. and Wilson E. M.: Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Molec. Endocr. 9 (1995) 208-218.