α2AP mediated myofibroblast formation and the development of renal fibrosis in unilateral ureteral obstruction

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Kanno, Yosuke ^a   Kawashita, Eri ^a   Kokado, Akiko ^a   Kuretake, Hiromi ^a   Ikeda, Kanako ^a   Okada, Kiyotaka ^b   Seishima, Mariko ^c   Ueshima, Shigeru ^b,d   Matsuo, Osamu ^b   Matsuno, Hiroyuki ^a  

^a DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^b KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ANTIPLASMIN; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL DIFFERENTIATION; COMPLICATION; DEFICIENCY; EPITHELIUM CELL; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; KIDNEY FAILURE; KNOCKOUT MOUSE; MALE; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; MYOFIBROBLAST; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; URETER; URETER OBSTRUCTION;

ALPHA-2-ANTIPLASMIN; ANIMALS; ANTHRACENES; CELL DIFFERENTIATION; EPITHELIAL CELLS; FIBROSIS; GENE EXPRESSION REGULATION; KIDNEY; MALE; MAP KINASE KINASE 4; MESENCHYMAL STROMAL CELLS; MICE; MICE, KNOCKOUT; MYOFIBROBLASTS; PRIMARY CELL CULTURE; PROTEIN KINASE INHIBITORS; RENAL INSUFFICIENCY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; URETER; URETERAL OBSTRUCTION;

EID: 84905706959     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05967     Document Type: Article

References (35)

1. Vernon, M. A., Mylonas, K. J. & Hughes, J. Macrophages and renal fibrosis. Semin Nephrol. 30, 302-17 (2010).
2. Kaneto, H., Morrissey, J. & Klahr, S. Increased expression of TGF-beta 1mRNAin the obstructed kidney of rats with unilateral ureteral ligation. Kidney Int. 44, 313-21 (1993). (Pubitemid 23228685)
3. Ueha, S., Shand, F. H. & Matsushima, K. Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis. Front Immunol. 3, 71 (2012).
4. LeBleu, V. S. et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 19, 1047-53 (2013).
5. Collen, D. Identification and some properties of a new fast-reacting plasmin inhibitor in human plasma. Eur J Biochem. 69, 209-216 (1976).
6. Lijnen, H. R. et al. Characterization of the interaction between plasminogen and staphylokinase. Eur J Biochem. 224, 143-149 (1994). (Pubitemid 24267115)
7. Yagame, M. et al. Fibrinolysis in patients with diabetic nephropathy determined by plasmin-alpha 2 plasmin inhibitor complexes in plasma. J Diabet Complications. 4, 175-8 (1990).
8. Ohmoto, K. et al. Clinical significance of thrombin-antithrombin III complex and plasmin-alpha 2 plasmin inhibitor complex in chronic liver diseases. Nihon Shokakibyo Gakkai Zasshi. 87, 1837-45 (1990). (Pubitemid 20304043)
9. Kawakami, M. et al. Elevated plasma levels of alpha 2-plasmin inhibitor-plasmin complex in patients with rheumatic diseases. Possible role of fibrinolytic mechanism in vasculitis. Arthritis Rheum. 32, 1427-33 (1989). (Pubitemid 20003910)
10. Jinnin, M. et al. Plasma plasmin-alpha2-plasmin inhibitor complex levels are increased in systemic sclerosis patients with pulmonary hypertension. Rheumatology (Oxford). 42, 240-3 (2003). (Pubitemid 36305609)
11. Kanno, Y. et al. Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions. J Thromb Haemost. 4, 1602-10 (2006).
12. Kanno, Y. et al. alpha2-Antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis. J Thromb Haemost. 5, 2266-73 (2007). (Pubitemid 47617880)
13. Kanno, Y. et al. alpha2-antiplasmin is associated with the progression of fibrosis. Am J Pathol. 176, 238-45 (2010).
14. Kanno, Y. et al. Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F2α synthesis through adipose triglyceride lipase/calcium-independent phospholipase A2. Arthritis Rheum. 65, 492-502 (2013).
15. Okada, K. et al. Characterization and targeting of the murine alpha2-antiplasmin gene. Thromb Haemost. 78, 1104-10 (1997). (Pubitemid 27417308)
16. Lijnen, H. R. et al. Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 93, 2274-2281 (1999). (Pubitemid 29153630)
17. Miyajima, A. et al. Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney Int. 58, 2301-13 (2000).
18. Kanno, Y. et al. The absence of uPAR is associated with the progression of dermal fibrosis. J Invest Dermatol. 128, 2792-2797 (2008).
19. Junqueira, L. C., Bignolas, G. & Brentani, R. R. Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J. 11, 447-55 (1979). (Pubitemid 9238595)
20. Sato, M. et al. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest. 112, 1486-94 (2003). (Pubitemid 38056275)
21. Müller, G. A., Markovic-Lipkovski, J. & Rodemann, H. P. The progression of renal diseases: on the pathogenesis of renal interstitial fibrosis. Klin Wochenschr. 69, 576-86 (1991).
22. Kanno, Y. et al. Urokinase-type plasminogen activator receptor is associated with the development of adipose tissue. Thromb Haemost. 104, 1124-32 (2010).
23. Kanno, Y., Into, T., Lowenstein, C. J. & Matsushita, K. Nitric oxide regulates vascular calcification by interfering with TGF-signalling. Cardiovasc Res. 77, 221-230 (2008). (Pubitemid 351195162)
24. Eddy, A. A. Serine proteases, inhibitors and receptors in renal fibrosis. Thromb Haemost. 101, 656-64 (2009).
25. Okada, K. et al. The regulation of liver regeneration by the plasmin/alpha 2-antiplasmin system. J Hepatol. 40, 110-116 (2004). (Pubitemid 38064719)
26. Edgtton, K. L. et al. Plasmin is not protective in experimental renal interstitial fibrosis. Kidney Int. 66, 68-76 (2004). (Pubitemid 38870083)
27. Yamaguchi, I. et al. Endogenous urokinase lacks antifibrotic activity during progressive renal injury. Am J Physiol Renal Physiol. 293, F12-9 (2007). (Pubitemid 47344995)
28. Oda, T. et al. PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction. Kidney Int. 60, 587-96 (2001). (Pubitemid 32678902)
29. Yang, J. et al. Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy. J Clin Invest. 110, 1525-38 (2002). (Pubitemid 35396923)
30. Grgic, I., Duffield, J. S. & Humphreys, B. D. The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol. 27, 183-93 (2012).
31. Annes, J. P., Munger, J. S. & Rifkin, D. B. Making sense of latent TGFbeta activation. J Cell Sci. 116, 217-24 (2003). (Pubitemid 36163863)
32. Alcorn, J. F. et al. c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis. Am J Respir Cell Mol Biol. 40, 422-432 (2009).
33. Shi-Wen, X. et al. Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors. Mol Cell Biol. 26, 5518-5527 (2006). (Pubitemid 44036217)
34. Utsugi, M. et al. C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 28, 754-761 (2003). (Pubitemid 36677180)
35. Wang, X. M. et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 203, 2895-2906 (2006). Technology