Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma

Frontiers in Immunology

Volumn 5, Issue JUL, 2014, Pages

  Gehrmann, Mathias ^a   Cervello, Melchiorre ^b   Montalto, Giuseppe ^b,c   Cappello, Francesco ^c,d   Gulino, Alessandro ^e   Knape, Clemens ^a   Specht, Hanno M ^a   Multhoff, Gabriele ^a,f  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b CNR   (Italy)

^c UNIVERSITY OF PALERMO   (Italy)

^d Euro Mediterranean Institute of Science and Technology   (Italy)

^e UNIVERSITY OF PALERMO   (Italy)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Chronic hepatitis; HCC; Inflammation; Liver cirrhosis; Prognostic biomarker; Serum HSP70

Indexed keywords

EID: 84905645522     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00307     Document Type: Article

References (24)

1. Aravalli RN. Role of innate immunity in the development of hepatocellular carcinoma. World J Gastroenterol (2013) 19(43):7500-14. doi: 10.3748/wjg.v19.i43.7500
2. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell (2009) 16(4):295-308. doi:10.1016/j.ccr.2009.08.021
3. Wolf MJ, Seleznik GM, Zeller N, Heikenwalder M. The unexpected role of lymphotoxin beta receptor signaling in carcinogenesis: from lymphoid tissue formation to liver and prostate cancer development. Oncogene (2010) 29(36):5006-18. doi:10.1038/onc.2010.260
4. Coussens LM, Werb Z. Inflammation and cancer. Nature (2002) 420(6917):860-7. doi:10.1038/nature01322
5. Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY. Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma. Gut Liver (2014) 8(1):79-87. doi:10.5009/gnl.2014.8.1.79
6. Sakamoto M. Early HCC: diagnosis and molecular markers. J Gastroenterol (2009) 44(Suppl 19):108-11. doi:10.1007/s00535-008-2245-y
7. Rappa F, Greco A, Podrini C, Cappello F, Foti M, Bourgoin L, et al. Immunopositivity for histone macroH2A1 isoforms marks steatosis-associated hepatocellular carcinoma. PLoS One (2013) 8(1):e54458. doi:10.1371/journal.pone.0054458
8. Rappa F, Farina F, Zummo G, David S, Campanella C, Carini F, et al. HSP-molecular chaperones in cancer biogenesis and tumor therapy: an overview. Anticancer Res (2012) 32(12):5139-50.
9. Rerole AL, Jego G, Garrido C. HSP70: anti-apoptotic and tumorigenic protein. Methods Mol Biol (2011) 787:205-30. doi:10.1007/978-1-61779-295-3_16
10. Multhoff G, Hightower LE. Distinguishing integral and receptor-bound heat shock protein 70 (HSP70) on the cell surface by HSP70-specific antibodies. Cell Stress Chaperones (2011) 16(3):251-5. doi:10.1007/s12192-010-0247-1
11. Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, et al. Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res (2005) 65(12):5238-47. doi:10.1158/0008-5472.CAN-04-3804
12. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6(10):715-27. doi:10.1038/nri1936
13. Xiao J, Zhao Y, Varghese RS, Zhou B, Di Poto C, Zhang L, et al. Evaluation of metabolite biomarkers for hepatocellular carcinoma through stratified analysis by gender, race, and alcoholic cirrhosis. Cancer Epidemiol Biomarkers Prev (2014) 23(1):64-72. doi:10.1158/1055-9965.EPI-13-0327
14. Dutta SK, Girotra M, Singla M, Dutta A, Otis Stephen F, Nair PP, et al. Serum HSP70: a novel biomarker for early detection of pancreatic cancer. Pancreas (2012) 41(4):530-4. doi:10.1097/MPA.0b013e3182374ace
15. Kleinjung T, Arndt O, Feldmann HJ, Bockmuhl U, Gehrmann M, Zilch T, et al. Heat shock protein 70 (HSP70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells. Int J Radiat Oncol Biol Phys (2003) 57(3):820-6. doi:10.1016/S0360-3016(03)00629-1
16. Stangl S, Gehrmann M, Dressel R, Alves F, Dullin C, Themelis G, et al. In vivo imaging of CT26 mouse tumours by using cm HSP70.1 monoclonal antibody. J Cell Mol Med (2011) 15(4):874-87. doi:10.1111/j.1582-4934.2010.01067.x
17. Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G, et al. HSP70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones (2000) 5(5):438-42.
18. Madu CO, Lu Y. Novel diagnostic biomarkers for prostate cancer. J Cancer (2010) 1:150-77. doi:10.7150/jca.1.150
19. Bayer C, Liebhardt ME, Schmid TE, Trajkovic-Arsic M, Hube K, Specht HM, et al. Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models. Int J Radiat Oncol Biol Phys (2014) 88(3):694-700. doi:10.1016/j.ijrobp.2013.11.008
20. Dakappagari N, Neely L, Tangri S, Lundgren K, Hipolito L, Estrellado A, et al. An investigation into the potential use of serum HSP70 as a novel tumour biomarker for Hsp90 inhibitors. Biomarkers (2010) 15(1):31-8. doi:10.3109/13547500903261347
21. Mambula SS, Stevenson MA, Ogawa K, Calderwood SK. Mechanisms for HSP70 secretion: crossing membranes without a leader. Methods (2007) 43(3):168-75. doi:10.1016/j.ymeth.2007.06.009
22. Kocsis J, Madaras B, Toth EK, Fust G, Prohaszka Z. Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis. Cell Stress Chaperones (2010) 15(2):143-51. doi:10.1007/s12192-009-0128-7
23. Zimmermann M, Nickl S, Lambers C, Hacker S, Mitterbauer A, Hoetzenecker K, et al. Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study. Clin Chim Acta (2012) 413(13-14):1115-20. doi:10.1016/j.cca.2012.03.008
24. De Maio A. Extracellular heat shock proteins, cellular export vesicles, and the stress observation system: a form of communication during injury, infection, and cell damage. It is never known how far a controversial finding will go! Dedicated to Ferruccio Ritossa. Cell Stress Chaperones (2011) 16(3):235-49. doi:10.1007/s12192-010-0236-4