Transcranial stimulation of the developing brain: A plea for extreme caution

Frontiers in Human Neuroscience

Volumn 8, Issue AUG, 2014, Pages

  Davis, Nick J ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Neuroethics; Non invasive; Paediatric; Safety; tDCS; TMS

Indexed keywords

ADVERSE OUTCOME; BRAIN DEPTH STIMULATION; BRAIN DEVELOPMENT; BRAIN ELECTROPHYSIOLOGY; BRAIN TISSUE; CHRONIC PAIN; COGNITION; COGNITIVE DEFECT; DEPRESSION; ELECTROSTIMULATION; EPILEPSY; HUMAN; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MEDICAL ETHICS; MEDICAL RESEARCH; MYELINATION; NERVE CELL PLASTICITY; NEUROANATOMY; NEUROLOGIC DISEASE; NEUROMODULATION; NOTE; PRACTICE GUIDELINE; THERAPY EFFECT; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84905592250     PISSN: None     EISSN: 16625161     Source Type: Journal    
DOI: 10.3389/fnhum.2014.00600     Document Type: Note

References (42)

1. Arul-Anandam, A. P., and Loo, C. (2009). Transcranial direct current stimulation: a new tool for the treatment of depression? J. Affect. Disord. 117, 137-145. doi: 10.1016/j.jad.2009.01.016
2. Barnea-Goraly, N., Menon, V., Eckert, M., Tamm, L., Bammer, R., Karchemskiy, A., et al. (2005). White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study. Cereb. Cortex 15, 1848-1854. doi: 10.1093/cercor/bhi062
3. Bikson, M., Datta, A., and Elwassif, M. (2009). Establishing safety limits for transcranial direct current stimulation. Clin. Neurophysiol. 120, 1033-1034. doi: 10.1016/j.clinph.2009.03.018
4. Bloch, Y., Harel, E., Aviram, S., Govezensky, J., Ratzoni, G., and Levkovitz, Y. (2010). Positive effects of repetitive transcranial magnetic stimula- tion on attention in ADHD Subjects: a randomized controlled pilot study. World J. Biol. Psychiatry 11, 755-758. doi: 10.3109/15622975.2010.484466
5. Brem, A.-K., Fried, P., Horvath, J., Robertson, E., and Pascual-Leone, A. (2014). Is neuroenhancement by noninvasive brain stimulation a net zero- sum proposition? Neuroimage 85, 1058-1068. doi: 10.1016/j.neuroimage.2013.07.038
6. Brunoni, A. R., Amadera, J., Berbel, B., Volz, M. S., Rizzerio, B. G., and Fregni, F. (2011). A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation. Int. J. Neuropsychopharmacol. 14, 1133-1145. doi: 10.1017/S1461145710001690
7. Burger, J., Frank, E., Kreuzer, P., Kleinjung, T., Vielsmeier, V., Landgrebe, M., et al. (2011). Transcranial magnetic stimulation for the treatment of tinnitus: 4-year follow-up in treatment responders - a retrospective analysis. Brain Stimul. 4, 222-227. doi: 10.1016/j.brs.2010.11.003
8. Caviness, V., Kennedy, D., Richelme, C., Rademacher, J., and Filipek, P. (1996). The human brain age 7-11 years: a volumetric analysis based on magnetic resonance images. Cereb. Cortex 6, 726-736. doi: 10.1093/cercor/6.5.726
9. Chambers, C., Polifka, J., and Friedman, J. (2008). Drug safety in pregnant women and their babies: ignorance not bliss. Clin. Pharmacol. Ther. 83, 181-183. doi: 10.1038/sj.clpt.6100448
10. Chiramberro, M., Lindberg, N., Isometsä, E., Kähkönen, S., and Appelberg, B. (2013). Repetitive transcranial magnetic stimulation induced seizures in an adolescent patient with major depression: a case report. Brain Stimul. 6, 830-831. doi: 10.1016/j.brs.2013.02.003
11. Cohen Kadosh, R., Levy, N., O'Shea, J., Shea, N., and Savulescu, J. (2012). The neuroethics of non-invasive brain stimulation. Curr. Biol. 22, R108-R111. doi: 10.1016/j.cub.2012.01.013
12. Costanzo, F., Menghini, D., Caltagirone, C., Oliveri, M., and Vicari, S. (2013). How to improve reading skills in dyslexics: the effect of high frequency rTMS. Neuropsychologia 51, 2953-2959. doi: 10.1016/j.neuropsychologia.2013.10.018
13. Davis, N. (2013). Neurodoping: brain stimulation as a performance-enhancing measure. Sports Med. 43, 649-653. doi: 10.1007/s40279-013-0027-z
14. Davis, N., Gold, E., Pascual-Leone, A., and Bracewell, R. (2013). Challenges of proper placebo control for noninvasive brain stimulation in clinical and experimental applications. Eur. J. Neurosci. 38, 2973-2977. doi: 10.1111/ejn.12307
15. Davis, N., and van Koningsbruggen, M. (2013). 'Non-invasive' brain stimulation is not non-invasive. Front. Syst. Neurosci.7:76. doi: 10.3389/fnsys.2013.00076
16. Earp, B., Sandberg, A., Kahane, G., and Savulescu, J. (2014). When is diminishment a form of enhancement? rethinking the enhancement debate in biomedical ethics. Front. Syst. Neurosci. 8:12. doi: 10.3389/fnsys.2014.00012
17. Eldaief, M., Press, D., and Pascual-Leone, A. (2013). Transcranial magnetic stimulation in neurology: a review of established and prospective applications. Neurol. Clin. Pract. 3, 519-526. doi: 10.1212/01.CPJ.0000436213.11132.8e
18. Enticott, P., Fitzgibbon, B., Kennedy, H., Arnold, S., Elliot, D., Peachey, A., et al. (2014). A Double-blind, randomized trial of deep repetitive transcranial magnetic stimulation (rTMS) for autism spectrum disorder. Brain Stimul. 7, 206-211. doi: 10.1016/j.brs.2013.10.004
19. Fitz, N., and Reiner, P. (2013). The challenge of crafting policy for do-it-yourself brain stimulation. J. Med. Ethics. doi: 10.1136/medethics-2013- 101458. [Epub ahead of print].
20. Friedenberg, Z., Roberts, P. J., Didizian, N., and Brighton, C. (1971). Stimulation of fracture healing by direct current in the rabbit fibula. J. Bone Joint Surg. 53, 1400-1408.
21. Friedenberg, Z., Zemsky, L., and Pollis, R. (1974). The response of non-traumatized bone to direct current. J. Bone Joint Surg. 56, 1023-1030.
22. Fritsch, B., Reis, J., Martinowich, K., Schambra, H. M., Ji, Y., Cohen, L. G., et al. (2010). Direct current stimulation promotes BDNF- dependent synaptic plasticity: potential implications for motor learning. Neuron 66, 198-204. doi: 10.1016/j.neuron.2010.03.035
23. Green, R., Pascual-Leone, A., and Wassermann, E. (1997). Ethical guidelines for rTMS research. IRB Ethics Hum. Res. 19, 1-7. doi: 10.2307/3563539
24. Hwang, T., Kesselheim, A., and Bourgeois, F. (2014). Postmarketing trials and pediatric device approvals. Pediatrics 133, e1197-e1202. doi: 10.1542/peds.2013-3348
25. Kessler, S., Minhas, P., Woods, A., Rosen, A., Gorman, C., and Bikson, M. (2013). Dosage considerations for transcranial direct current stimulation in children: a computational modeling study. PLoS ONE 8:e76112. doi: 10.1371/journal.pone.0076112
26. Klingberg, T., Vaidya, C., Gabrieli, J., Moseley, M., and Hedehus, M. (1999). Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport 10, 2817-2821. doi: 10.1097/00001756-199909090- 00022
27. Krause, B., and Cohen Kadosh, R. (2013). Can transcranial electrical stimulation improve learning difficulties in atypical brain development? a future possibility for cognitive training. Dev. Cogn. Neurosci. 6, 176-194. doi: 10.1016/j.dcn.2013.04.001
28. Mall, V., Berweck, S., Fietzek, U., Glocker, F.-X., Oberhuber, U., Walther, M., et al. (2004). Low levels of intracortical inhibition in children shown by transcranial magnetic stimulation. Neuropediatrics 35, 120-125. doi: 10.1055/s-2004-815834
29. Mendonca, M., Santana, M., Baptista, A., Datta, A., Bikson, M., Fregni, F., et al. (2011). Transcranial DC stimulation in fibromyalgia: optimized cortical target supported by high-resolution computational models. J. Pain 12, 610-617. doi: 10.1016/j.jpain.2010.12.015
30. Miranda, P. C., Lomarev, M., and Hallett, M. (2006). Modeling the current distribution during transcranial direct current stimulation. Clin. Neurophysiol. 117, 1623-1629. doi: 10.1016/j.clinph.2006.04.009
31. Nelson, J., McKinley, A., Goloba, E., Warm, J., and Parasuraman, R. (2014). Enhancing vigilance in operators with prefrontal cortex transcranial direct current stimulation (tDCS). Neuroimage 85, 909-917. doi: 10.1016/j.neuroimage.2012.11.061
32. Nowak, D. A., Bösl, K., Podubeckà, J., and Carey, J. R. (2010). Noninvasive brain stimulation and motor recovery after stroke. Restor. Neurol. Neurosci. 28, 531-544. doi: 10.3233/RNN-2010-0552
33. Oberman, L., Rotenberg, A., and Pascual-Leone, A. (2013). Use of transcranial magnetic stimulation in autism spectrum disorders. J. Autism Dev. Disord. doi: 10.1007/s10803-013-1960-2. [Epub ahead of print].
34. Rajpakse, T., and Kirton, A. (2013). Non-invasive brain stimulation in children: applications and future directions. Transl. Neurosci. 4, 217-233. doi: 10.2478/s13380-013-0116-3
35. Rossi S., Hallett M., Rossini P., Pascual-Leone A., and Group T.S.O.T.C. (2009). Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clini- cal practice and research. Clin. Neurophysiol. 120, 2008-2039. doi: 10.1016/j.clinph.2009.08.016
36. Shahid, S., Wen, P., and Ahfock, T. (2013). Numerical investigation of white matter anisotropic conduc- tivity in defining current distribution under tDCS. Comput. Methods Programs Biomed. 109, 48-64. doi: 10.1016/j.cmpb.2012.09.001
37. Snowball, A., Tachtsidis, I., Popescu, T., Thompson, J., Delazer, M., Zamarian, L., et al. (2013). Long-term enhancement of brain function and cognition using cognitive training and brain stimulation. Curr. Biol. 23, 987-992. doi: 10.1016/j.cub.2013.04.045
38. Stagg, C. J., and Nitsche, M. A. (2011). Physiological basis of transcranial direct current stimulation.Neuroscientist17,37-53. doi: 10.1177/1073858410386614
39. Stagg, C., Wylezinska, M., Matthews, P., Johansen- Berg, H., Jezzard, P., Rothwell, J., et al. (2009). Neurochemical effects of theta burst stimula- tion as assessed by magnetic resonance spec- troscopy. J. Neurophysiol. 101, 2872-2877. doi: 10.1152/jn.91060.2008
40. Vicario, C., and Nitsche, M. (2013a). Non-invasive brain stimulation for the treatment of brain diseases in childhood and adolescence: state of the art, current limits and future challenges. Front. Syst. Neurosci. 7:94. doi: 10.3389/fnsys. 2013.00094
41. Vicario, C., and Nitsche, M. (2013b). Transcranial direct current stimulation: a remediation tool for the treatment of childhood congenital dyslexia? Front. Hum. Neurosci. 7:139. doi: 10.3389/fnhum.2013.00139
42. Young, L., Camprodon, J. A., Hauser, M., Pascual-Leone, A., and Saxe, R. (2010). Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments. Proc. Natl. Acad. Sci. U.S.A. 107, 6753-6758. doi: 10.1073/pnas.0914 826107