Zinc-excess intake causes the deterioration of renal function accompanied by an elevation in systemic blood pressure primarily through superoxide radical-induced oxidative stress

International Journal of Toxicology

Volumn 33, Issue 4, 2014, Pages 288-296

  Yanagisawa, Hiroyuki ^a   Miyazaki, Takashi ^b   Nodera, Makoto ^b   Miyajima, Yuka ^b   Suzuki, Takashi ^a   Kido, Takamasa ^a   Suka, Machi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

blood pressure; oxidative stress; renal function; zinc

Indexed keywords

8-OXO-7-HYDRODEOXYGUANOSINE; BIOLOGICAL MARKER; COPPER ZINC SUPEROXIDE DISMUTASE; DEOXYGUANOSINE; ENZYME INHIBITOR; INULIN; NITRIC OXIDE SYNTHASE; SCAVENGER; SOD1 PROTEIN, RAT; ZINC;

ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; COMPARATIVE STUDY; DIETARY SUPPLEMENT; DRUG EFFECTS; HEAVY METAL POISONING; INTOXICATION; KIDNEY; KIDNEY FAILURE; MALE; METABOLIC CLEARANCE RATE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PATHOPHYSIOLOGY; RANDOMIZATION; RENOVASCULAR HYPERTENSION; SPRAGUE DAWLEY RAT; THORACIC AORTA; URINE; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ANIMALS; AORTA, THORACIC; BIOMARKERS; DEOXYGUANOSINE; DIETARY SUPPLEMENTS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; HEAVY METAL POISONING; HYPERTENSION, RENOVASCULAR; INULIN; KIDNEY; MALE; METABOLIC CLEARANCE RATE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY; SUPEROXIDE DISMUTASE-1; ZINC;

EID: 84905576086     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581814532958     Document Type: Article

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