Association of genetic predisposition to obesity with type 2 diabetes risk in Han Chinese individuals

Diabetologia

Volumn 57, Issue 9, 2014, Pages 1830-1833

  Zhu, Jingwen ^a   Zong, Geng ^a   Lu, Ling ^a   Gan, Wei ^a   Ji, Linong ^b   Hu, Renming ^c   Ye, Xingwang ^a   Sun, Liang ^a   Loos, Ruth J F ^d   Li, Huaixing ^a   Lin, Xu ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^c FUDAN UNIVERSITY   (China)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

BMI; Chinese; Genetic risk score; HOMA B; Type 2 diabetes

Indexed keywords

HEMOGLOBIN A1C; GLUCOSE; INSULIN;

ALLELE; ARTICLE; BODY MASS; CELL FUNCTION; CONTROLLED STUDY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK SCORE; GENETIC VARIABILITY; HAN CHINESE; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; CASE CONTROL STUDY; EAST ASIAN; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; INSULIN BLOOD LEVEL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; GENETICS;

ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS;

EID: 84905571677     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3308-7     Document Type: Article

References (7)

1. Okada Y, Kubo M, Ohmiya H, et al. (2012) Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet 44:302-306
2. Wen W, Cho YS, Zheng W, et al. (2012) Meta-analysis identifies common variants associated with body mass index in east Asians. Nat Genet 44:307-311
3. Monda KL, Chen GK, Taylor KC, et al. (2013) A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet 45:690-696
4. Robiou-du-Pont S, Bonnefond A, Yengo L, et al. (2013) Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. Int J Obes (Lond) 37:980-985
5. Li H, Kilpelainen TO, Liu C, et al. (2012) Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia 55:981-995
6. Li H, Gan W, Lu L, et al. (2013) A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 62:291-298
7. Meier JJ, Bonadonna RC (2013) Role of reduced beta-cell mass versus impaired beta-cell function in the pathogenesis of type 2 diabetes. Diabetes Care 36(Suppl 2):S113-S119