P21Waf1/Cip1 revisited: Oncogenic function in hepatocellular carcinoma

Gut

Volumn 63, Issue 9, 2014, Pages 1372-1373

  Goldenberg, Daniel ^a   Eferl, Robert ^b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; CYCLIN DEPENDENT KINASE INHIBITOR 1A;

AGING; CANCER CELL LINE; CANCER GROWTH; CANCER INCIDENCE; CANCER PROGNOSIS; CELL PROLIFERATION; CHOLESTASIS; DISEASE SEVERITY; GENETICS; HEPATITIS C; HUMAN; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER INJURY; LIVER PROGENITOR CELL; NONHUMAN; NOTE; ONSET AGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; STEM CELL; ANIMAL; CARCINOGENESIS; CELL CYCLE REGULATION; CHOLESTATIC LIVER DISEASES; FEMALE; INTRAHEPATIC CHOLESTASIS; LIVER FAILURE; LIVER REGENERATION; LIVER TUMOR; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

CELL CYCLE CONTROL; CHOLESTATIC LIVER DISEASES; HEPATOCELLULAR CARCINOMA;

ANIMALS; CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CHOLESTASIS, INTRAHEPATIC; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FEMALE; HEPATIC INSUFFICIENCY; HUMANS; LIVER NEOPLASMS; LIVER REGENERATION; MALE;

EID: 84905564443     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306343     Document Type: Note

References (10)

1. Abbas T, Dutta A. p21 in cancer: intricate networks and multiple activities. Nat Rev Cancer 2009;9:400-14.
2. Warfel NA, El-Deiry WS. p21WAF1 and tumourigenesis: 20 years after. Curr Opin Oncol 2013;25:52-8.
3. Romanov VS, Pospelov VA, Pospelova TV. Cyclin-dependent kinase inhibitor p21 (Waf1): contemporary view on its role in senescence and oncogenesis. Biochemistry (Mosc) 2012;77:575-84.
4. Huang Y, Wang W, Chen Y, et al. The opposite prognostic significance of nuclear and cytoplasmic p21 expression in resectable gastric cancer patients. J Gastroenterol Published Online First: 15 Oct. 2013. doi:10.1007/s00535-013-0900- 4
5. Kao JT, Chuah SK, Huang CC, et al. P21/WAF1 is an independent survival prognostic factor for patients with hepatocellular carcinoma after resection. Liver Int 2007;27:772-81.
6. Wagayama H, Shiraki K, Sugimoto K, et al. High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases. Hum Pathol 2002;33:429-34. (Pubitemid 34627594)
7. Shiraki K, Wagayama H. Cytoplasmic p21 (WAF1/CIP1) expression in human hepatocellular carcinomas. Liver Int 2006;26:1018-19. (Pubitemid 44323422)
8. Marhenke S, Buitrago-Molina LE, Endig J, et al. p21 promotes sustained liver regeneration and hepatocarcinogenesis in chronic cholestatic liver injury. Gut 2014;63:1501-12.
9. Buitrago-Molina LE, Marhenke S, Longerich T, et al. The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice. Hepatology 2013;58:1143-52.
10. Potikha T, Stoyanov E, Pappo O, et al. Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis. Hepatology 2013;58:192-204.