-
1
-
-
50949102412
-
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
-
Muckenthaler M.U., Galy B., Hentze M.W. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Ann Rev Nutr 2008, 28:197-213.
-
(2008)
Ann Rev Nutr
, vol.28
, pp. 197-213
-
-
Muckenthaler, M.U.1
Galy, B.2
Hentze, M.W.3
-
2
-
-
66149145303
-
Regulation of hepcidin and iron-overload disease
-
Lee P.L., Beutler E. Regulation of hepcidin and iron-overload disease. Ann Rev Pathol 2009, 4:489-515.
-
(2009)
Ann Rev Pathol
, vol.4
, pp. 489-515
-
-
Lee, P.L.1
Beutler, E.2
-
3
-
-
39149112760
-
The functional duality of iron regulatory protein 1
-
Volz K. The functional duality of iron regulatory protein 1. Curr Opin Struct Biol 2008, 18:106-111.
-
(2008)
Curr Opin Struct Biol
, vol.18
, pp. 106-111
-
-
Volz, K.1
-
4
-
-
0028131454
-
Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity
-
Guo B., Yu Y., Leibold E.A. Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J Biol Chem 1994, 269:24252-24260.
-
(1994)
J Biol Chem
, vol.269
, pp. 24252-24260
-
-
Guo, B.1
Yu, Y.2
Leibold, E.A.3
-
5
-
-
0141890273
-
Oxygen and iron regulation of iron regulatory protein 2
-
Hanson E.S., Rawlins M.L., Leibold E.A. Oxygen and iron regulation of iron regulatory protein 2. J Biol Chem 2003, 278:40337-40342.
-
(2003)
J Biol Chem
, vol.278
, pp. 40337-40342
-
-
Hanson, E.S.1
Rawlins, M.L.2
Leibold, E.A.3
-
6
-
-
0032508548
-
Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation?
-
Ke Y., Wu J., Leibold E.A., Walden W.E., Theil E.C. Loops and bulge/loops in iron-responsive element isoforms influence iron regulatory protein binding. Fine-tuning of mRNA regulation?. J Biol Chem 1998, 273:23637-23640.
-
(1998)
J Biol Chem
, vol.273
, pp. 23637-23640
-
-
Ke, Y.1
Wu, J.2
Leibold, E.A.3
Walden, W.E.4
Theil, E.C.5
-
7
-
-
33746864096
-
Molecular control of vertebrate iron homeostasis by iron regulatory proteins
-
Wallander M.L., Leibold E.A., Eisenstein R.S. Molecular control of vertebrate iron homeostasis by iron regulatory proteins. Biochim Biophys Acta 2006, 1763:668-689.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 668-689
-
-
Wallander, M.L.1
Leibold, E.A.2
Eisenstein, R.S.3
-
8
-
-
67349229276
-
The regulation of hepcidin and its effects on systemic and cellular iron metabolism
-
Fleming M.D. The regulation of hepcidin and its effects on systemic and cellular iron metabolism. Hematology Am Soc Hematol Educ Program 2008, 151-158.
-
(2008)
Hematology Am Soc Hematol Educ Program
, pp. 151-158
-
-
Fleming, M.D.1
-
9
-
-
84871434445
-
MTOR regulates cellular iron homeostasis through tristetraprolin
-
Bayeva M., Khechaduri A., Puig S., Chang H.C., Patial S., Blackshear P.J., et al. mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab 2012, 16:645-657.
-
(2012)
Cell Metab
, vol.16
, pp. 645-657
-
-
Bayeva, M.1
Khechaduri, A.2
Puig, S.3
Chang, H.C.4
Patial, S.5
Blackshear, P.J.6
-
10
-
-
84874611570
-
Rapalogs and mTOR inhibitors as anti-aging therapeutics
-
Lamming D.W., Ye L., Sabatini D.M., Baur J.A. Rapalogs and mTOR inhibitors as anti-aging therapeutics. J Clin Investig 2013, 123:980-989.
-
(2013)
J Clin Investig
, vol.123
, pp. 980-989
-
-
Lamming, D.W.1
Ye, L.2
Sabatini, D.M.3
Baur, J.A.4
-
11
-
-
84878880159
-
Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR)
-
Malik A.R., Urbanska M., Macias M., Skalecka A., Jaworski J. Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR). Biochim Biophys Acta 2013, 1834:1434-1448.
-
(2013)
Biochim Biophys Acta
, vol.1834
, pp. 1434-1448
-
-
Malik, A.R.1
Urbanska, M.2
Macias, M.3
Skalecka, A.4
Jaworski, J.5
-
12
-
-
33644623262
-
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis
-
Tong W.H., Rouault T.A. Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. Cell Metab 2006, 3:199-210.
-
(2006)
Cell Metab
, vol.3
, pp. 199-210
-
-
Tong, W.H.1
Rouault, T.A.2
-
13
-
-
84856800302
-
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
-
Alers S., Loffler A.S., Wesselborg S., Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012, 32:2-11.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 2-11
-
-
Alers, S.1
Loffler, A.S.2
Wesselborg, S.3
Stork, B.4
-
14
-
-
33846438568
-
Regulation of mTOR by phosphatidic acid?
-
Foster D.A. Regulation of mTOR by phosphatidic acid?. Cancer Res 2007, 67:1-4.
-
(2007)
Cancer Res
, vol.67
, pp. 1-4
-
-
Foster, D.A.1
-
15
-
-
84885187437
-
A central role for mTOR in lipid homeostasis
-
Lamming D.W., Sabatini D.M. A central role for mTOR in lipid homeostasis. Cell Metab 2013, 18:465-469.
-
(2013)
Cell Metab
, vol.18
, pp. 465-469
-
-
Lamming, D.W.1
Sabatini, D.M.2
-
16
-
-
62749096589
-
Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms
-
Dunlop E.A., Tee A.R. Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms. Cell Signal 2009, 21:827-835.
-
(2009)
Cell Signal
, vol.21
, pp. 827-835
-
-
Dunlop, E.A.1
Tee, A.R.2
-
17
-
-
70350094555
-
Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian target of rapamycin signaling pathway in rats and in COS-1 cells
-
Ndong M., Kazami M., Suzuki T., Uehara M., Katsumata S., Inoue H., et al. Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian target of rapamycin signaling pathway in rats and in COS-1 cells. Nutr Res 2009, 29:640-647.
-
(2009)
Nutr Res
, vol.29
, pp. 640-647
-
-
Ndong, M.1
Kazami, M.2
Suzuki, T.3
Uehara, M.4
Katsumata, S.5
Inoue, H.6
-
18
-
-
65349129409
-
The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1
-
Ohyashiki J.H., Kobayashi C., Hamamura R., Okabe S., Tauchi T., Ohyashiki K. The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1. Cancer Sci 2009, 100:970-977.
-
(2009)
Cancer Sci
, vol.100
, pp. 970-977
-
-
Ohyashiki, J.H.1
Kobayashi, C.2
Hamamura, R.3
Okabe, S.4
Tauchi, T.5
Ohyashiki, K.6
-
19
-
-
84874699908
-
Neuronal-specific iron deficiency dysregulates mammalian target of rapamycin signaling during hippocampal development in nonanemic genetic mouse models
-
Fretham S.J., Carlson E.S., Georgieff M.K. Neuronal-specific iron deficiency dysregulates mammalian target of rapamycin signaling during hippocampal development in nonanemic genetic mouse models. J Nutr 2013, 143:260-266.
-
(2013)
J Nutr
, vol.143
, pp. 260-266
-
-
Fretham, S.J.1
Carlson, E.S.2
Georgieff, M.K.3
-
20
-
-
39749108111
-
SiRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake
-
Galvez T., Teruel M.N., Heo W.D., Jones J.T., Kim M.L., Liou J., et al. siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol 2007, 8:R142.
-
(2007)
Genome Biol
, vol.8
-
-
Galvez, T.1
Teruel, M.N.2
Heo, W.D.3
Jones, J.T.4
Kim, M.L.5
Liou, J.6
-
21
-
-
84877146678
-
Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism
-
La P., Yang G., Dennery P.A. Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism. J Biol Chem 2013, 288:12901-12909.
-
(2013)
J Biol Chem
, vol.288
, pp. 12901-12909
-
-
La, P.1
Yang, G.2
Dennery, P.A.3
-
22
-
-
73649106499
-
Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages
-
Leppanen T., Jalonen U., Korhonen R., Tuominen R.K., Moilanen E. Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages. Eur J Pharmacol 2010, 628:220-225.
-
(2010)
Eur J Pharmacol
, vol.628
, pp. 220-225
-
-
Leppanen, T.1
Jalonen, U.2
Korhonen, R.3
Tuominen, R.K.4
Moilanen, E.5
-
23
-
-
0033049125
-
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
-
Lai W.S., Carballo E., Strum J.R., Kennington E.A., Phillips R.S., Blackshear P.J. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 1999, 19:4311-4323.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4311-4323
-
-
Lai, W.S.1
Carballo, E.2
Strum, J.R.3
Kennington, E.A.4
Phillips, R.S.5
Blackshear, P.J.6
-
24
-
-
16044369031
-
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
-
Taylor G.A., Carballo E., Lee D.M., Lai W.S., Thompson M.J., Patel D.D., et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 1996, 4:445-454.
-
(1996)
Immunity
, vol.4
, pp. 445-454
-
-
Taylor, G.A.1
Carballo, E.2
Lee, D.M.3
Lai, W.S.4
Thompson, M.J.5
Patel, D.D.6
-
25
-
-
78751504841
-
Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment
-
Clement S.L., Scheckel C., Stoecklin G., Lykke-Andersen J. Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment. Mol Cell Biol 2011, 31:256-266.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 256-266
-
-
Clement, S.L.1
Scheckel, C.2
Stoecklin, G.3
Lykke-Andersen, J.4
-
26
-
-
4143051431
-
Transferrin receptor 1
-
Aisen P. Transferrin receptor 1. The Int J Biochem Cell Biol 2004, 36:2137-2143.
-
(2004)
The Int J Biochem Cell Biol
, vol.36
, pp. 2137-2143
-
-
Aisen, P.1
-
27
-
-
79952104568
-
MTOR couples cellular nutrient sensing to organismal metabolic homeostasis
-
Howell J.J., Manning B.D. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab 2011, 22:94-102.
-
(2011)
Trends Endocrinol Metab
, vol.22
, pp. 94-102
-
-
Howell, J.J.1
Manning, B.D.2
-
28
-
-
33644873957
-
Marked erythrocyte microcytosis under primary immunosuppression with sirolimus
-
Kim M.J., Mayr M., Pechula M., Steiger J., Dickenmann M. Marked erythrocyte microcytosis under primary immunosuppression with sirolimus. Transpl Int 2006, 19:12-18.
-
(2006)
Transpl Int
, vol.19
, pp. 12-18
-
-
Kim, M.J.1
Mayr, M.2
Pechula, M.3
Steiger, J.4
Dickenmann, M.5
-
29
-
-
77951693717
-
Anaemia, microcytosis and sirolimus-is iron the missing link?
-
Sofroniadou S., Kassimatis T., Goldsmith D. Anaemia, microcytosis and sirolimus-is iron the missing link?. Nephrol Dial Transplant 2010, 25:1667-1675.
-
(2010)
Nephrol Dial Transplant
, vol.25
, pp. 1667-1675
-
-
Sofroniadou, S.1
Kassimatis, T.2
Goldsmith, D.3
-
30
-
-
84873293006
-
Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of rapamycin
-
Przybylowski P., Malyszko J.S., Macdougall I.C., Malyszko J. Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of rapamycin. Transplant Proc 2013, 45:387-390.
-
(2013)
Transplant Proc
, vol.45
, pp. 387-390
-
-
Przybylowski, P.1
Malyszko, J.S.2
Macdougall, I.C.3
Malyszko, J.4
-
31
-
-
33744956665
-
Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly
-
Li K., Tong W.H., Hughes R.M., Rouault T.A. Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly. J Biol Chem 2006, 281:12344-12351.
-
(2006)
J Biol Chem
, vol.281
, pp. 12344-12351
-
-
Li, K.1
Tong, W.H.2
Hughes, R.M.3
Rouault, T.A.4
-
32
-
-
33746920351
-
Iron-dependent metabolic remodeling in S. cerevisiae
-
Kaplan J., McVey Ward D., Crisp R.J., Philpott C.C. Iron-dependent metabolic remodeling in S. cerevisiae. Biochim Biophys Acta 2006, 1763:646-651.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 646-651
-
-
Kaplan, J.1
McVey Ward, D.2
Crisp, R.J.3
Philpott, C.C.4
-
33
-
-
11844257593
-
Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation
-
Puig S., Askeland E., Thiele D.J. Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell 2005, 120:99-110.
-
(2005)
Cell
, vol.120
, pp. 99-110
-
-
Puig, S.1
Askeland, E.2
Thiele, D.J.3
-
34
-
-
44349183685
-
Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency
-
Puig S., Vergara S.V., Thiele D.J. Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency. Cell Metab 2008, 7:555-564.
-
(2008)
Cell Metab
, vol.7
, pp. 555-564
-
-
Puig, S.1
Vergara, S.V.2
Thiele, D.J.3
-
35
-
-
84863611083
-
Regulation of the ATPase activity of ABCE1 from Pyrococcus abyssi by Fe-S cluster status and Mg(2)(+): implication for ribosomal function
-
Sims L.M., Igarashi R.Y. Regulation of the ATPase activity of ABCE1 from Pyrococcus abyssi by Fe-S cluster status and Mg(2)(+): implication for ribosomal function. Arch Biochem Biophys 2012, 524:114-122.
-
(2012)
Arch Biochem Biophys
, vol.524
, pp. 114-122
-
-
Sims, L.M.1
Igarashi, R.Y.2
-
36
-
-
0037137380
-
Growth signaling: TSC takes its place
-
Marygold S.J., Leevers S.J. Growth signaling: TSC takes its place. Curr Biol 2002, 12:R785-R787.
-
(2002)
Curr Biol
, vol.12
-
-
Marygold, S.J.1
Leevers, S.J.2
-
37
-
-
0142070928
-
Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling
-
Ballou L.M., Jiang Y.P., Du G., Frohman M.A., Lin R.Z. Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling. FEBS Lett 2003, 550:51-56.
-
(2003)
FEBS Lett
, vol.550
, pp. 51-56
-
-
Ballou, L.M.1
Jiang, Y.P.2
Du, G.3
Frohman, M.A.4
Lin, R.Z.5
-
38
-
-
79955133814
-
MTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?
-
Frost R.A., Lang C.H. mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?. Physiology (Bethesda) 2011, 26:83-96.
-
(2011)
Physiology (Bethesda)
, vol.26
, pp. 83-96
-
-
Frost, R.A.1
Lang, C.H.2
-
39
-
-
24044442298
-
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
-
Tee A.R., Blenis J., Proud C.G. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 2005, 579:4763-4768.
-
(2005)
FEBS Lett
, vol.579
, pp. 4763-4768
-
-
Tee, A.R.1
Blenis, J.2
Proud, C.G.3
-
40
-
-
0033826764
-
Iron regulatory proteins and the molecular control of mammalian iron metabolism
-
Eisenstein R.S. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Ann Rev Nutr 2000, 20:627-662.
-
(2000)
Ann Rev Nutr
, vol.20
, pp. 627-662
-
-
Eisenstein, R.S.1
-
41
-
-
0018850974
-
Transferrin and transferrin receptors in carcinoma of the breast
-
Faulk W.P., Hsi B.L., Stevens P.J. Transferrin and transferrin receptors in carcinoma of the breast. Lancet 1980, 2:390-392.
-
(1980)
Lancet
, vol.2
, pp. 390-392
-
-
Faulk, W.P.1
Hsi, B.L.2
Stevens, P.J.3
|