Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans

BMC Research Notes

Volumn 7, Issue 1, 2014, Pages

  Onur, Simone ^a   Niklowitz, Petra ^b   Jacobs, Gunnar ^a   Nöthlings, Ute ^c   Lieb, Wolfgang ^a   Menke, Thomas ^b   Döring, Frank ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

Antioxidants; Gene expression; Liver enzymes; Oxidative stress; Supplementation study; Ubiquinol

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; GAMMA GLUTAMYLTRANSFERASE; UBIDECARENONE; UBIQUINOL; UBIQUINONE;

ADULT; ANALOGS AND DERIVATIVES; BLOOD; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG EFFECTS; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; MITOCHONDRION; OXIDATIVE STRESS; RISK FACTOR;

ADULT; ANTIOXIDANTS; BIOLOGICAL MARKERS; DIETARY SUPPLEMENTS; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; OXIDATIVE STRESS; RISK FACTORS; UBIQUINONE;

EID: 84905560685     PISSN: None     EISSN: 17560500     Source Type: Journal    
DOI: 10.1186/1756-0500-7-427     Document Type: Article

References (38)

1. Biochemical functions of coenzyme Q10. Crane FL, J Am Coll Nutr 2001 20 6 591 598
2. Is coenzyme Q a key factor in aging? Lopez-Lluch G, Rodriguez-Aguilera JC, Santos-Ocana C, Navas P, Mech Ageing Dev 2010 131 4 225 235
3. Coenzyme Q - biosynthesis and functions. Bentinger M, Tekle M, Dallner G, Biochem Biophys Res Commun 2010 396 1 74 79
4. Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, Doring F, Int J Biochem Cell Biol 2005 37 6 1208 1218
5. Identification of LPS-inducible genes downregulated by ubiquinone in human THP-1 monocytes. Schmelzer C, Doring F, Biofactors 2010 36 3 222 228
6. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA, Free Radic Biol Med 2004 36 8 1043 1057
7. Influence of Coenzyme Q-{10} on release of pro-inflammatory chemokines in the human monocytic cell line THP-1. Schmelzer C, Lorenz G, Rimbach G, Doring F, Biofactors 2007 31 3-4 211 217
8. In Vitro Effects of the Reduced Form of Coenzyme Q(10) on Secretion Levels of TNF-alpha and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1. Schmelzer C, Lorenz G, Rimbach G, Doring F, J Clin Biochem Nutr 2009 44 1 62 66
9. Effects of Coenzyme Q10 on TNF-alpha secretion in human and murine monocytic cell lines. Schmelzer C, Lorenz G, Lindner I, Rimbach G, Niklowitz P, Menke T, Doring F, Biofactors 2007 31 1 35 41
10. Plasma membrane ubiquinone controls ceramide production and prevents cell death induced by serum withdrawal. Barroso MP, Gomez-Diaz C, Villalba JM, Buron MI, Lopez-Lluch G, Navas P, J Bioenerg Biomembr 1997 29 3 259 267
11. N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Gonzalez R, Ferrin G, Hidalgo AB, Ranchal I, Lopez-Cillero P, Santos-Gonzalez M, Lopez-Lluch G, Briceno J, Gomez MA, Poyato A, Villalba JM, Navas P, de la Mata M, Muntané J, Chem Biol Interact 2009 181 1 95 106
12. The diversity of coenzyme Q function. Crane FL, Navas P, Mol Aspects Med 1997 18 Suppl 1 S6
13. Biochemical, physiological and medical aspects of ubiquinone function. Ernster L, Dallner G, Biochim Biophys Acta 1995 1271 1 195 204
14. The antioxidant role of coenzyme Q. Bentinger M, Brismar K, Dallner G, Mitochondrion 2007 7 Suppl 41 S50
15. Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death. Karp DR, Shimooku K, Lipsky PE, J Biol Chem 2001 276 6 3798 3804
16. Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase. Hanigan MH, Ricketts WA, Biochemistry 1993 32 24 6302 6306
17. Expression of multiple gamma-glutamyltransferase genes in man. Courtay C, Heisterkamp N, Siest G, Groffen J, Biochem J 1994 297 Pt 3 503 508
18. Induction of hepatic microsomal gamma-glutamyltransferase activity following chronic alcohol consumption. Teschke R, Brand A, Strohmeyer G, Biochem Biophys Res Commun 1977 75 3 718 724
19. Distribution, determinants, and prognostic value of gamma- glutamyltransferase for all-cause mortality in a cohort of construction workers from southern Germany. Brenner H, Rothenbacher D, Arndt V, Schuberth S, Fraisse E, Fliedner TM, Prev Med 1997 26 3 305 310
20. Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Lee DH, Jacobs DR Jr, Gross M, Kiefe CI, Roseman J, Lewis CE, Steffes M, Clin Chem 2003 49 8 1358 1366
21. Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke. Jousilahti P, Rastenyte D, Tuomilehto J, Stroke 2000 31 8 1851 1855
22. Prospective study of serum gamma-glutamyltransferase and risk of NIDDM. Perry IJ, Wannamethee SG, Shaper AG, Diabetes Care 1998 21 5 732 737
23. Is serum gamma glutamyltransferase a marker of oxidative stress? Lee DH, Blomhoff R, Jacobs DR Jr, Free Radic Res 2004 38 6 535 539
24. Is serum gamma-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress? Lim JS, Yang JH, Chun BY, Kam S, Jacobs DR Jr, Lee DH, Free Radic Biol Med 2004 37 7 1018 1023
25. Serum gamma-glutamyltransferase within its normal range predicts a chronic elevation of alanine aminotransferase: a four year follow-up study. Lee DH, Lim JS, Yang JH, Ha MH, Jacobs DR Jr, Free Radic Res 2005 39 6 589 593
26. PopGen. A population-based biobank with prospective follow-up of a control group. Nothlings U, Krawczak M, Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2012 55 6-7 831 835
27. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. Schmelzer C, Niklowitz P, Okun JG, Haas D, Menke T, Doring F, IUBMB Life 2011 63 1 42 48
28. Simultaneous detection of ubiquinol-10, ubiquinone-10, and tocopherols in human plasma microsamples and macrosamples as a marker of oxidative damage in neonates and infants. Menke T, Niklowitz P, Adam S, Weber M, Schluter B, Andler W, Anal Biochem 2000 282 2 209 217
29. Association of serum carotenoids and tocopherols with gamma-glutamyltransferase: the Cardiovascular Risk Development in Young Adults (CARDIA) Study. Lee DH, Gross MD, Jacobs DR Jr, Clin Chem 2004 50 3 582 588
30. Determinants of plasma coenzyme Q10 in humans. Kaikkonen J, Nyyssonen K, Tuomainen TP, Ristonmaa U, Salonen JT, FEBS Lett 1999 443 2 163 166
31. Plasma coenzyme Q10 reference intervals, but not redox status, are affected by gender and race in self-reported healthy adults. Miles MV, Horn PS, Morrison JA, Tang PH, DeGrauw T, Pesce AJ, Clin Chim Acta 2003 332 1-2 123 132
32. The Tromso Study. Distribution and population determinants of gamma-glutamyltransferase. Nilssen O, Forde OH, Brenn T, Am J Epidemiol 1990 132 2 318 326
33. Effects of menstrual cycle and oral contraceptive use on serum levels of lipid-soluble antioxidants. Palan PR, Magneson AT, Castillo M, Dunne J, Mikhail MS, Am J Obstet Gynecol 2006 194 5 35 e38
34. Oral contraceptive therapy increases oxidative stress in pre-menopausal women. Chen JT, Kotani K, Int J Prev Med 2012 3 12 893 896
35. Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1alpha/cJun to enhance plasma ALT/AST. Josekutty J, Iqbal J, Iwawaki T, Kohno K, Hussain MM, J Biol Chem 2013 288 20 14372 14383
36. Serum liver enzymes are associated with all-cause mortality in an elderly population. Koehler EM, Sanna D, Hansen BE, van Rooij FJ, Heeringa J, Hofman A, Tiemeier H, Stricker BH, Schouten JN, Janssen HL, Liver Int 2014 34 2 296 304
37. Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles. Yuvaraj S, Premkumar VG, Shanthi P, Vijayasarathy K, Gangadaran SG, Sachdanandam P, Breast Cancer Res Treat 2009 114 2 377 384
38. Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. Brown KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR, Free Radic Biol Med 1998 24 4 545 555