Simultaneous detection of ubiquinol-10, ubiquinone-10, and tocopherols in human plasma microsamples and macrosamples as a marker of oxidative damage in neonates and infants

Analytical Biochemistry

Volumn 282, Issue 2, 2000, Pages 209-217

  Menke, Thomas ^a   Niklowitz, Petra ^a   Adam, Stefan ^b,c   Weber, Michael ^a   Schlüter, Bernhard ^a   Andler, Werner ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b Bischoff Analysentechnik GmbH   (Germany)

^c Schwarz Pharma AG   (Germany)

Author keywords

Childhood; Oxidative stress; Tocopherol; Ubiquinol; Ubiquinone

Indexed keywords

ANTIOXIDANTS; CHEMICAL DETECTION; INORGANIC COMPOUNDS; LITHIUM COMPOUNDS; OXIDATIVE STRESS;

CHILDHOOD; ELECTROCHEMICAL DETECTION; INTERNAL STANDARDIZATION; LIPOPHILIC ANTIOXIDANTS; SIMULTANEOUS DETECTION; TOCOPHEROL; UBIQUINOL; UBIQUINONE;

DAMAGE DETECTION;

ALPHA TOCOPHEROL; GAMMA TOCOPHEROL; UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE;

ACCURACY; ANALYTIC METHOD; ANTIOXIDANT ACTIVITY; ARTICLE; ELECTROCHEMISTRY; HUMAN; LIPOPHILICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REPRODUCIBILITY;

EID: 0034235965     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2000.4579     Document Type: Article

References (33)

1. Sies H. Sies H. Oxidative Stress. 1985;1-8 Academic Press, London.
2. Ames B. N., Shigenaga M. K., Hagen T. M. Oxidants, antioxidants and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA. 90:1993;7915-7922.
3. Stocker R., Bowry V. M., Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. USA. 88:1991;1646-1650.
4. Yamamoto Y., Yamashita S., Fujisawa A., Kokura S., Yoshikawa T. Oxidative stress in patients with hepatitis, cirrhosis, and hepatoma evaluated by plasma antioxidants. Biochem. Biophys. Res. Commun. 247:1998;166-170.
5. Lagendijk J., Ubbink J. B., Delport R., Vermaak W. J. H., Human J. A. Ubiquinol/ubiquinone ratio as marker of oxidative stress in coronary artery disease. Res. Commun. Mol. Pathol. Pharmacol. 95:1997;11-20.
6. Iarussi D., Auricchio U., Agretto A., Murano A., Guilano M., Casale F., Indolfi P., Iacono A. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: Control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma. Mol. Aspects Med. 15:1994;207-212.
7. Langsjoen H., Langsjoen P., Willis R., Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: A long-term study. Mol. Aspects Med. 15:1994;165-175.
8. Mohr D., Bowry V. W., Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-densitiy lipoprotein to the initiation of lipid peroxidation. Biochim. Biophys. Acta. 1126:1992;247-254.
9. Kaikonnen J., Kosonen L., Nyyssönen K., Porkakala-Sarataho E., Salonen R., Korpela H., Salonen J. T. Effect of combined coenzyme Q10 and d-α-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: A placebo-controlled double-blind study in marathon runners. Free Radical Res. 29:1998;85-92.
10. Ernster L., Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim. Biophys. Acta. 1271:1995;195-204.
11. Crane F. L., Sun I. L., Sun E. E. The essential functions of coenzyme Q. Clin. Invest. 71:1993;55-59.
12. Stoyanowski D. A., Osipov A. N., Quinn P. J., Kagan V. E. Ubiquinone-dependent recycling of vitamin E radicals by superoxide. Arch. Biochem. Biophys. 323:1995;343-351.
13. Yamamoto Y., Yamashita S. Plasma ratio of ubiquinol and ubiquinone as a marker of oxidative stress. Mol. Aspects Med. 18:1997;79-84.
14. Folkers K., Osterborg A., Nylander M., Morita M., Mellstedt H. Activities of vitamin Q10 in animal models and a serious deficiency in patients with cancer. Biochem. Biophys. Res. Commun. 234:1997;296-299.
15. Littaru G. P., Lippa S., Oradei A., Serino F. Coenzyme Q10: Blood levels and metabolic demand. Int. J. Tissue React. 12:1990;145-148.
16. Artuch R., Moreno J., Quintana M., Puig R. M., Vilaseca M. A. Serum ubiquinone-10 in a pediatric population. Clin. Chem. 44:1998;2378-2379.
17. Hara K., Yamashita S., Fujisawa A., Ishiwa S., Ogawa T., Yamamoto Y. Oxidative stress in newborn infants with and without asphyxia as measured by plasma antioxidants and free fatty acids. Biochem. Biophys. Res. Commun. 257:1999;244-248.
18. Lagendijk J., Ubbink J. B., Vermaak W. J. H. Measurement of the ratio between the reduced and oxidized forms of coenzyme Q10 in human plasma as a possible marker of oxidative stress. J. Lipid Res. 37:1996;67-75.
19. Finkh B., Kontush A., Commentz J., Hübner C., Burdelski M., Kohlschütter A. Monitoring of ubiquinol-10, ubiquinone-10, carotenoids, and tocopherols in neonatal plasma microsamples using high-performance liquid chromatography with coulometric electrochemical detection. Anal. Biochem. 232:1995;210-216.
20. Yamashita S., Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal. Biochem. 250:1997;66-73.
21. Wang Q., Lee B. L., Ong C. N. Automated high-performance liquid chromatographic method with precolumn reduction for the determination of ubiquinol and ubiquinone in human plasma. J. Chromatogr. B. 726:1999;297-302.
22. Lang J. K., Gohil K., Pacher L. Simultaneous determination of tocopherols, ubiquinols and ubiquinones in blood, plasma, tissue homogenates, and subcellular fractions. Anal. Biochem. 157:1986;106-116.
23. Finkh B., Kontush A., Commentz J., Hübner C., Burdelski M., Kohlschütter A. High-performance liquid chromatography-coulometric electrochemical detection of ubiquinol 10, ubiquinone 10, carotenoids and tocopherols in neonatal plasma. Methods Enzymol. 299:1999;341-348.
24. Edlund O. Determination of coenzyme Q10, α-tocopherol and cholesterol in biological samples by coupled-column liquid chromatography with coulometric and ultraviolet detection. J. Chromatogr. 425:1988;87-97.
25. Engelhardt H., Lobert T. Chromatographic determination of metallic impurities in reversed-phase HPLC columns. Anal. Chem. 71:1999;1885-1892.
26. Motchnik P. A., Frei B., Ames B. N. Measurement of antioxidants in human blood plasma. Methods Enzymol. 234:1994;269-279.
27. Podda M., Weber C., Traber M. G., Milbrandt R., Packer L. Sensitive high-performance liquid chromatography techniques for simultaneous determination of tocopherols, tocotrienols, ubiquinols and ubiquinones in biological samples. Methods Enzymol. 299:1999;330-341.
28. DiMauro S., Bonilla E., Davidson M., Hirano M., Schon E. A. Mitochondria in neuromuscular disorder. Biochim. Biophys. Acta. 1366:1998;199-210.
29. Beal M. F., Hensshaw D. R., Jenkins B. G., Rosen B. R., Schulz J. B. Coenzyme Q10 and nicotinamide block stratal lesions produced by the mitochondrial toxin malonate. Ann. Neurol. 36:1994;882-888.
30. Folkers K., Vadhanavikit S., Mortensen S. A. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc. Natl. Acad. Sci. USA. 82:1985;901-904.
31. McDonnel M. G., Archbold G. P. R. Plasma ubiquinol/cholesterol ratios in patiens with hyperlipaemia, those with diabetes mellitus and in patients requiring dialysis. Clin. Chim. Acta. 1996;117-126.
32. Jolliet P., Simon N., Barre J., Pons J. Y., Boukef M., Paniel B. J., Tillement J. P. Plasma coenzyme Q10 concentrations in breast cancer: Prognosis and therapeutic consequences. Int. J. Clin. Pharm. Ther. 36:1998;506-509.
33. Lindemann J. H. N., van Zoeren-Grobben D., Schrijver J., Speek A. J., Poorthuus B. J. H. M., Berger H. M. The total free radical trapping ability of cord blood plasma in preterm and term babies. Pediatr. Res. 26:1989;20-24.