A comparative study of dual versus monoantiplatelet therapy in patients with acute large-artery atherosclerosis stroke

Journal of Stroke and Cerebrovascular Diseases

Volumn 23, Issue 7, 2014, Pages 1975-1981

  Yi, Xingyang ^a   Lin, Jing ^b   Wang, Chun ^a   Zhang, Biao ^a   Chi, Wanzhang ^b  

^a People s Hospital of Deyang City   (China)

^b THE THIRD AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Acute ischemic stroke; dual antiplatelet therapy; monoantiplatelet therapy; neurologic degeneration; stroke recurrence

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ANTITHROMBOCYTIC AGENT; TICLOPIDINE;

ACUTE LARGE ARTERY ATHEROSCLEROSIS STROKE; AGED; ARTICLE; ATHEROSCLEROSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COMPARATIVE STUDY; CONTROLLED STUDY; DETERIORATION; DRUG EFFECT; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HEMATURIA; HUMAN; LEUKOCYTE AGGREGATION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; ANALOGS AND DERIVATIVES; BIOASSAY; COMPLICATION; DRUG COMBINATION; DRUG EFFECTS; INTRACRANIAL ARTERIOSCLEROSIS; MIDDLE AGED; PROSPECTIVE STUDY; STROKE;

AGED; ASPIRIN; DRUG THERAPY, COMBINATION; ENDPOINT DETERMINATION; FEMALE; HUMANS; INTRACRANIAL ARTERIOSCLEROSIS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; RECURRENCE; STROKE; TICLOPIDINE;

EID: 84905511740     PISSN: 10523057     EISSN: 15328511     Source Type: Journal    
DOI: 10.1016/j.jstrokecerebrovasdis.2014.01.022     Document Type: Article

References (32)

1. H.J.M. Barnett, M. Eliasziw, and H.E. Meldrum Drugs and surgery in the prevention of ischemic stroke N Engl J Med 332 1995 238 248
2. A. Algra, and J. van Gijn Aspirin at any dose above 30 mg offers only modest protection after cerebral ischemia J Neurol Neurosurg Psychiatry 60 1996 197 199
3. H.C. Diener, L. Cunha, and C. Forbes et al. European Stroke Prevention Study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke J Neurol Sci 143 1996 1 13
4. CAPRIE Steering Committee A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischemic events Lancet 348 1996 1329 1339
5. Y. Schwammenthal, R. Tsabari, and B. Shenkman et al. Aspirin responsiveness in acute brain ischaemia: association with stroke severity and clinical outcome Cerebrovasc Dis 25 2008 355 361
6. K. Grundmann, K. Jaschonek, and B. Kleine et al. Aspirin non-responder status in patients with recurrent cerebral ischemic attacks J Neurol 250 2003 63 66
7. P.A. Gurbel, K.P. Bliden, and B.L. Hiatt et al. Clopidogrel for coronary stenting: response variability, drug resistance and the effect of pretreatment platelet reactivity Circulation 107 2003 2908 2913
8. S. Yusuf, F. Zhao, and S.R. Mehta et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 345 2001 494 502
9. P.A. Teal Recent clinical trial results with antiplatelet therapy: implications in stroke prevention Cerebrovasc Dis 17 Suppl 3 2004 6 10
10. H.C. Diener, J. Bogousslavsky, and L.M. Brass et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial Lancet 364 2004 331 337
11. K.S. Wong, C. Chen, and J. Fu et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial Lancet Neurol 9 2010 489 497
12. H.S. Markus, D.W. Droste, and M. Kaps et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using Doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial Circulation 111 2005 2233 2240
13. J. Kennedy, M.D. Hill, and K.J. Ryckborst et al. Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomized controlled pilot trial Lancet Neurol 6 2007 961 969
14. R.U. Esagunde, K.S. Wong, and M.P. Lee et al. Efficacy of dual antiplatelet therapy in cerebrovascular disease as demonstrated by a decline in microembolic signals. A report of eight cases Cerebrovasc Dis 21 2006 242 246
15. J.A. Alawneh, R.R. Moustafa, and J.C. Baron Hemodynamic factors and perfusion abnormalities in early neurological deterioration Stroke 40 2009 e443 e450
16. C.H. Nolte, F.N. Albach, and P.U. Heuschmann et al. Silent new DWI lesions within the first week after stroke Cerebrovasc Dis 33 2012 248 254
17. P.C. Lavallée, J. Labreuche, and D. Faille et al. Circulating markers of endothelial dysfunction and platelet activation in patients with severe symptomatic cerebral small vessel disease Cerebrovasc Dis 36 2013 131 138
18. H. Toghi, H. Suzuki, and K. Tamura et al. Platelet volume, aggregation, and adenosine triphosphate release in cerebral thrombosis Stroke 22 1991 17 22
19. S.W. Han, S.H. Kim, and J.Y. Lee et al. A new subtype classification of ischemic stroke based on treatment and etiologic mechanism Eur Neurol 57 2007 96 102
20. X. Yi, Q. Zhou, and J. Lin et al. Platelet response to aspirin in Chinese stroke patients is independent of genetic polymorphisms of COX-1 C50T and COX-2 G765C J Atheroscler Thromb 20 2013 65 72
21. J.A. Zeller, K. Frahm, and R. Baron et al. Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke? J Neurol Neurosurg Psychiatry 75 2004 984 987
22. Q. Wang, C. Chen, and X.Y. Chen et al. Low-molecular-weight heparin and early neurologic deterioration in acute stroke caused by large artery occlusive disease Arch Neurol 69 2012 1454 1460
23. M.D. Hill, P.A. Barber, and A.M. Demchuk et al. Building a 'brain attack' team to administer thrombolytic therapy for acute ischemic stroke CMAJ 162 2000 1589 1593
24. P.A. Barber, J. Zhang, and A.M. Demchuk et al. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility Neurology 56 2001 1015 1020
25. R.J. Adams, G. Albers, and M.J. Alberts et al. Update to the AHA/ASA recommendations for the prevention of stroke in patients with stroke and transient ischemic attack Stroke 39 2008 1647 1652
26. G.W. Albers, P. Amarenco, and J.D. Easton et al. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition) Chest 133 2008 630S 669S
27. The European Stroke Association (ESO) Executive Committee and the ESO Writing Committee Guidelines for management of ischaemic stroke and transient ischaemic attack 2008 Cerebrovasc Dis 25 2008 457 507
28. Z.M. Ruggeri Platelets in atherothrombosis Nat Med 8 2002 1227 1234
29. S. Fateh-Moghadam, Z. Li, and S. Ersel et al. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type 2 Arterioscler Thromb Vasc Biol 25 2005 1299 1303
30. L. Marquardt, A. Ruf, and U. Mansmann et al. Course of platelet activation markers after ischemic stroke Stroke 33 2002 2570 2574
31. D.J. McCabe, P. Harrison, and I.J. Mackie et al. Platelet degranulation and monocyte-platelet complex formation are increased in the acute and convalescent phases after ischaemic stroke or transient ischaemic attack Br J Haematol 125 2004 777 787
32. D.L. Bhatt, K.A. Fox, and W. Hacke et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events N Engl J Med 354 2006 1706 1717