Aspirin at any dose above 30 mg offers only modest protection after cerebral ischaemia

Journal of Neurology Neurosurgery and Psychiatry

Volumn 60, Issue 2, 1996, Pages 197-199

  Algra, Ale ^a   Van Gijn, Jan ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Aspirin; Cerebral ischaemia; Meta analysis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; BRAIN ISCHEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STROKE; TRANSIENT ISCHEMIC ATTACK;

EID: 0030021512     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.60.2.197     Document Type: Article

References (24)

1. Alberts MJ Dawson DV, Massey EW. A follow-up survey of clinical practices for the use of heparin, warfarin and aspirin. Neurology 1994;44:618-21.
2. Hennerici MG. Aspirin dosage - a never-ending story? Cerebrovasc Dis 1995;5:308-9.
3. Dyken ML, Barnett HJM, Easton JD, et al. Low-dose aspirin and stroke; "It ain't necessarily so". Stroke 1992; 23:1395-9.
4. van Gijn J, Warlow CP, Norrving B. Low-dose aspirin and stroke, (letter) Stroke 1993;24:476.
5. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy - I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994;308:81-106.
6. Rothman KJ. Modern epidemiology. Boston: Little, Brown and Co, 1986:195-7.
7. Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC. Cumulative meta-analysis of therapeutic trials for myocardial infarction. N Engl J Med 1992;327:246-54.
8. Breslow NE, Day NE. Statistical methods in cancer research, II: the design and analysis of cohort studies. Lyon, France: IARC Scientific Publications, 1987:131-5.
9. Fields WS, Lemak NA, Frankowski RF, Hardy RJ. Controlled trial of aspirin in cerebral ischemia. Stroke 1977;8:301-16.
10. Fields WS, Lemak NA, Frankowski RF, Hardy RJ. Controlled trial of aspirin in cerebral ischemia. Part II: surgical group. Stroke 1978;9:309-18.
11. Reuther R, Dorndorf W, Loew D. Behandlung transitorisch-ischämischer Attacken mit Azetylsalizylsäure. Münchener Medizinische Wochenschrift 1980;122:795-8.
12. Canadian Cooperative Study Group. A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978;299:53-9.
13. Guiraud-Chaumeil B, Rascol A, David J, Boneu B, Clanet M, Bierme R. Prévention des récidives des accidents vasculaires cérébraux ischémiques par les anti-agrégants plaquettaires. Résultats d'un essai thérapeutique contrôlé de 3 ans. Rev Neurol (Paris) 1982;138:367-85.
14. Bousser MG, Eschwege E, Haguenau M, et al. "AICLA" controlled trial of aspirin and dipyridamole in the secondary prevention of atherothrombotic cerebral ischemia. Stroke 1983;14:5-14.
15. Sorensen PS, Pedersen H, Marquardsen J, et al. Acetylsalicylic acid in the prevention of stroke in patients with reversible cerebral ischemic attacks. A Danish cooperative study. Stroke 1983;14:15-22.
16. Swedish Cooperative Study. High-dose acetylsalicylic acid after cerebral infarction. Stroke 1987;18:325-34.
17. Boysen G, Sorensen PS, Juhler M, et al. Danish very-low-dose aspirin after carotid endarterectomy trial. Stroke 1988;19:1211-5.
18. UK-TIA Study Group. United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: interim results. BMJ 1988;296:316-20.
19. UK-TIA Study Group. The United Kingdom transient ischaemic attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 1991 ;54:1044-54.
20. The SALT Collaborative Group. Swedish Aspirin Low-dose Trial (SALT); 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet 1991;338:1345-9.
21. The Dutch TIA Trial Study Group. Predictors of major vascular events in patients with a transient ischemic attack or nondisabling stroke. Stroke 1993;24:527-31.
22. The Dutch TIA Trial Study Group. A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. N Engl J Med 1991;325:1261-6.
23. Barnett HJM, Eliasziw M, Meldrum HE. Drugs and surgery in the prevention of ischemic stroke. N Engl J Med 1995;332:238-48.
24. Algra A, van Gijn J. Science unblinded. (letter) Lancet 1994;343:1040.