No increase in autism-associated genetic events in children conceived by assisted reproduction

Fertility and Sterility

Volumn 102, Issue 2, 2014, Pages 388-393

  Ackerman, Sean ^a   Wenegrat, Julia ^b   Rettew, David ^a   Althoff, Robert ^a   Bernier, Raphael ^b  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Assisted reproduction; assisted reproductive technology; autism; copy number variation

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTISM; CASE CONTROL STUDY; CHILD; CONCEPTION; CONTROLLED STUDY; COPY NUMBER VARIATION; FEMALE; GENE DISRUPTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; INFERTILITY THERAPY; MAJOR CLINICAL STUDY; MALE; NORTH AMERICA; PRIORITY JOURNAL; RISK ASSESSMENT;

ASSISTED REPRODUCTION; ASSISTED REPRODUCTIVE TECHNOLOGY; AUTISM; COPY NUMBER VARIATION;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CHILD, PRESCHOOL; DNA COPY NUMBER VARIATIONS; GENE DOSAGE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; NORTH AMERICA; REPRODUCTIVE TECHNIQUES, ASSISTED; RISK ASSESSMENT; RISK FACTORS;

EID: 84905493883     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.04.020     Document Type: Article

References (44)

1. Diagnostic and statistical manual of mental disorders 5th ed. 2013 American Psychiatric Publishing Arlington, VA
2. S. Blumberg, M. Bramlett, M. Kogan, L. Schieve, J. Jones, and M. Lu Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children: 2007 to 2011-2012 National Health Statistics Reports No. 65 2013 National Center for Health Statistics Hyattsville, MD
3. C. Betancur Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting Brain Res 1380 2011 42 77
4. B.J. O'Roak, L. Vives, W. Fu, J.D. Egertson, I.B. Stanaway, and I.G. Phelps et al. Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders Science 338 2012 1619 1622
5. P.J. Landrigan What causes autism? Exploring the environmental contribution Curr Opin Pediatr 22 2010 219 225
6. H.O. Atladottir, T.B. Henriksen, D.E. Schendel, and E.T. Parner Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study Pediatrics 130 2012 e1447 e1454
7. K.M. Abel, C. Dalman, A.C. Svensson, E. Susser, H. Dal, and S. Idring et al. Deviance in fetal growth and risk of autism spectrum disorder Am. J Psychiatry 170 2013 391 398
8. B.M. Flashner, M.E. Russo, J.E. Boileau, D.W. Leong, and G.I. Gallicano Epigenetic factors and autism spectrum disorders Neuromolecular Med 15 2013 339 350
9. M.J. Millan An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy Neuropharmacology 68 2013 2 82
10. Centers for Disease Control and Prevention. What is assisted reproductive technology? Available at: http://www.cdc.gov/art/. Updated April 4, 2013.
11. V.M. Allen, R.D. Wilson, and A. Cheung Pregnancy outcomes after assisted reproductive technology J Obstet Gynaecol Can 28 2006 220 250
12. C.L. Wilson, J.R. Fisher, K. Hammarberg, D.J. Amor, and J.L. Halliday Looking downstream: a review of the literature on physical and psychosocial health outcomes in adolescents and young adults who were conceived by ART Hum Reprod 26 2011 1209 1219
13. L.A. Schieve, S.A. Rasmussen, G.M. Buck, D.E. Schendel, M.A. Reynolds, and V.C. Wright Are children born after assisted reproductive technology at increased risk for adverse health outcomes? Obstet Gynecol 103 2004 1154 1163
14. J. Barnes, A.G. Sutcliffe, I. Kristoffersen, A. Loft, U. Wennerholm, and B.C. Tarlatzis et al. The influence of assisted reproduction on family functioning and children's socio-emotional development: results from a European study Hum Reprod 19 2004 1480 1487
15. Z. Papaligoura, O. Panopoulou-Maratou, M. Solman, K. Arvaniti, and J. Sarafidou Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents Hum Reprod 19 2004 1488 1493
16. A.G. Sutcliffe, B. Taylor, K. Saunders, S. Thornton, B.A. Lieberman, and J.G. Grudzinskas Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study Lancet 35 2001 2080 2084
17. I. Ponjaert-Kristoffersen, M. Bonduelle, J. Barnes, J. Nekkebroeck, A. Loft, and U.B. Wennerholm et al. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments Pediatrics 115 2005 e283 e289
18. L. Leunens, S. Celestin-Westreich, M. Bonduelle, I. Liebaers, and I. Ponjaert-Kristoffersen Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children Hum Reprod 23 2008 105 111
19. L. Mains, M. Zimmerman, J. Blaine, B. Stegmann, A. Sparks, and T. Ansley et al. Achievement test performance in children conceived by IVF Hum Reprod 25 2010 2605 2611
20. P. Agarwal, S.K. Loh, S.B. Lim, B. Sriram, M.L. Daniel, and S.H. Yeo et al. Two-year neurodevelopmental outcome in children conceived by intracytoplasmic sperm injection: prospective cohort study BJOG 112 2005 1376 1383
21. A.G. Sutcliffe, K. Saunders, R. McLachlan, B. Taylor, P. Edwards, and G. Grudzinskas et al. A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom Fertil Steril 79 2003 512 516
22. D.A. Conway, S.S. Patel, J. Liem, K.J. Fan, R. Jalian, and J. Williams 3rd et al. The risk of cytogenetic abnormalities in the late first trimester of pregnancies conceived through assisted reproduction Fertil Steril 95 2011 503 506
23. T. Shevell, F.D. Malone, J. Vidaver, T.F. Porter, D.A. Luthy, and C.H. Comstock et al. Assisted reproductive technology and pregnancy outcome Obstet Gynecol 106 5 Pt 1 2005 1039 1045
24. J.P.W. Vermeiden, and R.E. Bernardus Are imprinting disorders more prevalent after human in vitro fertilization or intracytoplasmic sperm injection? Fertil Steril 99 2013 642 651
25. J. Wen, J. Jiang, C. Ding, J. Dai, Y. Liu, and Y. Xia et al. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis Fertil Steril 97 2012 1331 1337.e1-4
26. Y.A. Wang, E.A. Sullivan, D. Black, J. Dean, J. Bryant, and M. Chapman Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000 Fertil Steril 83 2005 1650 1658
27. P.G. McGovern, A.J. Llorens, J.H. Skurnick, G. Weiss, and L.T. Goldsmith Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: a meta-analysis Fertil Steril 82 2004 1514 1520
28. L.A. Schieve, S.F. Meikle, C. Ferre, H.B. Peterson, G. Jeng, and L.S. Wilcox Low and very low birth weight in infants conceived with use of assisted reproductive technology N Engl J Med 346 2002 731 737
29. G.D. Adamson, J. de Mouzon, P. Lancaster, K.G. Nygren, E. Sullivan, and F. Zegers-Hochschild World collaborative report on in vitro fertilization, 2000 Fertil Steril 85 2006 1586 1622
30. S. Sandin, K.G. Nygren, A. Iliadou, C.M. Hultman, and A. Reichenberg Autism and mental retardation among offspring born after in vitro fertilization JAMA 310 2013 75 84
31. V. Lehti, A.S. Brown, M. Gissler, M. Rihko, A. Suominen, and A. Sourander Autism spectrum disorders in IVF children: a national case-control study in Finland Hum Reprod 28 2013 812 818
32. K. Lyall, D.L. Pauls, D. Spiegelman, S.L. Santangelo, and A. Ascherio Fertility therapies, infertility and autism spectrum disorders in the Nurses' Health Study II Paediatr Perinat Epidemiol 26 2012 361 372
33. D.A. Zachor, and E. Ben Itzchak Assisted reproductive technology and risk for autism spectrum disorder Res Dev Disabil 32 2011 2950 2956
34. D. Hvidtjørn, J. Grove, D. Schendel, L.A. Schieve, C. Svaerke, and E. Ernst et al. Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study J Epidemiol Community Health 65 2011 497 502
35. D. Hvidtjørn, L. Schieve, D. Schendel, B. Jacobsson, C. Svaerke, and P. Thorsen Cerebral palsy, autism spectrum disorders, and developmental delay in children born after assisted conception: a systematic review and meta-analysis Arch Pediatr Adolesc Med 163 2009 72 83
36. B.J. O'Roak, L. Vives, S. Girirajan, E. Karakoc, N. Krumm, and B.P. Coe et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations Nature 485 2012 246 250
37. A. Kong, M.L. Frigge, G. Masson, S. Besenbacher, P. Sulem, and G. Magnusson et al. Rate of de novo mutations and the importance of father's age to disease risk Nature 488 2012 471 475
38. E. Conti, S. Mazzotti, S. Calderoni, I. Saviozzi, and A. Guzzetta Are children born after assisted reproductive technology at increased risk of autism spectrum disorders? A systematic review Hum Reprod 28 2013 3316 3327
39. S. Melnyk, G.J. Fuchs, E. Schulz, M. Lopez, S.G. Kahler, and J.J. Fussell et al. Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism J Autism Dev Disord 42 2012 367 377
40. G.D. Fischbach, and C. Lord The Simons Simplex Collection: a resource for identification of autism genetic risk factors Neuron 68 2010 192 195
41. Diagnostic and statistical manual of mental disorders. IV-TR ed 2000 American Psychiatric Publishing Washington, DC
42. S. Girirajan, J.A. Rosenfeld, B.P. Coe, S. Parikh, N. Friedman, and A. Goldstein et al. Phenotypic heterogeneity of genomic disorders and rare copy-number variants N Engl J Med 367 2012 1321 1331
43. S.J. Sanders, M.T. Murtha, A.R. Gupta, J.D. Murdoch, M.J. Raubeson, and A.J. Willsey et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism Nature 485 2012 237 241
44. S.J. Sanders, A.G. Ercan-Sencicek, V. Hus, R. Luo, M.T. Murtha, and D. Moreno-De-Luca et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism Neuron 70 2011 863 885