Regional brain metabolism in a murine systemic lupus erythematosus model

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 8, 2014, Pages 1315-1320

  Vo, An ^a   Volpe, Bruce T ^a   Tang, Chris C ^a   Schiffer, Wynne K ^a   Kowal, Czeslawa ^a   Huerta, Patricio T ^a   Uluǧ, Aziz M ^a   Dewey, Stephen L ^a   Eidelberg, David ^a   Diamond, Betty ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

autoantibodies; behavior; FDG microPET; N methyl D aspartate receptor; stereological neuron count

Indexed keywords

ADRENALIN; FLUORODEOXYGLUCOSE F 18; LIPOPOLYSACCHARIDE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CELL COUNT; COGNITIVE DEFECT; CONTROLLED STUDY; ENTORHINAL CORTEX; FEMALE; GLIA CELL; HIPPOCAMPUS; LATERAL AMYGDALA; MEMORY DISORDER; MOUSE; NERVE CELL; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SPATIAL MEMORY; SUBICULUM; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMYGDALA; ANIMALS; ANTIBODIES, ANTINUCLEAR; BEHAVIOR, ANIMAL; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; FEMALE; FLUORODEOXYGLUCOSE F18; HIPPOCAMPUS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED BALB C; NEURONS; POSITRON-EMISSION TOMOGRAPHY;

EID: 84905489490     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.85     Document Type: Article

References (32)

1. Tsokos GC. Systemic lupus erythematosus. New Engl J Med 2011; 365: 2110-2121.
2. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 1999; 42: 599-608.
3. Mackay M, Ulug AM, Volpe BT. Neuropsychiatric systemic lupus erythematosus: mechanisms of injury. In: Lahita RG, Tsokos G, Buyon IP, Koike T (eds). Systemic Lupus Erythematosus. Academic Press: London, 2011, pp 491-511.
4. Carbotte RM, Denburg SD, Denburg JA, Nahmias C, Garnett ES. Fluctuating cognitive abnormalities and cerebral glucose metabolism in neuropsychiatric systemic lupus erythematosus. J Neurol Neurosurg Psychiatry 1992; 55: 1054-1059.
5. Kao CH, Ho YJ, Lan JL, Changlai SP, Liao KK, Chieng PU. Discrepancy between regional cerebral blood flow and glucose metabolism of the brain in systemic lupus erythematosus patients with normal brain magnetic resonance imaging findings. Arthritis Rheum 1999; 42: 61-68.
6. Komatsu N, Kodama K, Yamanouchi N, Okada S, Noda S, Nawata Y et al. Decreased regional cerebral metabolic rate for glucose in systemic lupus erythematosus patients with psychiatric symptoms. Eur Neurol 1999; 42: 41-48.
7. Lee SW, Park MC, Lee SK, Park YB. The efficacy of brain (18)F-fluorodeoxyglucose positron emission tomography in neuropsychiatric lupus patients with normal brain magnetic resonance imaging findings. Lupus 2012; 21: 1531-1537.
8. Otte A, Weiner SM, Hoegerle S, Wolf R, Juengling FD, Peter HH et al. Neuropsychiatric systemic lupus erythematosus before and after immunosuppressive treatment: a FDG PET study. Lupus 1998; 7: 57-59.
9. Weiner SM, Otte A, Schumacher M, Klein R, Gutfleisch J, Brink I et al. Diagnosis and monitoring of central nervous system involvement in systemic lupus erythematosus: value of F-18 fluorodeoxyglucose PET. Ann Rheum Dis 2000; 59: 377-385.
10. Appenzeller S, Vasconcelos Faria A, Li LM, Costallat LT, Cendes F. Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients. Ann Neurol. 2008; 64: 635-643.
11. Kozora E, Filley CM. Cognitive dysfunction and white matter abnormalities in systemic lupus erythematosus. J Int Neuropsychol Soc 2011; 3: 1-8.
12. Ramage AE, Fox PT, Brey RL, Narayana S, Cykowski MD, Naqibuddin M et al. Neuroimaging evidence of white matter inflammation in newly diagnosed systemic lupus erythematosus. Arthritis Rheum 2011; 63: 3048-3057.
13. Luyendijk J, Steens SC, Ouwendijk WJ, Steup-Beekman GM, Bollen EL, van der Grond J et al. Neuropsychiatric systemic lupus erythematosus: lessons learned from magnetic resonance imaging. Arthritis Rheum 2011; 63: 722-732.
14. Curiel R, Akin EA, Beaulieu G, DePalma L, Hashefi M. PET/CT imaging in systemic lupus erythematosus. Ann N Y Acad Sci. 2011; 1228: 71-80.
15. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001; 7: 1189-1193.
16. Kowal C, Degiorgio LA, Lee JY, Edgar MA, Huerta PT, Volpe BT et al. Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci USA 2006; 103: 19854-19859.
17. Kowal C, DeGiorgio LA, Nakaoka T, Hetherington H, Huerta PT, Diamond B et al. Cognition and immunity; antibody impairs memory. Immunity 2004; 21: 179-188.
18. Putterman C, Diamond B. Immunization with a peptide surrogate for doublestranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition. J Exp Med 1998; 188: 29-38.
19. Faust TW, Chang EH, Kowal C, Berlin R, Gazaryan IG, Bertini E et al. Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms. Proc Natl Acad Sci USA 2010; 107: 18569-18574.
20. Huerta PT, Kowal C, DeGiorgio LA, Volpe BT, Diamond B. Immunity and behavior: antibodies alter emotion. Proc Natl Acad Sci USA 2006; 103: 678-683.
21. Mirrione MM, Schiffer WK, Fowler JS, Alexoff DL, Dewey SL, Tsirka SE. A novel approach for imaging brain-behavior relationships in mice reveals unexpected metabolic patterns during seizures in the absence of tissue plasminogen activator. NeuroImage. 2007; 38: 34-42.
22. Schiffer WK, Mirrione MM, Dewey SL. Optimizing experimental protocols for quantitative behavioral imaging with 18F-FDG in rodents. J Nucl Med 2007; 48: 277-287.
23. Franklin KBJ, Paxinos G. The Mouse Brain in Stereotaxic Coordinates. 3rd edn, Academic Publishers: San Diego, 2007.
24. Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA. Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry. Neurobiol Dis. 2009; 33: 20-27.
25. Ma Y, Hof PR, Grant SC, Blackband SJ, Bennett R, Slatest L et al. A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy. Neuroscience 2005; 135: 1203-1215.
26. Ulug AM, Vo A, Argyelan M, Tanabe L, Schiffer WK, Dewey S et al. Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice. Proc Natl Acad Sci USA 2011; 108: 6638-6643.
27. Deacon RM, Croucher A, Rawlins JN. Hippocampal cytotoxic lesion effects on species-typical behaviours in mice. Behav Brain Res 2002; 132: 203-213.
28. Laflamme N, Soucy G, Rivest S. Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem. 2001; 79: 648-657.
29. DiFrancesco MW, Holland SK, Ris MD, Adler CM, Nelson S, DelBello MP et al. Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: a pilot study. Arthritis Rheum 2007; 56: 4151-4163.
30. Fitzgibbon BM, Fairhall SL, Kirk IJ, Kalev-Zylinska M, Pui K, Dalbeth N et al. Functional MRI in NPSLE patients reveals increased parietal and frontal brain activation during a working memory task compared with controls. Rheumatology 2008; 47: 50-53.
31. Mackay M, Bussa MP, Aranow C, Ulug AM, Volpe BT, Huerta PT et al. Differences in regional brain activation patterns assessed by functional magnetic resonance imaging in patients with systemic lupus erythematosus stratified by disease duration. Mol Med 2011; 17: 1349-1356.
32. Rocca MA, Agosta F, Mezzapesa DM, Ciboddo G, Falini A, Comi G et al. An fMRI study of the motor system in patients with neuropsychiatric systemic lupus erythematosus. NeuroImage. 2006; 30: 478-484.