Performance assessment of a preclinical PET scanner with pinhole collimation by comparison to a coincidence-based small-animal PET scanner

Journal of Nuclear Medicine

Volumn 55, Issue 8, 2014, Pages 1368-1374

  Walker, Matthew D ^a   Goorden, Marlies C ^b   Dinelle, Katherine ^a   Ramakers, Ruud M ^b,c,d   Blinder, Stephan ^a   Shirmohammad, Maryam ^a   Van Der Have, Frans ^b,c   Beekman, Freek J ^b,c,d   Sossi, Vesna ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c MILabs   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Pinhole PET; Preclinical PET; Small animal PET; Vector

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BONE RADIOGRAPHY; CLINICAL ASSESSMENT; COLLIMATOR; CONCENTRATION (PARAMETERS); CONTRAST TO NOISE RATIO; CONTROLLED STUDY; EX VIVO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MOUSE; NEUROIMAGING; NONHUMAN; PET SCANNER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; ANIMAL; BRAIN; COMPARATIVE STUDY; DEVICES; IMAGE QUALITY; POSITRON EMISSION TOMOGRAPHY; SCINTISCANNING; SIGNAL NOISE RATIO;

ANIMALS; BRAIN; MICE; PHANTOMS, IMAGING; POSITRON-EMISSION TOMOGRAPHY; SIGNAL-TO-NOISE RATIO;

EID: 84905482212     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.136663     Document Type: Article

References (20)

1. Goorden MC, Beekman FJ. High-resolution tomography of positron emitters with clustered pinhole SPECT. Phys Med Biol. 2010;55:1265-1277.
2. Muehllehner G. Effect of resolution improvement on required count density in ECT imaging: a computer simulation. Phys Med Biol. 1985;30:163-173.
3. Goorden MC, van der Have F, Kreuger R, et al. VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET. J Nucl Med. 2013;54:306-312.
4. Kim JS, Lee JS, Im KC, et al. Performance measurement of the microPET focus 120 scanner. J Nucl Med. 2007;48:1527-1535.
5. Bahri MA, Plenevaux A, Warnock G, Luxen A, Seret A. NEMA NU4-2008 image quality performance report for the microPET focus 120 and for various transmission and reconstruction methods. J Nucl Med. 2009;50:1730-1738.
6. National Electrical Manufacturers Association. NEMA Standard Publication NU 4-2008: Performance Measurements of Small Animal Positron Emission Tomographs. Rosslyn, VA: National Electrical Manufacturers Association; 2008.
7. van der Have F, Vastenhouw B, Ramakers RM, et al. U-SPECT-II: an ultra-highresolution device for molecular small-animal imaging. J Nucl Med. 2009;50:599-605.
8. Vastenhouw B, Beekman FJ. Submillimeter total-body murine imaging with U-SPECT-I. J Nucl Med. 2007;48:487-493.
9. Vaissier PE, Goorden MC, Vastenhouw B. van der HF, Ramakers RM, Beekman FJ. Fast spiral SPECT with stationary gamma-cameras and focusing pinholes. J Nucl Med. 2012;53:1292-1299.
10. Chatziioannou A, Qi J, Moore A, et al. Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET. IEEE Trans Med Imaging. 2000;19:507-512.
11. Cheng JC, Shoghi K, Laforest R. Quantitative accuracy of MAP reconstruction for dynamic PET imaging in small animals. Med Phys. 2012;39:1029-1041.
12. Ogawa K, Harata Y, Ichihara T, Kubo A, Hashimoto S. A practical method for position-dependent Compton-scatter correction in single photon emission CT. IEEE Trans Med Imaging. 1991;10:408-412.
13. Goorden MC, van der, Have F, Beekman F. J. Optimizing image reconstruction for simultaneous sub-mm clustered pinhole PET-SPECT. In: Proceedings of the 12th International Meeting on Fully 3D Image Reconstruction in Radiology and Nuclear Medicine. http://www.fully3d.org/ Fully3D2013Proceedings.pdf. 2013:126-129. Accessed May 30, 2014.
14. Branderhorst W, Vastenhouw B, Beekman FJ. Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. Phys Med Biol. 2010;55:2023-2034.
15. Goertzen AL, Stout DB, Thompson CJ. A method for measuring the energy spectrum of coincidence events in positron emission tomography. Phys Med Biol. 2010;55:535-549.
16. Germano G, Hoffman EJ. A study of data loss and mispositioning due to pileup in 2-D detectors in PET. IEEE Trans Nucl Sci. 1990;37:671-675.
17. Kung MP, Kung HF. Mass effect of injected dose in small rodent imaging by SPECT and PET. Nucl Med Biol. 2005;32:673-678.
18. Funk T, Sun M, Hasegawa BH. Radiation dose estimate in small animal SPECT and PET. Med Phys. 2004;31:2680-2686.
19. Bogdándi EN, Balogh A, Felgyinszki N, et al. Effects of low-dose radiation on the immune system of mice after total-body irradiation. Radiat Res. 2010;174:480-489.
20. Goertzen AL, Bao Q, Bergeron M, et al. NEMA NU 4-2008 comparison of preclinical PET imaging systems. J Nucl Med. 2012;53:1300-1309.