VECTor: A preclinical imaging system for simultaneous submillimeter SPECT and PET

Journal of Nuclear Medicine

Volumn 54, Issue 2, 2013, Pages 306-312

  Goorden, Marlies C ^a   Frans van der Have, ^a,b   Kreuger, Rob ^a   Ramakers, Ruud M ^a,b   Vastenhouw, Brendan ^a,b   Burbach, J Peter H ^c   Booij, Jan ^d   Molthoff, Carla F M ^e   Beekman, Freek J ^a,b  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b MILabs   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiac imaging; Molecular imaging; Neuroimaging; PET; Pinhole; Small animal; SPECT

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BONE SCINTISCANNING; BRAIN SCINTISCANNING; COLLIMATOR; ECHOCARDIOGRAPHY; EQUIPMENT DESIGN; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE QUALITY; IMAGING SYSTEM; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VERSATILE EMISSION COMPUTED TOMOGRAPHY SYSTEM;

ANIMALS; CALIBRATION; COMPUTER SIMULATION; COMPUTERS; EQUIPMENT DESIGN; IMAGE ENHANCEMENT; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, INBRED C57BL; PHANTOMS, IMAGING; PHOTONS; POSITRON-EMISSION TOMOGRAPHY; SCATTERING, RADIATION; SENSITIVITY AND SPECIFICITY; SOFTWARE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84873558956     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.109538     Document Type: Article

References (35)

1. Rowland DJ, Cherry SR. Small-animal preclinical nuclear medicine instrumentation and methodology. Semin Nucl Med. 2008;38:209-222.
2. Weissleder R, Ross BD, Rehemtulla A, Gambhir SS. Molecular Imaging: Principles and Practice. Shelton, CT: People's Medical Publishing House-USA; 2010:844-1178.
3. Jaszczak RJ, Li JY, Wang HL, Zalutsky MR, Coleman RE. Pinhole collimation for ultra-high-resolution, small-field-of-view spect. Phys Med Biol. 1994;39: 425-437.
4. Ishizu K, Mukai T, Yonekura Y, et al. Ultra-high-resolution spect system using 4 pinhole collimators for small animal studies. J Nucl Med. 1995;36: 2282-2287.
5. Liu Z, Kastis GA, Stevenson GD, et al. Quantitative analysis of acute myocardial infarct in rat hearts with ischemia-reperfusion using a high-resolution stationary SPECT system. J Nucl Med. 2002;43:933-939.
6. Furenlid LR, Wilson DW, Chen YC, et al. Fast SPECT II: a second-generation highresolution dynamic SPECT imager. IEEE Trans Nucl Sci. 2004;51:631-635.
7. Metzler SD, Jaszczak RJ, Patil NH, Vemulapalli S, Akabani G, Chin BB. Molecular imaging of small animals with a triple-head SPECT system using pinhole collimation. IEEE Trans Med Imaging. 2005;24:853-862.
8. van der Have F, Vastenhouw B, Ramakers RM, et al. U-SPECT-II: an ultrahigh-resolution device for molecular small-animal imaging. J Nucl Med. 2009; 50:599-605.
9. Beekman F, van der Have F. The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. Eur J Nucl Med Mol Imaging. 2007;34:151-161.
10. Jeavons AP, Chandler RA, Dettmar CAR. A 3D HIDAC-PET camera with submillimetre resolution for imaging small animals. IEEE Trans Nucl Sci. 1999; 46:468-473.
11. Tai YC, Chatziioannou AF, Yang YF, et al. MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging. Phys Med Biol. 2003;48:1519-1537.
12. Yang Y, Tai YC, Siegel S, et al. Optimization and performance evaluation of the microPET II scanner for in vivo small-animal imaging. Phys Med Biol. 2004; 49:2527-2545.
13. Rouze NC, Schmand M, Siegel S, Hutchins GD. Design of a small animal PET imaging system with 1 microliter volume resolution. IEEE Trans Nucl Sci. 2004; 51:757-763.
14. Miyaoka RS, Janes ML, Lee K, Park B, Kinahan PE, Lewellen TK. Development of a single detector ring micro crystal element scanner: QuickPET II. Mol Imaging. 2005;4:117-127.
15. Tai YC, Ruangma A, Rowland D, et al. Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging. J Nucl Med. 2005;46:455-463.
16. Vastenhouw B, van der Have F, van der Linden AJ, et al. Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT. Mol Psychiatry. 2007;12:984-987.
17. Vaissier PEB, Goorden MC, Vastenhouw B, Van der Have F, Ramakers RM, Beekman FJ. Fast spiral SPECT with stationary g-cameras and focusing pinholes. J Nucl Med. 2012;53:1292-1299.
18. Goorden MC, Beekman FJ. High-resolution tomography of positron emitters with clustered pinhole SPECT. Phys Med Biol. 2010;55:1265-1277.
19. Beekman FJ, inventor; MILabs BV, assignee. Focused pinhole gamma detection device. U.S. patent 8,067,741. November 29, 2011. European patent application EP2073039.
20. Bom V, Goorden M, Beekman F. Comparison of pinhole collimator materials based on sensitivity equivalence. Phys Med Biol. 2011;56:3199-3214.
21. Branderhorst W, Vastenhouw B, van der Have F, Blezer ELA, Bleeker WK, Beekman FJ. Targeted multi-pinhole SPECT. Eur J Nucl Med Mol Imaging. 2011;38:552-561.
22. Vastenhouw B, Beekman F. Submillimeter total-body murine imaging with USPECT-I. J Nucl Med. 2007;48:487-493.
23. Branderhorst W, Vastenhouw B, Beekman FJ. Pixel-based subsets for rapid multi-pinhole SPECT reconstruction. Phys Med Biol. 2010;55:2023-2034.
24. van der Have F, Vastenhouw B, Rentmeester M, Beekman FJ. System calibration and statistical image reconstruction for ultra-high resolution stationary pinhole SPECT. IEEE Trans Med Imaging. 2008;27:960-971.
25. Goorden MC, van der Have F, Kreuger R, Beekman FJ. An efficient simulator for pinhole imaging of PET isotopes. Phys Med Biol. 2011;56:1617-1634.
26. Ogawa K, Harata Y, Ichihara T, Kubo A, Hashimoto S. A practical method for position-dependent Compton-scatter correction in single photon-emission ct. IEEE Trans Med Imaging. 1991;10:408-412.
27. Wu C, van der Have F, Vastenhouw B, Dierckx RAJO, Paans AMJ, Beekman FJ. Absolute quantitative total-body small-animal SPECT with focusing pinholes. Eur J Nucl Med Mol Imaging. 2010;37:2127-2135.
28. Delbeke D, Videlefsky S, Patton JA, et al. Rest myocardial perfusion/metabolism imaging using simultaneous dual-isotope acquisition spect with technetium-99m-MIBI/fluorine-18-FDG. J Nucl Med. 1995;36:2110-2119.
29. Reiman EM, Uecker A, Gonzalez-Lima F, et al. Tracking Alzheimer's disease in transgenic mice using fluorodeoxyglucose autoradiography. Neuroreport. 2000; 11:987-991.
30. Funk T, Sun MS, Hasegawa BH. Radiation dose estimate in small animal SPECT and PET. Med Phys. 2004;31:2680-2686.
31. O'Daly OG, Joyce D, Stephan KE, Murray RM, Shergill SS. Functional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers. Arch Gen Psychiatry. 2011;68:545-554.
32. Stoessl AJ, Martin WRW, McKeown M, Sossi V. Advances in imaging in Parkinson's disease. Lancet Neurol. 2011;10:987-1001.
33. Vunckx K, Suetens P, Nuyts J. Effect of overlapping projections on reconstruction image quality in multipinhole SPECT. IEEE Trans Med Imaging. 2008;27:972-983.
34. Mok GS, Tsui BM, Beekman FJ. The effects of object activity distribution on multiplexing multi-pinhole SPECT. Phys Med Biol. 2011;56:2635-2650.
35. Barrett HH, Furenlid LR, Freed M, et al. Adaptive SPECT. IEEE Trans Med Imaging. 2008;27:775-788.