Structural modifications of mitochondria-targeted chlorambucil alter cell death mechanism but preserve MDR evasion

Molecular Pharmaceutics

Volumn 11, Issue 8, 2014, Pages 2675-2682

  Jean, Sae Rin ^a   Pereira, Mark P ^b   Kelley, Shana O ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

alkylating activity; chlorambucil (Cbl); drug delivery; mitochondria; multidrug resistance (MDR)

Indexed keywords

ALKYLATING AGENT; CHLORAMBUCIL; GLUTATHIONE TRANSFERASE; MITOCHONDRIA TARGETED CHLORAMBUCIL; MITOCHONDRIAL PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CYTOCHROME C;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; LC 50; MITOCHONDRION; MODULATION; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; UPREGULATION; CELL NUCLEUS; CELL SURVIVAL; CHEMISTRY; COLORIMETRY; DNA DAMAGE; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG RESISTANCE; HELA CELL LINE; IC50; METABOLISM; NECROSIS; OVARIAN NEOPLASMS; TUMOR CELL LINE;

ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CHLORAMBUCIL; COLORIMETRY; CYTOCHROMES C; CYTOSOL; DNA DAMAGE; DRUG DELIVERY SYSTEMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MITOCHONDRIA; NECROSIS; OVARIAN NEOPLASMS;

EID: 84905482146     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500104j     Document Type: Article

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