Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes

Molecular Medicine Reports

Volumn 10, Issue 3, 2014, Pages 1576-1582

  Chen, Hui ^a   Chen, Yongjun ^a   Tang, Yanhong ^a   Yang, Jing ^a   Wang, Dandan ^a   Yu, Taihui ^a   Huang, Congxin ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Berberine; Human HCN channel; Spontaneous action potentials; Voltage clamp; Xenopus oocyte

Indexed keywords

ANTIARRHYTHMIC AGENT; BERBERINE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED 4 CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; UNCLASSIFIED DRUG; ZATEBRADINE; HCN4 PROTEIN, HUMAN; HERBACEOUS AGENT; MUSCLE PROTEIN; POTASSIUM CHANNEL;

ACTION POTENTIAL DURATION; ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CARDIOVASCULAR PARAMETERS; CHINESE MEDICINE; CONTROLLED STUDY; DIASTOLIC DEPOLARIZATION RATE; DRUG EFFECT; HEART ELECTROPHYSIOLOGY; IN VITRO STUDY; MAXIMAL DIASTOLIC POTENTIAL; NONHUMAN; RATE OF PACEMAKER FIRING; SINUS NODE; SINUS NODE MEMBRANE POTENTIAL; SPONTANEOUS ACTIVITY OF SINOATRIAL NODE; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS; ACTION POTENTIAL; ANIMAL; CYTOLOGY; DRUG EFFECTS; FEMALE; GENETICS; HEART; HEART MUSCLE CELL; HUMAN; MALE; METABOLISM; OOCYTE; RABBIT;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BERBERINE; DRUGS, CHINESE HERBAL; FEMALE; HEART; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; MALE; MUSCLE PROTEINS; MYOCYTES, CARDIAC; OOCYTES; POTASSIUM CHANNELS; RABBITS; SINOATRIAL NODE; XENOPUS LAEVIS;

EID: 84905463477     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2377     Document Type: Article

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