Inhibition of the purinergic pathway prolongs mouse lung allograft survival

American Journal of Respiratory Cell and Molecular Biology

Volumn 51, Issue 2, 2014, Pages 300-310

  Liu, Kaifeng ^a   Vergani, Andrea ^a   Zhao, Picheng ^a   Ben Nasr, Moufida ^a   Wu, Xiao ^a   Iken, Khadija ^a   Jiang, Dawei ^a   Su, Xiaofeng ^b   Fotino, Carmen ^c   Fiorina, Paolo ^a   Visner, Gary A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b TUFTS UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

CD8; Oxidized ATP; P2XR7; Transplant

Indexed keywords

CD8; OXIDIZED ATP; P2XR7; TRANSPLANT;

ADENOSINE TRIPHOSPHATE; ALLOGRAFTS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNOSUPPRESSIVE AGENTS; LUNG; LUNG TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; SURAMIN; TIME FACTORS;

EID: 84905450502     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2013-0362OC     Document Type: Article

References (33)

1. Weigt SS, Wallace WD, Derhovanessian A, Saggar R, Saggar R, Lynch JP, Belperio JA. Chronic allograft rejection: epidemiology, diagnosis, pathogenesis, and treatment. Semin Respir Crit Care Med 2010;31:189-207.
2. Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Dobbels F, Kirk R, Rahmel AO, Stehlik J, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. J Heart Lung Transplant 2012;31:1073-1086.
3. Schenk U, Westendorf AM, Radaelli E, Casati A, Ferro M, Fumagalli M, Verderio C, Buer J, Scanziani E, Grassi F. Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels. Sci Signal 2008;1:ra6.
4. Yegutkin GG, Mikhailov A, Samburski SS, Jalkanen S. The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensor. Mol Biol Cell 2006;17:3378-3385.
5. Junger WG. Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol 2011;11:201-212.
6. Yegutkin GG, Henttinen T, Samburski SS, Spychala J, Jalkanen S. The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. Biochem J 2002;367:121-128.
7. Spooner R, Yilmaz O. The role of reactive-oxygen-species in microbial persistence and inflammation. Int J Mol Sci 2011;12:334-352.
8. Trautmann A. Extracellular ATP in the immune system: more than just a "danger signal". Sci Signal 2009;2:pe6.
9. Placido R, Auricchio G, Falzoni S, Battistini L, Colizzi V, Brunetti E, Di Virgilio F, Mancino G. P2X (7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability. Cell Immunol 2006;244:10-18.
10. Lang PA, Merkler D, Funkner P, Shaabani N, Meryk A, Krings C, Barthuber C, Recher M, Bruck W, Haussinger D, et al. Oxidized ATP inhibits T-cellmediated autoimmunity. Eur J Immunol 2010;40:2401-2408.
11. Vergani A, Tezza S, D'Addio F, Fotino C, Liu K, Niewczas M, Bassi R, Molano RD, Kleffel S, Petrelli A, et al. Long-term heart transplant survival by targeting the ionotropic purinergic receptor P2X7. Circulation 2013;127:463-475.
12. Bizargity P, Liu K, Wang L, Hancock WW, Visner GA. Inhibitory effects of pirfenidone on dendritic cells and lung allograft rejection. Transplantation 2012;94:114-122.
13. Iken K, Liu K, Liu H, Bizargity P, Wang L, Hancock WW, Visner GA. Indoleamine 2, 3-dioxygenase and metabolites protect murine lung allografts and impair the calcium mobilization of T cells. Am J Respir Cell Mol Biol 2012;47:405-416.
14. Liu H, Liu L, Fletcher BS, Visner GA. Novel action of indoleamine 2, 3-dioxygenase attenuating acute lung allograft injury. Am J Respir Crit Care Med 2006;173:566-572.
15. Liu H, Liu L, Fletcher BS, Visner GA. Sleeping Beauty-based gene therapy with indoleamine 2, 3-dioxygenase inhibits lung allograft fibrosis. FASEB J 2006;20:2384-2386.
16. Stewart S, Fishbein MC, Snell GI, Berry GJ, Boehler A, Burke MM, Glanville A, Gould FK, Magro C, Marboe CC, et al. Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection. J Heart Lung Transplant 2007;26:1229-1242.
17. Vergani A, Fotino C, D'Addio F, Tezza S, Podetta M, Gatti F, Chin M, Bassi R, Molano RD, Corradi D, et al. Effect of the purinergic inhibitor oxidized ATP in a model of islet allograft rejection. Diabetes 2013;62:1665-1675.
18. Azzi J, Tang L, Moore R, Tong R, ElHaddad N, Akiyoshi T, Mfarrej B, Yang S, Jurewicz M, Ichimura T, et al. Polylactide-cyclosporin A nanoparticles for targeted immunosuppression. FASEB J 2010;24:3927-3938.
19. Gelman AE, Okazaki M, Lai J, Kornfeld CG, Kreisel FH, Richardson SB, Sugimoto S, Tietjens JR, Patterson GA, Krupnick AS, et al. CD41 T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants. J Immunol 2008;180:4754-4762.
20. De Vleeschauwer S, Jungraithmayr W, Wauters S, Willems S, Rinaldi M, Vaneylen A, Verleden S, Willems-Widyastuti A, Bracke K, Brusselle G, et al. Chronic rejection pathology after orthotopic lung transplantation in mice: the development of a murine BOS model and its drawbacks. PLoS ONE 2012;7:e29802.
21. Burnstock G, Brouns I, Adriaensen D, Timmermans JP. Purinergic signaling in the airways. Pharmacol Rev 2012;64:834-868.
22. Schnurr M, Then F, Galambos P, Scholz C, Siegmund B, Endres S, Eigler A. Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells. J Immunol 2000;165:4704-4709.
23. Riteau N, Gasse P, Fauconnier L, Gombault A, Couegnat M, Fick L, Kanellopoulos J, Quesniaux VF, Marchand-Adam S, Crestani B, et al. Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis. Am J Respir Crit Care Med 2010;182:774-783.
24. Arulkumaran N, Unwin RJ, Tam FW. A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases. Expert Opin Investig Drugs 2011;20:897-915.
25. Unsoeld H, Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol 2005;79:4510-4513.
26. Chused TM, Apasov S, Sitkovsky M. Murine T lymphocytes modulate activity of an ATP-activated P2Z-type purinoceptor during differentiation. J Immunol 1996;157:1371-1380.
27. Taylor SR, Gonzalez-Begne M, Sojka DK, Richardson JC, Sheardown SA, Harrison SM, Pusey CD, Tam FW, Elliott JI. Lymphocytes from P2X7-deficient mice exhibit enhanced P2X7 responses. J Leukoc Biol 2009;85:978-986.
28. Brook MO, Wood KJ, Jones ND. The impact of memory T cells on rejection and the induction of tolerance. Transplantation 2006;82:1-9.
29. Bishop GA, Ierino FL, Sharland AF, Hall BM, Alexander SI, Sandrin MS, Coates PT, McCaughan GW. Approaching the promise of operational tolerance in clinical transplantation. Transplantation 2011;91:1065-1074.
30. Wan N, Dai H, Wang T, Moore Y, Zheng XX, Dai Z. Bystander central memory but not effector memory CD81 T cells suppress allograft rejection. J Immunol 2008;180:113-121.
31. Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, et al. ATP drives lamina propria T (H) 17 cell differentiation. Nature 2008;455:808-812.
32. Shilling RA, Wilkes DS. Role of Th17 cells and IL-17 in lung transplant rejection. Semin Immunopathol 2011;33:129-134.
33. McGrath MM, Najafian N. The role of coinhibitory signaling pathways in transplantation and tolerance. Front Immunol 2012;3:47.