Thermodynamics of the interaction between oxytocin and its myometrial receptor in sheep: A stepwise binding mechanism

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 119-127

  Pliska, Vladimir ^a,b   Folkers, Gerd ^a,b   Spiwok, Vojtěch ^c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

G protein coupled receptors; Ligand receptor thermodynamics; Myometrium cell membranes; Oxytocin inhibitors; Oxytocin receptor; Receptor models

Indexed keywords

ARGIPRESSIN; ATOSIBAN; GUANOSINE TRIPHOSPHATE DERIVATIVE; OXYTOCIN; OXYTOCIN RECEPTOR; RECEPTOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONCENTRATION (PARAMETERS); ENTHALPY; ENTROPY; EXPERIMENTAL SHEEP; FEMALE; HEAT; MOLECULAR INTERACTION; MYOMETRIUM; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

ARGININE VASOPRESSIN; ATOSIBAN: [1-MERCAPTOPROPIONIC ACID, 2-D-(O-ETHYL)-TYROSINE,4-THREONINE, 8-ORNITHINE]OXYTOCIN; G PROTEIN-COUPLED RECEPTORS; GTP-ΓS: GUANOSINE-5′-O-(3-THIOTRIPHOSPHATE); LIGAND-RECEPTOR THERMODYNAMICS; MYOMETRIUM CELL MEMBRANES; OXYTOCIN; OXYTOCIN INHIBITORS; OXYTOCIN RECEPTOR; RECEPTOR MODELS; TRITIUM-LABELED ARGININE VASOPRESSIN: [8-ARGININE, 3-PHENYLALANINE-3,4,5-(3)H]VASOPRESSIN; TRITIUM-LABELED OXYTOCIN: [2-TYROSINE-2,6-(3)H]OXYTOCIN;

ANIMALS; ARGININE VASOPRESSIN; BINDING SITES; CELL MEMBRANE; FEMALE; MYOMETRIUM; OXYTOCIN; RECEPTORS, OXYTOCIN; SHEEP; TEMPERATURE; THERMODYNAMICS; VASOTOCIN;

EID: 84905440456     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.06.025     Document Type: Article

References (48)

1. T. Kimura, Y. Makino, F. Saji, M. Takemura, T. Inoue, and T. Kikuchi et al. Molecular characterization of a cloned human oxytocin receptor Eur J Endocrinol 131 1994 385 390 (Pubitemid 24309268)
2. T. Kimura, O. Tanizawa, K. Mori, M.J. Brownstein, and H. Okayama Structure and expression of a human oxytocin receptor Nature 356 1992 526 529
3. V. Pliska, J. Heiniger, A. Müller-Lhotsky, P. Pliska, and B. Ekberg Binding of oxytocin to uterine cells in vitro: occurrence of several binding site populations and reidentification of oxytocin receptors J Biol Chem 261 1986 16984 16989 (Pubitemid 17210347)
4. 2+ on the binding of oxytocin to sheep myometrial cells Biochem J 277 1991 97 101
5. D. Crankshaw, V. Gaspar, and V. Pliska Multiple [3H]-oxytocin binding sites in rat myometrial plasma membranes J Recept Res 10 1990 269 285
6. K. Jarnagin Receptor binding in drug discovery Nature encyclopedia of life sciences 2000 John Wiley & Sons, Inc. Chichester
7. M.E. Magar Data analysis in biochemistry and biophysics 1972 Academic Press, Inc. New York
8. V. Pliska Partial agonism: mechanisms based on ligand-receptor interactions and on stimulus-response coupling J Recept Sig Transd 19 1999 597 629 (Pubitemid 29152212)
9. G. Gimpl, K. Burger, and F. Fahrenholz Cholesterol as modulator of receptor function Biochemistry 36 1997 10959 10974 (Pubitemid 27396253)
10. K. Okuda, A. Miyamoto, H. Sauerwein, F.J. Schweigert, and D. Schams Evidence for oxytocin receptors in cultured bovine luteal cells Biol Reprod 46 1992 1001 1006
11. J. Bockaert G protein-coupled receptors Nature encyclopedia of life sciences 1999 John Wiley & Sons, Ltd Chichester
12. s complex: evidence for agonist-specific states Mol Pharmacol 52 1997 144 154 (Pubitemid 27318630)
13. R.J. Lefkowitz, S. Cotecchia, P. Samama, and T. Costa Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins Trends Pharmacol Sci 14 1993 303 307 (Pubitemid 23242583)
14. G. Gimpl, J. Reitz, S. Brauer, and C. Trossen Oxytocin receptors: ligand binding, signaling and cholesterol dependence Prog Brain Res 170 2008 183 204
15. R. Postina, E. Koiro, and F. Fahrenholz Separate agonists and peptide antagonist binding sites of the oxytocin receptor defined by their transfer into the V2 vasopressin receptor Biol Chem 271 1996 31593 31601 (Pubitemid 26408620)
16. V. Pliska Pharmacological approaches to the identification and classification of myometrial oxytocin receptors J Recept Res 8 1988 245 259
17. V. Pliska Pharmacological versus binding analysis of receptor systems: how do they interplay? Myometrial cell receptors for oxytocin as a paradigm Experientia 47 1991 216 221 (Pubitemid 21892797)
18. D.F. Sargent, and R. Schwyzer Membrane lipid phase as catalyst for peptide-receptor interactions Proc Natl Acad Sci USA 83 1986 5774 5778 (Pubitemid 16000594)
19. M. Åkerlund, A.M. Carlsson, P. Melin, and J. Trojnar The effect on the human uterus of two newly developed competitive inhibitors of oxytocin and vasopressin Acta Obstet Gyn Scan 64 1985 499 504 (Pubitemid 15241026)
20. P. Melin, J. Trojnar, B. Johansson, H. Vilhardt, and M. Åkelund Synthetic antagonists of the myometrial response to vasopressin and oxytocin J Endocrinol 111 1986 125 131 (Pubitemid 16003814)
21. V.J. Ayad, and D.C. Wathes Characterization of endometrial and myometrial oxytocin receptors in the non-pregnant ewe J Endocrinol 123 1989 11 18 (Pubitemid 19254926)
22. V. Pliska, H. Kohlhauf Albertin, and D.J. Crankshaw Oxytocin receptors in myometrium. Preliminary evidence for a receptor switch mechanism P.C.K. Leung, A.J.W. Hsueh, H.G. Friesen, Molecular basis of reproductive endocrinology 1993 Springer Verlag Berlin Berlin 270 276
23. M.S. Soloff, and T.L. Swartz Characterization of a proposed oxytocin receptor in the uterus of the rat and sow J Biol Chem 249 1974 1376 1381
24. V. Pliska Multiple receptor populations: binding isotherms and their numerical analysis J Recept Sig Transd 15 1995 651 675
25. H.J. Tobler, and G. Engel Affinity spectra: a novel way for the evaluation of equilibrium binding experiments Naunyn Schmiedebergs Arch Pharmacol 322 1983 183 192 (Pubitemid 13163240)
26. P.J. Munson, and D. Rodbard LIGAND: a versatile computerized approach for characterization of ligand-binding systems Anal Biochem 107 1980 220 239
27. L. Engelman Nonlinear models SYSTAT 9: Statistics II 1999 SPSS Inc. Chicago, IL 75 124
28. E. Bürgisser Model testing in radiologand/receptor interaction by Monte Carlo simulation J Recept Res 3 1983 261 281 (Pubitemid 13120534)
29. A. Hald Statistical theory with engineering applications 1952 J. Wiley & Sons, Inc. New York, NY
30. D.J. Crankshaw, L.A. Branda, M.A. Matlib, and E.E. Daniel Localization of the oxytocin receptor in the plasma membrane of rat myometrium Eur J Biochem 86 1978 481 486 (Pubitemid 8340077)
31. V. Pliska Thermodynamic descriptors, profiles and driving forces in membrane receptor-ligand interactions J Recept Sig Transd 30 2010 454 468
32. M. Maggi, P. del Carlo, G. Fantoni, S. Giannini, C. Torrisi, and D. Casparis et al. Human myometrium during pregnancy contains and responds to V1 vasopressin receptors as well as oxytocin receptors J Clin Endocrinol Metab 70 1990 1142 1153
33. F. Fahrenholz, M. Hackenberg, and M. Müller Identification of a myometrial oxytocin-receptor protein Eur J Biochem 174 1988 81 85
34. 2]-oxytocin Eur J Pharmacol 49 1978 213 222 (Pubitemid 9201876)
35. J.W. Bean, D.F. Sargent, and R. Schwyzer Ligand/receptor interactions - the influence of the microenvironment on macroscopic properties. Electrostatic interactions with the membrane phase J Recept Res 8 1988 375 389
36. R. Schwyzer Conformations and orientations of amphiphilic peptides induced by artificial lipid membranes: correlations with biological activity CHEMTRACTS - biochemistry and molecular biology vol. 3 1992 Data Trace Chemistry Publishers, Inc. 347 379
37. P.J. van der Sluis, G.J. Boer, and D.F. Swaab Vasopressin and oxytocin in the developing rat brain as shown by isoelectric focusing of radioimmunoassayable peptides Dev Brain Res 26 1986 85 90 (Pubitemid 16168198)
38. A. Rachkov, and N. Minoura Recognition of oxytocin and oxytocin-related peptides in aqueous media using a molecularly imprinted polymer synthesized by the epitope approach J Chromatogr A 889 2000 111 118 (Pubitemid 30466259)
39. J.G. Pierce, S. Gordon, and V. du Vigneaud Further distribution studies on the oxytocic hormone of the posterior lobe of the pituitary gland and the preparation of an active crystalline flavianate J Biol Chem 199 1952 929 940
40. V. du Vigneaud, C. Ressler, J.M. Swan, C.W. Roberts, and P.G. Katsoyannis The synthesis of oxytocin J Am Chem Soc 76 1954 3115 3121
41. V. Pliska, T. Barth, and N.A. Thorn Some metabolites of specifically tritium labelled lysine vasopressin: indentification by thin-layer chromatography and determination by liquid scintillation technique Acta Endocrinol (Copenh) 67 1971 1 11
42. V. Pliska, M. Schmidt, and J.-L. Fauchère Partition coefficients of amino acids and hydrophobic parameters pi of their side-chains as measured by thin-layer chromatography J Chromatogr 216 1981 79 91
43. A. Liwo, A. Tempczyk, S. Ołdziej, M.D. Shenderovich, S. Talluri, and J. Ciarkowski et al. Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods Biopolymers 38 1996 157 175
44. S. Ołdziej, J. Ciarkowski, A. Liwo, M.D. Shenderovich, and Z. Grzonka Conformational aspects of differences in requirements for oxytocin and vasopressin receptors J Recept Sig Transd 15 1995 703 713
45. V. Spiwok, M. Jakusch, P. Pospisil, G. Folkers, and V. Pliska Molecular modelling study of free-energy landscape of oxytocin and atosiban J Pept Sci 10 2004 232
46. Y. Sugita, and Y. Okamoto Replica-exchange molecular dynamics method for protein folding Chem Phys Lett 314 1999 141 151 (Pubitemid 129556751)
47. M.J. Ślusarz, R. Ślusarz, and J. Ciarkowski Molecular dynamics study of the internal water molecules in vasopressin and oxytocin receptors Protein Pept Lett 16 2009 342 350
48. i receptor interaction Am J Physiol 272 1997 E870 E876