메뉴 건너뛰기




Volumn 23, Issue 5, 2014, Pages 361-371

Chemopreventive effect of zingerone against colon carcinogenesis induced by 1,2-dimethylhydrazine in rats

Author keywords

1,2 dimethylhydrazine; aberrant crypt foci; lipid peroxidation; zingerone

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ALKENE DERIVATIVE; ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HYDROXYL RADICAL; LIPID; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; ZINGERONE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARCINOGEN; GUAIACOL;

EID: 84905373301     PISSN: 09598278     EISSN: 14735709     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e32836473ac     Document Type: Article
Times cited : (71)

References (59)
  • 1
    • 64649106046 scopus 로고    scopus 로고
    • Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis
    • Aranganathan S, Panneer Selvam J, Nalini N (2009). Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis. Invest New Drugs 27:203-213.
    • (2009) Invest New Drugs , vol.27 , pp. 203-213
    • Aranganathan, S.1    Panneer Selvam, J.2    Nalini, N.3
  • 2
    • 79958747121 scopus 로고    scopus 로고
    • Chemoprevention by Triticum aestivum of mouse skin carcinogenesis induced by DMBA and croton oil: Association with oxidative status
    • Arya P, Madhu K (2011). Chemoprevention by Triticum aestivum of mouse skin carcinogenesis induced by DMBA and croton oil: association with oxidative status. Asian Pac J Cancer Prev 12:143-148.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 143-148
    • Arya, P.1    Madhu, K.2
  • 3
    • 0029003648 scopus 로고
    • Role of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • Bird RP (1995). Role of aberrant crypt foci in understanding the pathogenesis of colon cancer. Cancer Lett 93:55-71.
    • (1995) Cancer Lett , vol.93 , pp. 55-71
    • Bird, R.P.1
  • 4
    • 0034653351 scopus 로고    scopus 로고
    • The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • Bird RP, Good CK (2000). The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett 113:395-402.
    • (2000) Toxicol Lett , vol.113 , pp. 395-402
    • Bird, R.P.1    Good, C.K.2
  • 5
    • 77957363916 scopus 로고    scopus 로고
    • Exogenous antioxidants - Double-edged swords in cellular redox state
    • Bouayed J, Bohn T (2010). Exogenous antioxidants - double-edged swords in cellular redox state. Oxid Med Cell Longev 3:228-237.
    • (2010) Oxid Med Cell Longev , vol.3 , pp. 228-237
    • Bouayed, J.1    Bohn, T.2
  • 6
    • 0023815321 scopus 로고    scopus 로고
    • Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
    • Brady JF, Li D, Ishizaki H, Yang CS (1998). Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities. Cancer Res 48:3937-3940.
    • (1998) Cancer Res , vol.48 , pp. 3937-3940
    • Brady, J.F.1    Li, D.2    Ishizaki, H.3    Yang, C.S.4
  • 8
    • 0032128332 scopus 로고    scopus 로고
    • Human health perspective on environmental exposure to hydrazines; A review
    • Choudhary G, Hansen H (1998). Human health perspective on environmental exposure to hydrazines; a review. Chemosphere 37:801-843.
    • (1998) Chemosphere , vol.37 , pp. 801-843
    • Choudhary, G.1    Hansen, H.2
  • 9
    • 67649515751 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats
    • Chung SW, Kim MK, Chung JH, Kim DH, Choi JS, Anton S, et al. (2009). Peroxisome proliferator-activated receptor activation by a short-term feeding of zingerone in aged rats. J Med Food 12:345-350.
    • (2009) J Med Food , vol.12 , pp. 345-350
    • Chung, S.W.1    Kim, M.K.2    Chung, J.H.3    Kim, D.H.4    Choi, J.S.5    Anton, S.6
  • 10
    • 0021288822 scopus 로고
    • Vitamin e analysis methods for animal tissues
    • Desai ID (1971). Vitamin E analysis methods for animal tissues. Methods Enzymol 105:138-147.
    • (1971) Methods Enzymol , vol.105 , pp. 138-147
    • Desai, I.D.1
  • 11
    • 3042934967 scopus 로고
    • Tissue sulphydryl groups
    • Ellman GL (1959). Tissue sulphydryl groups. Arch Biochem Biophys 82:70-77.
    • (1959) Arch Biochem Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 13
    • 0025305055 scopus 로고
    • Possible mutagens derived from lipids and lipid precursors
    • Estabauer H, Eckl P, Ortner A (1990). Possible mutagens derived from lipids and lipid precursors. Mutat Res 238:223-233.
    • (1990) Mutat Res , vol.238 , pp. 223-233
    • Estabauer, H.1    Eckl, P.2    Ortner, A.3
  • 14
    • 0021288821 scopus 로고
    • Assays of glutathione peroxidase
    • Folhe L, Gunzler WA (1984). Assays of glutathione peroxidase. Methods Enzymol 105:114-121.
    • (1984) Methods Enzymol , vol.105 , pp. 114-121
    • Folhe, L.1    Gunzler, W.A.2
  • 15
    • 0030455701 scopus 로고    scopus 로고
    • Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts
    • Fujimitsu Y, Nakanishi H, Inada K, Yamachika T, Ichinose M, Fukami H, et al. (1996). Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts. Jpn J Cancer Res 12: 1199-1203.
    • (1996) Jpn J Cancer Res , vol.12 , pp. 1199-1203
    • Fujimitsu, Y.1    Nakanishi, H.2    Inada, K.3    Yamachika, T.4    Ichinose, M.5    Fukami, H.6
  • 16
    • 23044442934 scopus 로고    scopus 로고
    • Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders
    • Ghayur MN, Gilani AH (2005). Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig Dis Sci 50:1889-1897.
    • (2005) Dig Dis Sci , vol.50 , pp. 1889-1897
    • Ghayur, M.N.1    Gilani, A.H.2
  • 17
    • 0026650376 scopus 로고
    • Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats
    • Gopalan P, Jensen DE, Prabhakar D, Lotlikar PD (1992). Glutathione conjugation of microsome-mediated and synthetic aflatoxin B1-8,9-oxide by purified glutathione S-transferases from rats. Cancer Lett 64:225-233.
    • (1992) Cancer Lett , vol.64 , pp. 225-233
    • Gopalan, P.1    Jensen, D.E.2    Prabhakar, D.3    Lotlikar, P.D.4
  • 18
    • 52949118796 scopus 로고    scopus 로고
    • Chemistry, antioxidant and antimicrobial investigations on essential oil and oleoresins of Zingiber officinale
    • Gurdip S, Kapoor IP, Singh P, de Heluani CS, de Lampasona MP, Catalan CA (2008). Chemistry, antioxidant and antimicrobial investigations on essential oil and oleoresins of Zingiber officinale. Food Chem Toxicol 46:3295-3302.
    • (2008) Food Chem Toxicol , vol.46 , pp. 3295-3302
    • Gurdip, S.1    Kapoor, I.P.2    Singh, P.3    De Heluani, C.S.4    De Lampasona, M.P.5    Catalan, C.A.6
  • 19
    • 4043167857 scopus 로고    scopus 로고
    • Vegetables, fruits and phytoestrogens in the prevention of diseases
    • Heber D (2004). Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 50:145-149.
    • (2004) J Postgrad Med , vol.50 , pp. 145-149
    • Heber, D.1
  • 20
    • 28244447656 scopus 로고    scopus 로고
    • Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: Role in cell proliferation and response to oxidative stress
    • Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J (2005). Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem 47: 39485-39492.
    • (2005) J Biol Chem , vol.47 , pp. 39485-39492
    • Hu, Y.1    Rosen, D.G.2    Zhou, Y.3    Feng, L.4    Yang, G.5    Liu, J.6
  • 22
    • 0030980641 scopus 로고    scopus 로고
    • Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
    • Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, et al. (1997). Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275:1649-1652.
    • (1997) Science , vol.275 , pp. 1649-1652
    • Irani, K.1    Xia, Y.2    Zweier, J.L.3    Sollott, S.J.4    Der, C.J.5    Fearon, E.R.6
  • 23
    • 0027973077 scopus 로고
    • Molecular determinants of dysplasia in colorectal lesions
    • Jen J, Powell SM, Papadopoulus N (1994). Molecular determinants of dysplasia in colorectal lesions. Cancer Res 54:5523-5526.
    • (1994) Cancer Res , vol.54 , pp. 5523-5526
    • Jen, J.1    Powell, S.M.2    Papadopoulus, N.3
  • 24
    • 0026632930 scopus 로고
    • Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein
    • Jiang ZY, Hunt JV, Wolff SP (1993). Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 202:384-389.
    • (1993) Anal Biochem , vol.202 , pp. 384-389
    • Jiang, Z.Y.1    Hunt, J.V.2    Wolff, S.P.3
  • 25
    • 21144458114 scopus 로고    scopus 로고
    • Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum
    • Kabuto H, Nishizawa M, Tada M, Higashio C, Shishibori T, Kohno M (2005). Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum. Neurochem Res 30:325-332.
    • (2005) Neurochem Res , vol.30 , pp. 325-332
    • Kabuto, H.1    Nishizawa, M.2    Tada, M.3    Higashio, C.4    Shishibori, T.5    Kohno, M.6
  • 26
    • 0021681627 scopus 로고
    • A modified spectrophotometric assay of superoxide dismutase
    • Kakkar P, Das B, Viswanathan PN (1984). A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 2:130-132.
    • (1984) Indian J Biochem Biophys , vol.2 , pp. 130-132
    • Kakkar, P.1    Das, B.2    Viswanathan, P.N.3
  • 27
    • 84875897578 scopus 로고    scopus 로고
    • The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis
    • Karthikkumar V, Sivagami G, Victor ASJ, Nalini N (2012). The effect of rosmarinic acid on 1,2-dimethylhydrazine induced colon carcinogenesis. Exp Toxicol Pathol 4:409-418.
    • (2012) Exp Toxicol Pathol , vol.4 , pp. 409-418
    • Karthikkumar, V.1    Sivagami, G.2    Victor, A.S.J.3    Nalini, N.4
  • 28
    • 0030497344 scopus 로고    scopus 로고
    • Nutrition chemoprevention of gastrointestinal cancers: A critical review
    • Kim Y, Mason JB (1996). Nutrition chemoprevention of gastrointestinal cancers: a critical review. Nutr Rev 54:259-279.
    • (1996) Nutr Rev , vol.54 , pp. 259-279
    • Kim, Y.1    Mason, J.B.2
  • 29
    • 49149110899 scopus 로고    scopus 로고
    • NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression
    • Komatsu D, Kato M, Nakayama J, Miyagawa S, Kamata T (2008). NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene 34:4724-4732.
    • (2008) Oncogene , vol.34 , pp. 4724-4732
    • Komatsu, D.1    Kato, M.2    Nakayama, J.3    Miyagawa, S.4    Kamata, T.5
  • 30
    • 0028051826 scopus 로고
    • Increased plasma level of cholesterol- 5b, 6b epoxide in endometrial cancer patients
    • Kucuk O, Churley M, Goodman MT (1994). Increased plasma level of cholesterol- 5b, 6b epoxide in endometrial cancer patients. Cancer Epidemiol Biomark Prev 3:571-575.
    • (1994) Cancer Epidemiol Biomark Prev , vol.3 , pp. 571-575
    • Kucuk, O.1    Churley, M.2    Goodman, M.T.3
  • 32
    • 0027392752 scopus 로고
    • Reduction of aberrant crypt foci induced in rat colon with azoxymethane or methyl nitrosourea by feeding cholic acid
    • Magnuson BA, Bird RP (1993). Reduction of aberrant crypt foci induced in rat colon with azoxymethane or methyl nitrosourea by feeding cholic acid. Cancer Lett 68:15-23.
    • (1993) Cancer Lett , vol.68 , pp. 15-23
    • Magnuson, B.A.1    Bird, R.P.2
  • 33
    • 44449142812 scopus 로고    scopus 로고
    • Reactive oxygen species in tumor metastasis
    • Makiya N (2008). Reactive oxygen species in tumor metastasis. Cancer Lett 266:53-59.
    • (2008) Cancer Lett , vol.266 , pp. 53-59
    • Makiya, N.1
  • 34
    • 0026001897 scopus 로고
    • Dose response and proliferative characteristics of aberrant crypt foci: Putative preneoplastic lesions in rat colon
    • McLellan EA, Medline A, Bird RP (1991). Dose response and proliferative characteristics of aberrant crypt foci: putative preneoplastic lesions in rat colon. Carcinogenesis 12:2093-2098.
    • (1991) Carcinogenesis , vol.12 , pp. 2093-2098
    • McLellan, E.A.1    Medline, A.2    Bird, R.P.3
  • 35
    • 0028170326 scopus 로고
    • Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress
    • Michiels C, Martine R, Olivier T, Remacle J (1994). Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress. Free Radic Bio Med 17:235-248.
    • (1994) Free Radic Bio Med , vol.17 , pp. 235-248
    • Michiels, C.1    Martine, R.2    Olivier, T.3    Remacle, J.4
  • 36
    • 0031319696 scopus 로고    scopus 로고
    • Chemoprevention by naturally occurring and synthetic agents in oral, liver and large bowel carcinogenesis
    • Mori H, Tanaka T, Sugie S, Yoshimi N, Kawamori T, Hirose Y, Ohnishi M (1997). Chemoprevention by naturally occurring and synthetic agents in oral, liver and large bowel carcinogenesis. J Cell Biochem Suppl 27:35-41.
    • (1997) J Cell Biochem Suppl , vol.27 , pp. 35-41
    • Mori, H.1    Tanaka, T.2    Sugie, S.3    Yoshimi, N.4    Kawamori, T.5    Hirose, Y.6    Ohnishi, M.7
  • 37
    • 5144232016 scopus 로고    scopus 로고
    • The potent colon carcinogen 1,2-dimethylhydrazine induces mutations primarily in the colon
    • Newell LE, Heddle JA (2004). The potent colon carcinogen 1,2-dimethylhydrazine induces mutations primarily in the colon. Mutat Res 564:1-7.
    • (2004) Mutat Res , vol.564 , pp. 1-7
    • Newell, L.E.1    Heddle, J.A.2
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 39
    • 0018369625 scopus 로고
    • Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids
    • Omaye ST, Turnbull JD, Sauberlich HE (1979). Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3-11.
    • (1979) Methods Enzymol , vol.62 , pp. 3-11
    • Omaye, S.T.1    Turnbull, J.D.2    Sauberlich, H.E.3
  • 40
    • 38449121513 scopus 로고    scopus 로고
    • Studies on free radicals, antioxidants, and co-factors
    • Rahman K (2007). Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging 2:219-236.
    • (2007) Clin Interv Aging , vol.2 , pp. 219-236
    • Rahman, K.1
  • 41
    • 0037430537 scopus 로고    scopus 로고
    • Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv
    • Rajeshkumar NV, Kuttan R (2003). Modulation of carcinogenic response and antioxidant enzymes of rats administered with 1,2-dimethylhydrazine by Picroliv. Cancer Lett 191:137-143.
    • (2003) Cancer Lett , vol.191 , pp. 137-143
    • Rajeshkumar, N.V.1    Kuttan, R.2
  • 42
    • 84905382589 scopus 로고    scopus 로고
    • Antagonistic effects of zingerone, a phenolic alkanone against radiation induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro
    • Rao BN, Rao BS (2010). Antagonistic effects of zingerone, a phenolic alkanone against radiation induced cytotoxicity, genotoxicity, apoptosis and oxidative stress in Chinese hamster lung fibroblast cells growing in vitro. Mutagenesis 76:9577-9587.
    • (2010) Mutagenesis , vol.76 , pp. 9577-9587
    • Rao, B.N.1    Rao, B.S.2
  • 43
    • 67650071145 scopus 로고    scopus 로고
    • Radiomodifying and anticlastogenic effect of zingerone on Swiss albino mice exposed to whole body gamma radiation
    • Rao BN, Rao BS, Aithal BK, Kumar MR (2009). Radiomodifying and anticlastogenic effect of zingerone on Swiss albino mice exposed to whole body gamma radiation. Mutat Res 677:33-41.
    • (2009) Mutat Res , vol.677 , pp. 33-41
    • Rao, B.N.1    Rao, B.S.2    Aithal, B.K.3    Kumar, M.R.4
  • 44
    • 0021288839 scopus 로고
    • Spectrophotometric detection of lipid conjugated dienes
    • Recknagel RO, Glende EA (1984). Spectrophotometric detection of lipid conjugated dienes. Methods Enzymol 105:331-337.
    • (1984) Methods Enzymol , vol.105 , pp. 331-337
    • Recknagel, R.O.1    Glende, E.A.2
  • 45
    • 0026026294 scopus 로고
    • Identification and quantification of aberrant crypt foci and micro adenomas in the human colon
    • Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR (1991). Identification and quantification of aberrant crypt foci and micro adenomas in the human colon. Hum Pathol 22:287-294.
    • (1991) Hum Pathol , vol.22 , pp. 287-294
    • Roncucci, L.1    Stamp, D.2    Medline, A.3    Cullen, J.B.4    Bruce, W.R.5
  • 47
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK (1972). Colorimetric assay of catalase. Anal Biochem 47:389-394.
    • (1972) Anal Biochem , vol.47 , pp. 389-394
    • Sinha, A.K.1
  • 48
    • 84857211967 scopus 로고    scopus 로고
    • The modulatory influence of p-methoxycinnamic acid, an active rice bran phenolic acid, against 1,2-dimethylhydrazine-induced lipid peroxidation, antioxidant status and aberrant crypt foci in rat colon carcinogenesis
    • Sivagami G, Karthikkumar V, Balasubramanian T, Nalini N (2012). The modulatory influence of p-methoxycinnamic acid, an active rice bran phenolic acid, against 1,2-dimethylhydrazine-induced lipid peroxidation, antioxidant status and aberrant crypt foci in rat colon carcinogenesis. Chem Biol Interact 196:11-22.
    • (2012) Chem Biol Interact , vol.196 , pp. 11-22
    • Sivagami, G.1    Karthikkumar, V.2    Balasubramanian, T.3    Nalini, N.4
  • 50
    • 0030876658 scopus 로고    scopus 로고
    • Tocopherols and the etiology of colon cancer
    • Stone WL, Papas AM (1997). Tocopherols and the etiology of colon cancer. J Natl Cancer Inst 89:1006-1014.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1006-1014
    • Stone, W.L.1    Papas, A.M.2
  • 51
    • 17344391028 scopus 로고    scopus 로고
    • Citrus auraptene exerts dose dependent chemopreventive activity in rat large bowel tumorigenesis: The inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drugmetabolizing enzymes
    • Tanaka T, Kawabata K, Kakumoto M, Hara A, Murakami A, Kuki W, et al. (1998). Citrus auraptene exerts dose dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drugmetabolizing enzymes. Cancer Res 58:2550-2556.
    • (1998) Cancer Res , vol.58 , pp. 2550-2556
    • Tanaka, T.1    Kawabata, K.2    Kakumoto, M.3    Hara, A.4    Murakami, A.5    Kuki, W.6
  • 52
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROS mediated mechanisms: A radical therapeutic approach?
    • Trachootham D, Alexandre J, Huang P (2009). Targeting cancer cells by ROS mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8:579-591.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 53
    • 41949096621 scopus 로고    scopus 로고
    • Herbal compounds and toxins modulating TRP channels
    • Vriens J, Nilius B, Vennekens R (2008). Herbal compounds and toxins modulating TRP channels. Curr Neuropharmacol 6:79-96.
    • (2008) Curr Neuropharmacol , vol.6 , pp. 79-96
    • Vriens, J.1    Nilius, B.2    Vennekens, R.3
  • 54
    • 0029921139 scopus 로고    scopus 로고
    • Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat
    • Wargovich MJ, Chen CD, Jimenez A (1996). Aberrant crypts as a biomarker for colon cancer: evaluation of potential chemopreventive agents in the rat. Cancer Epidemiol Biomarkers Prev 5:355-360.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 355-360
    • Wargovich, M.J.1    Chen, C.D.2    Jimenez, A.3
  • 56
    • 78049408782 scopus 로고    scopus 로고
    • World Health Organization. Geneva, Switzerland: WHO
    • World Health Organization (2007). Cancer fact sheet no. 297. Geneva, Switzerland: WHO.
    • (2007) Cancer Fact Sheet No. 297
  • 57
    • 0003661910 scopus 로고    scopus 로고
    • World Health Organization; ISBN 978 92 4 0682740. Geneva, Switzerland: WHO
    • World Health Organization (2008). World Health Statistics; ISBN 978 92 4 0682740. Geneva, Switzerland: WHO.
    • (2008) World Health Statistics
  • 58
    • 0028904418 scopus 로고
    • Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
    • Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H (1995). Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression? Cancer 75:1527-1533.
    • (1995) Cancer , vol.75 , pp. 1527-1533
    • Yamashita, N.1    Minamoto, T.2    Ochiai, A.3    Onda, M.4    Esumi, H.5
  • 59
    • 1542345014 scopus 로고    scopus 로고
    • Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage, histopathological grade of malignancy and clinical features
    • Zalewski B (2004). Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage, histopathological grade of malignancy and clinical features. World J Gastroenterol 10: 583-585.
    • (2004) World J Gastroenterol , vol.10 , pp. 583-585
    • Zalewski, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.