And the beat goes on: Maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 3, 2014, Pages

  Grimes, Kelly M ^a   Reddy, Anilkumar K ^b,c   Lindsey, Merry L ^d   Buffenstein, Rochelle ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Indus Instruments   (United States)

^d UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Arterial stiffness; Cardiac reserve; Cardiovascular aging; Naked mole rat; Negligible senescence

Indexed keywords

DOBUTAMINE; COLLAGEN;

AGING; ANIMAL EXPERIMENT; AORTA PRESSURE; ARTERIAL STIFFNESS; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; FEMALE; HEART EJECTION FRACTION; HEART OUTPUT; HEART VENTRICLE HYPERTROPHY; HETEROCEPHALUS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHENOTYPE; PRIORITY JOURNAL; PULSE WAVE; RAT; SENESCENCE; TWO DIMENSIONAL ECHOCARDIOGRAPHY; AGE; ANIMAL; AORTA; ARTERIAL PRESSURE; CARDIAC MUSCLE; COMPARATIVE STUDY; COMPLIANCE (PHYSICAL); HEART; HEART LEFT VENTRICLE FUNCTION; HEART RATE; LONGEVITY; METABOLISM; MOLE RAT; PHYSIOLOGY; STRESS ECHOCARDIOGRAPHY; TIME FACTOR;

AGE FACTORS; AGING; ANIMALS; AORTA; ARTERIAL PRESSURE; COLLAGEN; COMPLIANCE; ECHOCARDIOGRAPHY, STRESS; FEMALE; HEART; HEART RATE; LONGEVITY; MALE; MOLE RATS; MYOCARDIUM; PULSE WAVE ANALYSIS; TIME FACTORS; VASCULAR STIFFNESS; VENTRICULAR FUNCTION, LEFT;

EID: 84905259788     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00305.2014     Document Type: Article

References (37)

1. Andziak B, O'Connor TP, Buffenstein R. Antioxidants do not explain the disparate longevity between mice and the longest-living rodent, the naked mole-rat. Mech Ageing Dev 126: 1206-1212, 2005.
2. Bodkin NL, Alexander TM, Ortmeyer HK, Johnson E, Hansen BC. Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci 58: 212-219, 2003.
3. Buffenstein R. Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species. J Comp Physiol B 178: 439-445, 2008.
4. Chiao YA, Ramirez TA, Zamilpa R, Okoronkwo SM, Dai Q, Zhang J, Jin YF, Lindsey ML. Matrix metalloproteinase-9 deletion attenuates myocardial fibrosis and diastolic dysfunction in ageing mice. Cardiovasc Res 96: 444-455, 2012.
5. Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, Ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol Heart Circ Physiol 293: H919-H927, 2007.
6. Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, Mac-Coss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119: 2789-2797, 2009.
7. Dai DF, Wessells RJ, Bodmer R, Rabinovitch PS. Cardiac Aging. In: The Comparative Biology of Aging, edited by Wolf NS. Seattle, WA: Springer, 2010, p. 259-286.
8. Delaney MA, Nagy L, Kinsel MJ, Treuting PM. Spontaneous histologic lesions of the adult naked mole rat (Heterocephalus glaber): a retrospective survey of lesions in a zoo population. Vet Pathol 50: 607-621, 2013.
9. Edrey YH, Casper D, Huchon D, Mele J, Gelfond JA, Kristan DM, Nevo E, Buffenstein R. Sustained high levels of neuregulin-1 in the longest-lived rodents; a key determinant of rodent longevity. Aging Cell 11: 213-222, 2012.
10. Edrey YH, Hanes M, Pinto M, Mele J, Buffenstein R. Successful aging and sustained good health in the naked mole rat: a long-lived mammalian model for biogerontology and biomedical research. ILAR J 52: 41-53, 2011.
11. Fleg JL, O'Connor F, Gerstenblith G, Becker LC, Clulow J, Schulman SP, Lakatta EG. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J Appl Physiol (1985) 78: 890-900, 1995.
12. Grimes KM, Lindsey ML, Gelfond JA, Buffenstein R. Getting to the heart of the matter: age-related changes in diastolic heart function in the longest-lived rodent, the naked mole rat. J Gerontol A Biol Sci Med Sci 67A: 384-394, 2012.
13. Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R. Cardiac function of the naked mole-rat: ecophysiological responses to working underground. Am J Physiol Heart Circ Physiol 306: H730-H737, 2014.
14. Haidet GC, Wennberg PW, Finkelstein SM, Morgan DJ. Effects of aging per se on arterial stiffness: systemic and regional compliance in beagles. Am Heart J 132: 319-327, 1996.
15. Hartley CJ, Taffet GE, Reddy AK, Entman ML, Michael LH. Noninvasive cardiovascular phenotyping in mice. ILAR J 43: 147-158, 2002.
16. Hulbert AJ, Pamplona R, Buffenstein R, Buttemer WA. Life and death: metabolic rate, membrane composition, and life span of animals. Physiol Rev 87: 1175-1213, 2007.
17. Kuznetsova T, Herbots L, Lopez B, Jin Y, Richart T, Thijs L, Gonzalez A, Herregods MC, Fagard RH, Diez J, Staessen JA. Prevalence of left ventricular diastolic dysfunction in a general population. Circ Heart Fail 2: 105-112, 2009.
18. Lakatta EG. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Fail Rev 7: 29-49, 2002.
19. Larson J, Park TJ. Extreme hypoxia tolerance of naked mole-rat brain. Neuroreport 20: 1634-1637, 2009.
20. Lemmens K, Doggen K, De Keulenaer GW. Role of neuregulin-1/ErbB signaling in cardiovascular physiology and disease: implications for therapy of heart failure. Circulation 116: 954-960, 2007.
21. Lewis KN, Andziak B, Yang T, Buffenstein R. The naked mole-rat response to oxidative stress: just deal with it. Antioxid Redox Signal 19: 1388-1399, 2013.
22. Lewis KN, Mele J, Hayes JD, Buffenstein R. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol 50: 829-843, 2010.
23. Lewis KN, Mele J, Hornsby PJ, Buffenstein R. Stress resistance in the naked mole-rat: the bare essentials-a mini-review. Gerontology 58: 453-462, 2012.
24. Liang S, Mele J, Wu Y, Buffenstein R, Hornsby PJ. Resistance to experimental tumorigenesis in cells of a long-lived mammal, the naked mole-rat (Heterocephalus glaber). Aging Cell 9: 626-635, 2010.
25. Lin J, Lopez EF, Jin Y, Van Remmen H, Bauch T, Han HC, Lindsey ML. Age-related cardiac muscle sarcopenia: combining experimental and mathematical modeling to identify mechanisms. Exp Gerontol 43: 296-306, 2008.
26. 2+ signaling. Am J Physiol Heart Circ Physiol 306: H1385-H1397, 2014.
27. Lovegrove BG. The cost of burrowing by the social mole rats (Bathyergidae) Cryptomys damarensis and Heterocephalus glaber: the Role of Soil Moisture. Physiol Zool 62: 449-469, 1989.
28. Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwenburgh C. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. Am J Physiol Heart Circ Physiol 305: H459-H476, 2013.
29. O'Connor TP, Lee A, Jarvis JU, Buffenstein R. Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function. Comp Biochem Physiol A Mol Integr Physiol 133: 835-842, 2002.
30. Overgaard CB, Dzavik V. Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation 118: 1047-1056, 2008.
31. Porter G, Urciuoli WR, Brookes PS, Nadtochiy SM. SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Am J Physiol Heart Circ Physiol 306: H1602-H1609, 2014.
32. Qiu H, Depre C, Vatner DE, Vatner SF. Cardiovascular effects of aging in primates-gender differences. In: Handbook of the Biology of Aging, edited by E. J. M, and Austad SN. Burlington, MA: Academic Press, 2011, p. 385-404.
33. Reddy AK, Li YH, Pham TT, Ochoa LN, Trevino MT, Hartley CJ, Michael LH, Entman ML, Taffet GE. Measurement of aortic input impedance in mice: effects of age on aortic stiffness. Am J Physiol Heart Circ Physiol 285: H1464-H1470, 2003.
34. Salmon AB, Sadighi Akha AA, Buffenstein R, Miller RA. Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. J Gerontol A Biol Sci Med Sci 63: 232-241, 2008.
35. Van Vleet JF. Age-related non-neoplastic lesions of the heart. In: Pathobiology of the Aging Dog, edited by Mohr U, Carlton WW, Dungworth DL, Benjamin SA, Capen CC, and Hahn FF. Ames: Iowa State University Press, 2001, p. 101-107.
36. Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF. Cardiac aging is initiated by matrix metalloproteinase-9-mediated endothelial dysfunction. Am J Physiol Heart Circ Physiol 306: H1398-H1407, 2014.
37. Yin FC, Spurgeon HA, Greene HL, Lakatta EG, Weisfeldt ML. Age-associated decrease in heart rate response to isoproterenol in dogs. Mech Ageing Dev 10: 17-25, 1979.