Timing and magnitude of systolic stretch affect myofilament activation and mechanical work

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 3, 2014, Pages

  Tangney, Jared R ^a   Campbell, Stuart G ^b   McCulloch, Andrew D ^a,c   Omens, Jeffrey H ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Yale University   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Dyssynchrony; Hypertrophy; Muscle mechanics; Papillary muscle; Stretch

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; ELECTROSTIMULATION; FORCE; FORCE TRANSDUCER; HEART MUSCLE COMPLIANCE; HEART PAPILLARY MUSCLE; MALE; MECHANICS; MOUSE; MUSCLE LENGTH; MUSCLE RIGIDITY; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC STRETCH; TENSION; VELOCITY; 129 MOUSE; ANIMAL; BIOLOGICAL MODEL; BIOMECHANICS; CALCIUM SIGNALING; ELASTICITY; HEART RIGHT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE HYPERTROPHY; MUSCLE FIBRIL; MUSCLE STRENGTH; PATHOPHYSIOLOGY; PHYSIOLOGY; SYSTOLE; TIME FACTOR;

ANIMALS; BIOMECHANICAL PHENOMENA; CALCIUM SIGNALING; ELASTICITY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; MICE, 129 STRAIN; MODELS, CARDIOVASCULAR; MUSCLE STRENGTH; MYOFIBRILS; PAPILLARY MUSCLES; SYSTOLE; TIME FACTORS; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT;

EID: 84905245386     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00233.2014     Document Type: Article

References (20)

1. Badke FR, Covell JW. Effects of ventricular pacing on regional left ventricular performance in the dog. Am J Physiol Heart Circ Physiol 238: H858-H867, 1980.
2. Coppola BA, Covell JW, McCulloch AD, Omens JH. Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. Am J Physiol Heart Circ Physiol 293: H754-H761, 2007.
3. de Tombe PP, ter Keurs HE. Force and velocity of sarcomere shortening in trabeculae from rat heart. Effects of temperature. Circ Res 66: 1239-1254, 1990.
4. Delhaas T, Arts T, Prinzen FW, Reneman RS. Regional fibre stressfibre strain area as an estimate of regional blood flow and oxygen demand in the canine heart. J Physiol 477: 481-496, 1994.
5. Delhaas T, Arts T, Prinzen FW, Reneman RS. Relation between regional electrical activation time and subepicardial fiber strain in the canine left ventricle. Pflügers Arch 423: 78-87, 1993.
6. Edman KA. Mechanical deactivation induced by active shortening in isolated muscle fibres of the frog. J Physiol 246: 255-275, 1975.
7. Ford LE, Huxley AF, Simmons RM. The relation between stiffness and filament overlap in stimulated frog muscle fibres. J Physiol 311: 219-249, 1981.
8. Howard EJ, Kerckhoffs RC, Vincent KP, Krishnamurthy A, Villongco CT, Mulligan LJ, McCulloch AD, Omens JH. Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart. Am J Physiol Heart Circ Physiol 305: H192-H202, 2013.
9. Konhilas JP, Irving TC, de Tombe PP. Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation. Pflügers Arch 445: 305-310, 2002.
10. Konhilas JP, Irving TC, de Tombe PP. Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing. Circ Res 90: 59-65, 2002.
11. 2+ bound to troponin C during relaxation in isolated cardiac muscle. Am J Physiol Heart Circ Physiol 260: H1013-H1024, 1991.
12. Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol Heart Circ Physiol 259: H300-H308, 1990.
13. Prinzen FW, Hunter WC, Wyman BT, McVeigh ER. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J Am Coll Cardiol 33: 1735-1742, 1999.
14. Raskin AM, Hoshijima M, Swanson E, McCulloch AD, Omens JH. Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle. Mol Cell Biomech 6: 145-159, 2009.
15. Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest 122: 1209-1221, 2012.
16. Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 32: 314-322, 1973.
17. Sweeney MO, Prinzen FW. A new paradigm for physiologic ventricular pacing. J Am Coll Cardiol 47: 282-288, 2006.
18. Tyberg JV, Parmley WW, Sonnenblick EH. In-vitro studies of myocardial asynchrony and regional hypoxia. Circ Res 25: 569-579, 1969.
19. van Oosterhout MF, Prinzen FW, Arts T, Schreuder JJ, Vanagt WY, Cleutjens JP, Reneman RS. Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall. Circulation 98: 588-595, 1998.
20. Wyman BT, Hunter WC, Prinzen FW, Faris OP, McVeigh ER. Effects of single-and biventricular pacing on temporal and spatial dynamics of ventricular contraction. Am J Physiol Heart Circ Physiol 282: H372-H379, 2002.