Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 3, 2014, Pages

  Borgdorff, Marinus A ^a   Bartelds, Beatrijs ^a   Dickinson, Michael G ^a   van Wiechen, Maarten P H ^a   Steendijk, Paul ^b   de Vroomen, Maartje ^a   Berger, Rolf M F ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diastolic dysfunction; Fibrosis; Pressure volume loops; Pulmonary artery banding; Right ventricular failure

Indexed keywords

SILDENAFIL; CARDIOTONIC AGENT; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLIC FUNCTION; DRUG EFFECT; EXERCISE; EXERCISE TOLERANCE; FIBROSING ALVEOLITIS; HEART AFTERLOAD; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART RIGHT VENTRICLE EJECTION FRACTION; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE ENDDIASTOLIC PRESSURE; LUNG ARTERY BANDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RIGHT VENTRICLE FIBROSIS; ANIMAL; CONVALESCENCE; DIASTOLE; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; FIBROSIS; HEART RIGHT VENTRICLE HYPERTROPHY; HEART STROKE VOLUME; HEART VENTRICLE; HEART VENTRICLE PRESSURE; PATHOLOGY; PATHOPHYSIOLOGY; TIME; WISTAR RAT;

ANIMALS; CARDIOTONIC AGENTS; DIASTOLE; DISEASE MODELS, ANIMAL; EXERCISE TOLERANCE; FIBROSIS; HEART VENTRICLES; HYPERTROPHY, RIGHT VENTRICULAR; MALE; PIPERAZINES; PURINES; RATS, WISTAR; RECOVERY OF FUNCTION; STROKE VOLUME; SULFONES; TIME FACTORS; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, RIGHT; VENTRICULAR PRESSURE;

EID: 84905241489     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00843.2013     Document Type: Article

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