The expression of platelet-activating factor receptor modulates the cisplatin sensitivity of ovarian cancer cells: A novel target for combination therapy

British Journal of Cancer

Volumn 111, Issue 3, 2014, Pages 515-524

  Yu, Y ^a,b,c   Zhang, X ^a,b,c   Hong, S ^a,b,c   Zhang, M ^a,b,c,d   Cai, Q ^a,b,c   Jiang, W ^a,b,c   Xu, C ^a,b,c  

^a OBSTETRICS AND GYNECOLOGY HOSPITAL OF FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d Department of Periodontology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CISPLATIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA; THROMBOCYTE ACTIVATING FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG SENSITIVITY; ENZYME PHOSPHORYLATION; EXPERIMENTAL NEOPLASM; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVARIAN CANCER CELL LINE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; AZEPINES; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; COMBINED MODALITY THERAPY; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAP KINASE SIGNALING SYSTEM; MICE, NUDE; OVARIAN NEOPLASMS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; TRANSCRIPTION FACTOR RELA; TRIAZOLES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84905237545     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.323     Document Type: Article

References (31)

1. Aponte M, Jiang W, Lakkis M, Li M-J, Edwards D, Albitar L, Vitonis A, Mok SC, Cramer DW, Ye B (2008) Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res 68(14): 5839-5848.
2. Arora S, Bhardwaj A, Srivastava SK, Singh S, McClellan S, Wang B, Singh AP (2011) Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS One 6(6): e21573.
3. Baird RD, Tan DSP, Kaye SB (2010) Weekly paclitaxel in the treatment of recurrent ovarian cancer. Nat Rev Clin Oncol 7(10): 575-582.
4. Braeuer RR, Zigler M, Villares GJ, Dobroff AS, Bar-Eli M (2011) Transcriptional control of melanoma metastasis: The importance of the tumor microenvironment. Semin Cancer Biol 21(2): 83-88.
5. Bruchim I, Ben-Harim Z, Piura E, Tepper R, Fishman A (2013) Preoperative clinical and radiological features of metastatic ovarian tumors. Arch Gynecol Obstet 288(3): 615-619.
6. Chan SL, Mok T (2010) PARP inhibition in BRCA-mutated breast and ovarian cancers. Lancet 376(9737): 211-213.
7. Darst M, Al-Hassani M, Li T, Yi QF, Travers JM, Lewis DA, Travers JB (2004) Augmentation of chemotherapy-induced cytokine production by expression of the platelet-activating factor receptor in a human epithelial carcinoma cell line. J Immunol 172(10): 6330-6335.
8. Ferreira MA, Barcelos LS, Teixeira MM, Bakhle YS, Andrade SP (2007) Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). Life Sci 81(3): 210-217.
9. Gao A-M, Ke Z-P, Shi F, Sun G-C, Chen H (2013) Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway. Chem Biol Interact 206(1): 100-108.
10. Garcia CC, Russo RC, Guabiraba R, Fagundes CT, Polidoro RB, Tavares LP, Salgado APC, Cassali GD, Sousa LP, Machado AV, Teixeira MM (2010) Platelet-activating factor receptor plays a role in lung injury and death caused by influenza a in mice. Plos Pathog 6(11): e1001171.
11. Ishii S, Shimizu T (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 39(1): 41-82.
12. Jiang W, Cong Q, Wang Y-S, Ye B, Xu C-J (2012) Ginkgo may sensitize ovarian cancer cells to cisplatin: antiproliferative and apoptosis-inducing effects of ginkgolide b on ovarian cancer cells. Integr Cancer Ther 13(43): NP10-NP17.
13. Jiang W, Wang Y-S, Cong Q, Li M-J, Ye B, Xu C-j (2011) Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro. Zhonghua Fu Chan Ke Za Zhi 46(12): 931-935.
14. Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, Colgan SP (2010) Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell 21(4): 538-546.
15. Kume K, Shimizu T (1997) Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272(36): 22898-22904.
16. Laffman-Johnson E (2011) Improving treatment options for ovarian cancer. Clin Pharmacol Ther 90(6): 757-757.
17. Li T, Southall MD, Yi QF, Pei Y, Lewis D, Al-Hassani M, Spandau D, Travers JB (2003) The epidermal platelet-activating factor receptor augments chemotherapy-induced apoptosis in human carcinoma cell lines. J Biol Chem 278(19): 16614-16621.
18. Liu C-J, Tsai M-M, Hung P-S, Kao S-Y, Liu T-Y, Wu K-J, Chiou S-H, Lin S-C, Chang K-W (2010) miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma. Cancer Res 70(4): 1635-1644.
19. Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A, Prieto VG, Hung M-C, Bar-Eli M (2009) Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem 284(42): 28845-28855.
20. Mollapour E, Linch DC, Roberts PJ (2001) Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosolic and calcium-independent phospholipase A(2). Blood 97(8): 2469-2477.
21. Oh YS, Kim HY, Song I-C, Yun H-J, Jo D-Y, Kim S, Lee HJ (2012) Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1 alpha. Oncol Rep 28(6): 2239-2246.
22. Rohwer N, Dame C, Haugstetter A, Wiedenmann B, Detjen K, Schmitt CA, Cramer T (2010) Hypoxia-inducible factor 1a promotes gastric cancer chemoresistance via modulation of p53 and NF-kappa B. EJC Suppl 8(7): 97-98.
23. Rooth C (2013) Ovarian cancer: risk factors, treatment and management. Br J Nurs 22(17): S23-S30.
24. Sahu RP, Turner MJ, DaSilva SC, Rashid BM, Ocana JA, Perkins SM, Konger RL, Touloukian CE, Kaplan MH, Travers JB (2012) The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis 33(7): 1360-1367.
25. Shen D-W, Pouliot LM, Hall MD, Gottesman MM (2012) Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes. Pharmacol Rev 64(3): 706-721.
26. Siddiqa A, Long LM, Li L, Marciniak RA, Kazhdan I (2008) Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways. BMC Cancer 8: 129.
27. Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S (2012) CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase-and akt kinase-mediated activation of nuclear factor kappa b implications for bidirectional tumor-stromal interactions. J Biol Chem 287(46): 39115-39124.
28. Ye M-X, Zhao Y-L, Li Y, Miao Q, Li Z-K, Ren X-L, Song L-Q, Yin H, Zhang J (2012) Curcumin reverses cis-platin resistance and promotes human lung adenocarcinoma A549/DDP cell apoptosis through HIF-1 alpha and caspase-3 mechanisms. Phytomedicine 19(8-9): 779-787.
29. Yoon H, Min J-K, Lee JW, Kim D-G, Hong HJ (2011) Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochem Biophys Res Commun 405(3): 333-337.
30. Yu S-M, Kim S-J (2013) Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway. Exp Biol Med 238(7): 811-820.
31. Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet LM, Rho J-H, Jin L, Seethappan V, Vitonis A, Wang J, Mok SC, Crum C, Cramer DW, Ye B (2010) Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrino 8: 74.