Inhibition of the DHT-induced PSA secretion by Verbascum xanthophoeniceum and Serenoa repens extracts in human LNCaP prostate epithelial cells

Journal of Ethnopharmacology

Volumn 155, Issue 1, 2014, Pages 616-625

  Marcoccia, D ^a,b   Georgiev, M I ^c   Alipieva, K I ^d   Lorenzetti, S ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^d INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

Author keywords

LNCaP; Prostate; Prostate specific antigen; Saw palmetto; Verbascoside (acteoside); Verbascum xanthophoeniceum

Indexed keywords

ACTEOSIDE; ANDROGEN; ANDROSTANOLONE; ANTIANDROGEN; ANTIINFLAMMATORY AGENT; GLUCOSIDE; PHENOL DERIVATIVE; PLANT EXTRACT; PROSTATE SPECIFIC ANTIGEN;

CELL LINE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; PROSTATE; SABAL; SECRETION (PROCESS); TURKEY; VERBASCUM;

ANDROGEN ANTAGONISTS; ANDROGENS; ANTI-INFLAMMATORY AGENTS; CELL LINE; DIHYDROTESTOSTERONE; EPITHELIAL CELLS; GLUCOSIDES; HUMANS; MALE; PHENOLS; PLANT EXTRACTS; PROSTATE; PROSTATE-SPECIFIC ANTIGEN; SERENOA; TURKEY; VERBASCUM;

EID: 84905115921     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.06.003     Document Type: Article

References (51)

1. M. Abe, Y. Ito, L. Oyunzul, T. Oki-Fujino, and S. Yamada Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free fatty acids contained in saw palmetto extract Biological and Pharmaceutical Bulletin 32 2009 646 650
2. B.G. Bachir, and K. Jarvi Infectious, inflammatory, and immunologic conditions resulting in male infertility The Urologic Clinics of North America 41 2014 67 81
3. A. Bommareddy, W. Eggleston, S. Prelewicz, A. Antal, Z. Witczak, D.F. McCune, and A.L. Vanwert Chemoprevention of prostate cancer by major dietary phytochemicals Anticancer Research 33 2013 4163 4174
4. T.G. Borovskaya, T.I. Fomina, A.V. Pakhomova, L.A. Ermolaeva, M.E. Poluektova, E.S. Zhavbert, J.L. Dugina, I.A. Kheifets, and O.I. Epstein Experimental study of the efficiency of impaza on the model of chronic aseptic prostatic inflammation Bulletin of Experimental Biology and Medicine 154 2012 217 219
5. D. Carrillo-Ocampo, S. Bazaldúa-Gómez, J.R. Bonilla-Barbosa, R. Aburto-Amar, and V. Rodríguez-López Anti-inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora Molecules 18 2013 12109 12118
6. N. Caturla, L. Funes, L. Pérez-Fons, and V. Micol A randomized, double-blinded, placebo-controlled study of the effect of a combination of lemon verbena extract and fish oil omega-3 fatty acid on joint management Journal of Alternative and Complementary Medicine 17 2011 1051 1063
7. J. Cuzick, F. Otto, J.A. Baron, P.H. Brown, J. Burn, P. Greenwald, J. Jankowski, C. La Vecchia, F. Meyskens, H.J. Senn, and M. Thun Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement The Lancet Oncology 10 2009 501 507
8. N.B. Delongchamps, G. de la Roza, and V. Chandan Evaluation of prostatitis in autopsied prostates-is chronic inflammation more associated with benign prostatic hyperplasia or cancer? The Journal of Urology 179 2008 1736 1740
9. P. Dimitrova, E. Kostadinova, V. Milanova, K. Alipieva, M. Georgiev, and N. Ivanovska Antiinflammatory properties of extracts and compounds isolated from Verbascum xanthophoeniceum Griseb Phytotherapy Research 26 2012 1681 1687
10. M. Domínguez, J.G. Avila, A. Nieto, and C.L. Céspedes Anti-inflammatory activity of Penstemon gentianoides and Penstemon campanulatus Pharmaceutical Biology 49 2011 118 124
11. EMEA, 2009. Assessment report on Verbascum thapsus L., V. densiflorum Bertol.; V. phlomoides L., Flos with traditional use. EMEA/HMPC/395206/2007Corr. : http://www.ema.europa.eu, WC50001783.pdf.
12. M. Georgiev, K. Ali, K. Alipieva, Y.H. Choi, and R. Verpoorte Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics Phytochemistry 72 2011 2045 2051
13. M. Georgiev, K. Alipieva, I. Orhan, R. Abrashev, P. Denev, and M. Angelova Antioxidant and cholinesterases inhibitory activities of Verbascum xanthophoeniceum Griseb. and its phenylethanoid glycosides Food Chemistry 128 2011 100 105
14. M.I. Georgiev, K. Alipieva, and I.E. Orhan Cholinesterases inhibitory and antioxidant activities of Harpagophytum procumbens from in vitro systems Phytotherapy Research 26 2012 313 316
15. M. Georgiev, S. Pastore, D. Lulli, K. Alipieva, V. Kostyuk, A. Potapovich, M. Panetta, and L. Korkina Verbascum xanthophoeniceum-derived phenylethanoid glycosides are potent inhibitors of inflammatory chemokines in dormant and interferon-gamma-stimulated human keratinocytes Journal of Ethnopharmacology 144 2012 754 760
16. F.K. Habib, M. Ross, C.K. Ho, V. Lyons, and K. Chapman Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression International Journal of Cancer 114 2005 190 194
17. R.E. Harris Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung Inflammopharmacology 17 2009 55 67
18. I. Ivanov, I. Landjev, and G. Neshev Bulgarian Herbs and Their Use in Folk Medicine M. Gergova, 1971 Zemizdat Sofia 128 130
19. A. Kahokehr, R. Vather, A. Nixon, and A.G. Hill Non-steroidal anti-inflammatory drugs for lower urinary tract symptoms in benign prostatic hyperplasia: systematic review and meta-analysis of randomized controlled trials British Journal of Urology International 111 2013 304 311
20. T.H. Kim, H.J. Lim, M.S. Kim, and M.S. Lee Dietary supplements for benign prostatic hyperplasia: an overview of systematic reviews Maturitas 73 2012 180 185
21. O.J. Kwon, L. Zhang, M.M. Ittmann, and L. Xin Prostatic inflammation enhances basal-to-luminal differentiation and accelerates initiation of prostate cancer with a basal cell origin Proceedings of the National Academy of Sciences of the United States of America 111 2014 E592 600
22. J.Y. Lee, J.G. Lee, S.S. Sim, W.K. Whang, and C.J. Kim Anti-asthmatic effects of phenylpropanoid glycosides from Clerodendron trichotomum leaves and Rumex gmelini herbes in conscious guinea-pigs challenged with aerosolized ovalbumin Phytomedicine 18 2011 134 142
23. S.Y. Lee, K.S. Lee, S.H. Yi, S.H. Kook, and J.C. Lee Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production PLoS One 8 2013 e80873
24. L. Lenoir, J. Joubert-Zakeyh, O. Texier, J.L. Lamaison, M.P. Vasson, and C. Felgines Aloysia triphylla infusion protects rats against dextran sulfate sodium-induced colonic damage Journal of the Science of Food and Agriculture 92 2012 1570 1572
25. Y.H. Liao, P.J. Houghton, and J.R. Hoult Novel and known constituents from Buddleja species and their activity against leukocyte eicosanoid generation Journal of Natural Products 62 1999 1241 1245
26. S. Lorenzetti, D. Marcoccia, L. Narciso, and A. Mantovani Cell viability and PSA secretion assays in LNCaP cells: a tiered in vitro approach to screen chemicals with a prostate-mediated effect on male reproduction within the ReProTect project Reproductive Toxicology 30 2010 25 35
27. S. Lorenzetti, I Altieri, S. Arabi, D. Balduzzi, N. Bechi, E. Cordelli, C. Galli, F. Ietta, S.C. Modina, L. Narciso, F. Pacchierotti, P. Villani, A. Galli, G. Lazzari, A.M. Luciano, L. Paulesu, M. Spanò, and A. Mantovani Innovative non-animal testing strategies for reproductive toxicology: the contribution of Italian partners within the EU project ReProTect Annals of Istituto Superiore di Sanità 47 2011 429 444
28. S. Lorenzetti, L. Narciso, D. Marcoccia, and I. Altieri A novel in vitro toxicological approach to identify chemicals with a prostate-mediated effect on male reproduction Journal of Biological Research 1 2012 36 41
29. S.M. Mahmud, E.L. Franco, and A.G. Aprikian Use of nonsteroidal anti-inflammatory drugs and prostate cancer risk: a meta-analysis International Journal of Cancer 127 2010 1680 1691
30. Y. Nakai, and N. Nonomura Inflammation and prostate carcinogenesis International Journal of Urology 20 2012 150 160
31. R.D. Paola, G. Oteri, E. Mazzon, C. Crisafulli, M. Galuppo, R.D. Toso, G. Pressi, G. Cordasco, and S. Cuzzocrea Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis The Journal of Pharmacy and Pharmacology 63 2011 707 717
32. P. Posadzki, M.S. Lee, I. Onakpoya, H.W. Lee, B.S. Ko, and E. Ernst Dietary supplements and prostate cancer: a systematic review of double-blind, placebo-controlled randomised clinical trials Maturitas 75 2013 125 130
33. A.I. Potapovich, D. Lulli, P. Fidanza, V.A. Kostyuk, C. De Luca, S. Pastore, and L.G. Korkina Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFkB and AhR and EGFR-ERK pathway Toxicology and Applied Pharmacology 255 2011 138 149
34. T.A. Prescott, N.C. Veitch, and M.S. Simmonds Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria Journal of Ethnopharmacology 137 2011 1306 1310
35. A.S. Obort, M.B. Ajadi, and O. Akinloye Prostate-specific antigen: any successor in sight? Reviews in Urology 15 2013 97 107
36. Y.K. Rao, S.H. Fang, S.C. Hsieh, T.H. Yeh, and Y.M. Tzeng The constituents of Anisomeles indica and their anti-inflammatory activities Journal of Ethnopharmacology 121 2009 292 296
37. P.M. Rothwell, F.G. Fowkes, J.F. Belch, H. Ogawa, C.P. Warlow, and T.W. Meade Effect of daily aspirin onlong-term risk of death due to cancer: analysis of individual patient data from randomised trials Lancet 377 2011 31 41
38. P.M. Sanchez, M.L. Villarreal, M. Herrera-Ruiz, A. Zamilpa, E. Jiménez-Ferrer, and G. Trejo-Tapia in vivo anti-inflammatory and anti-ulcerogenic activities of extracts from wild growing and in vitro plants of Castilleja tenuiflora Benth. (Orobanchaceae) Journal of Ethnopharmacology 150 2013 1032 1037
39. K.S. Sfanos, and A.M. De Marzo Prostate cancer and inflammation: the evidence Histopathology 60 2012 199 215
40. I. Silvestri, S. Cattarino, A. Aglianò, C. Nicolazzo, S. Scarpa, S. Salciccia, L. Frati, V. Gentile, and A. Sciarra Effect of Serenoa repens (Permixon®) on the expression of inflammation-related genes: analysis in primary cell cultures of human prostate carcinoma Journal of Inflammation (London, England) 10 2013 11
41. L. Speranza, S. Franceschelli, M. Pesce, M. Reale, L. Menghini, I. Vinciguerra, M.A. De Lutiis, M. Felaco, and A. Grilli Antiinflammatory effects in THP-1 cells treated with verbascoside Phytotherapy Research 24 2010 1398 1404
42. A. Smeriglio, D. Trombetta, D. Marcoccia, L. Narciso, A. Mantovani, and S. Lorenzetti Intracellular distribution and biological effects of plant bioactives in a sex steroid-sensitive model of human prostate adenocarcinoma Anti-Cancer Agents in Medicinal Chemistry 2014 (In press)
43. I. Suntar, I.I. Tatli, E. Kupeli Akkol, H. Keles, C. Kahraman, and Z. Akdemir An ethnopharmacological study on Verbascum species: from conventional wound healing use to scientific verification Journal of Ethnopharmacology 132 2010 408 413
44. W.H. Talib, and A.M. Mahasneh Antiproliferative activity of plant extracts used against cancer in traditional medicine Scientia Pharmaceutica 78 2010 33 45
45. N. Talpur, B. Echard, D. Bagchi, M. Bagchi, and H.G. Preuss Comparison of Saw Palmetto (extract and whole berry) and Cernitin on prostate growth in rats Molecular and Cellular Biochemistry 250 2003 21 26
46. A.U. Turker, and E. Gurel Common mullein (Verbascum thapsus L.): recent advances in research Phytotherapy Research 19 2005 733 739
47. L.N. Vandenberg, T. Colborn, T.B. Hayes, J.J. Heindel, D.R. Jacobs Jr., D.-H. Lee, T. Shioda, A.M. Soto, F.S. vom Saal, W.V. Welshons, R.T. Zoeller, and J.P. Myers Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses Endocrine Reviews 33 2012 378 455
48. D.B. Vendramini-Costa, and J.E. Carvalho Molecular link mechanisms between inflammation and cancer Current Pharmaceutical Design 18 2012 3831 3852
49. P. Yamada, R. Iijima, J. Han, H. Shigemori, S. Yokota, and H. Isoda Inhibitory effect of acteoside isolated from Cistanche tubulosa on chemical mediator release and inflammatory cytokine production by RBL-2H3 and KU812 cells Planta Medica 76 2010 1512 1518
50. Y. Yang, T. Ikezoe, Z. Zheng, H. Taguchi, H.P. Koeffler, and W.G. Zhu Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling International Journal of Oncology 31 2007 593 600
51. H.M. Wahba, S.F. AbouZid, A.A. Sleem, S. Apers, L. Pieters, and A.A. Shahat Chemical and biological investigation of some Clerodendrum species cultivated in Egypt Le Pharmacien Biologiste 49 2011 66 72