Discovery of novel inhibitors of vascular endothelial growth factor-A-Neuropilin-1 interaction by structure-based virtual screening

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 15, 2014, Pages 4042-4048

  Starzec, Anna ^a   Miteva, Maria A ^b,c   Ladam, Patrick ^a   Villoutreix, Bruno O ^b,c   Perret, Gérard Y ^a  

^a UNIVERSITÉ PARIS 13   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

Author keywords

Angiogenesis; Neuropilin; Protein protein interactions inhibitors; Structure based virtual screening; VEGF

Indexed keywords

CHLOROBENZYLOXY ALKYLOXY HALOGENOBENZYL AMINE DERIVATIVE; NEUROPILIN 1; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; AMINE; PROTEIN BINDING; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; BIOTINYLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; MOLECULAR DOCKING; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE;

AMINES; BINDING SITES; DRUG EVALUATION, PRECLINICAL; MOLECULAR DOCKING SIMULATION; NEUROPILIN-1; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84905100973     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.068     Document Type: Article

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