Antibiotic susceptibility in gram-positive chronic joint arthroplasty infections: Increased Aminoglycoside Resistance rate in patients with prior aminoglycoside-impregnated cement spacer use

Journal of Arthroplasty

Volumn 29, Issue 8, 2014, Pages 1617-1621

  Corona, Pablo S ^a   Espinal, Laia ^a   Rodríguez Pardo, Dolors ^a   Pigrau, Carles ^a   Larrosa, Nieves ^a   Flores, Xavier ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Antibiotic loaded spacers; Antibiotic resistance; Gentamicin; Periprosthetic joint infection; Tobramycin

Indexed keywords

AMINOGLYCOSIDE; AMPICILLIN; CEFOTAXIN; CIPROFLOXACIN; CLINDAMYCIN; CLOXACILLIN; COTRIMOXAZOLE; DAPTOMYCIN; ERYTHROMYCIN; GENTAMICIN; LEVOFLOXACIN; LINEZOLID; PENICILLIN DERIVATIVE; RIFAMPICIN; TEICOPLANIN; TOBRAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

AGED; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIUM ISOLATION; BETA HEMOLYTIC STREPTOCOCCUS; CEMENT SPACER; COAGULASE NEGATIVE STAPHYLOCOCCUS; COMPARATIVE STUDY; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; FEMALE; HIP ARTHROPLASTY; HUMAN; MAJOR CLINICAL STUDY; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PERIPROSTHETIC JOINT INFECTION; PRIMARY INFECTION; RETROSPECTIVE STUDY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; TOTAL KNEE REPLACEMENT;

ANTIBIOTIC LOADED SPACERS; ANTIBIOTIC RESISTANCE; GENTAMICIN; PERIPROSTHETIC JOINT INFECTION; TOBRAMYCIN;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; BONE CEMENTS; CHRONIC DISEASE; DRUG RESISTANCE, BACTERIAL; FEMALE; GENTAMICINS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MALE; MIDDLE AGED; PROSTHESIS-RELATED INFECTIONS; RECURRENCE; RETROSPECTIVE STUDIES; TOBRAMYCIN;

EID: 84905100399     PISSN: 08835403     EISSN: 15328406     Source Type: Journal    
DOI: 10.1016/j.arth.2014.03.029     Document Type: Article

References (32)

1. Tunney M.M., Ramage G., Patrick S., et al. Antimicrobial susceptibility of bacteria isolated from orthopedic implants following revision hip surgery. Antimicrob Agents Chemother 1998, 42(11):3002.
2. Fulkerson E., Valle C.J., Wise B., et al. Antibiotic susceptibility of bacteria infecting total joint arthroplasty sites. J Bone Joint Surg Am 2006, 88(6):1231.
3. Sharma D., Douglas J., Coulter C., et al. Microbiology of infected arthroplasty: implications for empiric peri-operative antibiotics. J Orthop Surg 2008, 16(3):339.
4. Nickinson R.S., Board T.N., Gambhir A.K., et al. The microbiology of the infected knee arthroplasty. Int Orthop 2010, 34(4):505.
5. Cui Q., Mihalko W.M., Shields J.S., et al. Antibiotic-impregnated cement spacers for the treatment of infection associated with total hip or knee arthroplasty. J Bone Joint Surg Am 2007, 89(4):871.
6. Mahmud T., Lyons M.C., Naudie D.D., et al. Assessing the gold standard: a review of 253 two-stage revisions for infected TKA. Clin Orthop Relat Res 2012, 470(10):2730-2736.
7. Iarikov D., Demian H., Rubin D., et al. Choice and doses of antibacterial agents for cement spacers in treatment of prosthetic joint infections: review of published studies. Clin Infect Dis 2012, 55(11):1474.
8. Jacobs C., Christensen C.P., Berend M.E. Static and mobile antibiotic-impregnated cement spacers for the management of prosthetic joint infection. J Am Acad Orthop Surg 2009, 17(6):356.
9. Zimmerli W., Trampuz A., Ochsner P.E. Prosthetic-joint infections. N Engl J Med 2004, 351(16):1645.
10. Pitto R.P., Castelli C.C., Ferrari R., et al. Pre-formed articulating knee spacer in two-stage revision for the infected total knee arthroplasty. Int Orthop 2005, 29(5):305.
11. Pattyn C., De Geest T., Ackerman P., et al. Preformed gentamicin spacers in two-stage revision hip arthroplasty: functional results and complications. Int Orthop 2011, 35(10):1471.
12. Romano C.L., Romano D., Logoluso N., et al. Long-stem versus short-stem preformed antibiotic-loaded cement spacers for two-stage revision of infected total hip arthroplasty. Hip Int 2010, 20(1):26.
13. Bertazzoni Minelli E., Della Bora T., Benini A. Different microbial biofilm formation on polymethylmethacrylate (PMMA) bone cement loaded with gentamicin and vancomycin. Anaerobe 2011, 17(6):380.
14. Bertazzoni Minelli E., Benini A., Magnan B., et al. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother 2004, 53(2):329.
15. Anguita-Alonso P., Hanssen A.D., Osmon D.R., et al. High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. Clin Orthop Relat Res 2005, 439:43.
16. Streuli J.C., Exner G.U., Reize C.L., et al. In vitro inhibition of coagulase-negative staphylococci by vancomycin/aminoglycoside-loaded cement spacers. Infection 2006, 34(2):81.
17. Campoccia D., Montanaro L., Speziale P., et al. Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials 2010, 31(25):6363.
18. Sanzen L., Walder M. Antibiotic resistance of coagulase-negative staphylococci in an orthopaedic department. J Hosp Infect 1988, 12(2):103.
19. Hope P.G., Kristinsson K.G., Norman P., et al. Deep infection of cemented total hip arthroplasties caused by coagulase-negative staphylococci. J Bone Joint Surg Br 1989, 71(5):851.
20. Osmon D.R., Berbari E.F., Berendt A.R., et al. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2013, 56(1):e1.
21. Tsukayama D.T., Goldberg V.M., Kyle R. Diagnosis and management of infection after total knee arthroplasty. J Bone Joint Surg Am 2003, 85-A(Suppl. 1):S75.
22. Corona Perez-Cardona P.S., Barro Ojeda V., Rodriguez Pardo D., et al. Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections. J Antimicrob Chemother 2012, 67(7):1749.
23. Wan Z., Momaya A., Karim A., et al. Preformed articulating knee spacers in 2-stage total knee revision arthroplasty: minimum 2-year follow-up. J Arthroplast 2012, 27(8):1469-1473.
24. Van Thiel G.S., Berend K.R., Klein G.R., et al. Intraoperative molds to create an articulating spacer for the infected knee arthroplasty. Clin Orthop Relat Res 2011, 469(4):994.
25. Joseph T.N., Chen A.L., Di Cesare P.E. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg 2003, 11(1):38.
26. Corona P., Gil E., Guerra E., et al. Percutaneous interface biopsy in dry-aspiration cases of chronic periprosthetic joint infections: a technique for preoperative isolation of the infecting organism. Int Orthop 2012, 36(6):1281.
27. Thomes B., Murray P., Bouchier-Hayes D. Development of resistant strains of Staphylococcus epidermidis on gentamicin-loaded bone cement in vivo. J Bone Joint Surg Br 2002, 84(5):758.
28. Watanakunakorn C., Tisone J.C. Synergism between vancomycin and gentamicin or tobramycin for methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother 1982, 22(5):903.
29. Penner M.J., Masri B.A., Duncan C.P. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplast 1996, 11(8):939.
30. Masri B.A., Duncan C.P., Beauchamp C.P. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplast 1998, 13(3):331.
31. Anagnostakos K., Hitzler P., Pape D., et al. Persistence of bacterial growth on antibiotic-loaded beads: is it actually a problem?. Acta Orthop 2008, 79(2):302.
32. Corona P.S., Barro V., Mendez M., et al. Industrially prefabricated cement spacers: do vancomycin- and gentamicin-impregnated spacers offer any advantage?. Clin Orthop Relat Res 2014, 472(3):923-932.