Industrially prefabricated cement spacers: Do vancomycin-and gentamicin-impregnated spacers offer any advantage?

Clinical Orthopaedics and Related Research

Volumn 472, Issue 3, 2014, Pages 923-932

  Corona, Pablo S ^a   Barro, Victor ^a   Mendez, Marye ^a   Cáceres, Enric ^a   Flores, Xavier ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIBIOTIC BONE CEMENT; GENTAMICIN BONE CEMENT; GENTAMICIN PLUS VANCOMYCIN BONE CEMENT; QUINOLONE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; CEMENT SPACER; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; COMPARATIVE STUDY; DEMOGRAPHY; DRUG MIXTURE; FEMALE; FOLLOW UP; GENTAMICIN CEMENT SPACER; GENTAMICIN PLUS VANCOMYCIN CEMENT SPACER; HEMATOMA; HIP SPACER; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; INFECTION CONTROL; KNEE PROSTHESIS; MALE; MEDICAL DEVICE COMPLICATION; MICROBIOLOGY; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; PATHOGEN CLEARANCE; PATIENT SATISFACTION; PERIPROSTHETIC JOINT INFECTION; PERONEUS NERVE PARALYSIS; PRIORITY JOURNAL; PROSTHESIS INFECTION; QUALITY OF LIFE; RECURRENT DISEASE; RELAPSE; RETROSPECTIVE STUDY; SKIN NECROSIS; SPACER DISLOCATION; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT, HIP; ARTHROPLASTY, REPLACEMENT, KNEE; BONE CEMENTS; CHI-SQUARE DISTRIBUTION; COATED MATERIALS, BIOCOMPATIBLE; DEVICE REMOVAL; FEMALE; GENTAMICINS; HIP PROSTHESIS; HUMANS; KNEE PROSTHESIS; MALE; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PATIENT SATISFACTION; PROSTHESIS-RELATED INFECTIONS; QUALITY OF LIFE; QUESTIONNAIRES; RECURRENCE; REOPERATION; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; VANCOMYCIN;

EID: 84898777978     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-013-3342-7     Document Type: Article

References (41)

1. Anagnostakos K, Hitzler P, Pape D, Kohn D, Kelm J. Persistence of bacterial growth on antibiotic-loaded beads: is it actually a problem? Acta Orthop. 2008;79:302-307. (Pubitemid 351878362)
2. Anagnostakos K, Wilmes P, Schmitt E, Kelm J. Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo. Acta Orthop. 2009;80:193-197.
3. Anguita-Alonso P, Hanssen AD, Osmon DR, Trampuz A, Steckelberg JM, Patel R. High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection. Clin Orthop Relat Res. 2005;439:43-47. (Pubitemid 41416347)
4. Bauer TW, Parvizi J, Kobayashi N, Krebs V. Diagnosis of periprosthetic infection. J Bone Joint Surg Am. 2006;88:869-882.
5. Bertazzoni Minelli E, Benini A, Magnan B, Bartolozzi P. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother. 2004;53:329-334. (Pubitemid 38239970)
6. Bertazzoni Minelli E, Della Bora T, Benini A. Different microbial biofilm formation on polymethylmethacrylate (PMMA) bone cement loaded with gentamicin and vancomycin. Anaerobe. 2011;17:380-383.
7. Booth RE Jr, Lotke PA. The results of spacer block technique in revision of infected total knee arthroplasty. Clin Orthop Relat Res. 1989;248:57-60. (Pubitemid 20204781)
8. Cahill JL, Shadbolt B, Scarvell JM, Smith PN. Quality of life after infection in total joint replacement. J Orthop Surg (Hong Kong). 2008;16:58-65.
9. Corona Perez-Cardona PS, Barro Ojeda V, Rodriguez Pardo D, Pigrau Serrallach C, Guerra Farfan E, Amat Mateu C, Flores Sanchez X. Clinical experience with daptomycin for the treatment of patients with knee and hip periprosthetic joint infections. J Antimicrob Chemother. 2012;67:1749-1754.
10. Cui Q, Mihalko WM, Shields JS, Ries M, Saleh KJ. Antibiotic-impregnated cement spacers for the treatment of infection associated with total hip or knee arthroplasty. J Bone Joint Surg Am. 2007;89:871-882. (Pubitemid 46564296)
11. Degen RM, Davey JR, Davey JR, Howard JL, McCalden RW, Naudie DD. Does a prefabricated gentamicin-impregnated, loadbearing spacer control periprosthetic hip infection? Clin Orthop Relat Res. 2012;470:2724-2729.
12. Flores X, Corona PS, Cortina J, Guerra E, Amat C. Temporary cement tectoplasty: a technique to improve prefabricated hip spacer stability in two-stage surgery for infected hip arthroplasty. Arch Orthop Trauma Surg. 2012;132:719-724.
13. Fulkerson E, Della Valle CJ, Wise B, Walsh M, Preston C, Di Cesare PE. Antibiotic susceptibility of bacteria infecting total joint arthroplasty sites. J Bone Joint Surg Am. 2006;88:1231-1237. (Pubitemid 43837116)
14. Haddad FS, Masri BA, Campbell D, McGraw RW, Beauchamp CP, Duncan CP. The PROSTALAC functional spacer in two-stage revision for infected knee replacements: prosthesis of antibiotic-loaded acrylic cement. J Bone Joint Surg Br. 2000;82:807-812. (Pubitemid 30624038)
15. Iarikov D, Demian H, Rubin D, Alexander J, Nambiar S. Choice and doses of antibacterial agents for cement spacers in treatment of prosthetic joint infections: review of published studies. Clin Infect Dis. 2012;55:1474-1480.
16. Jacobs C, Christensen CP, Berend ME. Static and mobile antibiotic-impregnated cement spacers for the management of prosthetic joint infection. J Am Acad Orthop Surg. 2009;17:356-368.
17. Joseph TN, Chen AL, Di Cesare PE. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg. 2003;11:38-47.
18. Klinger HM, Spahn G, Schultz W, Baums MH. Arthrodesis of the knee after failed infected total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2006;14:447-453. (Pubitemid 44112878)
19. Mahmud T, Lyons MC, Naudie DD, Macdonald SJ, McCalden RW. Assessing the gold standard: a review of 253 two-stage revisions for infected TKA. Clin Orthop Relat Res. 2012;470:2730-2736.
20. Mahomed N, Gandhi R, Daltroy L, Katz JN. The self-administered patient satisfaction scale for primary hip and knee arthroplasty. Arthritis. 2011;2011:591253.
21. Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty. 1998;13:331-338. (Pubitemid 28194004)
22. McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis M. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res. 2002;403:8-15. (Pubitemid 35168349)
23. Nickinson RS, Board TN, Gambhir AK, Porter ML, Kay PR. The microbiology of the infected knee arthroplasty. Int Orthop. 2010;34:505-510.
24. Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, Rao N, Hanssen A, Wilson WR; Infectious Diseases Society of America. Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:e1-e25.
25. Pattyn C, De Geest T, Ackerman P, Audenaert E. Preformed gentamicin spacers in two-stage revision hip arthroplasty: functional results and complications. Int Orthop. 2011;35:1471-1476.
26. Penner MJ, Masri BA, Duncan CP. Elution characteristics of vancomycin and tobramycin combined in acrylic bone-cement. J Arthroplasty. 1996;11:939-944.
27. Pitto RP, Castelli CC, Ferrari R, Munro J. Pre-formed articulating knee spacer in two-stage revision for the infected total knee arthroplasty. Int Orthop. 2005;29:305-308. (Pubitemid 41442876)
28. Romano CL, Romano D, Logoluso N, Meani E. Long-stem versus short-stem preformed antibiotic-loaded cement spacers for two-stage revision of infected total hip arthroplasty. Hip Int. 2010;20:26-33.
29. Sharma D, Douglas J, Coulter C, Weinrauch P, Crawford R. Microbiology of infected arthroplasty: implications for empiric peri-operative antibiotics. J Orthop Surg (Hong Kong). 2008;16:339-342.
30. Sherman SL, Cunneen KP, Walcott-Sapp S, Brause B, Westrich GH. Custom total femur spacer and second-stage total femur arthroplasty as a novel approach to infection and periprosthetic fracture. J Arthroplasty. 2008;23:781-786. (Pubitemid 352004109)
31. Singh J, Sloan JA, Johanson NA. Challenges with health-related quality of life assessment in arthroplasty patients: problems and solutions. J Am Acad Orthop Surg. 2010;18:72-82.
32. Soffiatti R. The preformed spacers: from the idea to the realization of an industrial device. In: Calonego G, Meani E, Romano C, Crosby L, Hofmann G (eds) Infection and Local Treatment in Orthopedic Surgery. Heidelberg, Germany: Springer; 2007:112-120.
33. Streuli JC, Exner GU, Reize CL, Merkofer C, Scott CP, Zbinden R. In vitro inhibition of coagulase-negative staphylococci by vancomycin/aminoglycoside- loaded cement spacers. Infection. 2006;34:81-86.
34. Tsukayama DT, Goldberg VM, Kyle R. Diagnosis and management of infection after total knee arthroplasty. J Bone Joint Surg Am. 2003;85(suppl 1):S75-80.
35. Tunney MM, Ramage G, Patrick S, Nixon JR, Murphy PG, Gorman SP. Antimicrobial susceptibility of bacteria isolated from orthopedic implants following revision hip surgery. Antimicrob Agents Chemother. 1998;42:3002-3005. (Pubitemid 28501241)
36. Van Thiel GS, Berend KR, Klein GR, Gordon AC, Lombardi AV, Della Valle CJ. Intraoperative molds to create an articulating spacer for the infected knee arthroplasty. Clin Orthop Relat Res. 2011;469:994-1001.
37. Villanueva-Martinez M, Rios-Luna A, Pereiro J, Fahandez-Saddi H, Villamor A. Hand-made articulating spacers in two-stage revision for infected total knee arthroplasty: good outcome in 30 patients. Acta Orthop. 2008;79:674-682.
38. Wan Z, Karim A, Momaya A, Incavo SJ, Mathis KB. Preformed articulating knee spacers in 2-stage total knee revision arthroplasty: minimum 2-year follow-up. J Arthroplasty. 2012;27:1469-1473.
39. Watanakunakorn C, Tisone JC. Synergism between vancomycin and gentamicin or tobramycin for methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. 1982;22:903-905. (Pubitemid 13210075)
40. Wilde AH, Ruth JT. Two-stage reimplantation in infected total knee arthroplasty. Clin Orthop Relat Res. 1988;236:23-35. (Pubitemid 18264695)
41. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004;351:1645-1654.