Screening and identification of neuroprotective compounds relevant to Alzheimer's disease from medicinal plants of S. Tomé e Príncipe

Journal of Ethnopharmacology

Volumn 155, Issue 1, 2014, Pages 830-840

  Currais, Antonio ^a   Chiruta, Chandramouli ^a   Goujon Svrzic, Marie ^a   Costa, Gustavo ^b,c   Santos, Tânia ^b,c   Batista, Maria Teresa ^b,c   Paiva, Jorge ^d   Do Céu Madureira, Maria ^d   Maher, Pamela ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Aging; Alzheimer; Dementia; Inflammation; Neurodegenerative disorders; Traditional medicine Africa

Indexed keywords

ALCOHOL; ALKALOID VOACAMINE; NATURAL PRODUCT; PLANT EXTRACT; PSYCHOTRIA PRINCIPENSIS EXTRACT; PSYCHOTRIA SUBOBLIQUA EXTARCT; SACOSPERMA PANICULATUM EXTRACT; TARENNA NITIDULOIDES EXTRACT; UNCLASSIFIED DRUG; VOACANGA AFRICANA EXTRACT; IBOGAINE; NEUROPROTECTIVE AGENT; VOACAMINE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DIFFERENTIATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISCHEMIA; MEDICINAL PLANT; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; PSYCHOTRIA; PSYCHOTRIA PRINCIPENSIS; PSYCHOTRIA SUBOBLIQUA; RUBIACEAE; SACOSPERMA PANICULATUM; SAO TOME AND PRINCIPE; TARENNA NITIDULOIDES; VOACANGA; VOACANGA AFRICANA; AFRICAN MEDICINE; ANALOGS AND DERIVATIVES; ANIMAL; ATLANTIC ISLANDS; CHEMISTRY; DOSE RESPONSE; ETHNOPHARMACOLOGY; HUMAN; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PROCEDURES; RAT; VALIDATION STUDY;

NITIDULOIDES; PSYCHOTRIA; SACOSPERMA PANICULATUM; TARENNA; VOACANGA AFRICANA;

ALZHEIMER DISEASE; ANIMALS; ATLANTIC ISLANDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHNOPHARMACOLOGY; HUMANS; IBOGAINE; MAGNETIC RESONANCE SPECTROSCOPY; MEDICINE, AFRICAN TRADITIONAL; MICE; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84905088871     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.06.046     Document Type: Article

References (39)

1. AFPD, 2009. African flowering plants database. 〈http://www.ville-ge. ch/musinfo/bd/cjb/africa/〉.
2. N.G. Bisset Phytochemistry and pharmacology of voacanga species Agricultural University Wageningen Papers 85 1985 83 122
3. H.M. Burkill The Useful Plants of West Tropical Africa, volume 4: Families M-R 1985 Royal Botanic Gardens Kew
4. C. Chiruta, D. Schubert, R. Dargusch, and P. Maher Chemical modification of the multitarget neuroprotective compound fisetin Journal of Medicinal Chemistry 55 2012 378 389
5. A. Currais, and P. Maher Functional consequences of age-dependent changes in glutathione status in the brain Antioxidants & Redox Signaling 19 2013 813 822
6. A. Currais, M. Prior, R. Dargusch, A. Armando, J. Ehren, D. Schubert, O. Quehenberger, and P. Maher Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice Aging Cell 13 2014 379 390
7. Q. Chen, M. Prior, R. Dargusch, A. Roberts, R. Riek, C. Eichmann, C. Chiruta, T. Akaishi, K. Abe, P. Maher, and D. Schubert A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease PLoS One 6 2011 e27865
8. E. Figueiredo, J. Paiva, T. Stevart, F. Oliveira, and G.F. Smith Annotated catalogue of the flowering plants of São Tomé and Príncipe Bothalia 41 2011 41 82
9. S.A. Frautschy, and G.M. Cole Why pleiotropic interventions are needed for Alzheimer's disease Molecular Neurobiology 41 2010 392 409
10. M. Gelderblom, F. Leypoldt, J. Lewerenz, G. Birkenmayer, D. Orozco, P. Ludewig, J. Thundyil, T.V. Arumugam, C. Gerloff, E. Tolosa, P. Maher, and T. Magnus The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice Journal of Cerebral Blood Flow & Metabolism 32 2012 835 843
11. L.A. Greene, and A.S. Tischler Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor Proceedings of the National Academy of Sciences of the United States of America 73 1976 2424 2428
12. S.A. Hitchcock, and L.D. Pennington Structure-brain exposure relationships Journal of Medicinal Chemistry 49 2006 7559 7583
13. Hotspots. The biodiversity hotspots. 〈http://www. biodiversityhotspots.org〉 (accessed 04.02.2014).
14. H. Hussain, J. Hussain, A. Al-Harrasi, and I.R. Green Chemistry and biology of the genus Voacanga Pharmaceutical Biology 50 2012 1183 1193
15. K. Ishige, D. Schubert, and Y. Sagara Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms Free Radical Biology and Medicine 30 2001 433 446
16. K. Keegan, and S. Halegoua Signal transduction pathways in neuronal differentiation Current Opinion in Neurobiology 3 1993 14 19
17. H.G. Kim, and M.S. Oh Herbal medicines for the prevention and treatment of Alzheimer's disease Current Pharmaceutical Design 18 2012 57 75
18. Y. Kim, H.J. Jung, and H.J. Kwon A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo Biochemical and Biophysical Research Communications 417 2012 330 334
19. A.R. Koroch, H.R. Juliani, H.A. Kulakowski, J. Asante-Dartey, and J.E. Simon Voacanga africana: chemistry, quality and pharmacological activity (ACS Symposium Series) African Natural Plant Products: New Discoveries and Challenges in Chemistry and Quality 1021 2009 363 380
20. Y. Liu, R. Dargusch, P. Maher, and D. Schubert A broadly neuroprotective derivative of curcumin Journal of Neurochemistry 105 2008 1336 1345
21. Madureira, M.C., 2006. Etnofarmacologia e Estudo de Espécies com Actividade Biológica da Flora de S. Tomé e Príncipe (Doctoral thesis) in Pharmacognosy and Phytochemistry, Faculdade de Farmácia, Universidade de Coimbra.
22. M.C. Madureira, A.P. Martins, L. Salgueiro, J. Paiva, and A. Proença da Cunha Medicinal Plants and Traditional Medicine in the Gulf of Guinea - S. Tomé and Príncipe Islands, in Medicinal Plants Ethnomedicine and Pharmacognosy Part II 7 2002 Researchco Book Centre New Delhi, India 361 381
23. M.C. Madureira, J.A. Paiva, A.F. Fernandes, A. Gonçalves, C. Catalão, C. Fernandes, J. Atalaia, J. Vieira, V. Gaspar, S. Pontes, S. Gino, and S. Costa Estudo Etnofarmacológico de Plantas Medicinais de S. Tomé e Príncipe 2008 Ed. Ministério da Saúde STP/Fundação Calouste Gulbenkian, Lisboa, Portugal
24. P. Maher, R. Dargusch, L. Bodai, P.E. Gerard, J.M. Purcell, and J.L. Marsh ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease Human Molecular Genetics 20 2011 261 270
25. P. Maher Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin Genes & Nutrition 4 2009 297 307
26. P. Maher, K.F. Salgado, J.A. Zivin, and P.A. Lapchak A novel approach to screening for new neuroprotective compounds for the treatment of stroke Brain Research 1173 2007 117 125
27. W.L.B. Medeiros, I.J.C. Vieira, L. Mathias, R. Braz-Filho, K.Z. Leal, E. Rodrigues-Filho, and J. Schripsema Two known bis-indole alkaloids isolated from Tabernaemontana laeta: complete 1H and 13C chemical shift assignments Magnetic Resonance in Chemistry 37 1999 676 681
28. S.B. Olaleye, J.M. Oke, A.K. Etu, I.O. Omotosho, and R.A. Elegbe Antioxidant and anti-inflammatory properties of a flavonoid fraction from the leaves of Voacanga africana Nigerian Journal of Physiological Sciences 19 2004 69 76
29. H. Pajouhesh, and G.R. Lenz Medicinal chemical properties of successful central nervous system drugs NeuroRx 2 2005 541 553
30. C.S. Passos, C.A. Simoes-Pires, A. Nurisso, T.C. Soldi, L. Kato, C.M. de Oliveira, E.O. de Faria, L. Marcourt, C. Gottfried, P.A. Carrupt, and A.T. Henriques Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors Phytochemistry 86 2013 8 20
31. M. Prior, R. Dargusch, J.L. Ehren, C. Chiruta, and D. Schubert The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice Alzheimer's Research & Therapy 5 2013 25
32. Y. Sagara, J. Vanhnasy, and P. Maher Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation Journal of Neurochemistry 90 2004 1144 1155
33. U. Saxena Bioenergetics failure in neurodegenerative diseases: back to the future Expert Opinion on Therapeutic Targets 16 2012 351 354
34. D. Schubert, and P. Maher An alternative approach to drug discovery for Alzheimer's disease dementia Future Medicinal Chemistry 4 2012 1681 1688
35. J.A. Sonnen, J.C. Breitner, M.A. Lovell, W.R. Markesbery, J.F. Quinn, and T.J. Montine Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models Free Radical Biology and Medicine 45 2008 219 230
36. B.L. Sopher, K. Fukuchi, T.J. Kavanagh, C.E. Furlong, and G.M. Martin Neurodegenerative mechanisms in Alzheimer disease. A role for oxidative damage in amyloid beta protein precursor-mediated cell death Molecular and Chemical Neuropathology 29 1996 153 168
37. S. Tan, D. Schubert, and P. Maher Oxytosis: a novel form of programmed cell death Current Topics in Medicinal Chemistry 1 2001 497 506
38. B.S. Winkler, M.W. Sauer, and C.A. Starnes Modulation of the Pasteur effect in retinal cells: implications for understanding compensatory metabolic mechanisms Experimental Eye Research 76 2003 715 723
39. T. Wyss-Coray, and J. Rogers Inflammation in Alzheimer disease - a brief review of the basic science and clinical literature Cold Spring Harbor Perspectives in Medicine 2 2012 a006346