Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function

British Journal of Anaesthesia

Volumn 113, Issue SUPPL. 1, 2014, Pages

  Baptista Hon, D T ^a   Robertson, F M ^a   Robertson, G B ^a   Owen, S J ^a   Rogers, G W ^a   Lydon, E L ^a   Lee, N H ^b   Hales, T G ^a,b  

^a NINEWELLS HOSPITAL   (United Kingdom)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

colorectal cancer; electrophysiology; ion channels; local anaesthetics

Indexed keywords

MESSENGER RNA; ROPIVACAINE; SODIUM CHANNEL NAV1.5;

ADULT; AREA UNDER THE CURVE; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CELL INVASION; COLON METASTASIS; CONCENTRATION RESPONSE; DRUG POTENCY; EMBRYO; HUMAN; HUMAN TISSUE; IC 50; MEMBRANE POTENTIAL; METASTASIS POTENTIAL; NEWBORN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEADY STATE; VOLTAGE CLAMP TECHNIQUE;

COLORECTAL CANCER; ELECTROPHYSIOLOGY; ION CHANNELS; LOCAL ANAESTHETICS;

ADULT; AGE FACTORS; AMIDES; ANESTHETICS, LOCAL; CELL MOVEMENT; COLLAGEN; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; INFANT, NEWBORN; LAMININ; LIDOCAINE; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PATCH-CLAMP TECHNIQUES; PROTEOGLYCANS;

EID: 84905058783     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu104     Document Type: Article

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