Physiological roles of gonadotropin-inhibitory hormone signaling in the control of mammalian reproductive axis: Studies in the NPFF1 receptor null mouse

Endocrinology

Volumn 155, Issue 8, 2014, Pages 2953-2965

  León, Silvia ^a   García Galiano, David ^a   Ruiz Pino, Francisco ^a   Barroso, Alexia ^a   Manfredi Lozano, María ^a   Romero Ruiz, Antonio ^a   Roa, Juan ^a   Vázquez, María J ^a   Gaytan, Francisco ^a   Blomenrohr, Marion ^a   Van Duin, Marcel ^a   Pinilla, Leonor ^a   Tena Sempere, Manuel ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; FASTING; FEEDBACK, PHYSIOLOGICAL; FEMALE; FERTILITY; GONADOTROPINS; KISSPEPTINS; LITTER SIZE; MALE; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; PHENOTYPE; RECEPTORS, NEUROPEPTIDE; SEXUAL MATURATION; STRESS, PHYSIOLOGICAL;

EID: 84905041425     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2014-1030     Document Type: Article

References (39)

1. Herbison AE. 2006 Physiology of the gonadotropin-releasing hormone neuronal network. In: Neill JD ed. The physiology of reproduction. San Diego: Academic Press/Elservier; 1415-1482.
2. Pinilla L, Aguilar E, Dieguez C, Millar R.P., Tena-Sempere M. Kiss-peptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev. 2012; 92:1235-1316.
3. Navarro VM, Tena-Sempere M. Neuroendocrine control by kiss-peptins: roleinmetabolic regulation of fertility. Nat Rev Endocrinol. 2012; 8:40-53.
4. Tsutsui K, Saigoh E, Ukena K, et al. A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun. 2000; 275:661-667.
5. Kriegsfeld LJ, Mei DF, Bentley GE, et al. Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. Proc Natl Acad Sci USA. 2006; 103:2410-2415.
6. Kriegsfeld LJ. Driving reproduction: RFamide peptides behind the wheel. Horm Behav. 2006; 50:655-666.
7. Hinuma S, Shintani Y, Fukusumi S, et al. New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol. 2000; 2:703-708.
8. Clarke IJ, Qi Y, Puspita Sari I, Smith JT. Evidence that RF-amide related peptides are inhibitors of reproduction in mammals. Front Neuroendocrinol. 2009; 30:371-378.
9. Smith JT, Clarke IJ. Gonadotropin inhibitory hormone function in mammals. Trends Endocrinol Metab. 2010; 21:255-260.
10. Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, et al. Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of Gn IH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies. Am J Physiol Endocrinol Metab. 2010; 299: E39-E46.
11. Ubuka T, Son YL, Tobari Y, Tsutsui K. Gonadotropin-inhibitory hormone action in the brain and pituitary. Front Endocrinol (Lausanne). 2012; 3:148.
12. Qi Y, Oldfield BJ, Clarke IJ. Projections of RFamide-related pep-tide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. J Neuroendo-crinol. 2009; 21:690-697.
13. Ducret E, Anderson GM, Herbison AE. RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology. 2009; 150:2799-2804.
14. Wu M, Dumalska I, Morozova E, van den Pol AN, Alreja M. Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism. J Physiol. 2009; 587:1401-1411.
15. Poling MC, Quennell JH, Anderson GM, Kauffman AS. Kisspeptin Neurones do not Directly Signal to RFRP-3 Neurones but RFRP-3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice. J Neuroendocrinol. 2013; 25:876-886.
16. Clarke IJ, Smith JT, Henry BA, et al. Gonadotropin-inhibitory hormone is a hypothalamic peptide that provides a molecular switch between reproduction and feeding. Neuroendocrinology. 2012; 95: 305-316.
17. Pineda R, Garcia-Galiano D, Sanchez-Garrido MA, et al. Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. Endocrinology. 2010; 151:1902-1913.
18. Garcia-Galiano D, van Ingen Schenau D, Leon S, et al. Kisspeptin Signaling Is Indispensable for Neurokinin B, but not Glutamate, Stimulation of Gonadotropin Secretion in Mice. Endocrinology. 2012; 153:316-328.
19. Navarro VM, Ruiz-Pino F, Sanchez-Garrido MA, et al. Role of Neurokinin B in the Control of Female Puberty and Its Modulation by Metabolic Status. J Neurosci. 2012; 32:2388-2397.
20. Garcia-Galiano D, Navarro VM, Roa J, et al. The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci. 2010; 30:7783-7792.
21. Ruiz-Pino F, Navarro VM, Bentsen A.H., et al. Neurokin in Band the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids. Endocrinology. 2012; 153:4818-4929.
22. Aguilar E, Pineda R, Gaytan F, et al. Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies. Neuroendocrinology. 2013; 98:38-50.
23. Roa J, Garcia-Galiano D, Varela L, et al. The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology. 2009; 150: 5016-5026.
24. Wintermantel TM, Campbell RE, Porteous R, et al. Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin- releasing hormone neurons and fertility. Neuron. 2006; 52:271-280.
25. Garcia-Galiano D, Pineda R, Roa J, et al. Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptider-gic, and nitric oxide neurotransmission. Am J Physiol Endocrinol Metab. 2012; 303:E1252-E1263.
26. Paxinos G, Franklin KBJ. 2001 The mouse brain in stereotaxic coordinates. San Diego: Academic Press.
27. Kim J, Semaan SJ, Clifton D.K., Steiner RA, Dhamija S, Kauffman AS. Regulation of kiss1 expressionby sex steroidsin the amygdala of the rat and mouse. Endocrinology. 2011; 152:2020-2030.
28. Pinilla L, Pineda R, Gaytan F, et al. Characterization of the reproductive effects of the anorexigenic VGF-derived peptide TLQP-21: in vivo and in vitro studies in male rats. Am J Physiol Endocrinol Metab. 2011; 300:E837-E847.
29. Elias CF, Purohit D. Leptin signaling and circuits in puberty and fertility. Cell Mol Life Sci. 2012; 70:841-862.
30. Caraty A, Blomenrohr M, Vogel G.M., Lomet D., Briant C, Beltramo M. RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity. J Neuroendocrinol. 2012; 24:725-736.
31. Maletinska L, Ticha A, Nagelova V, et al. Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration. Brain Res. 2013; 1498:33-40.
32. Iwasa T, Matsuzaki T, Murakami M, et al. Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus. Int J Dev Neu-rosci. 2012; 30:31-37.
33. McTavish KJ, Jimenez M, Walters KA, et al. Rising follicle-stimulating hormone levels with age accelerate female reproductive failure. Endocrinology. 2007; 148:4432-4439.
34. Sari IP, Rao A, Smith J.T., Tilbrook AJ, Clarke IJ. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology. 2009; 150:5549-5556.
35. Murakami M, Matsuzaki T, Iwasa T, et al. Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats. J Endocrinol. 2008; 199:105-112.
36. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006; 3:379-386.
37. Poling MC, Kim J, Dhamija S, Kauffman AS. Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus. Endocrinology. 2012; 153:1827-1840.
38. Quennell JH, Rizwan MZ, Relf HL, Anderson GM. Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland. J Neuroendocrinol. 2010; 22:309-316.
39. Gibson EM, Humber SA, Jain S, et al. Alterations in RFamide-re-lated peptide expression are coordinated with the preovulatory lu-teinizing hormone surge. Endocrinology. 2008; 149:4958-4969.