Pathophysiology, epidemiology, and assessment of obesity in adults

Journal of Family Practice

Volumn 63, Issue 7, 2014, Pages

  Skolnik, Neil S ^a,b   Ryan, Donna H ^c  

^a ABINGTON MEMORIAL HOSPITAL   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CHOLECYSTOKININ; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY; TRIACYLGLYCEROL;

ADIPOCYTE; ADULT; ATHEROGENESIS; AUTOCRINE EFFECT; BODY MASS; BRAIN FUNCTION; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CEREBROVASCULAR ACCIDENT; CHILDHOOD OBESITY; CLINICAL ASSESSMENT; CLINICAL TRIAL (TOPIC); CONGESTIVE HEART FAILURE; DEPRESSION; DIASTOLIC BLOOD PRESSURE; DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; HUMAN; HUNGER; HYPERTENSION; HYPOTHALAMUS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; LIFESTYLE MODIFICATION; LIPID STORAGE; MATERNAL OBESITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PARACRINE SIGNALING; PATIENT ATTITUDE; REVIEW; SATIETY; SYSTOLIC BLOOD PRESSURE; WEIGHT CONTROL; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

ADULT; AGED; BODY MASS INDEX; ENERGY INTAKE; HUMANS; MIDDLE AGED; OBESITY; PREVALENCE; PRIMARY HEALTH CARE; RISK FACTORS;

EID: 84905033199     PISSN: 00943509     EISSN: 15337294     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Pi-Sunyer FX, Becker DM, Bouchard C, et al. The Practical Guide. Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. http://www.nhlbi.nih.gov/guidelines/obesity/prctgd-c.pdf. National Institutes of Health. Published 2000. Accessed June 2, 2014.
2. Romero-Corral A, Somers VK, Sierra-Johnson J, et al. Accuracy of body mass index in diagnosing obesity in the adult general population. Int J Obes (Lond). 2008;32(6):959-966. (Pubitemid 351986216)
3. Flegal KM, Shepherd JA, Looker AC, et al. Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr. 2009;89(2):500-508.
4. McKenney RL, Short DK. Tipping the balance: the pathophysiology of obesity and type 2 diabetes mellitus. Surg Clin North Am. 2011;91(6):1139-1148, vii.
5. Chugh PK, Sharma S. Recent advances in the pathophysiology and pharmacological treatment of obesity. J Clin Pharm Ther. 2012;37(5):525-535.
6. Munoz-Pareja M, Guallar-Castillon P, Mesas AE, Lopez-Garcia E, Rodriguez-Artalejo F. Obesity-related eating behaviors are associated with higher food energy density and higher consumption of sugary and alcoholic beverages: a cross-sectional study. PLoS One. 2013;8(10):e77137.
7. Sam AH, Troke RC, Tan TM, Bewick GA. The role of the gut/brain axis in modulating food intake. Neuropharmacology. 2012;63(1):46-56.
8. Lenard NR, Berthoud HR. Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity (Silver Spring). 2008;16(suppl 3):S11-S22.
9. Yu JH, Kim MS. Molecular mechanisms of appetite regulation. Diabetes Metab J. 2012;36(6):391-398.
10. Duca FA, Covasa M. Current and emerging concepts on the role of peripheral signals in the control of food intake and development of obesity. Br J Nutr. 2012;108(5):778-793.
11. Volkow ND, Wang GJ, Tomasi D, Baler RD. Obesity and addiction: neurobiological overlaps. Obes Rev. 2013;14(1):2-18.
12. Wise RA. Dual roles of dopamine in food and drug seeking: the drive-reward paradox. Biol Psychiatry. 2013;73(9):819-826.
13. Adamczak M, Wiecek A. The adipose tissue as an endocrine organ. Semin Nephrol. 2013;33(1):2-13.
14. Gu P, Xu A. Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction. Rev Endocr Metab Disord. 2013;14(1):49-58.
15. Knights AJ, Funnell AP, Pearson RC, Crossley M, Bell-Anderson KS. Adipokines and insulin action: A sensitive issue. Adipocyte. 2014;3(2):88-96.
16. Schwartz MW, Woods SC, Porte D, Jr., Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661-671. (Pubitemid 30205071)
17. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW. Central nervous system control of food intake and body weight. Nature. 2006;443(7109):289-295. (Pubitemid 44435142)
18. Pan H, Guo J, Zhengquan S. Advances in understanding the interrelations between leptin resistance and obesity. Physiol Behav. 2014;130:157-169.
19. van Bloemendaal L, Ten Kulve JS, la Fleur SE, Ijzerman RG, Diamant M. Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS. J Endocrinol. 2014;221(1):T1-T16.
20. Schwartz A, Doucet E. Relative changes in resting energy expenditure during weight loss: a systematic review. Obes Rev. 2010;11(7):531-547.
21. Thrush AB, Dent R, McPherson R, Harper ME. Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity. FEBS J. 2013;280(20):5015-5029.
22. Sumithran P, Prendergast LA, Delbridge E, et al. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011;365(17):1597-1604.
23. Cornier MA. Is your brain to blame for weight regain? Physiol Behav. 2011;104(4):608-612.
24. Sumithran P, Proietto J. The defence of body weight: a physiological basis for weight regain after weight loss. Clin Sci (Lond). 2013;124(4):231-241.
25. Hill JO, Galloway JM, Goley A, et al. Scientific statement: Socioecological determinants of prediabetes and type 2 diabetes. Diabetes Care. 2013;36(8):2430-2439.
26. Centers for Disease Control and Prevention. Health, United States, 2011: With Special Feature on Socioeconomic Status and Health. National Center for Health Statistics. http://www.cdc.gov/nchs/data/hus/hus11.pdf. Published 2012. Accessed June 2, 2014.
27. Redinger RN. The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol (NY). 2007;3(11):856-863. (Pubitemid 350305232)
28. Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health. 2009;9:88.
29. Booth HP, Prevost AT, Gulliford MC. Impact of body mass index on prevalence of multimorbidity in primary care: cohort study. Fam Pract. 2014;31(1):38-43.
30. Kulie T, Slattengren A, Redmer J, Counts H, Eglash A, Schrager S. Obesity and women's health: an evidence-based review. J Am Board Fam Med. 2011;24(1):75-85.
31. Maggio CA, Pi-Sunyer FX. Obesity and type 2 diabetes. Endocrinol Metab Clin North Am. 2003;32(4):805-822, viii. (Pubitemid 38029982)
32. Carey VJ, Walters EE, Colditz GA, et al. Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women. The Nurses' Health Study. Am J Epidemiol. 1997;145(7):614-619. (Pubitemid 27154864)
33. Ostchega Y, Hughes JP, Terry A, Fakhouri TH, Miller I. Abdominal obesity, body mass index, and hypertension in US adults: NHANES 2007-2010. Am J Hypertens. 2012;25(12):1271-1278.
34. Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria C, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. November 2013:1-69.
35. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci. 2012;1271:37-43.
36. Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr. 2013;13(1):121.
37. Paulis WD, Silva S, Koes BW, van MM. Overweight and obesity are associated with musculoskeletal complaints as early as childhood: a systematic review. Obes Rev. 2014;15(1):52-67.
38. Walders-Abramson N, Nadeau KJ, Kelsey MM, et al. Psychological functioning in adolescents with obesity co-morbidities. Child Obes. 2013;9(4):319-325.
39. Rejeski WJ, Ip EH, Bertoni AG, et al. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012;366(13):1209-1217.
40. Espeland MA, Rejeski WJ, West DS, et al. Intensive weight loss intervention in older individuals: results from the action for health in diabetes type 2 diabetes mellitus trial. J Am Geriatr Soc. 2013;61(6):912-922.
41. Williamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med. 2009;169(2):163-171.
42. Unick JL, Beavers D, Bond DS, et al. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med. 2013;126(3):236-242.
43. Jakicic JM, Egan CM, Fabricatore AN, et al. Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial. Diabetes Care. 2013;36(5):1297-1303.
44. Leblanc ES, O'Connor E, Whitlock EP, Patnode CD, Kapka T. Effectiveness of primary care-relevant treatments for obesity in adults: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2011;155(7):434-447.
45. Ratner R, Goldberg R, Haffner S, et al. Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program. Diabetes Care. 2005;28(4):888-894. (Pubitemid 40434491)
46. Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346(6):393-403. (Pubitemid 34437694)
47. Knowler WC, Fowler SE, Hamman RF, et al. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009;374(9702):1677-1686.
48. Pi-Sunyer X, Blackburn G, Brancati FL, et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial. Diabetes Care. 2007;30(6):1374-1383. (Pubitemid 46871141)
49. Faulconbridge LF, Wadden TA, Rubin RR, et al. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity (Silver Spring). 2012;20(4):783-793.
50. Foster GD, Borradaile KE, Sanders MH, et al. A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. Arch Intern Med. 2009;169(17):1619-1626.
51. Wing RR, Bond DS, Gendrano IN, III, et al. Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: Results from an ancillary Look AHEAD study. Diabetes Care. 2013;36(10):2937-2944.
52. Phelan S, Kanaya AM, Subak LL, et al. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012;187(3):939-944.
53. Gregg EW, Chen H, Wagenknecht LE, et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 2012;308(23):2489-2496.
54. Wing RR, Bolin P, Brancati FL, et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369(2):145-154.
55. Pan XR, Li GW, Hu YH, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537-544.
56. Li G, Zhang P, Wang J et al. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet. 2008;371(9626):1783-1789. (Pubitemid 351697954)
57. Epling JW, Morley CP, Ploutz-Snyder R. Family physician attitudes in managing obesity: a cross-sectional survey study. BMC Res Notes. 2011;4:473.
58. Jay M, Kalet A, Ark T, et al. Physicians' attitudes about obesity and their associations with competency and specialty: a cross-sectional study. BMC Health Serv Res. 2009;9:106.
59. Bleich SN, Bennett WL, Gudzune KA, Cooper LA. National survey of US primary care physicians' perspectives about causes of obesity and solutions to improve care. BMJ Open. 2012;2(6):e001871.
60. Wee CC, Hamel MB, Apovian CM, et al. Expectations for weight loss and willingness to accept risk among patients seeking weight loss surgery. JAMA Surg. 2013;148(3):264-271.
61. Siervo M, Montagnese C, Muscariello E, et al. Weight loss expectations and body dissatisfaction in young women attempting to lose weight. J Hum Nutr Diet. 2014;27(suppl 2):84-89.
62. White DB, Bursac Z, Dilillo V, West DS. Weight loss goals among African-American women with type 2 diabetes in a behavioral weight control program. Obesity (Silver Spring). 2011;19(11):2283-2285.
63. Kaly P, Orellana S, Torrella T, Takagishi C, Saff-Koche L, Murr MM. Unrealistic weight loss expectations in candidates for bariatric surgery. Surg Obes Relat Dis. 2008;4(1):6-10.
64. Foster GD, Wadden TA, Vogt RA, Brewer G. What is a reasonable weight loss? Patients' expectations and evaluations of obesity treatment outcomes. J Consult Clin Psychol. 1997;65(1):79-85. (Pubitemid 27086138)
65. Gudzune KA, Beach MC, Roter DL, Cooper LA. Physicians build less rapport with obese patients. Obesity (Silver Spring). 2013;21(10):2146-2152.
66. Moyer VA. Screening for and management of obesity in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2012;157(5):373-378.
67. Rao G, Burke LE, Spring BJ, et al. New and emerging weight management strategies for busy ambulatory settings: a scientific statement from the American Heart Association endorsed by the Society of Behavioral Medicine. Circulation. 2011;124(10):1182-1203.
68. Garber AJ, Abrahamson MJ, Barzilay JI, et al. American Association of Clinical Endocrinologists' comprehensive diabetes management algorithm 2013 consensus statement. Endocr Pract. 2013;19(suppl 2):1-48.
69. Greenwood JL, Joy EA, Stanford JB. The Physical Activity Vital Sign: a primary care tool to guide counseling for obesity. J Phys Act Health. 2010;7(5):571-576.
70. Coleman KJ, Ngor E, Reynolds K, et al. Initial validation of an exercise "vital sign" in electronic medical records. Med Sci Sports Exerc. 2012;44(11):2071-2076.
71. Strath SJ, Kaminsky LA, Ainsworth BE, et al. Guide to the assessment of physical activity: Clinical and research applications: a scientific statement from the American Heart Association. Circulation. 2013;128(20):2259-2279.
72. Sharma AM, Kushner RF. A proposed clinical staging system for obesity. Int J Obes (Lond). 2009;33(3):289-295.
73. Fitch A, Everling L, Fox C, et al. Health care guideline: Prevention and management of obesity for adults. https://www.icsi.org/-asset/s935hy/ ObesityAdults.pdf. Institute for Clinical Systems Improvement. Published 2013. Accessed June 2, 2014.