Cholinesterases as biomarkers for parasympathetic dysfunction and inflammation-related disease

Journal of Molecular Neuroscience

Volumn 53, Issue 3, 2014, Pages 298-305

  Shenhar Tsarfaty, Shani ^a,b   Berliner, Shlomo ^b   Bornstein, Natan M ^b   Soreq, Hermona ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Acetylcholinesterase; Biomarkers; Butyrylcholinesterase; Cholinesterases; Diseases; Inflammation

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; BIOLOGICAL MARKER; CHOLINESTERASE; MICRORNA; NEUROTRANSMITTER;

ADRENERGIC SYSTEM; ANXIETY; ARTICLE; CEREBROVASCULAR DISEASE; CHOLINERGIC SYSTEM; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DEGENERATIVE DISEASE; DIABETES MELLITUS; ENZYME ACTIVITY; EPIGENETICS; GENE EXPRESSION; HUMAN; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY DISEASE; METABOLIC SYNDROME X; NONHUMAN; PARASYMPATHETIC FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; AUTONOMIC NERVOUS SYSTEM DISEASES; ENZYMOLOGY; GENETICS; INFLAMMATION; METABOLISM;

ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; BIOLOGICAL MARKERS; CHOLINESTERASES; HUMANS; INFLAMMATION;

EID: 84905030903     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0176-4     Document Type: Article

References (87)

1. Adabag AS et al (2008) Relation of heart rate parameters during exercise test to sudden death and all-cause mortality in asymptomatic men. Am J Cardiol 101(10):1437-1443
2. Alcantara VM et al (2002) Butyrylcholinesterase activity and risk factors for coronary artery disease. Scand J Clin Lab Invest 62(5):399-404
3. Alkalay A et al (2013) Plasma acetylcholinesterase activity correlates with intracerebral beta-amyloid load. Curr Alzheimer Res 10(1):48-56
4. Alvarez GE et al (2002) Sympathetic neural activation in visceral obesity. Circulation 106(20):2533-2536 (Pubitemid 35340687)
5. Arena R et al (2006) Prognostic value of heart rate recovery in patients with heart failure. Am Heart J 151(4):851.e7-851.e13
6. Bai A, Guo Y, Lu N (2007) The effect of the cholinergic anti-inflammatory pathway on experimental colitis. Scand J Immunol 66(5):538-545 (Pubitemid 47609702)
7. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215-233
8. Ben Assayag E et al (2010) Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-monthmortality. Mol Med 16(7-8):278-286
9. Benmoyal-Segal L et al (2005) Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. FASEB J 19(3):452-454 (Pubitemid 40316547)
10. Berson A et al (2012) Cholinergic-associated loss of hnRNP-A/B in Alzheimer 's disease impairs cortical splicing and cognitive function in mice. EMBO Mol Med 4(8):730-742
11. Bhuiyan MB, Murad F, Fant ME (2006) The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide. Cell Commun Signal 4:4
12. Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 69(3):89-95
13. Birikh KR et al (2003) Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. Proc Natl Acad Sci U S A 100(1):283-288 (Pubitemid 36078066)
14. Borovikova LV et al (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785):458-462
15. Calabresi P et al (2006) A convergentmodel for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance. Lancet Neurol 5(11):974-983 (Pubitemid 44556553)
16. Calderon-Margalit R et al (2006) Butyrylcholinesterase activity, cardiovascular risk factors, and mortality in middle-aged and elderly men and women in Jerusalem. Clin Chem 52(5):845-852 (Pubitemid 43673263)
17. Cole CR et al (1999) Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 341(18):1351-1357 (Pubitemid 29503574)
18. Conner JM et al (2003) Lesions of the basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning. Neuron 38(5):819-829 (Pubitemid 36694787)
19. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285(19):2486-2497
20. Ford ES, Giles WH, Dietz WH (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287(3):356-359 (Pubitemid 34251969)
21. Frank R, Hargreaves R (2003) Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2(7):566-580 (Pubitemid 37361748)
22. Ganguli SC et al (2007) A comparison of autonomic function in patients with inflammatory bowel disease and in healthy controls. Neurogastroenterol Motil 19(12):961-967 (Pubitemid 350198319)
23. Ghia JE et al (2006) The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 131(4):1122-1130 (Pubitemid 44498700)
24. Giacobini E (2003) Cholinergic function and Alzheimer's disease. Int J Geriatr Psychiatry 18(Suppl 1):S1-S5
25. Goliasch G et al (2012a) Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score. Eur Heart J 33(18):2282-2289
26. Goliasch G et al (2012b) Butyrylcholinesterase activity predicts long-term survival in patients with coronary artery disease. Clin Chem 58(6):1055-1058
27. Greenwood JP, Stoker JB, Mary DA (1999) Single-unit sympathetic discharge: quantitative assessment in human hypertensive disease. Circulation 100(12):1305-1310 (Pubitemid 29440123)
28. Guest PC, Gottschalk MG, Bahn S (2013) Proteomics: improving biomarker translation to modern medicine? Genome Med 5(2):17
29. Hanin G, Soreq H (2011) Cholinesterase-targeting microRNAs identified in silico affect specific biological processes. Front Mol Neurosci 4:28
30. Honda K et al (2013) Proteomic approaches to the discovery of cancer biomarkers for early detection and personalizedmedicine. Jpn J Clin Oncol 43(2):103-109
31. Humpel C (2011) Identifying and validating biomarkers for Alzheimer's disease. Trends Biotechnol 29(1):26-32
32. Jouven X et al (2005) Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352(19):1951-1958 (Pubitemid 40638365)
33. Kaufer D et al (1998) Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393(6683):373-377 (Pubitemid 28269711)
34. Kawashima K, Fujii T (2000) Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 86(1):29-48 (Pubitemid 30173143)
35. Kawashima K, Fujii T (2003) The lymphocytic cholinergic systemand its contribution to the regulation of immune activity. Life Sci 74(6):675-696 (Pubitemid 37494897)
36. Koennecke HC et al (2011) Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit. Neurology 77(10):965-972
37. Lahiri MK, Kannankeril PJ, Goldberger JJ (2008) Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications. J Am Coll Cardiol 51(18):1725-1733 (Pubitemid 351608496)
38. Lau P, de Strooper B (2010) Dysregulated microRNAs in neurodegenerative disorders. Semin Cell Dev Biol 21(7):768-773
39. Lau P et al (2013) Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 5(10):1613-1634
40. Leeper NJ et al (2007) Prognostic value of heart rate increase at onset of exercise testing. Circulation 115(4):468-474 (Pubitemid 46184198)
41. Lev-Lehman E et al (1997) Immature human megakaryocytes produce nuclear-associated acetylcholinesterase. Blood 89(10):3644-3653 (Pubitemid 27227087)
42. Loewenstein-Lichtenstein Y et al (1995) Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers. Nat Med 1(10):1082-1085
43. Loewi O (1921) Über humorale Übertragbarkeit der Herznervenwirkung. I. Pflügers Archiv 189:239-242
44. Maharshak N et al (2013) MicroRNA-132 modulates cholinergic signaling and inflammation in human inflammatory bowel disease. Inflamm Bowel Dis 19(7):1346-1353
45. Massoulie J et al (2008) Old and new questions about cholinesterases. Chem Biol Interact 175(1-3):30-44
46. Mayer EA, Craske M, Naliboff BD (2001) Depression, anxiety, and the gastrointestinal system. J Clin Psychiatry 62(Suppl 8):28-36, discussion 37
47. McCafferty DM, Wallace JL, Sharkey KA (1997) Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat. Am J Physiol 272(2 Pt 1):G272-G280 (Pubitemid 27137240)
48. Meisel C, Meisel A (2011) Suppressing immunosuppression after stroke. N Engl J Med 365(22):2134-2136
49. Meregnani J et al (2011) Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease. Auton Neurosci 160(1-2):82-89
50. Meshorer E et al (2002) Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science 295(5554):508-512 (Pubitemid 34101643)
51. Meshorer E et al (2004) Combinatorial complexity of 5′ alternative acetylcholinesterase transcripts and protein products. J Biol Chem 279(28):29740-29751 (Pubitemid 38915857)
52. Meshorer E et al (2006) Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 10(1):105-116 (Pubitemid 43025681)
53. Metz CN, Tracey KJ (2005) It takes nerve to dampen inflammation. Nat Immunol 6(8):756-757 (Pubitemid 43090460)
54. Najarian RM et al (2006) Metabolic syndrome compared with type 2 diabetes mellitus as a risk factor for stroke: the Framingham Offspring Study. Arch Intern Med 166(1):106-111 (Pubitemid 43063849)
55. Ofek K, Soreq H (2013) Cholinergic involvement and manipulation approaches in multiple system disorders. Chem Biol Interact 203(1):113-119
56. Ofek K et al (2007) Cholinergic status modulations in human volunteers under acute inflammation. J Mol Med (Berl) 85(11):1239-1251 (Pubitemid 47622221)
57. Parnetti L, Chiasserini D (2011) Role of CSF biomarkers in the diagnosis of prodromal Alzheimer 's disease. Biomark Med 5(4):479-484
58. Perry EK et al (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 2(6150):1457-1459 (Pubitemid 9061468)
59. Podoly E et al (2009) The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology. J Biol Chem 284(25):17170-17179
60. Pohjavaara P, Telaranta T, Vaisanen E (2003) The role of the sympathetic nervous system in anxiety: is it possible to relieve anxiety with endoscopic sympathetic block? Nord J Psychiatry 57(1):55-60 (Pubitemid 36410908)
61. Prass K et al (2003) Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med 198(5):725-736 (Pubitemid 37087772)
62. Pritchard CC, Cheng HH, Tewari M (2012) MicroRNA profiling: approaches and considerations. Nat Rev Genet 13(5):358-369
63. Rachakonda V, Pan TH, Le WD (2004) Biomarkers of neurodegenerative disorders: how good are they? Cell Res 14(5):347-358
64. Rao AA, Sridhar GR, Das UN (2007) Elevated butyrylcholinesterase and acetylcholinesterase may predict the development of type 2 diabetes mellitus and Alzheimer's disease. Med Hypotheses 69(6):1272-1276
65. Rodriguez-Diaz R et al (2011) Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans. Nat Med 17:882-892
66. Roger VL et al (2012) Heart disease and stroke statistics - 2012 update: a report from the American Heart Association. Circulation 125(1):e2-e220
67. Rosas-Ballina M et al (2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 334(6052):98-101
68. Sailaja BS et al (2012) Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. Proc Natl Acad Sci U S A 109(52):E3687-E3695
69. Savonen KP et al (2008) Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease. Eur Heart J 29(15):1896-1902
70. Schwartz J (2000) Neurotransmitters. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neuronal science. McGraw-Hill, New-York, pp 281-297
71. Shaked I et al (2009) MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity 31(6):965-973
72. Shaltiel G et al (2013) Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target. Brain Struct Funct 218(1):59-72
73. Shenhar-Tsarfaty S et al (2010) Interleukin-6 as an early predictor for one-year survival following an ischaemic stroke/transient ischaemic attack. Int J Stroke 5(1):16-20
74. Shenhar-Tsarfaty S et al (2011) Post-stroke cholinergic biomarkers. Science. Available at http://www.sciencemag.org/content/334/6052/101/reply
75. Shenhar-Tsarfaty S et al (2011b) Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. J Cell Mol Med 15(8):1747-1756
76. Shishehbor MH, Hoogwerf BJ, Lauer MS (2004) Association of triglyceride-to-HDL cholesterol ratio with heart rate recovery. Diabetes Care 27(4):936-941 (Pubitemid 38420218)
77. Sklan EH et al (2004) Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci U S A 101(15):5512-5517 (Pubitemid 38481188)
78. Soreq H, Seidman S (2001) Acetylcholinesterase - new roles for an old actor. Nat Rev Neurosci 2(4):294-302 (Pubitemid 33673070)
79. Soreq H, Wolf Y (2011) NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol Med 17(10):548-555
80. Straznicky NE et al (2008) Mediators of sympathetic activation in metabolic syndrome obesity. Curr Hypertens Rep 10(6):440-447
81. Sykora M et al (2011) Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage. Stroke 42(5):1218-1223
82. Thalamas C et al (2000) Glucose-induced sympathetic activity and energy expenditure during acute alpha2-adrenergic antagonism in obese subjects. Int J Obes Relat Metab Disord 24(6):695-700 (Pubitemid 30339266)
83. Tracey KJ (2010) Understanding immunity requires more than immunology. Nat Immunol 11(7):561-564
84. Trakhtenberg EF, Goldberg JL (2011) Immunology neuroimmune communication. Science 334(6052):47-48
85. Wessler I, Kirkpatrick CJ (2008) Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 154(8):1558-1571
86. Wessler I, Kirkpatrick CJ, Racke K (1998) Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther 77:59-79 (Pubitemid 28059940)
87. Wong CH et al (2011) Functional innervation of hepatic iNKT cells is immunosuppressive following stroke. Science 334(6052):101-105