Genome-wide analyses of borderline personality features

Molecular Psychiatry

Volumn 19, Issue 8, 2014, Pages 923-929

  Lubke, G H ^a,b   Laurin, C ^b   Amin, N ^c   Hottenga, J J ^b   Willemsen, G ^b   Van Grootheest, G ^d,e   Abdellaoui, A ^b   Karssen, L C ^c   Oostra, B A ^c   Van Duijn, C M ^c,e,f   Penninx, B W J H ^d,e   Boomsma, D I ^b,e  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

^f Centre of Medical Systems Biology   (Netherlands)

Author keywords

borderline personality disorder; GCTA; GWAS; heterogeneity; PAI BOR

Indexed keywords

PROTEIN; SERINC5 PROTEIN; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; N ACETYLASPARTIC ACID;

ADULT; AGED; ARTICLE; BORDERLINE STATE; CHROMOSOME 5; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MYELINATION; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL INTERACTION; VERY ELDERLY; AGE DISTRIBUTION; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; META ANALYSIS; ADOLESCENT; ASSESSMENT OF HUMANS; GENE LINKAGE DISEQUILIBRIUM; GENETIC MODEL; HERITABILITY; LIPOGENESIS; PERSONALITY ASSESSMENT INVENTORY BORDERLINE FEATURES SCALE; QUALITY CONTROL; SMOKING CESSATION; SOCIAL ISOLATION;

AGE DISTRIBUTION; BORDERLINE PERSONALITY DISORDER; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MEMBRANE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84904973284     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2013.109     Document Type: Article

References (42)

1. Grant BF, Goldstein RB, Chou SP, Huang B, Stinson FS, Dawson DA et al. Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: Results from the wave 2 national epidemiologic survey on alcohol and related conditions. Mol Psychiatry 2008; 14: 1051-1066.
2. Friborg O, Martinussen M, Kaiser S, Overgård KT, Rosenvinge JH. Comorbidity of personality disorders in anxiety disorders: A meta-Analysis of 30 years of research. J Affect Disord 2012; 145: 143-155.
3. Distel MA, Carlier A, Middeldorp CM, Derom CA, Lubke GH, Boomsma DI. Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: A genetic analysis of comorbidity. Am J Med Genet Part B 2011; 156: 817-825.
4. Bornovalova MA, Hicks BM, Iacono WG, McGue M. Stability, change, and heritability of borderline personality disorder traits from adolescence to adulthood: A longitudinal twin study. Dev Psychopathol 2009; 21: 1353.
5. Clark LA. Stability and change in personality disorder. Curr Dir Psychol Sci 2009; 18: 27-31.
6. Distel MA, Trull TJ, Derom CA, Thiery EW, Grimmer MA, Martin NG et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med 2008; 38: 1219-1229.
7. Distel MA, Trull TJ, Willemsen G, Vink JM, Derom CA, Lynskey M et al. The fivefactor model of personality and borderline personality disorder: A genetic analysis of comorbidity. Biol Psychiatry 2009; 66: 1131-1138.
8. Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ et al. Netherlands Twin Register: From twins to twin families. Twin Res Hum Genet 2006; 9: 849-857. (Pubitemid 46093769)
9. Penninx BW, Beekman AT, Smit JH, Zitman FG, Nolen WA, Spinhoven P et al. The Netherlands Study of Depression and Anxiety (NESDA): Rationale, objectives and methods. Int J Meth Psych Res 2008; 17: 121-140.
10. Pardo LM, MacKay I, Oostra B, van Duijn CM, Aulchenko YS. The effect of genetic drift in a young genetically isolated population. Ann Hum Genet 2005; 69: 288-295. (Pubitemid 40613730)
11. Morey LC. The Personality Assessment Inventory: Professional manual. Psychological Assessment Resources: Odessa, FL, USA, 1991.
12. Jackson KM, Trull TJ. The Factor Structure of the Personality Assessment Inventory-Borderline Features (PAI-BOR) Scale in a nonclinical sample. J Personal Disord 2001; 15: 536-545. (Pubitemid 34008334)
13. Gardner K, Qualter P. Reliability and validity of three screening measures of borderline personality disorder in a nonclinical population. Pers Individ Differ 2009; 46: 636-641.
14. Stein MB, Pinsker-Aspen JH, Hilsenroth MJ. Borderline pathology and the personality assessment inventory (PAI): An evaluation of criterion and concurrent validity. J Pers Assess 2007; 88: 81-89. (Pubitemid 46280449)
15. Bell-Pringle VJ, Pate JL, Brown RC. Assessment of borderline personality disorder using the MMPI-2 and the Personality Assessment Inventory. Assessment 1997; 4: 131-139. (Pubitemid 127663636)
16. Kurtz J, Morey L. Use of structured self-report assessment to diagnose borderline personality disorder during major depressive episodes. Assessment 2001; 8: 291-300. (Pubitemid 33595218)
17. Johansen M, Karterud S, Pedersen G, Gude T, Falkum E. An investigation of the prototype validity of the borderline DSM-IV construct. Acta Psychiatr Scand 2004; 109: 289-298. (Pubitemid 38406711)
18. Sanislow CA, Grilo CM, Morey LC, Bender SD, Skodol AE, Gunderson JG et al. Confirmatory factor analysis of the DSM-IV criteria for borderline personality disorder: Findings from the Collaborative Longitudinal Personality Disorders Study. Am J Psychiatry 2002; 159: 284-290. (Pubitemid 34126907)
19. Andion O , Ferrer M, Gancedo B, Calvo N, Barral C, Torrubia R et al. Confirmatory factor analysis of borderline personality disorder symptoms based on two different interviews: The structured clinical interview for DSM-IV Axis II disorder and the revised diagnostic interview for borderlines. Psychiatry Res 2011; 190: 304-308.
20. Skodol AE, Gunderson JG, Pfohl B, Widiger TA, Livesley WJ, Siever LJ. The borderline diagnosis I: Psychopathology, comorbidity, and personality structure. Biol Psychiatry 2002; 51: 936-950. (Pubitemid 34607710)
21. Skodol AE, Siever LJ, Livesley WJ, Gunderson JG, Pfohl B, Widiger TA. The borderline diagnosis II: Biology, genetics, and clinical course. Biol Psychiatry 2002; 51: 951-963. (Pubitemid 34607711)
22. Aggen SH, Neale MC, Roysamb E, Reichborn-Kjennerud T, Kendler KS. A psychometric evaluation of the DSM-IV borderline personality disorder criteria: Age and sex moderation of criterion functioning. Psychol Med 2009; 39: 1967-1978.
23. Banzhaf A, Ritter K, Merkl A, Schulte-Herbrüggen O, Lammers CH, Roepke S. Gender differences in a clinical sample of patients with borderline personality disorder. J Personal Disord 2012; 26: 368-380.
24. Distel MA, Willemsen G, Ligthart L, Derom CA, Martin NG, Neale MC et al. Genetic covariance structure of the four main features of borderline personality disorder. J Personal Disord 2010; 24: 427-444.
25. Yang J, Wray NR, Visscher PM. Comparing apples and oranges: Equating the power of case-control and quantitative trait association studies. Genet Epidemiol 2010; 34: 254-257.
26. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010; 42: 565-569.
27. Torgersen S, Czajkowski N, Jacobson K, Reichborn-Kjennerud T, Roysamb E, Neale MC et al. Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: A multivariate study. Psychol Med 2008; 38: 1617-1625.
28. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D et al. PLINK: A toolset for whole-genome association and population-based linkage analysis. Am J Hum Genet 2007; 81: 559-575. (Pubitemid 47330214)
29. R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria, 2011.
30. Rush AJ, Giles DE, Schlesser MA, Fulton CI, Weissenburger JE, Burns CT. The Inventory of Depressive Symptomatology (IDS): Preliminary findings. Psychiatry Res 1986; 18: 65-87. (Pubitemid 16085767)
31. Kruskal JB. Nonmetric multidimensional scaling: A numerical method. Psychometrika 1964; 29: 115-129.
32. Zeger SL, Liang KY, Albert PS. Models for longitudinal data: A generalized estimating equation approach. Biometrics 1988; 44: 1049-1060. (Pubitemid 19026037)
33. Svishcheva GR, Axenovich TI, Belonogova NM, van Duijn CM, Aulchenko YS. Rapid variance components-based method for whole-genome association analysis. Nat Genet 2012; 44: 1166-1170.
34. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 2004; 74: 765-769. (Pubitemid 38420107)
35. Hunter JE, Schmidt FL, Jackson GB. Meta-Analysis. Sage publications: Beverly Hills, CA, USA, 1982.
36. Krueger WHH, Gonye GE, Madison DL, Murray KE, Kumar M, Spoerel N et al. TPO1, a member of a novel protein family, is developmentally regulated in cultured oligodendrocytes. J Neurochem 1997; 69: 1343-1355. (Pubitemid 27406934)
37. Liu Jia, Dietz Karen, DeLoyht Jacqueline M, Pedre Xiomara, Kelkar Dipti, Kaur Jasbir et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci 2012; 15: 1621-1623.
38. van Elst LT, Thiel T, Hesslinger B, Lieb K, Bohus M, Hennig J et al. Subtle prefrontal neuropathology in a pilot magnetic resonance spectroscopy study in patients with borderline personality disorder. J Neuropsychiatry Clin Neurosci 2001; 13: 511-514. (Pubitemid 33140925)
39. Chakraborty G, Mekala P, Yahya D, Wu G, Ledeen RW. Intraneuronal N-Acetylaspartate supplies acetyl groups for myelin lipid synthesis: Evidence for myelin-Associated aspartoacylase. J Neurochem 2001; 78: 736-745. (Pubitemid 32777975)
40. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR. Personalized smoking cessation: Interactions between nicotine dose, dependence and quit-success genotype score. Mol Med 2010; 16: 247-253.
41. van der Sluis S, Posthuma D, Dolan CV. TATES: Efficient multivariate Genotype-Phenotype analysis for genome-wide association studies. PLoS Genet 2013; 9: E1003235.
42. Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Evidence for a differential role of HPA-Axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry 2012; 18: 692-699.