Effects and mechanisms of Fenofibrate on the secretion of vascular endothelial contraction factors in hypertensive rats

Genetics and Molecular Research

Volumn 13, Issue 3, 2014, Pages 5269-5275

  Zhu, Y ^a   Wang, H S ^a   Li, X M ^a   Qu, C ^b  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b SHENYANG MEDICAL COLLEGE   (China)

Author keywords

Cyclooxygenase; Fenofibrate; Peroxisome proliferator activated receptor a; Vascular endothelial contraction factors

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CYCLOOXYGENASE 1; FENOFIBRATE; MK 866; MK866; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PROSTAGLANDIN F1 ALPHA; PROSTAGLANDIN F2 ALPHA; THROMBOXANE B2; UNCLASSIFIED DRUG; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; ANTILIPEMIC AGENT; MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN F; PROSTAGLANDIN F1; PTGS1 PROTEIN, RAT;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART MUSCLE CONTRACTILITY; HYPERTENSION; IN VITRO STUDY; INCUBATION TIME; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR ENDOTHELIUM; VASCULAR RING; VASOCONSTRICTION; WESTERN BLOTTING; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; SECRETION (PROCESS); TISSUE CULTURE TECHNIQUE; WISTAR KYOTO RAT;

ANILIDES; ANIMALS; AORTA; CYCLOOXYGENASE 1; DINOPROST; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FENOFIBRATE; GENE EXPRESSION; HYPERTENSION; HYPOLIPIDEMIC AGENTS; MALE; MEMBRANE PROTEINS; PPAR ALPHA; PPAR GAMMA; PROSTAGLANDINS F; RATS; RATS, INBRED SHR; RATS, INBRED WKY; THROMBOXANE B2; TISSUE CULTURE TECHNIQUES; VASOCONSTRICTION;

EID: 84904968640     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2014.July.24.5     Document Type: Article

References (10)

1. Auch-Schwelk W, Katusic ZS and Vanhoutte PM (1992). Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta. Hypertension19: 442-445.
2. Berger JP, Akiyama TE and Meinke PT (2005). PPARs: therapeutic targets for metabolic disease. Trends Pharmacol. Sci. 26: 244-251.
3. Karbowska J, Kochan Z and Smolenski RT (2003). Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart. Cell. Mol. Biol. Lett.8: 49-53.
4. Lüscher TF and Vanhoutte PM (1986). Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension8: 344-348.
5. Mombouli JV and Vanhoutte PM (1999). Endothelial dysfunction: from physiology to therapy. J. Mol. Cell. Cardiol.31: 61-74.
6. Tang EH, Feletou M, Huang Y, Man RY, et al. (2005a). Acetylcholine and sodium nitroprusside cause long-term inhibition of EDCF-mediated contractions. Am. J. Physiol. Heart Circ. Physiol.289: H2434-H2440.
7. Tang EH, Ku DD, Tipoe GL, Feletou M, et al. (2005b). Endothelium-dependent contractions occur in the aorta of wildtype and COX2-/-knockout but not COX1-/-knockout mice. J. Cardiovasc. Pharmacol.46: 761-765.
8. Vanhoutte PM, Shimokawa H, Tang EH and Feletou M (2009). Endothelial dysfunction and vascular disease. Acta Physiol. 196: 193-222.
9. Yang D, Feletou M, Levens N, Zhang JN, et al. (2003). A diffusible substance(s) mediates endothelium-dependent contractions in the aorta of SHR. Hypertension41: 143-148.
10. Yang D, Gluais P, Zhang JN, Vanhoutte PM, et al. (2004). Nitric oxide and inactivation of the endothelium-dependent contracting factor released by acetylcholine in spontaneously hypertensive rat. J. Cardiovasc. Pharmacol.43: 815-820.