Transcription factors as master regulator for cancer stemness: Remove milk from fox?

Expert Review of Anticancer Therapy

Volumn 14, Issue 8, 2014, Pages 873-875

  Nakano, Ichiro ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

brain tumor; FOXM1; GBM; glioblastoma; glioma stem cell; MELK

Indexed keywords

CYCLIN B1; MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE; PHOSPHOTRANSFERASE; PROTEIN CDC25B; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXM1; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXM1 PROTEIN, HUMAN; MELK PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; BREAST CANCER; CANCER INHIBITION; CANCER RECURRENCE; CANCER STEM CELL; CANCER THERAPY; CARCINOGENESIS; CELL DIFFERENTIATION; CELL FATE; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL CANCER; CYTOTOXICITY; DNA PROTEIN COMPLEX; FOXM1 GENE; GENE DISRUPTION; GENE FUNCTION; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA STEM CELL; HEMATOLOGIC MALIGNANCY; HUMAN; LIVER CELL CARCINOMA; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; MITOSIS; NEURAL STEM CELL; NEUROBLASTOMA; NONHUMAN; NUCLEAR REPROGRAMMING; OUTCOME ASSESSMENT; PANCREAS CANCER; PLEIOTROPY; PROTO ONCOGENE; REVIEW; SIGNAL TRANSDUCTION; SOLID TUMOR; STEM CELL TRANSPLANTATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT; TUMOR SUPPRESSOR GENE; ANIMAL; BRAIN TUMOR; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; NEOPLASM; PATHOLOGY;

ANIMALS; BRAIN NEOPLASMS; CELL DIFFERENTIATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84904968230     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/14737140.2014.940324     Document Type: Review

References (19)

1. Koo CY, Muir KW, Lam EW. FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta 2012; 1819(1):28-37
2. Laoukili J, Stahl M, Medema RH. FoxM1: At the crossroads of ageing and cancer. Biochim Biophys Acta 2007;1775(1):92-102
3. Katoh Y, Katoh M. Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 2009;9(7):873-86
4. Kaufmann E, Knochel W. Five years on the wings of fork head. Mech Dev 1996;57(1): 3-20
5. Kalinichenko VV, Major ML, Wang X, et al. Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev 2004;18(7):830-50
6. Zhang N, Wei P, Gong A, et al. FoxM1 promotes beta-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell 2011;20(4):427-42
7. Park YY, Jung SY, Jennings NB, et al. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis 2012;33(10)):1843-53
8. Huynh KM, Soh JW, Dash R, et al. FOXM1 expression mediates growth suppression during terminal differentiation of HO-1 human metastatic melanoma cells. J Cell Physiol 2011;226(1):194-204
9. Bergamaschi A, Christensen BL, Katzenellenbogen BS. Reversal of endocrine resistance in breast cancer: Interrelationships among 14-3-3zeta, FOXM1, and a gene signature associated with mitosis. Breast Cancer Res 2011;13(3):R70
10. Xue J, Lin X, Chiu WT, et al. Sustained activation of. SMAD3/SMAD4 by FOXM1 promotes TGF-beta-dependent cancer metastasis. J Clin Invest 2014;124(2): 564-79
11. Laoukili J, Kooistra MR, Bras A, et al. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol 2005;7(2):126-36
12. Wang Z, Ahmad A, Banerjee S, et al. FoxM1 is a novel target of a natural agent in pancreatic cancer. Pharm Res 2010;27(6): 1159-68
13. Visnyei K, Onodera H, Damoiseaux R, et al. A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells. Mol Cancer Ther 2011;10(10):1818-28
14. Nakano I, Joshi K, Visnyei K, et al. Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro Oncol 2011;13(6):622-34
15. Choi S, Ku JL. Resistance of colorectal cancer cells to radiation and 5-FU is associated with MELK expression. Biochem Biophys Res Commun 2011;412(2):207-13
16. Gu C, Banasavadi-Siddegowda YK, Joshi K, et al. Tumor-specific activation of the CJUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner. Stem Cells 2013;31(5):870-81
17. Nakano I, Masterman-Smith M, Saigusa K, et al. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. J Neurosci Res 2008; 86(1):48-60
18. Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008;455(7216):1061-8
19. Joshi K, Banasavadi-Siddegowda Y, Mo X, et al. MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells. Stem Cells 2013;31(6):1051-63