Blocking phosphatidylcholine utilization in Pseudomonas aeruginosa, via mutagenesis of fatty acid, glycerol and choline degradation pathways, confirms the importance of this nutrient source in vivo

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Sun, Zhenxin ^a   Kang, Yun ^a   Norris, Michael H ^a   Troyer, Ryan M ^c   Son, Mike S ^b   Schweizer, Herbert P ^c   Dow, Steven W ^c   Hoang, Tung T ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b PLYMOUTH STATE UNIVERSITY   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A ACETYLTRANSFERASE; CHOLINE; FATTY ACID; GLYCEROL; LONG CHAIN FATTY ACID; MEDIUM CHAIN FATTY ACID; PHOSPHATIDYLCHOLINE; VIRULENCE FACTOR; BACTERIAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CELL DENSITY; CELL GROWTH; CONTROLLED STUDY; FADBA1 OPERON; FADBA145 OPERON; FADBA2 OPERON; FADBA3 OPERON; FADBA4 OPERON; FADBA5 OPERON; GROWTH RATE; HIGH CELL DENSITY; IN VITRO STUDY; IN VIVO STUDY; LIPID DEGRADATION; LUNG INFECTION; MOUSE; MUTAGENESIS; MUTANT; NONHUMAN; OPERON; PSEUDOMONAS AERUGINOSA; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CYSTIC FIBROSIS; GENETICS; HOST PATHOGEN INTERACTION; LUNG; METABOLISM; MICROBIOLOGY; MOLECULAR GENETICS; MUTATION; PATHOLOGY; PHYSIOLOGY; PSEUDOMONAS INFECTION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

3-HYDROXYACYL-COA DEHYDROGENASE; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CHOLINE; CYSTIC FIBROSIS; FATTY ACIDS; GLYCEROL; HOST-PATHOGEN INTERACTIONS; LUNG; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; OPERON; PHOSPHATIDYLCHOLINES; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84904908858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103778     Document Type: Article

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