Conjectures concerning cross-sex hormone treatment of aging transsexual persons

Journal of Sexual Medicine

Volumn 11, Issue 8, 2014, Pages 2012-2019

  Gooren, Louis ^a,b   Lips, Paul ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU University Medical Center ^*

Author keywords

Aging; Cancer; Cardiovascular disease; Cross Sex hormones; Transsexual

Indexed keywords

ANTIANDROGEN; ESTROGEN; GESTAGEN; SEX HORMONE; TESTOSTERONE;

AGING; ANDROGEN THERAPY; ARTICLE; BONE DENSITY; BONE MASS; BREAST CANCER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DRUG METABOLISM; FEMALE TO MALE TRANSSEXUAL; HEART FAILURE; HEMATOCRIT; HORMONAL THERAPY; HUMAN; HYPOPHYSIS TUMOR; MALE TO FEMALE TRANSSEXUAL; POSTMENOPAUSE; PRIORITY JOURNAL; PROSTATE CANCER; RISK ASSESSMENT; TREATMENT OUTCOME;

AGING; CANCER; CARDIOVASCULAR DISEASE; CROSS-SEX HORMONES; TRANSSEXUAL;

AGE FACTORS; AGED; AGING; BONE DISEASES; CARDIOVASCULAR DISEASES; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; PROGESTINS; PROSPECTIVE STUDIES; TESTOSTERONE; TRANSSEXUALISM;

EID: 84904902710     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12563     Document Type: Article

References (51)

1. Benjamin H. The transsexual phenomenon. New York: Julian Press; 1966.
2. Migeon CJ, Rivarola MA, Forest MG. Studies of androgens in transsexual subjects. Effects of estrogen therapy. Johns Hopkins Med J 1968;123:128-133.
3. Hamburger C. Endocrine treatment of male and female transsexualism. In: Green R, Money J, eds. Transsexualism and sex reassignment. Baltimore: Johns Hopkins Press; 1969:291-307.
4. Meyer WJ 3rd, Walker PA, Suplee ZR. A survey of transsexual hormonal treatment in twenty gender-treatment centers. J Sex Res 1981;17:344-349.
5. Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, etal. Endocrine treatment of transsexual persons: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2009;94:3132-3154.
6. Gooren LJ. Clinical practice. Care of transsexual persons. N Engl J Med 2011;364:1251-1257.
7. Elamin MB, Garcia MZ, Murad MH, Erwin PJ, Montori VM. Effect of sex steroid use on cardiovascular risk in transsexual individuals: A systematic review and meta-analyses. Clin Endocrinol (Oxf) 2010;72:1-10.
8. Ettner R, Wylie K. Psychological and social adjustment in older transsexual people. Maturitas 2012. doi: S0378-5122(12)00380-5. [pii] 101016/jmaturitas201211011.
9. Gooren LJ, van Trotsenburg MA, Giltay EJ, van Diest PJ. Breast cancer development in transsexual subjects receiving cross-sex hormone treatment. J Sex Med 2013;10:3129-3134.
10. Gooren L, Morgentaler A. Prostate cancer incidence in orchidectomised male-to-female transsexual persons treated with oestrogens. Andrologia 2013. doi: 101111/and12208.
11. Gooren LJ, Giltay EJ. Men and women, so different, so similar: Observations from cross-sex hormone treatment of transsexual subjects. Andrologia 2013. doi: 101111/and12111.
12. Fuente-Martin E, Argente-Arizon P, Ros P, Argente J, Chowen JA. Sex differences in adipose tissue: It is not only a question of quantity and distribution. Adipocyte 2013;2:128-134.
13. Kuchuk NO, van Schoor NM, Pluijm SM, Smit JH, de Ronde W, Lips P. The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women. Clin Endocrinol (Oxf) 2007;67:295-303.
14. Camacho EM, Huhtaniemi IT, O'Neill TW, etal. Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: Longitudinal results from the European Male Ageing Study. Eur J Endocrinol 2013;168:445-455.
15. Saylor PJ, Smith MR. Metabolic complications of androgen deprivation therapy for prostate cancer. J Urol 2013;189:S34-42, discussion S43-4.
16. Tajar A, Huhtaniemi IT, O'Neill TW, etal. Characteristics of androgen deficiency in late-onset hypogonadism: Results from the European Male Aging Study (EMAS). J Clin Endocrinol Metab 2012;97:1508-1516.
17. Yeap BB, Araujo AB, Wittert GA. Do low testosterone levels contribute to ill-health during male ageing? Crit Rev Clin Lab Sci 2012;49:168-182.
18. Saad F, Gooren LJ. The role of testosterone in the etiology and treatment of obesity, the metabolic syndrome, and diabetes mellitus type 2. J Obes 2011. doi: 10.1155/2011/471584. Epub 2010 Aug 10.
19. Whitley H, Lindsey W. Sex-based differences in drug activity. Am Fam Physician 2009;80:1254-1258.
20. Beierle I, Meibohm B, Derendorf H. Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 1999;37:529-547.
21. Spoletini I, Vitale C, Malorni W, Rosano GM. Sex differences in drug effects: Interaction with sex hormones in adult life. Handb Exp Pharmacol 2012;214:91-105.
22. Wierckx K, Elaut E, Declercq E, etal. Prevalence of cardiovascular disease and cancer during cross-sex hormone therapy in a large cohort of trans persons: A case-control study. Eur J Endocrinol 2013;169:471-478.
23. Asscheman H, Giltay EJ, Megens JA, de Ronde WP, van Trotsenburg MA, Gooren LJ. A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol 2011;164:635-642.
24. Goodman MP. Are all estrogens created equal? A review of oral vs. transdermal therapy. J Womens Health (Larchmt) 2012;21:161-169.
25. Vehkavaara S, Silveira A, Hakala-Ala-Pietila T, etal. Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost 2001;85:619-625.
26. Wierckx K, Elaut E, Van Caenegem E, etal. Sexual desire in female-to-male transsexual persons: Exploration of the role of testosterone administration. Eur J Endocrinol 2011;165:331-337.
27. Barrett-Connor E. The Rancho Bernardo Study: 40 years studying why women have less heart disease than men and how diabetes modifies women's usual cardiac protection. Glob Heart 2013;8(2). doi: 101016/jgheart2012.12.002.
28. Callewaert F, Sinnesael M, Gielen E, Boonen S, Vanderschueren D. Skeletal sexual dimorphism: Relative contribution of sex steroids, GH-IGF1, and mechanical loading. J Endocrinol 2010;207:127-134.
29. Van Caenegem E, Taes Y, Wierckx K, etal. Low bone mass is prevalent in male-to-female transsexual persons before the start of cross-sex hormonal therapy and gonadectomy. Bone 2013;54:92-97.
30. Van Kesteren P, Lips P, Gooren LJ, Asscheman H, Megens J. Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones. Clin Endocrinol (Oxf) 1998;48:347-354.
31. Lips P, Asscheman H, Uitewaal P, Netelenbos JC, Gooren L. The effect of cross-gender hormonal treatment on bone metabolism in male-to-female transsexuals. J Bone Miner Res 1989;4:657-662.
32. Ruetsche AG, Kneubuehl R, Birkhaeuser MH, Lippuner K. Cortical and trabecular bone mineral density in transsexuals after long-term cross-sex hormonal treatment: A cross-sectional study. Osteoporos Int 2005;16:791-798.
33. Van Caenegem E, Wierckx K, Taes Y, etal. Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy. J Clin Endocrinol Metab 2012;97:2503-2511.
34. Lips P, van Kesteren PJ, Asscheman H, Gooren LJ. The effect of androgen treatment on bone metabolism in female-to-male transsexuals. J Bone Miner Res 1996;11:1769-1773.
35. Lapauw B, Taes Y, Simoens S, etal. Body composition, volumetric and areal bone parameters in male-to-female transsexual persons. Bone 2008;43:1016-1021.
36. T'Sjoen G, Weyers S, Taes Y, etal. Prevalence of low bone mass in relation to estrogen treatment and body composition in male-to-female transsexual persons. J Clin Densitom 2009;12:306-313.
37. Main C, Knight B, Moxham T, etal. Hormone therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database Syst Rev 2013;4:CD002229. doi: 101002/14651858CD002229pub3.
38. Santen RJ. Menopausal hormone therapy and breast cancer. J Steroid Biochem Mol Biol. doi: 10.1016/j.jsbmb.2013.06.010. [Epub ahead of print].
39. Stegeman BH, de Bastos M, Rosendaal FR, etal. Different combined oral contraceptives and the risk of venous thrombosis: Systematic review and network meta-analysis. BMJ 2013;347:f5298.
40. Turner A, Chen TC, Barber TW, Malabanan AO, Holick MF, Tangpricha V. Testosterone increases bone mineral density in female-to-male transsexuals: A case series of 15 subjects. Clin Endocrinol (Oxf) 2004;61:560-566.
41. Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol 2013;75:685-705.
42. Mueller A, Gooren L. Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol 2008;159:197-202.
43. Bunck MC, Debono M, Giltay EJ, Verheijen AT, Diamant M, Gooren LJ. Autonomous prolactin secretion in two male-to-female transgender patients using conventional oestrogen dosages. BMJ. doi: 101136/bcr0220091589. case reports, pii: bcr0220091589 Epub 2009 Aug 10.
44. Bergoglio MT, Gomez-Balaguer M, Almonacid Folch E, Hurtado Murillo F, Hernandez-Mijares A. Symptomatic meningioma induced by cross-sex hormone treatment in a male-to-female transsexual. Endocrinol Nutr 2012;60:264-267.
45. Shao T, Grossbard ML, Klein P. Breast cancer in female-to-male transsexuals: Two cases with a review of physiology and management. Clin Breast Cancer 2011;11:417-419.
46. Burcombe RJ, Makris A, Pittam M, Finer N. Breast cancer after bilateral subcutaneous mastectomy in a female-to-male trans-sexual. Breast 2003;12:290-293.
47. Nikolic DV, Djordjevic ML, Granic M, etal. Importance of revealing a rare case of breast cancer in a female to male transsexual after bilateral mastectomy. World J Surg Oncol 2012;10:10-13.
48. Schenck TL, Holzbach T, Zantl N, etal. Vaginal carcinoma in a female-to-male transsexual. J Sex Med 2010;7:2899-2902.
49. Urban RR, Teng NN, Kapp DS. Gynecologic malignancies in female-to-male transgender patients: The need of original gender surveillance. Am J Obstet Gynecol 2011;204:e9-12.
50. Driak D, Samudovsky M. Cervical cancer in a female-to-male trans-sexual. Eur J Cancer 2004;40:1795.
51. Bhattacharya RK, Khera M, Blick G, Kushner H, Miner MM. Testosterone replacement therapy among elderly males: The Testim Registry in the US (TRiUS). Clin Interv Aging 2012;7:321-330.