Body composition, volumetric and areal bone parameters in male-to-female transsexual persons

Bone

Volumn 43, Issue 6, 2008, Pages 1016-1021

  Lapauw, Bruno ^a   Taes, Youri ^a   Simoens, Steven ^a   Van Caenegem, Eva ^a   Weyers, Steven ^a   Goemaere, Stefan ^a   Toye, Kaatje ^a   Kaufman, Jean Marc ^a   T'Sjoen, Guy G ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Body composition; Bone size; Cross sectional; Transsexualism; Volumetric BMD

Indexed keywords

BIOCHEMICAL MARKER; SEX HORMONE; TESTOSTERONE;

ADULT; ARTICLE; BICEPS BRACHII MUSCLE; BODY COMPOSITION; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERAL; BONE TURNOVER; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; DYNAMOMETER; FEMALE; GRIP STRENGTH; HIP; HUMAN; LEAN BODY WEIGHT; LUMBAR SPINE; MUSCLE MASS; MUSCLE STRENGTH; OSSIFICATION; OSTEOLYSIS; PHYSICAL ACTIVITY; QUADRICEPS FEMORIS MUSCLE; QUANTITATIVE ANALYSIS; RADIUS; SPORT; TIBIA; TRABECULAR BONE; TRANSSEXUALISM;

ABSORPTIOMETRY, PHOTON; ADULT; BODY COMPOSITION; BONE AND BONES; BONE DENSITY; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HORMONES; HUMANS; MALE; MIDDLE AGED; TRANSSEXUALISM;

EID: 57049158126     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.09.001     Document Type: Article

References (32)

1. Orwoll E.S., and Klein R.F. Osteoporosis in men. Endocr. Rev. 16 (1995) 87-116
2. Vanderschueren D., Venken K., Ophoff J., Bouillon R., and Boonen S. Sex steroids and the periosteum - reconsidering the roles of androgens and estrogens in periosteal expansion. J. Clin. Endocrinol. Metab. 91 (2006) 378-382
3. Cohen-Kettenis P.T., and Gooren L.J.G. Transsexualism: a review of etiology, diagnosis and treatment. J. Psychosom. Res. 46 (1999) 315-333
4. Stoch S.A., Parker R.A., Chen L., Bubley G., Ko Y.J., Vincelette A., et al. Bone loss in men with prostate cancer treated with gonadotropin-releasing hormone agonists. J. Clin. Endocrinol. Metab. 86 (2001) 2787-2791
5. van Kesteren P.J., Lips P., Deville W., Popp-Snijders C., Asscheman H., Megens J., et al. The effect of one-year cross-sex hormonal treatment on bone metabolism and serum insulin-like growth factor-1 in transsexuals. J. Clin. Endocrinol. Metab. 81 (1996) 2227-2232
6. van Kesteren P.J., Lips P., Gooren L.J.G., Asscheman H., and Megens J. Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones. Clin. Endocrinol. (Oxf) 48 (1998) 347-354
7. Schlatterer K., Auer D.P., Yassouridis A., von Werder K., and Stalla G.K. Transsexualism and osteoporosis. Exp. Clin. Endocrinol. Diabetes 106 (1998) 365-368
8. Reutrakul S., Ongphiphadhanakul B., Piaseu N., Krittiyawong S., Chanprasertyothin S., Bunnag P., et al. The effects of oestrogen exposure on bone mass in male to female transsexuals. Clin. Endocrinol. (Oxf) 49 (1998) 811-814
9. Dittrich R., Binder H., Cupisti S., Hoffmann I., Beckmann M.W., and Mueller A. Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist. Exp. Clin. Endocrinol. Diabetes 113 (2005) 586-592
10. Mueller A., Dittrich R., Binder H., Kuehnel W., Maltaris T., Hoffmann I., et al. High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. Eur. J. Endocrinol. 153 (2005) 107-113
11. Ruetsche A.G., Kneubuehl R., Birkhaeuser M.H., and Lippuner K. Cortical and trabecular bone mineral density in transsexuals after long-term cross-sex hormonal treatment: a cross-sectional study. Osteoporos. Int. 16 (2005) 791-798
12. Haraldsen I.R., Haug E., Falch J., Egeland T., and Opjordsmoen S. Cross-sex pattern of bone mineral density in early onset gender identity disorder. Horm. Behav. 52 (2007) 334-343
13. Lips P., Asscheman H., Uitewaal P., Netelenbos J.C., and Gooren L.J.G. The effect of cross-gender hormonal treatment on bone metabolism in male-to-female transsexuals. J. Bone. Miner. Res. 4 (1989) 657-662
14. De Cuypere G., T'Sjoen G.G., Beerten R., Selvaggi G., De Sutter P., Hoebeke P., et al. Sexual and Physical Health After Sex Reassignment Surgery. Arch. Sex. Behav. 34 (2005) 679-690
15. Baecke J.A., Burema J., and Frijters J.E. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am. J. Clin. Nutr. 36 (1982) 936-942
16. Looker A.C., Wahner H.W., Dunn W.L., Calvo M.S., Harris T.B., Heyse S.P., et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos. Int. 8 (1998) 468-490
17. Van Pottelbergh I., Goemaere S., and Kaufman J.M. Bioavailable estradiol and an aromatase gene polymorphism are determinants of bone mineral density changes in men over 70 years of age. J. Clin. Endocrinol. Metab. 88 (2003) 3075-3081
18. Vermeulen A., Verdonck L., and Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84 (1999) 3666-3672
19. Szulc P., Claustrat B., Munoz F., Marchand F., and Delmas P.D. Assessment of the role of 17beta-oestradiol in bone metabolism in men: does the assay technique matter? The MINOS study. Clin. Endocrinol. (Oxf) 61 (2004) 447-457
20. Elbers J.M.H., Asscheman H., Seidell J.C., and Gooren L.J.G. Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. Am. J. Physiol. Endocrinol. Metab. 276 (1999) E317-E325
21. Boxer R.S., Kenny A.M., Dowsett R., and Taxel P. The effect of 6 months of androgen deprivation therapy on muscle and fat mass in older men with localized prostate cancer. Aging Male 8 (2005) 207-212
22. Lips P., van Kesteren P.J., Asscheman H., and Gooren L.J.G. The effect of androgen treatment on bone metabolism in female-to-male transsexuals. J. Bone Miner. Res. 11 (1996) 1769-1773
23. Bailey J.M., and Zucker K.J. Childhood sex-typed behavior and sexual orientation: a conceptual analysis and quantitative review. Dev. Psychol. 31 (1995) 43-55
24. Kemper H.C.G., Twisk J.W.R., van Mechelen W., Post G.B., Roos J.C., and Lips P. A fifteen-year longitudinal study in young adults on the relation of physical activity and fitness with the development of the bone mass: the Amsterdam growth and health longitudinal study. Bone 27 (2000) 847-853
25. Schoenau E., Neu C.M., Rauch F., and Manz F. Gender-specific pubertal changes in volumetric cortical bone mineral density at the proximal radius. Bone 31 (2002) 110-113
26. Frost H.M. Bone "mass" and the "mechanostat": a proposal. Anat. Rec. 219 (1987) 1-9
27. Schoenau E., Neu C.M., Mokov E., Wassmer G., and Manz F. Influence of puberty on muscle area and cortical bone area of the forearm in boys and girls. J. Clin. Endocrinol. Metab. 85 (2000) 1095-1098
28. de Voogt H.J. The position of cyproterone acetate (CPA), a steroidal anti-androgen, in the treatment of prostate cancer. Prostate. Suppl. 4 (1992) 91-95
29. T'Sjoen G.G., Rubens R., De Sutter P., and Gooren L.J.G. Authors' response: the endocrine care of transsexual people. J. Clin. Endocrinol. Metab. 89 (2004) 1014-1015
30. Speroff L., Rowan J., Symons J., Genant H., and Wilborn W. The comparative effect on bone density, endometrium, and lipids of continuous hormones as replacement therapy (CHART study). A randomized controlled trial. JAMA 276 (1996) 1397-1403
31. Lorentzon M., Mellström D., Haug E., and Ohlsson C. Smoking is associated with lower bone mineral density and reduced cortical thickness in young men. J. Clin. Endocrinol. Metab. 92 (2007) 497-503
32. Bachrach L.K. Dual energy X-ray absorptiometry (DEXA) measurements of bone density and body composition: promise and pitfalls. J. Pediatr. Endocrinol. Metab. 13 Suppl. 2 (2000 Sep) 983-988