Sex-based differences in drug activity

American Family Physician

Volumn 80, Issue 11, 2009, Pages 1254-1258

  Whitley, Heather P ^a,b   Lindsey, Wesley ^a  

^a AUBURN UNIVERSITY   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMINOGLYCOSIDE DERIVATIVE; AMPICILLIN; ANTIARRHYTHMIC AGENT; ANTIVIRUS AGENT; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CAFFEINE; CAPTOPRIL; CILOSTAZOL; DEMECLOCYCLINE; DIGOXIN; DOXORUBICIN; FELODIPINE; FIBRINOLYTIC AGENT; HEPARIN; KETOCONAZOLE; LEVOTHYROXINE; LIDOCAINE; LORATADINE; METOPROLOL; MUSCLE RELAXANT AGENT; NEUROLEPTIC AGENT; OPIATE; PARACETAMOL; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SEROTONIN UPTAKE INHIBITOR; THEOPHYLLINE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

BODY WEIGHT; CLINICAL TRIAL; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; ENZYME ACTIVITY; GASTROINTESTINAL MOTILITY; GLOMERULUS FILTRATION RATE; HUMAN; MORTALITY; QT INTERVAL; REVIEW; SEX DIFFERENCE; STOMACH EMPTYING;

EID: 72049121225     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Bren L. Does sex make a difference? FDA Consum. 2005;39(4)10-15.
2. Schwartz JB. The influence of sex on pharmacokinetics [published correction appears in Clin Pharmacokinet. 2004;43(11):732]. Clin Pharmacokinet. 2003;42(2):107-121.
3. Fletcher CV, Acosta EP, Strykowski JM. Gender differences in human pharmacokinetics and pharmacodynamics. J Adolesc Health. 1994;15(8):619-629.
4. Kimura T, Higaki K. Gastrointestinal transit and drug absorption. Biol Pharm Bull. 2002;25(2):149-164.
5. Fleisher D, Li C, Zhou Y, Pao LH, Karim A. Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications. Clin Pharmacokinet. 1999;36(3):233-254.
6. Mojaverian P, Rocci ML Jr, Conner DP, Abrams WB, Vlasses PH. Effect of food on the absorption of enteric-coated aspirin: correlation with gastric residence time. Clin Pharmacol Ther. 1987;41(1):11-17. (Pubitemid 17008124)
7. Baraona E, Abittan CS, Dohmen K, et al. Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res. 2001;25(4):502-507.
8. Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clin Pharmacol Ther. 2007;82(1):87-96.
9. Ochs HR, Greenblatt DJ, Divoll M, Abernethy DR, Feyerabend H, Dengler HJ. Diazepam kinetics in relation to age and sex. Pharmacology. 1981;23(1):24-30. (Pubitemid 11071660)
10. Xue FS, Tong SY, Liao X, Liu JH, An G, Luo LK. Dose-response and time course of effect of rocuronium in male and female anesthetized patients. Anesth Analg. 1997;85(3):667-671. (Pubitemid 27381326)
11. Wedel M, Pieters JE, Pikaar NA, Ockhuizen T. Application of a three-compartment model to a study of the effects of sex, alcohol dose and concentration, exercise and food consumption on the pharmacokinetics of ethanol in healthy volunteers. Alcohol. 1991;26(3):329-336.
12. Sowinski KM, Abel SR, Clark WR, Mueller BA. Effect of gender on the pharmacokinetics of ofloxacin. Pharmacotherapy. 1999;19(4):442-446.
13. Whitley HP, Fermo JD, Chumney EC, Brzezinski WA. Effect of patient-specific factors on weekly warfarin dose. Ther Clin Risk Manag. 2007;3(3):499-504. (Pubitemid 47214991)
14. Garcia D, Regan S, Crowther M, Hughes RA, Hylek EM. Warfarin maintenance dosing patterns in clinical practice: implications for safer anticoagulation in the elderly population. Chest. 2005;127(6):2049-2056. (Pubitemid 46260095)
15. Bock KW, Schrenk D, Forster A, et al. The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. Pharmacogenetics. 1994;4(4):209-218. (Pubitemid 24269825)
16. Yukawa E, Honda T, Ohdo S, Higuchi S, Aoyama T. Population-based investigation of relative clearance of digoxin in Japanese patients by multiple trough screen analysis: an update. J Clin Pharmacol. 1997;37(2):92-100. (Pubitemid 27131539)
17. Dobbs NA, Twelves CJ, Gillies H, James CA, Harper PG, Rubens RD. Gender affects doxorubicin pharmacokinetics in patients with normal liver biochemistry. Cancer Chemother Pharmacol. 1995;36(6):473-476.
18. Walle T, Walle UK, Cowart TD, Conradi EC. Pathway-selective sex differences in the metabolic clearance of propranolol in human subjects. Clin Pharmacol Ther. 1989;46(3):257-263. (Pubitemid 19254757)
19. Anderson GD. Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J Womens Health (Larchmt). 2005;14(1):19-29.
20. Anderson GD. Gender differences in pharmacological response. Int Rev Neurobiol. 2008;83:1-10.
21. Baca E, Garcia-Garcia M, Porras-Chavarino A. Gender differences in treatment response to sertraline versus imipramine in patients with nonmelancholic depressive disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(1):57-65.
22. Kornstein SG, Schatzberg AF, Thase ME, et al. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry. 2000;157(9):1445-1452.
23. Bano S, Akhter S, Afridi MI. Gender based response to fluoxetine hydrochloride medication in endogenous depression. J Coll Physicians Surg Pak. 2004;14(3):161-165. (Pubitemid 38967670)
24. Seeman MV. Gender differences in the prescribing of antipsychotic drugs. Am J Psychiatry. 2004;161(8):1324-1333.
25. Melkersson KI, Hulting AL, Rane AJ. Dose requirement and prolactin elevation of antipsychotics in male and female patients with schizophrenia or related psychoses. Br J Clin Pharmacol. 2001;51(4):317-324.
26. Berkley KJ. Sex differences in pain. Behav Brain Sci. 1997;20(3):371-380.
27. Pleym H, Spigset O, Kharasch ED, Dale O. Gender differences in drug effects: implications for anesthesiologists. Acta Anaesthesiol Scand. 2003;47(3):241-259. (Pubitemid 36384661)
28. Craft RM. Sex differences in drug- and non-drug-induced analgesia. Life Sci. 2003;72(24):2675-2688. (Pubitemid 36385075)
29. Luzier AB, Killian A, Wilton JH, Wilson MF, Forrest A, Kazierad DJ. Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther. 1999;66(6):594-601. (Pubitemid 30014086)
30. Berger JS, Roncaglioni MC, Avanzini F, Pangrazzi I, Tognoni G, Brown DL. Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials [published correction appears in JAMA. 2006;295(17):2002]. JAMA. 2006;295(3):306-313.
31. Cavallari LH, Helgason CM, Brace LD, Viana MA, Nutescu EA. Sex difference in the antiplatelet effect of aspirin in patients with stroke. Ann Pharmacother. 2006;40(5):812-817.
32. Rademaker M. Do women have more adverse drug reactions? Am J Clin Dermatol. 2001;2(6):349-351. (Pubitemid 34017040)
33. Drici MD, Clément N. Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome. Drug Saf. 2001;24(8):575-585. (Pubitemid 32656071)
34. The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group. N Engl J Med. 1997;336(8):525-533.
35. Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med. 2002;347(18):1403- 1411. (Pubitemid 35239712)
36. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov. 2006;5(5):425-438.