Metformin promotes focal angiogenesis and neurogenesis in mice following middle cerebral artery occlusion

Neuroscience Letters

Volumn 579, Issue , 2014, Pages 46-51

  Liu, Yanqun ^a   Tang, Guanghui ^b   Zhang, Zhijun ^b   Wang, Yongting ^b   Yang, Guo Yuan ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Angiogenesis; Ischemia; Metformin; Neurogenesis; Recovery

Indexed keywords

METFORMIN; NESTIN; NITRIC OXIDE SYNTHASE; ANTIDIABETIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN INJURY; CAPILLARY DENSITY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUBVENTRICULAR ZONE; ANIMAL; ATROPHY; BIOSYNTHESIS; BRAIN; DRUG EFFECTS; LATERAL BRAIN VENTRICLE; LIGATION; METABOLISM; MIDDLE CEREBRAL ARTERY; NEOVASCULARIZATION, PATHOLOGIC; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; ATROPHY; BRAIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HYPOGLYCEMIC AGENTS; LATERAL VENTRICLES; LIGATION; MALE; METFORMIN; MICE; MIDDLE CEREBRAL ARTERY; NEOVASCULARIZATION, PATHOLOGIC; NEUROGENESIS; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION;

EID: 84904859625     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.07.006     Document Type: Article

References (22)

1. Mendis S. Stroke disability and rehabilitation of stroke: World Health Organization perspective. Int. J. Stroke 2013, 8:3-4.
2. Langhorne P., Bernhardt J., Kwakkel G. Stroke rehabilitation. Lancet 2011, 377:1693-1702.
3. Moskowitz M.A., Lo E.H., Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
4. Dijkhuizen R.M., Singhal A.B., Mandeville J.B., Wu O., Halpern E.F., Finklestein S.P., Rosen B.R., Lo E.H. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J. Neurosci. 2003, 23:510-517.
5. Arai K., Jin G., Navaratna D., Lo E.H. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009, 276:4644-4652.
6. Greenberg D.A., Jin K. Vascular endothelial growth factors (VEGFs) and stroke. Cell. Mol. Life Sci. 2013, 70:1753-1761.
7. Chen J., Zacharek A., Zhang C., Jiang H., Li Y., Roberts C., Lu M., Kapke A., Chopp M. Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice. J. Neurosci. 2005, 25:2366-2375.
8. Wang L., Zhang Z., Wang Y., Zhang R., Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke 2004, 35:1732-1737.
9. Martin-Montalvo A., Mercken E.M., Mitchell S.J., Palacios H.H., Mote P.L., Scheibye-Knudsen M., Gomes A.P., Ward T.M., Minor R.K., Blouin M.J., Schwab M., Pollak M., Zhang Y., Yu Y., Becker K.G., Bohr V.A., Ingram D.K., Sinclair D.A., Wolf N.S., Spindler S.R., Bernier M., de Cabo R. Metformin improves healthspan and lifespan in mice. Nat. Commun. 2013, 4:2192.
10. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998, 352:854-865.
11. Li J., Benashski S.E., Venna V.R., McCullough L.D. Effects of metformin in experimental stroke. Stroke 2010, 41:2645-2652.
12. Wang J., Gallagher D., DeVito L.M., Cancino G.I., Tsui D., He L., Keller G.M., Frankland P.W., Kaplan D.R., Miller F.D. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012, 11:23-35.
13. Prakash R., Li W., Qu Z., Johnson M.A., Fagan S.C., Ergul A. Vascularization pattern after ischemic stroke is different in control versus diabetic rats: relevance to stroke recovery. Stroke 2013, 44:2875-2882.
14. Calvert J.W., Gundewar S., Jha S., Greer J.J., Bestermann W.H., Tian R., Lefer D.J. Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling. Diabetes 2008, 57:696-705.
15. He X., Li Y., Lu H., Zhang Z., Wang Y., Yang G.Y. Netrin-1 overexpression promotes white matter repairing and remodeling after focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 2013, 33:1921-1927.
16. Li Q., Tang G., Xue S., He X., Miao P., Li Y., Wang J., Xiong L., Wang Y., Zhang C., Yang G.Y. Silica-coated superparamagnetic iron oxide nanoparticles targeting of EPCs in ischemic brain injury. Biomaterials 2013, 34:4982-4992.
17. Li W., Qu Z., Prakash R., Chung C., Ma H., Hoda M.N., Fagan S.C., Ergul A. Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res. 2013, 1541:106-114.
18. Global Guideline for Type 2 Diabetes: recommendations for standard, comprehensive, and minimal care. Diabetes Med. 2006, 23:579-593.
19. Venna V.R., Li J., Hammond M.D., Mancini N.S., McCullough L.D. Chronic metformin treatment improves post-stroke angiogenesis and recovery after experimental stroke. Eur. J. Neurosci. 2014, 39:2129-2138.
20. Miao J., Shen L.H., Tang Y.H., Wang Y.T., Tao M.X., Jin K.L., Zhao Y.J., Yang G.Y. Overexpression of adiponectin improves neurobehavioral outcomes after focal cerebral ischemia in aged mice. CNS Neurosci. Ther. 2013, 19:969-977.
21. Duda D.G., Fukumura D., Jain R.K. Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol. Med. 2004, 10:143-145.
22. Jin Q., Cheng J., Liu Y., Wu J., Wang X., Wei S., Zhou X., Qin Z., Jia J., Zhen X. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav. Immun. 2014, 40:131-142.