메뉴 건너뛰기




Volumn 19, Issue 12, 2013, Pages 969-977

Overexpression of adiponectin improves neurobehavioral outcomes after focal cerebral ischemia in aged mice

Author keywords

Adiponectin; Aged mice; Angiogenesis; Cerebral ischemia; Neurobehavioral recovery

Indexed keywords

ADIPONECTIN; PARVOVIRUS VECTOR;

EID: 84888203203     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12198     Document Type: Article
Times cited : (37)

References (54)
  • 1
    • 84863078754 scopus 로고    scopus 로고
    • Chinese guidelines for the secondary prevention of ischemic stroke and transient ischemic attack 2010
    • Wang YJ, Zhang SM, Zhang L, et al. Chinese guidelines for the secondary prevention of ischemic stroke and transient ischemic attack 2010. CNS Neurosci Ther 2012;18:93-101.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 93-101
    • Wang, Y.J.1    Zhang, S.M.2    Zhang, L.3
  • 2
    • 79952117976 scopus 로고    scopus 로고
    • New approaches to neuroprotective drug development
    • Fisher M. New approaches to neuroprotective drug development. Stroke 2011;42:S24-S27.
    • (2011) Stroke , vol.42
    • Fisher, M.1
  • 3
    • 84868192331 scopus 로고    scopus 로고
    • Window of opportunity for neuroprotection with an antioxidant, allene oxide synthase, after hypoxia-ischemia in adult male rats
    • Mathai S, Gunn AJ, Backhaus RA, Guan J. Window of opportunity for neuroprotection with an antioxidant, allene oxide synthase, after hypoxia-ischemia in adult male rats. CNS Neurosci Ther 2012;18:887-894.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 887-894
    • Mathai, S.1    Gunn, A.J.2    Backhaus, R.A.3    Guan, J.4
  • 4
    • 34548475597 scopus 로고    scopus 로고
    • How can we improve the pre-clinical development of drugs for stroke?
    • Sena E, van der Worp HB, Howells D, Macleod M. How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci 2007;30:433-439.
    • (2007) Trends Neurosci , vol.30 , pp. 433-439
    • Sena, E.1    van der Worp, H.B.2    Howells, D.3    Macleod, M.4
  • 6
    • 84866757384 scopus 로고    scopus 로고
    • Age differences in clinical characteristics, health care, and outcomes after ischemic stroke in China
    • Deng YX, Wang YL, Gao BQ, et al. Age differences in clinical characteristics, health care, and outcomes after ischemic stroke in China. CNS Neurosci Ther 2012;18:819-826.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 819-826
    • Deng, Y.X.1    Wang, Y.L.2    Gao, B.Q.3
  • 7
    • 0035124069 scopus 로고    scopus 로고
    • Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease
    • Kang DH, Anderson S, Kim YG, Mazzalli M. Impaired angiogenesis in the aging kidney: vascular endothelial growth factor and thrombospondin-1 in renal disease. Am J Kidney Dis 2001;37:601-611.
    • (2001) Am J Kidney Dis , vol.37 , pp. 601-611
    • Kang, D.H.1    Anderson, S.2    Kim, Y.G.3    Mazzalli, M.4
  • 8
    • 70350561897 scopus 로고    scopus 로고
    • Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice
    • Gao P, Shen F, Gabriel RA, et al. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice. Stroke 2009;40:3596-3600.
    • (2009) Stroke , vol.40 , pp. 3596-3600
    • Gao, P.1    Shen, F.2    Gabriel, R.A.3
  • 9
    • 84867571458 scopus 로고    scopus 로고
    • Differential characteristics of the aging process and the vascular cognitive impairment in the organization of memory retrieval
    • Di Cesare F, D'Ilario D, Fioravanti M. Differential characteristics of the aging process and the vascular cognitive impairment in the organization of memory retrieval. J Neurol Sci 2012;322:148-151.
    • (2012) J Neurol Sci , vol.322 , pp. 148-151
    • Di Cesare, F.1    D'Ilario, D.2    Fioravanti, M.3
  • 10
    • 84872621463 scopus 로고    scopus 로고
    • Alterations in ventricular K(ATP) channel properties during aging
    • Bao L, Taskin E, Foster M, et al. Alterations in ventricular K(ATP) channel properties during aging. Aging Cell 2013;12:167-176.
    • (2013) Aging Cell , vol.12 , pp. 167-176
    • Bao, L.1    Taskin, E.2    Foster, M.3
  • 11
    • 13844257284 scopus 로고    scopus 로고
    • Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain
    • Jin K, Minami M, Xie L, et al. Ischemia-induced neurogenesis is preserved but reduced in the aged rodent brain. Aging Cell 2004;3:373-377.
    • (2004) Aging Cell , vol.3 , pp. 373-377
    • Jin, K.1    Minami, M.2    Xie, L.3
  • 12
    • 33751192462 scopus 로고    scopus 로고
    • Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke
    • Won SJ, Xie L, Kim SH, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res 2006;1123:237-244.
    • (2006) Brain Res , vol.1123 , pp. 237-244
    • Won, S.J.1    Xie, L.2    Kim, S.H.3
  • 13
    • 84866619317 scopus 로고    scopus 로고
    • Relation of leptin and adiponectin with cardiovascular risk factors, intact parathormone, and vitamin D levels in patients with primary hyperparathyroidism
    • de Luis DA, Soto GD, Conde R, Izaola O, de la Fuente B. Relation of leptin and adiponectin with cardiovascular risk factors, intact parathormone, and vitamin D levels in patients with primary hyperparathyroidism. J Clin Lab Anal 2012;26:398-402.
    • (2012) J Clin Lab Anal , vol.26 , pp. 398-402
    • de Luis, D.A.1    Soto, G.D.2    Conde, R.3    Izaola, O.4    de la Fuente, B.5
  • 14
    • 84860691012 scopus 로고    scopus 로고
    • Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects
    • Oliveira CS, Saddi-Rosa P, Crispim F, et al. Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects. J Diabetes Complications 2012;26:94-98.
    • (2012) J Diabetes Complications , vol.26 , pp. 94-98
    • Oliveira, C.S.1    Saddi-Rosa, P.2    Crispim, F.3
  • 15
    • 84873056481 scopus 로고    scopus 로고
    • Beneficial effects of grape resveratrol on serum adiponectin and inflammation: clinical trial in patients with stable coronary artery disease: editorial to: "Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease" by J. Tome-Carneiro
    • Das SK, Patel VB, Oudit GY. Beneficial effects of grape resveratrol on serum adiponectin and inflammation: clinical trial in patients with stable coronary artery disease: editorial to: "Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease" by J. Tome-Carneiro et al. Cardiovasc Drugs Ther 2013;27:1-4.
    • (2013) Cardiovasc Drugs Ther , vol.27 , pp. 1-4
    • Das, S.K.1    Patel, V.B.2    Oudit, G.Y.3
  • 16
    • 34548407202 scopus 로고    scopus 로고
    • Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses
    • Hashimoto N, Kanda J, Nakamura T, et al. Association of hypoadiponectinemia in men with early onset of coronary heart disease and multiple coronary artery stenoses. Metabolism 2006;55:1653-1657.
    • (2006) Metabolism , vol.55 , pp. 1653-1657
    • Hashimoto, N.1    Kanda, J.2    Nakamura, T.3
  • 18
    • 0037129861 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    • Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002;105:2893-2898.
    • (2002) Circulation , vol.105 , pp. 2893-2898
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 19
    • 0037180472 scopus 로고    scopus 로고
    • Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice
    • Okamoto Y, Kihara S, Ouchi N, et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 2002;106:2767-2770.
    • (2002) Circulation , vol.106 , pp. 2767-2770
    • Okamoto, Y.1    Kihara, S.2    Ouchi, N.3
  • 20
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    • Ouchi N, Kobayashi H, Kihara S, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 2004;279:1304-1309.
    • (2004) J Biol Chem , vol.279 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3
  • 21
    • 3142616447 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    • Shibata R, Ouchi N, Kihara S, Sato K, Funahashi T, Walsh K. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J Biol Chem 2004;279:28670-28674.
    • (2004) J Biol Chem , vol.279 , pp. 28670-28674
    • Shibata, R.1    Ouchi, N.2    Kihara, S.3    Sato, K.4    Funahashi, T.5    Walsh, K.6
  • 22
    • 38049178556 scopus 로고    scopus 로고
    • Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms
    • Nishimura M, Izumiya Y, Higuchi A, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 2008;117:216-223.
    • (2008) Circulation , vol.117 , pp. 216-223
    • Nishimura, M.1    Izumiya, Y.2    Higuchi, A.3
  • 23
    • 84871969825 scopus 로고    scopus 로고
    • Overexpression of adiponectin promotes focal angiogenesis in the mouse brain following middle cerebral artery occlusion
    • Shen L, Miao J, Yuan F, et al. Overexpression of adiponectin promotes focal angiogenesis in the mouse brain following middle cerebral artery occlusion. Gene Ther 2013;20:93-101.
    • (2013) Gene Ther , vol.20 , pp. 93-101
    • Shen, L.1    Miao, J.2    Yuan, F.3
  • 24
    • 80055084863 scopus 로고    scopus 로고
    • Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion
    • Lu H, Wang Y, Yuan F, Liu J, Zeng L, Yang GY. Overexpression of netrin-1 improves neurological outcomes in mice following transient middle cerebral artery occlusion. Front Med 2011;5:86-93.
    • (2011) Front Med , vol.5 , pp. 86-93
    • Lu, H.1    Wang, Y.2    Yuan, F.3    Liu, J.4    Zeng, L.5    Yang, G.Y.6
  • 25
    • 79957765704 scopus 로고    scopus 로고
    • Treatment of focal brain ischemia with viral vector-mediated gene transfer
    • Su H, Yang GY. Treatment of focal brain ischemia with viral vector-mediated gene transfer. Methods Mol Biol 2011;686:429-446.
    • (2011) Methods Mol Biol , vol.686 , pp. 429-446
    • Su, H.1    Yang, G.Y.2
  • 27
    • 33947652677 scopus 로고    scopus 로고
    • Advances in ischemic stroke treatment: neuroprotective and combination therapies
    • Lapchak PA, Araujo DM. Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs 2007;12:97-112.
    • (2007) Expert Opin Emerg Drugs , vol.12 , pp. 97-112
    • Lapchak, P.A.1    Araujo, D.M.2
  • 28
    • 84867519244 scopus 로고    scopus 로고
    • Microvascular protection is essential for successful neuroprotection in stroke
    • Gursoy-Ozdemir Y, Yemisci M, Dalkara T. Microvascular protection is essential for successful neuroprotection in stroke. J Neurochem 2012;123(Suppl 2):2-11.
    • (2012) J Neurochem , vol.123 , Issue.SUPPL. 2 , pp. 2-11
    • Gursoy-Ozdemir, Y.1    Yemisci, M.2    Dalkara, T.3
  • 29
    • 84857835223 scopus 로고    scopus 로고
    • Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles
    • Terpolilli NA, Kim SW, Thal SC, et al. Inhalation of nitric oxide prevents ischemic brain damage in experimental stroke by selective dilatation of collateral arterioles. Circ Res 2012;110:727-738.
    • (2012) Circ Res , vol.110 , pp. 727-738
    • Terpolilli, N.A.1    Kim, S.W.2    Thal, S.C.3
  • 30
    • 41149114751 scopus 로고    scopus 로고
    • Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice
    • Zhu W, Fan Y, Frenzel T, et al. Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice. Stroke 2008;39:1254-1261.
    • (2008) Stroke , vol.39 , pp. 1254-1261
    • Zhu, W.1    Fan, Y.2    Frenzel, T.3
  • 31
    • 77954233247 scopus 로고    scopus 로고
    • VEGF promotes angiogenesis and functional recovery in stroke rats
    • Yang JP, Liu HJ, Liu XF. VEGF promotes angiogenesis and functional recovery in stroke rats. J Invest Surg 2010;23:149-155.
    • (2010) J Invest Surg , vol.23 , pp. 149-155
    • Yang, J.P.1    Liu, H.J.2    Liu, X.F.3
  • 32
    • 84857656067 scopus 로고    scopus 로고
    • Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia
    • Lu H, Wang Y, He X, et al. Netrin-1 hyperexpression in mouse brain promotes angiogenesis and long-term neurological recovery after transient focal ischemia. Stroke 2012;43:838-843.
    • (2012) Stroke , vol.43 , pp. 838-843
    • Lu, H.1    Wang, Y.2    He, X.3
  • 33
    • 37249078258 scopus 로고    scopus 로고
    • Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice
    • Shen F, Fan Y, Su H, et al. Adeno-associated viral vector-mediated hypoxia-regulated VEGF gene transfer promotes angiogenesis following focal cerebral ischemia in mice. Gene Ther 2008;15:30-39.
    • (2008) Gene Ther , vol.15 , pp. 30-39
    • Shen, F.1    Fan, Y.2    Su, H.3
  • 35
    • 0033844402 scopus 로고    scopus 로고
    • Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice
    • Li Y, Chopp M, Chen J, et al. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 2000;20:1311-1319.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1311-1319
    • Li, Y.1    Chopp, M.2    Chen, J.3
  • 36
    • 0037199090 scopus 로고    scopus 로고
    • A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia
    • Zhang L, Schallert T, Zhang ZG, et al. A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods 2002;117:207-214.
    • (2002) J Neurosci Methods , vol.117 , pp. 207-214
    • Zhang, L.1    Schallert, T.2    Zhang, Z.G.3
  • 37
    • 84865793660 scopus 로고    scopus 로고
    • Protective effect of carnosine on subcortical ischemic vascular dementia in mice
    • Ma J, Xiong JY, Hou WW, et al. Protective effect of carnosine on subcortical ischemic vascular dementia in mice. CNS Neurosci Ther 2012;18:745-753.
    • (2012) CNS Neurosci Ther , vol.18 , pp. 745-753
    • Ma, J.1    Xiong, J.Y.2    Hou, W.W.3
  • 38
    • 33744483138 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain
    • Shen F, Su H, Liu W, Kan YW, Young WL, Yang GY. Recombinant adeno-associated viral vector encoding human VEGF165 induces neomicrovessel formation in the adult mouse brain. Front Biosci 2006;11:3190-3198.
    • (2006) Front Biosci , vol.11 , pp. 3190-3198
    • Shen, F.1    Su, H.2    Liu, W.3    Kan, Y.W.4    Young, W.L.5    Yang, G.Y.6
  • 40
    • 16844372455 scopus 로고    scopus 로고
    • Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor
    • Zhang L, Zhang RL, Wang Y, et al. Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 2005;36:847-852.
    • (2005) Stroke , vol.36 , pp. 847-852
    • Zhang, L.1    Zhang, R.L.2    Wang, Y.3
  • 41
    • 1842507654 scopus 로고    scopus 로고
    • Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease
    • Heeschen C, Lehmann R, Honold J, et al. Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation 2004;109:1615-1622.
    • (2004) Circulation , vol.109 , pp. 1615-1622
    • Heeschen, C.1    Lehmann, R.2    Honold, J.3
  • 42
    • 4944242707 scopus 로고    scopus 로고
    • Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse
    • Shimada T, Takeshita Y, Murohara T, et al. Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation 2004;110:1148-1155.
    • (2004) Circulation , vol.110 , pp. 1148-1155
    • Shimada, T.1    Takeshita, Y.2    Murohara, T.3
  • 43
    • 0033547805 scopus 로고    scopus 로고
    • Age-dependent impairment of angiogenesis
    • Rivard A, Fabre JE, Silver M, et al. Age-dependent impairment of angiogenesis. Circulation 1999;99:111-120.
    • (1999) Circulation , vol.99 , pp. 111-120
    • Rivard, A.1    Fabre, J.E.2    Silver, M.3
  • 44
    • 0018819468 scopus 로고
    • Decrease in capillary growth during aging
    • Yamaura H, Matsuzawa T. Decrease in capillary growth during aging. Exp Gerontol 1980;15:145-150.
    • (1980) Exp Gerontol , vol.15 , pp. 145-150
    • Yamaura, H.1    Matsuzawa, T.2
  • 45
    • 84882921257 scopus 로고    scopus 로고
    • Targeted delivery of Neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury
    • Deng B, Gou X, Chen H, et al. Targeted delivery of Neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury. Biomaterials 2013;34:8786-8797.
    • (2013) Biomaterials , vol.34 , pp. 8786-8797
    • Deng, B.1    Gou, X.2    Chen, H.3
  • 46
    • 67349287017 scopus 로고    scopus 로고
    • TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice
    • Doeppner TR, Nagel F, Dietz GP, et al. TAT-Hsp70-mediated neuroprotection and increased survival of neuronal precursor cells after focal cerebral ischemia in mice. J Cereb Blood Flow Metab 2009;29:1187-1196.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1187-1196
    • Doeppner, T.R.1    Nagel, F.2    Dietz, G.P.3
  • 47
    • 84876719872 scopus 로고    scopus 로고
    • Stem cell-mediated gene delivering for the treatment of cerebral ischemia: progress and prospectives
    • Chen C, Wang Y, Yang GY. Stem cell-mediated gene delivering for the treatment of cerebral ischemia: progress and prospectives. Curr Drug Targets 2013;14:81-89.
    • (2013) Curr Drug Targets , vol.14 , pp. 81-89
    • Chen, C.1    Wang, Y.2    Yang, G.Y.3
  • 48
    • 33751544180 scopus 로고    scopus 로고
    • Tracking neural stem cells in patients with brain trauma
    • Zhu J, Zhou L, XingWu F. Tracking neural stem cells in patients with brain trauma. N Engl J Med 2006;355:2376-2378.
    • (2006) N Engl J Med , vol.355 , pp. 2376-2378
    • Zhu, J.1    Zhou, L.2    XingWu, F.3
  • 49
    • 20444419744 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cell transplantation in stroke patients
    • Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005;57:874-882.
    • (2005) Ann Neurol , vol.57 , pp. 874-882
    • Bang, O.Y.1    Lee, J.S.2    Lee, P.H.3    Lee, G.4
  • 50
    • 72749123129 scopus 로고    scopus 로고
    • Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection
    • Barbosa da Fonseca LM, Gutfilen B, Rosado de Castro PH, et al. Migration and homing of bone-marrow mononuclear cells in chronic ischemic stroke after intra-arterial injection. Exp Neurol 2010;221:122-128.
    • (2010) Exp Neurol , vol.221 , pp. 122-128
    • Barbosa da Fonseca, L.M.1    Gutfilen, B.2    Rosado de Castro, P.H.3
  • 51
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 2003;111:1843-1851.
    • (2003) J Clin Invest , vol.111 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3
  • 52
    • 30744477950 scopus 로고    scopus 로고
    • From angiogenesis to neuropathology
    • Greenberg DA, Jin K. From angiogenesis to neuropathology. Nature 2005;438:954-959.
    • (2005) Nature , vol.438 , pp. 954-959
    • Greenberg, D.A.1    Jin, K.2
  • 53
    • 0042733154 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress
    • Nagata D, Mogi M, Walsh K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J Biol Chem 2003;278:31000-31006.
    • (2003) J Biol Chem , vol.278 , pp. 31000-31006
    • Nagata, D.1    Mogi, M.2    Walsh, K.3
  • 54
    • 18044393806 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle
    • Ouchi N, Shibata R, Walsh K. AMP-activated protein kinase signaling stimulates VEGF expression and angiogenesis in skeletal muscle. Circ Res 2005;96:838-846.
    • (2005) Circ Res , vol.96 , pp. 838-846
    • Ouchi, N.1    Shibata, R.2    Walsh, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.