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Volumn 47, Issue 4-5, 2014, Pages 121-130

The glutamate hypothesis: A pathogenic pathway from which pharmacological interventions have emerged

Author keywords

clozapine; glutamate; glycine; NMDA receptor; schizophrenia

Indexed keywords

CLOZAPINE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; IONOTROPIC RECEPTOR AGONIST; MEMANTINE; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR;

EID: 84904823964     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0034-1383657     Document Type: Article
Times cited : (31)

References (73)
  • 3
    • 33750029861 scopus 로고    scopus 로고
    • Glutamate involvement in schizophrenia: Focus on N-methyl-D-aspartate receptors
    • Javitt D. C. glutamate involvement in schizophrenia: focus on N-methyl-D-aspartate receptors. Prim Psychiatry: 2006; 13 38 46 (Pubitemid 44571906)
    • (2006) Primary Psychiatry , vol.13 , Issue.10 , pp. 38-46
    • Javitt, D.C.1
  • 4
    • 34447547642 scopus 로고    scopus 로고
    • Glutamate and dopamine dysregulation in schizophrenia - A synthesis and selective review
    • DOI 10.1177/0269881106073126
    • Stone J. M., Morrison P. D., Pilowsky L. S. Review: glutamate and dopamine dysregulation in schizophrenia - a synthesis and selective review. J Psychopharmacol: 2007; 21 440 452 (Pubitemid 47077295)
    • (2007) Journal of Psychopharmacology , vol.21 , Issue.4 , pp. 440-452
    • Stone, J.M.1    Morrison, P.D.2    Pilowsky, L.S.3
  • 5
    • 24944500457 scopus 로고    scopus 로고
    • Randomized controlled augmentation trials in clozapine-resistant schizophrenic patients: A critical review
    • DOI 10.1016/j.eurpsy.2004.12.007, PII S0924933805000155
    • Kontaxakis V. P., Ferentinos P. P., Havaki-Kontaxaki B. J. et al. Randomized controlled augmentation trials in clozapine-resistant schizophrenic patients: a critical review. Eur Psychiatry: 2005; 20 409 415 (Pubitemid 41318007)
    • (2005) European Psychiatry , vol.20 , Issue.5-6 , pp. 409-415
    • Kontaxakis, V.P.1    Ferentinos, P.P.2    Havaki-Kontaxaki, B.J.3    Roukas, D.K.4
  • 6
    • 84995342852 scopus 로고    scopus 로고
    • Clozapin bei therapieresistenter Schizophrenie. Plasmaspiegel und Dauer eines ausreichenden Behandlungs-versuchs
    • Schulte R. Clozapin bei therapieresistenter Schizophrenie. Plasmaspiegel und Dauer eines ausreichenden Behandlungs-versuchs. Psychopharmakotherapie: 2003; 1 11
    • (2003) Psychopharmakotherapie , pp. 1-11
    • Schulte, R.1
  • 7
    • 78149386499 scopus 로고    scopus 로고
    • Functional psychopharmacology is the way to go in pharmacotherapy for psychiatric disorders
    • Loonen AJ M., Stahl S. M. Functional psychopharmacology is the way to go in pharmacotherapy for psychiatric disorders. Acta Psychiatr Scand: 2010; 122 435 437
    • (2010) Acta Psychiatr Scand , vol.122 , pp. 435-437
    • Loonen, A.J.M.1    Stahl, S.M.2
  • 8
    • 84864232916 scopus 로고    scopus 로고
    • Parallels between spacing effects during behavioural and cellular learning
    • Kornmeier J., Sosic-Vasic Z. Parallels between spacing effects during behavioural and cellular learning. Front Hum Neurosci: 2012; 6 203
    • (2012) Front Hum Neurosci , vol.6 , pp. 203
    • Kornmeier, J.1    Sosic-Vasic, Z.2
  • 9
    • 0034843738 scopus 로고    scopus 로고
    • The emerging role of glutamate in the pathophysiology and treatment of schizophrenia
    • DOI 10.1176/appi.ajp.158.9.1367
    • Goff D. C., Coyle J. T. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry: 2001; 158 1367 1377 (Pubitemid 32847232)
    • (2001) American Journal of Psychiatry , vol.158 , Issue.9 , pp. 1367-1377
    • Goff, D.C.1    Coyle, J.T.2
  • 10
    • 84873455187 scopus 로고    scopus 로고
    • When the drugs don't work: The potential of glutamatergic antipsychotics in schizophrenia
    • Papanastasiou E., Stone J. M., Shergill S. When the drugs don't work: the potential of glutamatergic antipsychotics in schizophrenia. Br J Psychiatry: 2013; 202 91 93
    • (2013) Br J Psychiatry , vol.202 , pp. 91-93
    • Papanastasiou, E.1    Stone, J.M.2    Shergill, S.3
  • 11
    • 39449104625 scopus 로고    scopus 로고
    • The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): Expression, function and involvement in schizophrenia
    • DOI 10.1177/0269881108089818
    • Harrison P. J., Lyon L., Sartorius L. J. et al. The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia. J Psychopharmacol: 2008; 22 308 322 (Pubitemid 351847454)
    • (2008) Journal of Psychopharmacology , vol.22 , Issue.3 , pp. 308-322
    • Harrison, P.J.1    Lyon, L.2    Sartorius, L.J.3    Burnet, P.W.J.4    Lane, T.A.5
  • 12
    • 0038798022 scopus 로고    scopus 로고
    • Direct and indirect modulation of the N-methyl D-aspartate receptor
    • Marino M. J., Conn P. J. Direct and indirect modulation of the N-methyl D-aspartate receptor. Curr Drug Targets CNS Neurol Disord: 2002; 1 1 16
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , pp. 1-16
    • Marino, M.J.1    Conn, P.J.2
  • 13
    • 84856097892 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia
    • Fell M. J., McKinzie D. L., Monn J. A. et al. Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia. Neuropharmacology: 2012; 62 1473 1483
    • (2012) Neuropharmacology , vol.62 , pp. 1473-1483
    • Fell, M.J.1    McKinzie, D.L.2    Monn, J.A.3
  • 14
    • 84869010512 scopus 로고    scopus 로고
    • Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
    • Allen P., Luigjes J., Howes O. D. et al. Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals. Schizophr Bull: 2012; 38 1268 1276
    • (2012) Schizophr Bull , vol.38 , pp. 1268-1276
    • Allen, P.1    Luigjes, J.2    Howes, O.D.3
  • 15
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam B., Adams B., Verma A. et al. Activation of glutmatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci: 1997; 17 2921 2927 (Pubitemid 27155025)
    • (1997) Journal of Neuroscience , vol.17 , Issue.8 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 17
    • 84874529521 scopus 로고    scopus 로고
    • A population-specific uncommon variant in GRIN3A associated with schizophrenia
    • Takata A., Iwayama Y., Fukuo Y. et al. A population-specific uncommon variant in GRIN3A associated with schizophrenia. Biol Psychiatry: 2013; 73 532 539
    • (2013) Biol Psychiatry , vol.73 , pp. 532-539
    • Takata, A.1    Iwayama, Y.2    Fukuo, Y.3
  • 18
    • 79952454124 scopus 로고    scopus 로고
    • Anti-NMDA-receptor encephalitis: A severe, multistage, treatable disorder presenting with psychosis
    • Wandinger K. P., Saschenbrecker S., Soecker W. et al. Anti-NMDA-receptor encephalitis: A severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol: 2011; 231 86 91
    • (2011) J Neuroimmunol , vol.231 , pp. 86-91
    • Wandinger, K.P.1    Saschenbrecker, S.2    Soecker, W.3
  • 19
    • 84874876185 scopus 로고    scopus 로고
    • Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: Specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis
    • Steiner J., Walter M., Glanz W. et al. Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry: 2013; 70 271 278
    • (2013) JAMA Psychiatry , vol.70 , pp. 271-278
    • Steiner, J.1    Walter, M.2    Glanz, W.3
  • 21
    • 35548991088 scopus 로고    scopus 로고
    • NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons
    • DOI 10.1523/JNEUROSCI.2213-07.2007
    • Homayoun H., Moghaddam B. NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons. J Neurosci: 2007; 27 11496 11500 (Pubitemid 350006886)
    • (2007) Journal of Neuroscience , vol.27 , Issue.43 , pp. 11496-11500
    • Homayoun, H.1    Moghaddam, B.2
  • 22
    • 73949132228 scopus 로고    scopus 로고
    • Testing the glutamate hypothesis of schizophrenia
    • Gordon J. A. Testing the glutamate hypothesis of schizophrenia. Nat Neurosci: 2010; 13 2 4
    • (2010) Nat Neurosci , vol.13 , pp. 2-4
    • Gordon, J.A.1
  • 23
    • 2942537881 scopus 로고    scopus 로고
    • NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex
    • Jackson M., Homayoun H., Moghaddam B. NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex. Proc Natl Acad Sic USA: 2004; 101 6391 6396
    • (2004) Proc Natl Acad Sic USA , vol.101 , pp. 6391-6396
    • Jackson, M.1    Homayoun, H.2    Moghaddam, B.3
  • 24
    • 80052996482 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia
    • Singh S. P., Singh V. Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS drugs: 2011; 25 859 885
    • (2011) CNS Drugs , vol.25 , pp. 859-885
    • Singh, S.P.1    Singh, V.2
  • 26
    • 58149119377 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
    • Conn P. J., Lindsley C. W., Jones C. K. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends in Pharmacol Sci: 2009; 30 25 31
    • (2009) Trends in Pharmacol Sci , vol.30 , pp. 25-31
    • Conn, P.J.1    Lindsley, C.W.2    Jones, C.K.3
  • 27
    • 69949125537 scopus 로고    scopus 로고
    • Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia
    • Fraley M. E. Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia. Expert Opin Ther Pat: 2009; 19 1259 1275
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 1259-1275
    • Fraley, M.E.1
  • 29
    • 79955594301 scopus 로고    scopus 로고
    • A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia
    • HBBI Study Group
    • Kinon B. J., Zhang L., Millen B. A. et al. HBBI Study Group A multicenter, inpatient, phase 2, double-blind, placebo-controlled dose-ranging study of LY2140023 monohydrate in patients with DSM-IV schizophrenia. J Clin Psychopharmacol: 2011; 31 349 355
    • (2011) J Clin Psychopharmacol , vol.31 , pp. 349-355
    • Kinon, B.J.1    Zhang, L.2    Millen, B.A.3
  • 30
    • 84995347372 scopus 로고    scopus 로고
    • LY, 2140023 monohydrate in the treatment of patients with schizophrenia: Results of 2 clinical trials assessing efficacy in treating acutely ill and those with prominent negative symptoms
    • Kinon B., Millen B. A., Downing A. C. et al. LY, 2140023 monohydrate in the treatment of patients with schizophrenia: results of 2 clinical trials assessing efficacy in treating acutely ill and those with prominent negative symptoms. Schizophr Bull: 2013; 39 S338
    • (2013) Schizophr Bull , vol.39
    • Kinon, B.1    Millen, B.A.2    Downing, A.C.3
  • 31
    • 84878009124 scopus 로고    scopus 로고
    • A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia
    • Adams D. H., Kinon B. J., Baygani S. et al. A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia. BMC Psychiatry: 2013; 13 143
    • (2013) BMC Psychiatry , vol.13 , pp. 143
    • Adams, D.H.1    Kinon, B.J.2    Baygani, S.3
  • 32
    • 84907976568 scopus 로고    scopus 로고
    • Pomaglumetad methionil (LY2140023 monohydrate) and aripiprazole in patients with schizophrenia: A phase 3, multicenter, double-blind comparison
    • Adams D. H., Zhang L., Millen B. A. et al. Pomaglumetad methionil (LY2140023 monohydrate) and aripiprazole in patients with schizophrenia: a phase 3, multicenter, double-blind comparison. Schizophr Res Treatment: 2014; 1 11
    • (2014) Schizophr Res Treatment , pp. 1-11
    • Adams, D.H.1    Zhang, L.2    Millen, B.A.3
  • 33
    • 84876562945 scopus 로고    scopus 로고
    • MGluR2 positive allosteric modulators: A patent review (2009-present)
    • Trabanco A. A., Cid J. M. mGluR2 positive allosteric modulators: a patent review (2009-present). Expert Opin Ther Pat: 2013; 23 629 647
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 629-647
    • Trabanco, A.A.1    Cid, J.M.2
  • 34
    • 84874035617 scopus 로고    scopus 로고
    • Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia
    • Hopkins C. R. Is there a path forward for mGlu(2) positive allosteric modulators for the treatment of schizophrenia? ACS Chem Neurosci: 2013; 20 211 213
    • (2013) ACS Chem Neurosci , vol.20 , pp. 211-213
    • Hopkins, C.R.1
  • 35
    • 84866684683 scopus 로고    scopus 로고
    • Twenty-five years of glutamate in schizophrenia: Are we there yet
    • Javitt D. C. Twenty-five years of glutamate in schizophrenia: are we there yet? Schizophr Bull: 2012; 38 911 913
    • (2012) Schizophr Bull , vol.38 , pp. 911-913
    • Javitt, D.C.1
  • 36
    • 0025949567 scopus 로고
    • Actions of D-cycloserine at the N-methyl-D-aspartate-associated glycine receptor site in vivo
    • Emmett M. R., Mick S. J., Cler J. A. et al. Actions of D-cycloserine at the N-methyl-D-aspartate-associated glycine receptor site in vivo. Neuropharmacology: 1991; 30 1167 1171
    • (1991) Neuropharmacology , vol.30 , pp. 1167-1171
    • Emmett, M.R.1    Mick, S.J.2    Cler, J.A.3
  • 37
    • 33748751382 scopus 로고    scopus 로고
    • Glycine transporter i inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia
    • Lane H. Y., Huang C. L., Wu P. L. et al. Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia. Biol Psychiatry: 2006; 60 645 649
    • (2006) Biol Psychiatry , vol.60 , pp. 645-649
    • Lane, H.Y.1    Huang, C.L.2    Wu, P.L.3
  • 38
    • 0023812652 scopus 로고
    • Clozapine for the treatment-resistant schizophrenic: A double-blind comparison with chlorpromazine
    • Kane J., Honigfeld G., Singer J. et al. Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry: 1988; 45 789 796
    • (1988) Arch Gen Psychiatry , vol.45 , pp. 789-796
    • Kane, J.1    Honigfeld, G.2    Singer, J.3
  • 40
    • 69249145260 scopus 로고    scopus 로고
    • Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: Insights form PET and SPECT imaging
    • Howes O. D., Egerton A., Allan V. et al. Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights form PET and SPECT imaging. Current Pharmaceutical Design: 2009; 15 2550 2559
    • (2009) Current Pharmaceutical Design , vol.15 , pp. 2550-2559
    • Howes, O.D.1    Egerton, A.2    Allan, V.3
  • 41
    • 78650635546 scopus 로고    scopus 로고
    • Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors
    • Yeun E. Y., Zhong P., Yan Z. Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proc Natl Acad Sci USA: 2010; 107 22308 22313
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 22308-22313
    • Yeun, E.Y.1    Zhong, P.2    Yan, Z.3
  • 42
    • 84857082115 scopus 로고    scopus 로고
    • Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes
    • Tanahashi S., Yamamura S., Nakagawa M. et al. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. Br J Pharmacol: 2012; 165 1543 1555
    • (2012) Br J Pharmacol , vol.165 , pp. 1543-1555
    • Tanahashi, S.1    Yamamura, S.2    Nakagawa, M.3
  • 43
    • 85027951368 scopus 로고    scopus 로고
    • Clozapine Augmented with Glutamate Modulators in Refractory Schizophrenia: A Review and Meta-analysis
    • in press
    • Veerman SR T., Schulte PF J., Begemann MJ H. et al. Clozapine Augmented with Glutamate Modulators in Refractory Schizophrenia: A Review and Meta-analysis. Pharmacopsychiatry: 2014; in press
    • (2014) Pharmacopsychiatry
    • Veerman, S.R.T.1    Schulte, P.F.J.2    Begemann, M.J.H.3
  • 44
    • 34548615390 scopus 로고    scopus 로고
    • Coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of Held synapse
    • DOI 10.1523/JNEUROSCI.2506-07.2007
    • Joshi I., Yang Y-M, Wang L-Y. Cellular/molecular coincident activation of metabotropic glutamate receptors and NMDA receptors (NMDARs) downregulates perisynaptic/extrasynaptic NMDARs and enhances high-fidelity neurotransmission at the developing calyx of the held synapse. J Neurosci: 2007; 27 9989 9999 (Pubitemid 47403997)
    • (2007) Journal of Neuroscience , vol.27 , Issue.37 , pp. 9989-9999
    • Joshi, I.1    Yang, Y.-M.2    Wang, L.-Y.3
  • 47
    • 84864407350 scopus 로고    scopus 로고
    • Effect of topiramate augmentation in chronic schizophrenia: A placebo-controlled trial
    • Behdani F., Hebrani P., Rezaei Ardani A. et al. Effect of topiramate augmentation in chronic schizophrenia: a placebo-controlled trial. Arch Iran Med: 2011; 14 270 275
    • (2011) Arch Iran Med , vol.14 , pp. 270-275
    • Behdani, F.1    Hebrani, P.2    Rezaei Ardani, A.3
  • 48
    • 77954650148 scopus 로고    scopus 로고
    • How should we treat a patient with early Parkinson's disease
    • Tsouli S., Konitsiotis S. How should we treat a patient with early Parkinson's disease? Int J Clin Pract: 2010; 64 1210 1219
    • (2010) Int J Clin Pract , vol.64 , pp. 1210-1219
    • Tsouli, S.1    Konitsiotis, S.2
  • 49
    • 80955179603 scopus 로고    scopus 로고
    • Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GDNF in astroglia
    • Ossola B., Schendzielorz N., Chen S. H. et al. Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia. Neuropharmacology: 2011; 61 574 582
    • (2011) Neuropharmacology , vol.61 , pp. 574-582
    • Ossola, B.1    Schendzielorz, N.2    Chen, S.H.3
  • 50
    • 72849132183 scopus 로고    scopus 로고
    • Improvement of negative and positive symptoms in treatment-refractory schizophrenia: A double-blind, randomized, placebo-controlled trial with memantine as add-on therapy to clozapine
    • de Lucena D., Fernandes B. S., Berk M. et al. Improvement of negative and positive symptoms in treatment-refractory schizophrenia: a double-blind, randomized, placebo-controlled trial with memantine as add-on therapy to clozapine. J Clin Psychiatry: 2009; 70 1416 1423
    • (2009) J Clin Psychiatry , vol.70 , pp. 1416-1423
    • De Lucena, D.1    Fernandes, B.S.2    Berk, M.3
  • 51
    • 4444352847 scopus 로고    scopus 로고
    • Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia
    • DOI 10.1016/j.biopsych.2004.06.029, PII S0006322304007073
    • Kremer I., Vass A., Gorelik I. et al. Placebo-controlled trial of lamotrigine added to conventional and atypical antipsychotics in schizophrenia. Biol Psychiatry: 2004; 56 441 446 (Pubitemid 39195324)
    • (2004) Biological Psychiatry , vol.56 , Issue.6 , pp. 441-446
    • Kremer, I.1    Vass, A.2    Gorelik, I.3    Bar, G.4    Blanaru, M.5    Javitt, D.C.6    Heresco-Levy, U.7
  • 52
    • 84880133046 scopus 로고    scopus 로고
    • NMDA receptor antagonists interventions in schizophrenia: Meta-analysis of randomized, placebo-controlled trials
    • Kishi T., Iwata N. NMDA receptor antagonists interventions in schizophrenia: Meta-analysis of randomized, placebo-controlled trials. J Psychiatr Res: 2013; 1 7
    • (2013) J Psychiatr Res , pp. 1-7
    • Kishi, T.1    Iwata, N.2
  • 53
    • 0030995082 scopus 로고    scopus 로고
    • A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia
    • DOI 10.1097/00004714-199704000-00004
    • Angus S., Sugars J., Boltezar R. et al. A controlled trial of amantadine hydrochloride and neuroleptics in the treatment of tardive dyskinesia. J Clin Psychopharmacol: 1997; 17 88 91 (Pubitemid 27148302)
    • (1997) Journal of Clinical Psychopharmacology , vol.17 , Issue.2 , pp. 88-91
    • Angus, S.1    Sugars, J.2    Boltezar, R.3    Koskewich, S.4    Schneider, N.M.5
  • 54
    • 26944441259 scopus 로고    scopus 로고
    • A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients
    • DOI 10.1097/00004850-200511000-00007
    • Silver H., Goodman C., Isakov V. et al. A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients. Int Clin Psychopharmacol: 2005; 20 319 326 (Pubitemid 41475322)
    • (2005) International Clinical Psychopharmacology , vol.20 , Issue.6 , pp. 319-326
    • Silver, H.1    Goodman, C.2    Isakov, V.3    Knoll, G.4    Modai, I.5
  • 55
    • 78651415131 scopus 로고    scopus 로고
    • Effects if amantadine on tardive dyskinesia: A randomized, double-blind, placebo-controlled study
    • Pappa S., Tsouli S., Apostolou G. et al. Effects if amantadine on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. Clin Neuropharmacol: 2010; 33 271 275
    • (2010) Clin Neuropharmacol , vol.33 , pp. 271-275
    • Pappa, S.1    Tsouli, S.2    Apostolou, G.3
  • 56
    • 84877583223 scopus 로고    scopus 로고
    • Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Randomized, double-blind, placebo-controlled study
    • Rezaei F., Mohammad-karimi M., Seddighi S. et al. Memantine add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol: 2013; 33 1 7
    • (2013) J Clin Psychopharmacol , vol.33 , pp. 1-7
    • Rezaei, F.1    Mohammad-Karimi, M.2    Seddighi, S.3
  • 57
    • 62349116484 scopus 로고    scopus 로고
    • A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia
    • MEM-MD-29 Study Group
    • Lieberman J. A., Papadakis K., Csernansky J. et al. MEM-MD-29 Study Group A randomized, placebo-controlled study of memantine as adjunctive treatment in patients with schizophrenia. Neuropsychopharmacology: 2009; 34 1322 1329
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1322-1329
    • Lieberman, J.A.1    Papadakis, K.2    Csernansky, J.3
  • 58
    • 84863429650 scopus 로고    scopus 로고
    • Adjunctive memantine therapy for cognitive impairment in chronic schizophrenia: A placebo-controlled pilot study
    • Lee J. G., Lee S. W., Lee B. J. et al. Adjunctive memantine therapy for cognitive impairment in chronic schizophrenia: a placebo-controlled pilot study. Psychiatry Investig: 2012; 9 166 173
    • (2012) Psychiatry Investig , vol.9 , pp. 166-173
    • Lee, J.G.1    Lee, S.W.2    Lee, B.J.3
  • 59
    • 33846514778 scopus 로고    scopus 로고
    • Remissiecriteria voor de diagnose schizofrenie
    • Os van J., Kahn R. Remissiecriteria voor de diagnose schizofrenie. Tijdschr Psychiatr: 2007; 49 21 26 (Pubitemid 46150732)
    • (2007) Tijdschrift voor Psychiatrie , vol.49 , Issue.1 , pp. 21-26
    • Van Os, J.1    Kahn, R.2
  • 62
    • 33847065797 scopus 로고    scopus 로고
    • Computerized assessment of cognition in schizophrenia: Promises and pitfalls of CANTAB
    • DOI 10.1016/j.eurpsy.2006.11.004, PII S0924933806002094
    • Levaux M. N., Potvin S., Sepehry A. A. et al. Computerized assessment of cognition in schizophrenia: Promises and pitfalls of CANTAB. Eur Psychiatry: 2007; 22 104 115 (Pubitemid 46274188)
    • (2007) European Psychiatry , vol.22 , Issue.2 , pp. 104-115
    • Levaux, M.-N.1    Potvin, S.2    Sepehry, A.A.3    Sablier, J.4    Mendrek, A.5    Stip, E.6
  • 63
    • 0003412404 scopus 로고
    • In Guy W. ECDEU Assessment Manual for Psychopharmacology- Revised Rockville MD US Dept. of Health, Education and Welfare, ADAMHA, MIMH Psychopharmacology Research Branch
    • Guy W. Clinical Global Impression Scale. In Guy W. ECDEU Assessment Manual for Psychopharmacology- Revised. Rockville MD US Dept. of Health, Education and Welfare, ADAMHA, MIMH Psychopharmacology Research Branch: 1976; 218 222
    • (1976) Clinical Global Impression Scale , pp. 218-222
    • Guy, W.1
  • 64
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay S. R., Flszbein A., Opfer L. A. The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia. Schizophr Bull: 1987; 13 261 276 (Pubitemid 18039085)
    • (1987) Schizophrenia Bulletin , vol.13 , Issue.2 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 65
    • 0035087628 scopus 로고    scopus 로고
    • The Reading the Mind in the Eyes Test revised version: A study with normal adults, and adults with Asperger syndrome or high-functioning autism
    • DOI 10.1017/S0021963001006643
    • Baron-Cohen S., Wheelwright S., Hill J. et al. The Reading the Mind in the Eyes Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry: 2001; 42 241 251 (Pubitemid 32233124)
    • (2001) Journal of Child Psychology and Psychiatry and Allied Disciplines , vol.42 , Issue.2 , pp. 241-251
    • Baron-Cohen, S.1    Wheelwright, S.2    Hill, J.3    Raste, Y.4    Plumb, I.5
  • 66
    • 0032991783 scopus 로고    scopus 로고
    • Reliability and validity of HoNOS (multiple letters) [2]
    • Wing J., Lelliott P., Chaplin R. H. Reliability and validity of HoNOS (multiple letters). Psychiatric Bull: 1999; 23 375 (Pubitemid 29265328)
    • (1999) Psychiatric Bulletin , vol.23 , Issue.6 , pp. 375
    • Wing, J.1    Lelliott, P.2    Chaplin, R.H.3
  • 68
    • 47749150634 scopus 로고    scopus 로고
    • A systematic review of off-label uses of memantine for psychiatric disorders
    • DOI 10.1016/j.pnpbp.2008.01.008, PII S0278584608000237
    • Zdanys K., Tampi R. R. A systematic review of off-label uses of memantine for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry: 2008; 32 1362 1374 (Pubitemid 352033662)
    • (2008) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.32 , Issue.6 , pp. 1362-1374
    • Zdanys, K.1    Tampi, R.R.2
  • 69
    • 42249095073 scopus 로고    scopus 로고
    • Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence
    • Muhonen L. H., Lönnqvist J., Juva K. et al. Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence. J Clin Psychiatry: 2008; 69 392 399 (Pubitemid 351549391)
    • (2008) Journal of Clinical Psychiatry , vol.69 , Issue.3 , pp. 392-399
    • Muhonen, L.H.1    Lonnqvist, J.2    Juva, K.3    Alho, H.4
  • 70
    • 74549223527 scopus 로고    scopus 로고
    • A single-blinded case-control study of memantine in severe obsessive-compulsive disorder
    • Stewart S. E., Jenike E. A., Hezel D. M. et al. A single-blinded case-control study of memantine in severe obsessive-compulsive disorder. J Clin Psychopharmacol: 2010; 30 34 39
    • (2010) J Clin Psychopharmacol , vol.30 , pp. 34-39
    • Stewart, S.E.1    Jenike, E.A.2    Hezel, D.M.3
  • 71
    • 0025362664 scopus 로고
    • A depression rating scale for schizophrenics
    • DOI 10.1016/0920-9964(90)90005-R
    • Addington D., Addington J., Schissel B. A depression rating scale for schizophrenics. Schizophr Res: 1990; 3 247 251 (Pubitemid 20228720)
    • (1990) Schizophrenia Research , vol.3 , Issue.4 , pp. 247-251
    • Addington, D.1    Addington, J.2    Schissel, B.3
  • 73
    • 0029044513 scopus 로고
    • A self-rating scale for measuring neuroleptic side-effects. Validation in a group of schizophrenic patients
    • Day J. C., Wood G., Dewey M. et al. A self-rating scale for measuring neuroleptic side-effects. Validation in a group of schizophrenic patients. Br J Psychiatry: 1995; 166 650 653
    • (1995) Br J Psychiatry , vol.166 , pp. 650-653
    • Day, J.C.1    Wood, G.2    Dewey, M.3


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