Development of a novel precipitation technique for the production of highly respirable powders: The atomized rapid injection for solvent extraction process

ACS Symposium Series

Volumn 1006, Issue , 2009, Pages 309-347

  Foster, Neil R ^a   Sih, Roderick ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; METEOROLOGICAL INSTRUMENTS; SUPERCRITICAL FLUID EXTRACTION;

AERODYNAMIC EFFICIENCY; PHARMACEUTICAL INGREDIENTS; PRECIPITATION TECHNIQUES; PRESSURE DIFFERENTIAL; PROCESSING PLATFORM; RESPIRABLE FRACTIONS; SOLVENT-EXTRACTION PROCESS; SUPERCRITICAL CARBON DIOXIDES;

POWDERS;

EID: 84904818746     PISSN: 00976156     EISSN: 19475918     Source Type: Book Series    
DOI: 10.1021/bk-2009-1006.ch017     Document Type: Conference Paper

References (44)

1. McHugh, M. A.; Krukonis, V. J., Supercritical Fluid Extraction. Principles and Practice. 2nd ed.; Butterworth-Heinemann: Newton, MA, 1994.
2. Bustami, R. T.; Chan, H.-K.; Dehghani, F.; Foster, N. R., Generation of Microparticles of Proteins for Aerosol Delivery Using High Pressure Modified Carbon Dioxide. Pharmaceutical Research 2000, 17, (11), 1360-1366.
3. Perez de Diego, Y.; Pellikaan, H. C.; Wubbolts, F. E.; Witkamp, G. J.; Jansens, P. J., Operating Regimes and Mechanism of Particle Formation During the Precipitation of Polymers Using the PCA Process. Journal of Supercritical Fluids 2005, 35, (2), 147-156.
4. Dukhin, S. S.; Shen, Y.; Dave, R.; Pfeffer, R., Droplet Mass Transfer, Intradroplet Nucleation and Submicron Particle Production in Two-Phase Flow of Solvent-Supercritical Antisolvent Emulsion. Colloids and Surfaces, A: Physicochemical and Engineering Aspects 2005, 261, (1-3), 163-176.
5. Reverchon, E., Supercritical Antisolvent Precipitation of Micro- and Nano-Particles. Journal of Supercritical Fluids 1999, 15, (1), 1-21.
6. Reverchon, E.; Caputo, G.; De Marco, I., Role of Phase Behavior and Atomization in the Supercritical Antisolvent Precipitation. Industrial & Engineering Chemistry Research 2003, 42, (25), 6406-6414.
7. Yeo, S.-D.; Kiran, E., Formation of Polymer Particles with Supercritical Fluids: A Review. Journal of Supercritical Fluids 2005, 34, (3), 287-308.
8. Perrut, M.; Clavier, J.-Y., Supercritical Fluid Formulation: Process Choice and Scale-up. Industrial & Engineering Chemistry Research 2003, 42, (25), 6375-6383.
9. Harjo, B.; Ng, K. M.; Wibowo, C., Synthesis of Supercritical Crystallization Processes. Industrial & Engineering Chemistry Research 2005, 44, (22), 8248-8259.
10. Thiering, R.; Dehghani, F.; Dillow, A.; Foster, N. R., Solvent Effects on the Controlled Dense Gas Precipitation of Model Proteins. Journal of Chemical Technology & Biotechnology 2000, 75, (1), 42-53.
11. Thiering, R.; Dehghani, F.; Dillow, A.; Foster, N. R., The Influence of Operating Conditions on the Dense Gas Precipitation of Model Proteins. Journal of Chemical Technology & Biotechnology 2000, 75, (1), 29-41.
12. Mawson, S.; Kanakia, S.; Johnston, K. P., Coaxial Nozzle for Control of Particle Morphology in Precipitation with a Compressed Fluid Antisolvent. Journal of Applied Polymer Science 1997, 64, (11), 2105-2118.
13. Chattopadhyay, P.; Gupta, R. B., Supercritical CO2 Based Production of Magnetically Responsive Micro- and Nanoparticles for Drug Targeting. Industrial & Engineering Chemistry Research 2002, 41, (24), 6049-6058.
14. Thote, A. J.; Gupta, R. B., Formation of nanoparticles of a hydrophilic drug using supercritical carbon dioxide and microencapsulation for sustained release. Nanomedicine 2005, 1, (1), 85-90.
15. Snavely, W. K.; Subramaniam, B.; Rajewski, R. A.; Defelippis, M. R., Micronization of Insulin from Halogenated Alcohol Solution Using Supercritical Carbon Dioxide as an Antisolvent. Journal of Pharmaceutical Sciences 2002, 91, (9), 2026-2039.
16. Bustami, R. T.; Chan, H.-K.; Sweeney, T.; Dehghani, F.; Foster, N. R., Generation of Fine Powders of Recombinant Human Deoxyribonuclease Using the Aerosol Solvent Extraction System. Pharmaceutical Research 2003, 20, (12), 2028-2035.
17. Jarmer, D. J.; Lengsfeld, C. S.; Randolph, T. W., Scale-up Criteria for an Injector with a Confined Mixing Chamber During Precipitation with a Compressed-Fluid Antisolvent. Journal of Supercritical Fluids 2006, 37, (2), 242-253.
18. Shekunov, B. Y.; York, P., Crystallization Processes in Pharmaceutical Technology and Drug Delivery Design. Journal of Crystal Growth 2000, 211, (1-4), 122-136.
19. Bristow, S.; Shekunov, T.; Shekunov, B. Y.; York, P., Analysis of the Supersaturation and Precipitation Process with Supercritical CO2. Journal of Supercritical Fluids 2001, 21, (3), 257-271.
20. Elvassore, N.; Bertucco, A.; Caliceti, P., Production of Protein-Loaded Polymeric Microcapsules by Compressed CO2 in a Mixed Solvent. Industrial & Engineering Chemistry Research 2001, 40, (3), 795-800.
21. Chavez, F.; Debenedetti, P. G.; Luo, J. J.; Dave, R. N.; Pfeffer, R., Estimation of the Characteristic Time Scales in the Supercritical Antisolvent Process. Industrial & Engineering Chemistry Research 2003, 42, (13), 3156-3162.
22. Lobo, J. M.; Schiavone, H.; Palakodaty, S.; York, P.; Clark, A.; Tzannis, S. T., SCF-engineered Powders for Delivery of Budesonide from Passive DPI Devices. Journal of Pharmaceutical Sciences 2005, 94, (10), 2276-2288.
23. Perez, Y.; Wubbolts, F. E.; Witkamp, G. J.; Jansens, P. J.; de Loos, T. W., Improved PCA Process for the Production of Nano- and Microparticles of Polymers. AIChE Journal 2004, 50, (10), 2408-2417.
24. Jovanovic, N.; Bouchard, A.; Hofland, G. W.; Witkamp, G.-J.; Crommelin, D. J. A.; Jiskoot, W., Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology. Pharmaceutical Research 2004, 21, (11), 1955-1969.
25. Thiering, R.; Dehghani, F.; Foster, N. R., Current Issues Relating to Anti-Solvent Micronisation Techniques and their Extension to Industrial Scales. Journal of Supercritical Fluids 2001, 21, (2), 159-177.
26. Todo, H.; Iida, K.; Okamoto, H.; Danjo, K., Improvement of Insulin Absorption from Intratracheally Administrated Dry Powder Prepared by Supercritical Carbon Dioxide Process. Journal of Pharmaceutical Sciences 2003, 92, (12), 2475-2486.
27. Reverchon, E.; Delia Porta, G.; Di Trolio, A.; Pace, S., Supercritical Antisolvent Precipitation of Nanoparticles of Superconductor Precursors. Industrial & Engineering Chemistry Research 1998, 37, (3), 952-958.
28. Reverchon, E.; De Marco, I.; Torino, E., Nanoparticles production by supercritical antisolvent precipitation: A general interpretation. Journal of Supercritical Fluids 2007, 43, (1), 126-138.
29. Adami, R.; Reverchon, E.; Jaervenpaeae, E.; Huopalahti, R., Supercritical AntiSolvent micronization of nalmefene HCl on laboratory and pilot scale. Powder Technology 2008, 182, (1), 105-112
30. Yeo, S. D.; Lim, G. B.; Debenedetti, P. G.; Bernstein, H., Formation of Microparticulate Protein Powders Using a Supercritical Fluid Antisolvent. Biotechnology and Bioengineering 1993, 41, (3), 341-346.
31. Mammucari, R.; Dehghani, F.; Foster, N. R., Dense Gas Processing of Micron-Sized Drug Formulations Incorporating Hydroxypropylated and Methylated Beta-Cyclodextrin. Pharmaceutical Research 2006, 23, (2), 429-437.
32. Ben-Jebria, A.; Eskew, M. L.; Edwards, D. A., Inhalation System for Pulmonary Aerosol Drug Delivery in Rodents Using Large Porous Particles. Aerosol Science and Technology 2000, 32, (5), 421-433.
33. Dunbar, C.; Scheuch, G.; Sommerer, K.; DeLong, M.; Verma, A.; Batycky, R., In vitro and in vivo Dose Delivery Characteristics of Large Porous Particles for Inhalation. International Journal of Pharmaceutics 2002, 245, (1-2), 179-189.
34. Edwards, D. A.; Ben-Jebria, A.; Langer, R., Recent Advances in Pulmonary Drug Delivery Using Large, Porous Inhaled Particles. Journal of Applied Physiology 1998, 85, (2), 379-385.
35. Edwards, D. A.; Hanes, J.; Caponetti, G.; Hrkach, J.; Ben-Jebria, A.; Eskew, M. L.; Mintzes, J.; Deaver, D.; Lotan, N.; Langer, R., Large Porous Particles for Pulmonary Drug Delivery. Science (Washington, D. C) 1997, 276, (5320), 1868-1871.
36. Weng, W.-L.; Chen, J.-T.; Yang, J.-W.; Chang, J.-S., Isothermal Vapor-Liquid Equilibria of Binary Mixtures of Nitrogen with Dimethyl Sulfoxide, N-Methyl-2-pyrrolidone, and Diethylene Glycol Monobutyl Ether at Elevated Pressures. Journal of Chemical and Engineering Data 2007, 52, (2), 511-516.
37. Vos, W. L.; Schouten, J. A., Improved Phase Diagram of Nitrogen up to 85 kbar. Journal of Chemical Physics 1989, 91, (10), 6302-6305.
38. Chan, H.-K., Dry Powder Aerosol Delivery Systems: Current and Future Research Directions. Journal of Aerosol Medicine 2006, 19, (1), 21-27.
39. Tang, P.; Chan, H. K.; Raper, J. A., Prediction of Aerodynamic Diameter of Particles with Rough Surfaces. Powder Technology 2004, 147, (1-3), 64-78.
40. Brain, J. D., Inhalation, Deposition, and Fate of Insulin and Other Therapeutic Proteins. Diabetes Technology & Therapeutics 2007, 9, (S1), 4-15.
41. Crowder, T. M.; Rosati, J. A.; Schroeter, J. D.; Hickey, A. J.; Martonen, T. B., Fundamental Effects of Particle Morphology on Lung Delivery: Predictions of Stokes' Law and the Particular Relevance to Dry Powder Inhaler Formulation and Development. Pharmaceutical Research 2002, 19, (3), 239-245.
42. Chew, N. Y. K.; Chan, H.-K., Use of Solid Corrugated Particles to Enhance Powder Aerosol Performance. Pharmaceutical Research 2001, 18, (11), 1570-1577.
43. Mohamed, F.; van der Walle, C. F., PLGA Microcapsules with Novel Dimpled Surfaces for Pulmonary Delivery of DNA. International Journal of Pharmaceutics 2006, 311, (1-2), 97-107.
44. Ganser, G. H., A Rational Approach to Drag Prediction of Spherical and Nonspherical Particles. Powder Technology 1993, 77, (2), 143-152.