메뉴 건너뛰기




Volumn 7, Issue 4, 2014, Pages 156-166

Colonic smooth muscle cells and colonic motility patterns as a target for irritable bowel syndrome therapy: Mechanisms of action of otilonium bromide

Author keywords

gastrointestinal motility; irritable bowel syndrome; L type calcium channel; otilonium bromide; smooth muscle relaxants; spasmolytics; tachykinin receptor; visceral sensitization

Indexed keywords

CALCIUM; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; MUSCARINIC RECEPTOR; NEUROTRANSMITTER; NICOTINIC RECEPTOR; OTILONIUM BROMIDE; TACHYKININ RECEPTOR;

EID: 84904810839     PISSN: 1756283X     EISSN: 17562648     Source Type: Journal    
DOI: 10.1177/1756283X14525250     Document Type: Review
Times cited : (21)

References (53)
  • 1
    • 56749158003 scopus 로고    scopus 로고
    • Effects of excitatory and inhibitory neurotransmission on motor patterns of human sigmoid colon in vitro
    • Auli M. Martinez E. Gallego D. Opazo A. Espin F. Marti-Gallostra M. et al. (2008) Effects of excitatory and inhibitory neurotransmission on motor patterns of human sigmoid colon in vitro. Br J Pharmacol 155: 1043–1055.
    • (2008) Br J Pharmacol , vol.155 , pp. 1043-1055
    • Auli, M.1    Martinez, E.2    Gallego, D.3    Opazo, A.4    Espin, F.5    Marti-Gallostra, M.6
  • 2
    • 84878728679 scopus 로고    scopus 로고
    • High resolution colonic manometry – what have we learnt? A review of the literature 2012
    • Bampton P. Dinning P. (2013) High resolution colonic manometry – what have we learnt? A review of the literature 2012. Curr Gastroenterol Rep 15: 328.
    • (2013) Curr Gastroenterol Rep , vol.15 , pp. 328
    • Bampton, P.1    Dinning, P.2
  • 4
    • 84855541503 scopus 로고    scopus 로고
    • Targeting ion channels for the treatment of gastrointestinal motility disorders
    • Beyder A. Farrugia G. (2012) Targeting ion channels for the treatment of gastrointestinal motility disorders. Therap Adv Gastroenterol 5: 5–21.
    • (2012) Therap Adv Gastroenterol , vol.5 , pp. 5-21
    • Beyder, A.1    Farrugia, G.2
  • 6
    • 80054942059 scopus 로고    scopus 로고
    • The evaluation of otilonium bromide treatment in Asian patients with irritable bowel syndrome
    • Chang F. Lu C. Luo J. Chen T. Chen M. Chang H. (2011) The evaluation of otilonium bromide treatment in Asian patients with irritable bowel syndrome. J Neurogastroenterol Motil 17: 402–410.
    • (2011) J Neurogastroenterol Motil , vol.17 , pp. 402-410
    • Chang, F.1    Lu, C.2    Luo, J.3    Chen, T.4    Chen, M.5    Chang, H.6
  • 7
    • 0035012106 scopus 로고    scopus 로고
    • Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea
    • Chey W. Jin H. Lee M. Sun S. Lee K. (2001) Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea. Am J Gastroenterol 96: 1499–1506.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1499-1506
    • Chey, W.1    Jin, H.2    Lee, M.3    Sun, S.4    Lee, K.5
  • 9
    • 79960563170 scopus 로고    scopus 로고
    • Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome
    • Clave P. Acalovschi M. Triantafillidis J. Uspensky Y. Kalayci C. Shee V. et al. (2011) Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther 34: 432–442.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 432-442
    • Clave, P.1    Acalovschi, M.2    Triantafillidis, J.3    Uspensky, Y.4    Kalayci, C.5    Shee, V.6
  • 11
    • 0034751221 scopus 로고    scopus 로고
    • Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome
    • Czimmer J. Suto G. Kiraly A. Mozsik G. (2001) Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome. J Physiol Paris 95: 153–156.
    • (2001) J Physiol Paris , vol.95 , pp. 153-156
    • Czimmer, J.1    Suto, G.2    Kiraly, A.3    Mozsik, G.4
  • 12
    • 84884705426 scopus 로고    scopus 로고
    • Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: initial results from fiber-optic high-resolution manometry studies
    • Dinning P. Wiklendt L. Gibbins I. Patton V. Bampton P. Lubowski D. et al. (2013) Low-resolution colonic manometry leads to a gross misinterpretation of the frequency and polarity of propagating sequences: initial results from fiber-optic high-resolution manometry studies. Neurogastroenterol Motil 25: 640–649.
    • (2013) Neurogastroenterol Motil , vol.25 , pp. 640-649
    • Dinning, P.1    Wiklendt, L.2    Gibbins, I.3    Patton, V.4    Bampton, P.5    Lubowski, D.6
  • 14
    • 5744241657 scopus 로고    scopus 로고
    • Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome
    • Evangelista S. (2004) Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Curr Pharm Des 10: 3561–3568.
    • (2004) Curr Pharm Des , vol.10 , pp. 3561-3568
    • Evangelista, S.1
  • 15
    • 0033625649 scopus 로고    scopus 로고
    • A distribution study with (14) C-otilonium bromide in the rat: evidence for selective tropism for large intestine after oral administration
    • Evangelista S. Cochet P. Bromet N. Criscuoli M. Maggi C.A., (2000) A distribution study with (14)C-otilonium bromide in the rat: evidence for selective tropism for large intestine after oral administration. Drug Metab Dispos 28: 643–647.
    • (2000) Drug Metab Dispos , vol.28 , pp. 643-647
    • Evangelista, S.1    Cochet, P.2    Bromet, N.3    Criscuoli, M.4    Maggi, C.A.5
  • 17
    • 84859832232 scopus 로고    scopus 로고
    • The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide
    • Forte E. Pizzoferrato M. Lopetuso L. Scaldaferri F. (2012) The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide. Eur Rev Med Pharmacol Sci 16: 25–37.
    • (2012) Eur Rev Med Pharmacol Sci , vol.16 , pp. 25-37
    • Forte, E.1    Pizzoferrato, M.2    Lopetuso, L.3    Scaldaferri, F.4
  • 18
    • 0036903620 scopus 로고    scopus 로고
    • Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets
    • Furness J. Sanger G. (2002) Intrinsic nerve circuits of the gastrointestinal tract: identification of drug targets. Curr Opin Pharmacol 2: 612–622.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 612-622
    • Furness, J.1    Sanger, G.2
  • 20
    • 84884988959 scopus 로고    scopus 로고
    • In vitro motor patterns and electrophysiological changes in patients with colonic diverticular disease
    • Gallego D. Espin F. Mikulka J. Smirg O. Gil V. Faundez-Zanuy M. et al. (2013) In vitro motor patterns and electrophysiological changes in patients with colonic diverticular disease. Int J Colorectal Dis 28: 1413–1422.
    • (2013) Int J Colorectal Dis , vol.28 , pp. 1413-1422
    • Gallego, D.1    Espin, F.2    Mikulka, J.3    Smirg, O.4    Gil, V.5    Faundez-Zanuy, M.6
  • 21
    • 0030040181 scopus 로고    scopus 로고
    • Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells
    • Gandia L. Villarroya M. Lara B. Olmos V. Gilabert J. Lopez M. et al. (1996) Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol 117: 463–470.
    • (1996) Br J Pharmacol , vol.117 , pp. 463-470
    • Gandia, L.1    Villarroya, M.2    Lara, B.3    Olmos, V.4    Gilabert, J.5    Lopez, M.6
  • 22
    • 77951195847 scopus 로고    scopus 로고
    • The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes
    • Gibbons S. Strege P. Lei S. Roeder J. Mazzone A. Ou Y. et al. (2009) The alpha1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes. J Cell Mol Med 13: 4422–4431.
    • (2009) J Cell Mol Med , vol.13 , pp. 4422-4431
    • Gibbons, S.1    Strege, P.2    Lei, S.3    Roeder, J.4    Mazzone, A.5    Ou, Y.6
  • 23
    • 33750448274 scopus 로고    scopus 로고
    • Cholinergic regulation of epithelial ion transport in the mammalian intestine
    • Hirota C. McKay D. (2006) Cholinergic regulation of epithelial ion transport in the mammalian intestine. Br J Pharmacol 149: 463–479.
    • (2006) Br J Pharmacol , vol.149 , pp. 463-479
    • Hirota, C.1    McKay, D.2
  • 24
    • 0030983591 scopus 로고    scopus 로고
    • Tachykinins in the gut. Part I. Expression, release and motor function
    • Holzer P. Holzer-Petsche U. (1997) Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol Ther 73: 173–217.
    • (1997) Pharmacol Ther , vol.73 , pp. 173-217
    • Holzer, P.1    Holzer-Petsche, U.2
  • 25
    • 0035656920 scopus 로고    scopus 로고
    • Tachykinin receptors in the gut: physiological and pathological implications
    • Holzer P. Holzer-Petsche U. (2001) Tachykinin receptors in the gut: physiological and pathological implications. Curr Opin Pharmacol 1: 583–590.
    • (2001) Curr Opin Pharmacol , vol.1 , pp. 583-590
    • Holzer, P.1    Holzer-Petsche, U.2
  • 26
    • 0025951311 scopus 로고
    • Effect of voltage and cyclic AMP on frequency of slow-wave-type action potentials in canine colon smooth muscle
    • Huizinga J. Farraway L. Den Hertog A. (1991) Effect of voltage and cyclic AMP on frequency of slow-wave-type action potentials in canine colon smooth muscle. J Physiol 442: 31–45.
    • (1991) J Physiol , vol.442 , pp. 31-45
    • Huizinga, J.1    Farraway, L.2    Den Hertog, A.3
  • 27
    • 77949273309 scopus 로고    scopus 로고
    • Diarrhea-predominant irritable bowel syndrome is associated with diverticular disease: a population-based study
    • Jung H. Choung R. Locke G. 3rd Schleck C. Zinsmeister A. Talley N. (2010) Diarrhea-predominant irritable bowel syndrome is associated with diverticular disease: a population-based study. Am J Gastroenterol 105: 652–661.
    • (2010) Am J Gastroenterol , vol.105 , pp. 652-661
    • Jung, H.1    Choung, R.2    Locke, G.3    Schleck, C.4    Zinsmeister, A.5    Talley, N.6
  • 28
    • 34247594340 scopus 로고    scopus 로고
    • The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine
    • Lee H. Hennig G. Fleming N. Keef K. Spencer N. Ward S. et al. (2007) The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine. Gastroenterology 132: 1852–1865.
    • (2007) Gastroenterology , vol.132 , pp. 1852-1865
    • Lee, H.1    Hennig, G.2    Fleming, N.3    Keef, K.4    Spencer, N.5    Ward, S.6
  • 29
    • 0036900395 scopus 로고    scopus 로고
    • The colon-selective spasmolytic otilonium bromide inhibits muscarinic M. (3) receptor-coupled calcium signals in isolated human colonic crypts
    • Lindqvist S. Hernon J. Sharp P. Johns N. Addison S. Watson M. et al. (2002) The colon-selective spasmolytic otilonium bromide inhibits muscarinic M (3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol 137: 1134–1142.
    • (2002) Br J Pharmacol , vol.137 , pp. 1134-1142
    • Lindqvist, S.1    Hernon, J.2    Sharp, P.3    Johns, N.4    Addison, S.5    Watson, M.6
  • 30
    • 84862651150 scopus 로고    scopus 로고
    • Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis
    • Lovell R. Ford A. (2012) Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 10: 712–721.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 712-721
    • Lovell, R.1    Ford, A.2
  • 31
    • 0031213529 scopus 로고    scopus 로고
    • Tachykinins as peripheral modulators of primary afferent nerves and visceral sensitivity
    • Maggi C. (1997) Tachykinins as peripheral modulators of primary afferent nerves and visceral sensitivity. Pharmacol Res 36: 153–169.
    • (1997) Pharmacol Res , vol.36 , pp. 153-169
    • Maggi, C.1
  • 32
    • 0020518528 scopus 로고
    • Octylonium bromide: a smooth muscle relaxant which interferes with calcium ions mobilization
    • Maggi C. Manzini S. Meli A. (1983) Octylonium bromide: a smooth muscle relaxant which interferes with calcium ions mobilization. Arch Int Pharmacodyn Ther 264: 305–323.
    • (1983) Arch Int Pharmacodyn Ther , vol.264 , pp. 305-323
    • Maggi, C.1    Manzini, S.2    Meli, A.3
  • 33
    • 79960597293 scopus 로고    scopus 로고
    • T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome
    • Marger F. Gelot A. Alloui A. Matricon J. Ferrer J. Barrere C. et al. (2011) T-type calcium channels contribute to colonic hypersensitivity in a rat model of irritable bowel syndrome. Proc Natl Acad Sci U S A 108: 11268–11273.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11268-11273
    • Marger, F.1    Gelot, A.2    Alloui, A.3    Matricon, J.4    Ferrer, J.5    Barrere, C.6
  • 34
    • 2342467291 scopus 로고    scopus 로고
    • Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon
    • Martin M. Hove-Madsen L. Jimenez M. (2004) Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon. Neurogastroenterol Motil 16: 175–183.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 175-183
    • Martin, M.1    Hove-Madsen, L.2    Jimenez, M.3
  • 35
    • 84888053748 scopus 로고    scopus 로고
    • Mechanisms of action of otilonium bromide (OB) in human cultured smooth muscle cells and rat colonic strips
    • Martinez-Cutillas M. Gil V. Gallego D. Mane N. Martin M. Jimenez M. (2013) Mechanisms of action of otilonium bromide (OB) in human cultured smooth muscle cells and rat colonic strips. Neurogastroenterol Motil 12: 803–812.
    • (2013) Neurogastroenterol Motil , vol.12 , pp. 803-812
    • Martinez-Cutillas, M.1    Gil, V.2    Gallego, D.3    Mane, N.4    Martin, M.5    Jimenez, M.6
  • 36
    • 0028965467 scopus 로고
    • Heterogeneous functional expression of calcium channels at sensory and synaptic regions in nodose neurons
    • Mendelowitz D. Reynolds P. Andresen M. (1995) Heterogeneous functional expression of calcium channels at sensory and synaptic regions in nodose neurons. J Neurophysiol 73: 872–875.
    • (1995) J Neurophysiol , vol.73 , pp. 872-875
    • Mendelowitz, D.1    Reynolds, P.2    Andresen, M.3
  • 37
    • 0022633434 scopus 로고
    • Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide
    • Narducci F. Bassotti G. Granata M. Pelli M. Gaburri M. Palumbo R. et al. (1986) Colonic motility and gastric emptying in patients with irritable bowel syndrome. Effect of pretreatment with octylonium bromide. Dig Dis Sci 31: 241–246.
    • (1986) Dig Dis Sci , vol.31 , pp. 241-246
    • Narducci, F.1    Bassotti, G.2    Granata, M.3    Pelli, M.4    Gaburri, M.5    Palumbo, R.6
  • 38
    • 84875331207 scopus 로고    scopus 로고
    • Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid
    • Qian A. Song D. Li Y. Liu X. Tang D. Yao W. et al. (2013) Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid. Mol Pain 9: 15.
    • (2013) Mol Pain , vol.9 , pp. 15
    • Qian, A.1    Song, D.2    Li, Y.3    Liu, X.4    Tang, D.5    Yao, W.6
  • 40
    • 18744417893 scopus 로고    scopus 로고
    • Postjunctional electrical mechanisms of enteric neurotransmission
    • Suppl. 4
    • Sanders K. (2000) Postjunctional electrical mechanisms of enteric neurotransmission. Gut 47(Suppl. 4): 23–25.
    • (2000) Gut , vol.47 , pp. 23-25
    • Sanders, K.1
  • 41
    • 41949116232 scopus 로고    scopus 로고
    • Regulation of smooth muscle excitation and contraction
    • Suppl. 1
    • Sanders K. (2008) Regulation of smooth muscle excitation and contraction. Neurogastroenterol Motil 20(Suppl. 1): 39–53.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 39-53
    • Sanders, K.1
  • 42
    • 0013639286 scopus 로고    scopus 로고
    • Antimuscarinic, calcium channel blocker and tachykinin NK 2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon
    • Santicioli P. Zagorodnyuk V. Renzetti A. Maggi C. (1999) Antimuscarinic, calcium channel blocker and tachykinin NK 2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon. Naunyn Schmiedebergs Arch Pharmacol 359: 420–427.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.359 , pp. 420-427
    • Santicioli, P.1    Zagorodnyuk, V.2    Renzetti, A.3    Maggi, C.4
  • 43
    • 33749434109 scopus 로고    scopus 로고
    • Molecular, functional, and pharmacological targets for the development of gut promotility drugs
    • Sarna S. (2006) Molecular, functional, and pharmacological targets for the development of gut promotility drugs. Am J Physiol Gastrointest Liver Physiol 291: 545–555.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291 , pp. 545-555
    • Sarna, S.1
  • 44
    • 40349094787 scopus 로고    scopus 로고
    • Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats
    • Shin B. Kim J. Kim J. Hu S. Kim H. Hong S. et al. (2008) Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats. Arch Pharm Res 31: 117–124.
    • (2008) Arch Pharm Res , vol.31 , pp. 117-124
    • Shin, B.1    Kim, J.2    Kim, J.3    Hu, S.4    Kim, H.5    Hong, S.6
  • 45
    • 0026670326 scopus 로고
    • Potential-dependent inward currents in single isolated smooth muscle cells of the rat ileum
    • Smirnov S. Zholos A. Shuba M. (1992) Potential-dependent inward currents in single isolated smooth muscle cells of the rat ileum. J Physiol 454: 549–571.
    • (1992) J Physiol , vol.454 , pp. 549-571
    • Smirnov, S.1    Zholos, A.2    Shuba, M.3
  • 46
    • 84861084509 scopus 로고    scopus 로고
    • Is it diverticular disease or is it irritable bowel syndrome?
    • Spiller R. (2012) Is it diverticular disease or is it irritable bowel syndrome? Dig Dis 30: 64–69.
    • (2012) Dig Dis , vol.30 , pp. 64-69
    • Spiller, R.1
  • 47
    • 2342484968 scopus 로고    scopus 로고
    • Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle
    • Strege P. Evangelista S. Lyford G. Sarr M. Farrugia G. (2004) Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle. Neurogastroenterol Motil 16: 167–173.
    • (2004) Neurogastroenterol Motil , vol.16 , pp. 167-173
    • Strege, P.1    Evangelista, S.2    Lyford, G.3    Sarr, M.4    Farrugia, G.5
  • 49
    • 0030794522 scopus 로고    scopus 로고
    • The clinical pharmacology of single doses of otilonium bromide in healthy volunteers
    • Sutton J. Kilminster S. Mould G. (1997) The clinical pharmacology of single doses of otilonium bromide in healthy volunteers. Eur J Clin Pharmacol 52: 365–369.
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 365-369
    • Sutton, J.1    Kilminster, S.2    Mould, G.3
  • 50
    • 65949103174 scopus 로고    scopus 로고
    • Muscarinic receptor subtypes in the alimentary tract
    • Tobin G. Giglio D. Lundgren O. (2009) Muscarinic receptor subtypes in the alimentary tract. J Physiol Pharmacol 60: 3–21.
    • (2009) J Physiol Pharmacol , vol.60 , pp. 3-21
    • Tobin, G.1    Giglio, D.2    Lundgren, O.3
  • 51
    • 0005956503 scopus 로고    scopus 로고
    • Role of tachykinin NK 2 receptors in normal and altered rectal sensitivity in rats
    • Toulouse M. Coelho A. Fioramonti J. Lecci A. Maggi C. Buéno L. (2000) Role of tachykinin NK 2 receptors in normal and altered rectal sensitivity in rats. Br J Pharmacol 129: 193–199.
    • (2000) Br J Pharmacol , vol.129 , pp. 193-199
    • Toulouse, M.1    Coelho, A.2    Fioramonti, J.3    Lecci, A.4    Maggi, C.5    Buéno, L.6
  • 52
    • 0003096661 scopus 로고    scopus 로고
    • Fundamentals of neurogastroenterology
    • Suppl. 2
    • Wood J. Alpers D. Andrews P. (1999) Fundamentals of neurogastroenterology. Gut 45(Suppl. 2): 6–16.
    • (1999) Gut , vol.45 , pp. 6-16
    • Wood, J.1    Alpers, D.2    Andrews, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.