Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon

Neurogastroenterology and Motility

Volumn 16, Issue 2, 2004, Pages 175-183

  Martin, M T ^a   Hove Madsen, L ^a   Jimenez, M ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Electrophysiology; Muscle bath; Otilonium bromide; Patch clamp; Rat colon

Indexed keywords

AMPHOTERICIN; CALCIUM CHANNEL L TYPE; CALCIUM ION; NIFEDIPINE; OTILONIUM BROMIDE; TETRODOTOXIN; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; COLON; COLON MOTILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; MALE; MUSCLE ACTION POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SPASMOLYSIS;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELLS, CULTURED; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; MALE; MICROELECTRODES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; QUATERNARY AMMONIUM COMPOUNDS; RATS;

EID: 2342467291     PISSN: 13501925     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2004.00518.x     Document Type: Article

References (26)

1. Evangelista S. Otilonium bromide: a selective spasmolytic for the gastrointestinal tract. J Int Med Res 1999; 27: 207-22.
2. Glende M, Morselli-Labate AM, Battaglia G, Evangelista S. Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome. Eur J Gastroenterol Hepatol 2002; 14: 1331-8.
3. Battaglia G, Morselli-Labate AM, Camarri E et al. Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther 1998; 12: 1003-10.
4. Czimmer J, Suto G, Kiraly A, Mozsik G. Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome. J Physiol Paris 2001; 95: 153-45.
5. Lindqvist S, Hemon J, Sharp P et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol 2002; 137: 1134-42.
6. Santicioli P, Zagorodnyuk V, Renzetti AR, Maggi CA. Antimuscarinic, calcium channel blocker and tachykinin NK2 receptor antagonist actions of otilonium bromide in the circular muscle of guinea-pig colon. Naunyn Schmiedebergs Arch Pharmacol 1999; 359: 420-7.
7. Evangelista S, Giachetti A, Chapelain B, Neliat G, Maggi CA. Receptor binding profile of otilonium bromide. Pharmacol Res 1998; 38: 111-7.
8. Gandia L, Lopez MG, Villarroya M et al. Blocking effects of otilonium on Ca2+ channels and secretion in rat chromaffin cells. Eur J Pharmacol 1996; 298: 199-205.
9. Evangelista S, Cochet P, Bromet N, Criscuoli M, Maggi CA. A distribution study with (14)C-otilonium bromide in the rat: evidence for selective tropism for large intestine after oral administration. Drug Metab Dispos 2000; 28: 643-7.
10. Pluja L, Fernandez E, Jimenez M. Neural modulation of the cyclic electrical and mechanical activity in the rat colonic circular muscle: putative role of ATP and NO. Br J Pharmacol 1999; 126: 883-92.
11. Pluja L, Alberti E, Fernandez E, Mikkelsen HB, Thuneberg L, Jimenez M. Evidence supporting presence of two pacemakers in rat colon. Am J Physiol Gastrointest Liver Physiol 2001; 281: G255-66.
12. Gonzalez A, Sarna SK. Different types of contractions in rat colon and their modulation by oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001; 280: G546-54.
13. Gonzalez A, Sarna SK. Neural regulation of in vitro giant contractions in the rat colon. Am J Physiol Gastrointest Liver Physiol 2001; 281: G275-82.
14. Li M, Johnson CP, Adams MB, Sarna SK. Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colon. Am J Physiol Gastrointest Liver Physiol 2002; 283: G544-52.
15. Pluja L, Fernandez E, Jimenez M. Electrical and mechanical effects of vasoactive intestinal peptide and pituitary adenylate cyclase-activating peptide in the rat colon involve different mechanisms. Eur J Pharmacol 2000; 389: 217-24.
16. Rae MG, Fleming N, McGregor DB, Sanders KM, Keef KD. Control of motility patterns in the human colonic circular muscle layer by pacemaker activity. J Physiol 1998; 510: 309-20.
17. Boeckxstaens GE, Pelckmans PA, Herman AG, Van Maercke YM. Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 1993; 104: 690-7.
18. Xue L, Farrugia G, Sarr MG, Szurszewski JH. ATP is a mediator of the fast inhibitory junction potential in human jejunal circular smooth muscle. Am J Physiol 1999; 276: 1373-9.
19. Hollywood MA, Woolsey S, Walsh IK, Keane PF, McHale NG, Thornbury KD. T- and L-type Ca2+ currents in freshly dispersed smooth muscle cells from the human proximal urethra. J Physiol 2003; 550: 753-64.
20. Mery PF, Hove-Madsen L, Mazet JL, Hanf R, Fischmeister R. Binding constants determined from Ca2+ current responses to rapid applications and washouts of nifedipine in frog cardiac myocytes. J Physiol 1996; 494: 105-20.
21. Giachetti A. Pharmacological studies on otilonium bromide. Ital J Gastroenterol 1991; 23: 56-9.
22. Borderies JR, Gonalons E, Angel F, Vergara P, Jimenez M. Effect of different calcium channel blockers on inhibitory junction potentials and slow waves in porcine ileum. Life Sci 1997; 60: 883-92.
23. Cayabyab FS, deBruin H, Jimenez M, Daniel EE. Ca2+ role in myogenic and neurogenic activities of canine ileum circular muscle. Am J Physiol 1996; 271: 1053-66.
24. Borderies JR, Jimenez M, Angel F. Non-adrenergic, non-cholinergic inhibitory junction potential in rat colonic circular muscle is partly sensitive to omega-conotoxin GVIA and resistant to L-, P- or Q-type calcium channel blockers. Neurosci Lett 1996; 210: 91-4.
25. Zagorodnyuk V, Maggi CA. Neuronal tachykinin NK2 receptors mediate release of non-adrenergic non-cholinergic inhibitory transmitters in the circular muscle of guinea-pig colon. Neuroscience 1995; 69: 643-50.
26. Mule F, D'Angelo S, Tabacchi G, Serio R. Involvement of tachykinin NK2 receptors in the modulation of spontaneous motility in rat proximal colon. Neurogastroenterol Motil 2000; 12: 459-66.