In vitro and in vivo antitumor activity of scutebarbatine a on human lung carcinoma A549 cell lines

Molecules

Volumn 19, Issue 7, 2014, Pages 8740-8751

  Yang, Xiao Kun ^a   Xu, Ming Yuan ^a   Xu, Gui Sen ^a   Zhang, Yu Lan ^a   Xu, Zhao Xia ^a  

^a CHENGDU MILITARY GENERAL HOSPITAL   (China)

Author keywords

A549 cells; Antitumor; Apoptosis; Lung cancer; Scutebarbatine a

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; NAPHTHOL DERIVATIVE; NICOTINIC ACID; SCUTEBARBATINE A;

ANIMAL; APOPTOSIS; CELL PROLIFERATION; CELL SHAPE; DRUG EFFECTS; DRUG SCREENING; HUMAN; METABOLISM; NUDE MOUSE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; HUMANS; MICE, NUDE; NAPHTHOLS; NIACIN; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904786885     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19078740     Document Type: Article

References (23)

1. Jemal, A.; Siegel, R.; Ward, E. Cancer statistics. CA Cancer J. Clin. 2007, 57, 43-66.
2. Wen, J.; Fu, J.H.; Zhang, W.; Guo, M. Genetic and epigenetic changes in lung carcinoma and their clinical implications. Modern Pathol. 2011, 24, 932-943.
3. Liu, Y.; Sun, W.Y.; Zhang, K.T.; Zheng, H.W.; Ma, Y.; Lin, D.M. Identification of genes differentially expressed in human primary lung squamous cell carcinoma. Lung Cancer 2007, 56, 307-317.
4. Smith, E.L.; Denissenko, M.F.; Bennett, W.P. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J. Natl. Cancer Inst. 2000, 92, 803-811.
5. Li, X.J.; Zhang, H.Y. Western healers in traditional Chinese medicine. EMBO Rep. 2008, 9, 112-113.
6. Schmidt, B.M.; Ribnicky, D.M.; Lipsky, P.E.; Raskin, I. Revisiting the ancient concept of botanical therapeutics. Nat. Chem. Biol. 2007, 3, 360-366.
7. Peng, W.; Guo, L.; Zheng, C.J.; Zhang, Q.Y.; Zhang, H.; Huang, B.K. Two new azaphilone alkaloids dimers from endophytic Chaetomium fusiform of the liverwort Scapania verrucosa Heeg. Biochem. Syst. Ecol. 2012, 45, 124-126.
8. Meng, Z.; Garrett, C.R.; Shen, Y.; Liu, L.; Yang, P.; Huo, Y. Prospective randomized evaluation of traditional chinese medicine combined with chemotherapy: A randomize phase III study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas. Br. J. Cancer 2012, 107, 411-416.
9. Ye, C.L.; Huang, Q. Extraction of polysaccharides from herbal Scutellaria barbata D. Don (Ban-Zhi-Lian) and their antioxidant activity. Carbohydr. Polym. 2012, 89, 1131-1137.
10. Yin, X.L.; Zhou, J.B.; Jie, C.F.; Xing, D.M.; Zhang, Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci. 2004, 75, 2233-2244.
11. Shiau, A.L.; Shen, Y.T.; Hsieh, J.L.; Wu, C.L.; Lee, C.H. Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 α in lung tumor. Environ. Toxicol. 2014, 29, 363-370.
12. Marconett, C.N.; Morgenstern, T.J.; Roman, A.K.S.; Sundar, S.N.; Singhal, A.K.; Firestone, G.L. BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. Cancer Biol. Ther. 2010, 10, 397-405.
13. Jiangsu New Medical College. Dictionary of Chinese Materia Medica; Science and Technology Press of Shanghai: Shanghai, China, 1977.
14. Dai, S.J.; Tao, J.Y.; Liu, K.; Jiang, Y.T.; Shen, L. neo-Clerodane diterpenoids from Scutellaria barbata with cytotoxic activities. Phytochemistry 2006, 67, 1326-1330.
15. Wang, G.; Wang, F.; Liu, J.K. Two new phenols from Scutellaria barbata. Molecules 2011, 16, 1402-1408.
16. Dai, S.J.; Peng, W.B.; Shen, L.; Zhang, D.W.; Ren, Y. New norditerpenoid alkaloids from Scutellaria barbata with cytotoxic activities. Nat. Prod. Res. 2011, 25, 1019-1024.
17. Yang, X.K.; Yang, Y.D.; Tang, S.Q. Inhibitory effect of polysaccharides from Scutellaria barbata D. Don on invasion and metastasis of 95-D cells lines via regulation of C-MET and E-CAD expressions. Trop. J. Pharm. Res. 2013, 12, 517-522.
18. Ma, Y.S.; Weng, S.W.; Lin, M.W.; Lu, C.C.; Chiang, J.H.; Yang, J.S. Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model. Food Chem. Toxicol. 2012, 50, 1271-1278.
19. Zhang, X.T.; Zhao, M.; Chen, L.Y. Triterpenoid from Thalictrum fortunei induces apoptosis in BEL-7402 cells through the P53-induced apoptosis pathway. Molecules 2011, 16, 9505-9519.
20. Skerman, N.B.; Joubert, A.M.; Cronjé, M.J. The apoptosis inducing effects of Sutherlandia spp. extracts on an oesophageal cancer cell line. J. Ethnopharmacol. 2011, 137, 1250-1260.
21. Hsu, S.C.; Chung, J.G. Anticancer potential of emodin. BioMedicine 2012, 2, 108-116.
22. Wu, J.G.; Ma, L.; Zhang, S.Y. Essential oil from rhizomes of Ligusticum chuanxiong induces apoptosis in hypertrophic scar fibroblasts. Pharm. Biol. 2011, 49, 86-93.
23. Su, Y.T.; Chang, H.L.; Shyue, S.K.; Hsu, S.L. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochem. Pharmacol. 2005, 70, 229-241.